EKS-CAE-00184

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAE-00184

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/NKF2	582.9	3.0E-175	137	483	347

Status

Reviewed

Ensembl Protein

EEED8.9.1

UniProt Accession

Q09298;

Protein Name

Serine/threonine-protein kinase pink-1, mitochondrial

Protein Synonyms/Alias

PTEN-induced kinase 1 homolog;

Gene Name

pink-1

Gene Synonyms/Alias

pink-1; EEED8.9;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
EEED8.9	EEED8.9.2	EEED8.9.2
EEED8.9	EEED8.9.1	EEED8.9.1

Organism

Caenorhabditis elegans

Functional Description

Protects against mitochondrial dysfunction duringcellular stress, potentially by phosphorylating mitochondrial proteins (By similarity).

Protein Length

641

Protein Sequence
(FASTA)

MSMKRFGKAA YRIANELVAK GGRLPIFQRF LPRIFPATYN LGVHVVLKKA PFPRQNALRI 60

ARLVTRHGRV FRPFSSVIIE RHRFQNQNDW RRKFQPIRKE LPRNVDLVER IRQIFGNSLR 120

YNEDLKSTEW PNRIDSYEFG EFLGQGCNAA VYSARLANSD AESSGNTHYG AGFNEVTNIL 180

AEIPPVSKVA QKKFPLAIKL MFNFEHDRDG DAHLLKSMGN ELAPYPNAAK LLNGQMGTFR 240

PLPAKHPNVV RIQTAFIDSL KVLPDAIERY PDALHTARWY ESIASEPKTM YVVMRRYRQT 300

LHEYVWTRHR NYWTGRVIIA QLLEACTYLH KHKVAQRDMK SDNILLEYDF DDEIPQLVVA 360

DFGCALACDN WQVDYESDEV SLGGNAKTKA PEIATAVPGK NVKVNFEMAD TWAAGGLSYE 420

VLTRSNPFYK LLDTATYQES ELPALPSRVN FVARDVIFDL LKRDPNERVK PNIAANALNL 480

SLFRMGEDVK QMMEKCGISQ MTTLLAGSSK VLSQKINSRL DKVMNLITAE TIMANLAPHL 540

ISRAERQLRA TFLSRMNRED IWRSLQYFFP AGVQLDTPAT SSDCLETISS LMSSFSNDSE 600

NYEKQQKPAK NGYNNVPLLL RNVIRTDADG INGIVHRVRS K 641

Nucleotide Sequence
(FASTA)

