EKS-CAE-00125

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAE-00125

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/RSK	319.3	3.3E-95	17	284	268

Status

Reviewed

Ensembl Protein

C54G4.1a

UniProt Accession

Q18846; Q1ZXU3;

Protein Name

Putative ribosomal protein S6 kinase alpha-2

Protein Synonyms/Alias

Ribosomal protein S6 kinase alpha-5 homolog;

Gene Name

rskn-2

Gene Synonyms/Alias

rskn-2; C54G4.1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
C54G4.1	C54G4.1a	C54G4.1a
C54G4.1	C54G4.1b	C54G4.1b

Organism

Caenorhabditis elegans

Functional Description

Serine/threonine kinase that may play a role inmediating the mitogen- and stress-induced effects on transcription. May repress transcription via phosphorylation of 'Ser-1' of histone H2A. May phosphorylate histone H3 (By similarity).

Protein Length

772

Protein Sequence
(FASTA)

MEDILMPEGE KVSMENFALL RVLGKGAYGK VFLVRKVGGK DHNTIYAMKV LRKTRVLTKQ 60

KTLEHTMAER QVLERLRGTP FLVNLFYAFQ TDTKLHIVME YVRGGELFTH LCSRGHFDLE 120

AARFVIAELV VAIDSLHQRK VIYRDLKLEN ILLDEEGHVK LTDFGLSKLF LPGELDRANS 180

YCGTIEYMSP EVINRPEGGY SDVVDWWSLG VISFELLTGC SPFTVDGAQN SSKDIAKRIM 240

TKKVPFPKTM DVDARDFIGQ LLEKKLEKRL GYNGVDEIKN HKFMSSIDWD AAVKRTLKPV 300

IVPRIGHDLD TQFFSAEFTS QPPLYSPAES PLNANTLFRG YSYVSPSVIF ANDNVIGEEL 360

MAEDVNALLA SSSFFAKYKL DKSDAGLLGK GAFSVVRRCE RVVDGAQFAV KIVSQKFASQ 420

AQREARILEM VQGHPNIVQL HDVHSDPLHF YLVMEILTGN ELLERIRKLE RFTESEAADI 480

MRQLVSAVKY LHDKRIVHRD LKPENILFES IDSSARLRLV DFGFARLLPN SMEQQLKSVQ 540

VLRKMTPCFT LQYAAPEVLD VGDSQPEYNE QCDLWSLGVV LFTMLSGQVP FHARSRQESA 600

TEIMQRICRA EFSFTGDAWT NVSADAKNLI TGLLTVDPKK RLSMQELTAH MWLKSSASMD 660

TPLQTPSILP SSADETFNET LRAFLHANRD GFHLLDVAAA PLMKRRGIKR QSGDKDASGN 720

SKNSRVTQFE CLPEEQEAEM TSSTSRPSNL GMMNYREPNS GTIRETRGSD SS 772

Nucleotide Sequence
(FASTA)

ATGGAAGATA TATTGATGCC TGAAGGAGAG AAAGTTTCCA TGGAGAACTT TGCTCTCCTC 60

AGAGTTCTTG GAAAAGGAGC ATATGGAAAA GTATTCCTTG TGCGAAAAGT TGGTGGAAAG 120

GATCATAATA CTATATATGC TATGAAAGTG TTGAGAAAGA CCAGAGTGCT CACAAAACAA 180

AAAACCCTGG AGCACACAAT GGCAGAGCGT CAAGTACTTG AACGTCTACG TGGAACACCA 240

TTTCTTGTCA ATTTGTTCTA TGCTTTCCAA ACTGATACCA AATTGCACAT TGTAATGGAA 300

TATGTGAGAG GAGGAGAATT ATTCACACAT CTTTGCTCGA GAGGTCATTT TGATTTAGAA 360

GCTGCTAGAT TTGTAATTGC TGAACTTGTG GTTGCAATTG ATAGTCTTCA TCAAAGAAAA 420

GTTATTTATC GAGATTTGAA GCTTGAGAAT ATTTTATTGG ACGAAGAAGG ACACGTTAAG 480

TTGACAGATT TTGGATTAAG TAAATTGTTT CTACCCGGAG AGTTGGATAG AGCCAATTCA 540

TATTGTGGAA CTATTGAATA TATGTCGCCA GAAGTAATCA ATCGCCCTGA AGGAGGATAC 600

AGTGATGTTG TCGATTGGTG GTCTTTGGGT GTAATTTCAT TTGAATTGCT CACTGGATGC 660

TCACCATTTA CTGTAGATGG AGCACAAAAC TCTAGTAAAG ATATTGCCAA ACGAATTATG 720

ACAAAGAAGG TCCCTTTCCC AAAAACTATG GATGTTGATG CTCGCGATTT CATCGGCCAA 780

TTGTTGGAAA AGAAACTTGA AAAACGTCTC GGATACAATG GAGTTGATGA AATTAAAAAT 840

CATAAATTTA TGTCAAGTAT TGACTGGGAT GCAGCTGTTA AGCGTACATT GAAGCCAGTG 900

ATTGTTCCAA GAATTGGACA TGATTTGGAT ACACAGTTCT TCTCAGCTGA ATTCACTTCT 960

CAGCCACCAT TATATTCTCC TGCAGAGTCA CCATTAAATG CTAATACTCT GTTTAGAGGA 1020

TACTCATATG TCTCCCCATC TGTTATATTT GCCAATGACA ATGTTATCGG TGAAGAACTA 1080

ATGGCTGAAG ATGTCAATGC ACTTCTCGCG AGTTCTTCAT TTTTTGCCAA GTACAAACTA 1140

GACAAGTCGG ACGCTGGTCT TTTAGGAAAA GGAGCTTTTT CGGTGGTCAG ACGATGCGAA 1200

CGCGTAGTTG ACGGAGCCCA GTTTGCAGTC AAAATCGTAT CACAAAAGTT CGCAAGTCAG 1260

GCTCAACGTG AAGCACGAAT TCTTGAAATG GTTCAAGGAC ATCCGAATAT TGTTCAACTT 1320

CATGATGTAC ATTCGGATCC TCTTCATTTT TATCTCGTCA TGGAGATTCT GACTGGAAAT 1380

GAGCTGCTCG AGAGAATTCG AAAATTGGAA CGATTTACAG AGAGTGAAGC AGCAGACATC 1440

ATGCGGCAGT TGGTATCAGC TGTGAAATAT CTTCATGATA AAAGAATTGT TCATCGAGAT 1500

TTGAAACCAG AGAATATTCT ATTTGAAAGT ATCGATTCAA GTGCCCGCCT TCGTCTAGTC 1560

GATTTTGGAT TTGCACGTCT ACTTCCAAAT TCAATGGAAC AACAACTGAA GTCTGTTCAA 1620

GTTCTGCGCA AGATGACCCC CTGCTTCACA CTACAGTATG CTGCTCCAGA AGTTTTAGAT 1680

GTTGGAGATT CTCAACCAGA ATACAACGAA CAATGTGATT TATGGTCACT TGGAGTTGTA 1740

CTGTTCACAA TGCTATCGGG TCAAGTTCCA TTCCATGCAC GTTCTCGTCA AGAATCGGCA 1800

ACTGAAATAA TGCAGAGAAT TTGTAGAGCA GAATTCTCAT TCACAGGAGA CGCATGGACA 1860

AACGTGTCAG CAGATGCTAA GAATTTAATA ACCGGTCTTC TTACTGTGGA TCCAAAGAAA 1920

CGTCTTTCAA TGCAAGAGCT TACAGCTCAT ATGTGGCTCA AGTCTTCGGC TTCAATGGAT 1980

ACACCACTTC AAACTCCTAG TATTCTGCCA TCATCAGCAG ATGAAACATT CAATGAGACA 2040

CTGCGCGCAT TCCTCCACGC TAATCGTGAT GGATTCCATC TTCTCGATGT TGCTGCTGCT 2100

CCTCTCATGA AACGACGCGG AATCAAAAGA CAATCTGGGG ACAAGGATGC TTCTGGAAAC 2160