ATGTCTATGA AACGATTCGG AAAAGCAGCA TATCGAATCG CAAATGAGTT AGTTGCAAAA 60

GGTGGACGAC TACCAATTTT CCAACGCTTC CTGCCGAGAA TATTTCCCGC CACTTATAAT 120

TTAGGAGTTC ATGTCGTACT CAAAAAGGCT CCATTTCCAC GACAAAATGC TCTACGAATT 180

GCTCGCCTTG TAACTCGCCA CGGTCGAGTT TTCCGGCCAT TTTCCTCAGT AATAATCGAA 240

AGACATCGAT TTCAAAATCA AAATGATTGG CGTCGAAAGT TTCAACCGAT TCGTAAAGAA 300

TTGCCAAGAA ATGTGGATTT AGTCGAACGA ATCAGGCAGA TATTTGGCAA TTCTCTACGA 360

TACAATGAGG ATTTGAAAAG CACTGAATGG CCGAATAGAA TTGATTCTTA TGAGTTTGGG 420

GAATTTCTCG GTCAAGGATG CAATGCAGCA GTTTACTCTG CGAGATTAGC CAATTCTGAT 480

GCAGAATCCT CAGGGAATAC TCACTATGGT GCAGGGTTTA ATGAAGTCAC AAATATACTT 540

GCAGAAATTC CGCCAGTTAG CAAAGTTGCA CAAAAGAAAT TCCCGTTGGC AATCAAATTA 600

ATGTTTAATT TTGAACATGA TCGCGATGGA GATGCTCATC TCTTGAAATC AATGGGAAAT 660

GAATTGGCTC CATATCCGAA TGCTGCAAAG TTGCTCAATG GACAAATGGG AACATTTAGA 720

CCTCTTCCAG CAAAACATCC AAATGTTGTT CGAATTCAGA CAGCTTTTAT TGATTCGTTA 780

AAAGTTTTGC CAGATGCGAT TGAACGATAT CCAGATGCCC TTCACACTGC ACGTTGGTAT 840

GAGTCAATTG CCTCCGAACC GAAAACAATG TACGTAGTAA TGAGACGATA CCGACAAACA 900

CTTCATGAAT ATGTATGGAC TCGTCATCGA AATTATTGGA CAGGACGAGT GATAATTGCT 960

CAACTATTAG AAGCATGTAC ATATCTTCAT AAGCATAAAG TTGCTCAGCG AGACATGAAA 1020

AGTGATAATA TTCTTCTGGA ATATGATTTT GACGACGAGA TTCCCCAATT AGTTGTCGCC 1080

GATTTTGGAT GTGCACTTGC ATGTGACAAT TGGCAAGTAG ACTATGAATC AGATGAAGTT 1140

AGTCTTGGAG GAAATGCCAA GACAAAAGCA CCAGAAATTG CGACGGCTGT TCCTGGAAAG 1200

AATGTAAAAG TAAACTTCGA AATGGCAGAT ACATGGGCAG CTGGAGGCCT TTCTTATGAA 1260

GTTCTAACAC GATCAAATCC ATTCTACAAA CTTCTTGATA CTGCAACATA CCAGGAATCA 1320

GAACTACCAG CACTCCCATC TCGTGTCAAT TTTGTGGCAC GAGATGTCAT TTTTGACCTA 1380

CTCAAGCGAG ATCCTAATGA AAGAGTCAAG CCGAATATTG CTGCAAATGC GTTGAATTTG 1440

TCATTGTTCA GAATGGGAGA AGATGTGAAG CAGATGATGG AAAAATGTGG AATATCTCAA 1500

ATGACTACTC TATTGGCTGG AAGTTCTAAA GTTTTGAGTC AAAAAATCAA TAGTCGTCTG 1560

GACAAAGTGA TGAATCTGAT TACTGCTGAA ACTATCATGG CCAACCTAGC TCCACATTTG 1620

ATTAGTCGAG CAGAACGACA ACTTCGAGCA ACATTTCTTT CAAGAATGAA TCGAGAAGAT 1680

ATTTGGAGAA GTCTTCAATA TTTCTTCCCA GCTGGTGTTC AACTTGACAC ACCTGCCACA 1740

TCATCAGACT GTTTGGAGAC TATTTCCAGT TTGATGTCGA GTTTTTCAAA TGATTCAGAA 1800

AATTACGAGA AGCAACAGAA ACCGGCTAAA AATGGATACA ACAATGTTCC ACTTCTTCTC 1860

AGAAATGTTA TCCGTACAGA TGCGGATGGA ATCAATGGAA TTGTACATAG AGTTCGATCT 1920

AAATAG 1926

Domain Profile

S: 1     yligealgkgcnaavyeatlatldqelekakhlgllgkevtvvlaeidqesavaakkfpl  60

         y++ge+lg+gcnaavy+a+la++d+e+++++h+g++++evt++laei+++s+va+kkfpl

Q: 137   YEFGEFLGQGCNAAVYSARLANSDAESSGNTHYGAGFNEVTNILAEIPPVSKVAQKKFPL  196

         99**********************************************************

S: 61    aiklmfnieadsssea.llksmsqelvpasrva..ldgeygavpkllakhPnivrvlraf  117

         aiklmfn+e+d++++a llksm++el+p++++a  l+g++g++++l+akhPn+vr+++af

Q: 197   AIKLMFNFEHDRDGDAhLLKSMGNELAPYPNAAklLNGQMGTFRPLPAKHPNVVRIQTAF  256

         **********************************9*************************

S: 118   idsvkllPdalldyPdal.parlypeglgegktlylvmkrydqtlreylesqdrstrlaa  176

         ids+k+lPda+++yPdal +ar+y+++++e+kt+y+vm+ry+qtl+ey+++++r++++++

Q: 257   IDSLKVLPDAIERYPDALhTARWYESIASEPKTMYVVMRRYRQTLHEYVWTRHRNYWTGR  316

         ******************9*****************************************

S: 177   lllaqlleavdhlvkhgvahrdlksdnilveld.ddeiPvlviadfGCcladkvdglrlp  235

         +++aqllea+++l+kh+va+rd+ksdnil+e+d ddeiP+lv+adfGC+la  +d+++++

Q: 317   VIIAQLLEACTYLHKHKVAQRDMKSDNILLEYDfDDEIPQLVVADFGCALA--CDNWQVD  374

         ***************************************************..*******

S: 236   yessevdkGGnaalmaPeistavpGpsavinyekadtWavGalayeifglsnPfygegka  295

         yes+ev+ GGna+++aPei+tavpG+++++n+e+adtWa+G+l+ye++++snPfy    +

Q: 375   YESDEVSLGGNAKTKAPEIATAVPGKNVKVNFEMADTWAAGGLSYEVLTRSNPFY----K  430

         *******************************************************....9

S: 296   slesasyqeaqlPalpesvppelrqlvydllkreaskrvsadiaanvlqlslf  348

         +l++a+yqe++lPalp++v++++r++++dllkr++++rv+++iaan+l+lslf

Q: 431   LLDTATYQESELPALPSRVNFVARDVIFDLLKRDPNERVKPNIAANALNLSLF  483

         ***************************************************98

Domain Sequence
(FASTA)

YEFGEFLGQG CNAAVYSARL ANSDAESSGN THYGAGFNEV TNILAEIPPV SKVAQKKFPL 60

AIKLMFNFEH DRDGDAHLLK SMGNELAPYP NAAKLLNGQM GTFRPLPAKH PNVVRIQTAF 120

IDSLKVLPDA IERYPDALHT ARWYESIASE PKTMYVVMRR YRQTLHEYVW TRHRNYWTGR 180

VIIAQLLEAC TYLHKHKVAQ RDMKSDNILL EYDFDDEIPQ LVVADFGCAL ACDNWQVDYE 240

SDEVSLGGNA KTKAPEIATA VPGKNVKVNF EMADTWAAGG LSYEVLTRSN PFYKLLDTAT 300

YQESELPALP SRVNFVARDV IFDLLKRDPN ERVKPNIAAN ALNLSLF 347

Keyword

ATP-binding; Complete proteome; Kinase; Magnesium; Metal-binding; Mitochondrion; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Transit peptide.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005739	; C:mitochondrion
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0048846	; P:axon extension involved in axon guidance
GO:0034599	; P:cellular response to oxidative stress
GO:0007005	; P:mitochondrion organization
GO:0034976	; P:response to endoplasmic reticulum stress

KEGG

cel:CELE_EEED8.9

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013