TCGAAAAATT CGCGAGTTAC CCAATTCGAG TGTCTTCCGG AAGAACAAGA AGCAGAGATG 2220

ACATCATCAA CATCCCGTCC AAGCAATTTG GGAATGATGA ACTATCGAGA ACCAAATTCT 2280

GGAACAATCC GAGAAACTCG TGGCTCAGAC TCCTCCTAG 2319

Domain Profile

S: 1     fellkvlgkGaygkvflvrkvekkdtgklyavKvlkkaelvk..kkkertkeereiLeev  58

         f ll+vlgkGaygkvflvrkv +kd++++ya+Kvl+k+++++  k+ e+t++er++Le++

Q: 17    FALLRVLGKGAYGKVFLVRKVGGKDHNTIYAMKVLRKTRVLTkqKTLEHTMAERQVLERL  76

         7899***********************************99877899*************

S: 59    eh.pfivklheafqdekklylvlellkGgeLlerlkkkklfseeeasfilaelvlaleyl  117

         +  pf+v+l++afq+++kl++v+e+++GgeL+++l ++++f+ e a+f++aelv+a++ l

Q: 77    RGtPFLVNLFYAFQTDTKLHIVMEYVRGGELFTHLCSRGHFDLEAARFVIAELVVAIDSL  136

         ************************************************************

S: 118   HskgvvyrDLkpeNilldeeghvkltDfglakekiaeneekaysfcgTleyvaPevlkrk  177

         H+++v+yrDLk+eNilldeeghvkltDfgl+k   + +  +a+s+cgT+ey++Pev++r

Q: 137   HQRKVIYRDLKLENILLDEEGHVKLTDFGLSKLFLPGELDRANSYCGTIEYMSPEVINRP  196

         *********************************************************876

S: 178   ..gydeavDlwslGvllyemLtGktPftgeerketlarilkgkfslklpaweelseeakd  235

           gy++ vD+wslGv+ +e+LtG++Pft +  +++ + i k  ++ k+p  ++++ +a+d

Q: 197   egGYSDVVDWWSLGVISFELLTGCSPFTVDGAQNSSKDIAKRIMTKKVPFPKTMDVDARD  256

         569****************************9998888888888888888888*******

S: 236   lvkklLkkdpakRlga.taeeikehkfl  262

         ++ +lL+k+ +kRlg+ +++eik+hkf+

Q: 257   FIGQLLEKKLEKRLGYnGVDEIKNHKFM  284

         ***************99*********96

Domain Sequence
(FASTA)

FALLRVLGKG AYGKVFLVRK VGGKDHNTIY AMKVLRKTRV LTKQKTLEHT MAERQVLERL 60

RGTPFLVNLF YAFQTDTKLH IVMEYVRGGE LFTHLCSRGH FDLEAARFVI AELVVAIDSL 120

HQRKVIYRDL KLENILLDEE GHVKLTDFGL SKLFLPGELD RANSYCGTIE YMSPEVINRP 180

EGGYSDVVDW WSLGVISFEL LTGCSPFTVD GAQNSSKDIA KRIMTKKVPF PKTMDVDARD 240

FIGQLLEKKL EKRLGYNGVD EIKNHKFM 268

Keyword

Alternative splicing; ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0009792	; P:embryo development ending in birth or egg hatching
GO:0040007	; P:growth
GO:0007243	; P:intracellular protein kinase cascade
GO:0002119	; P:nematode larval development

KEGG

cel:CELE_C54G4.1

;

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016239	; Ribosomal_S6_kinase_II.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 2.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 2.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 2.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00108	; PROTEIN_KINASE_ST; 2.

Prints

Created Date

20-Feb-2013