EKS-ANC-00429

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ANC-00429

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/DMPK	454.8	8.5E-137	45	307	263

Status

Unreviewed

Ensembl Protein

ENSACAP00000000239

UniProt Accession

G1K8E0;

Protein Name

Protein Synonyms/Alias

Gene Name

ROCK2

Gene Synonyms/Alias

ROCK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSACAG00000000198	ENSACAP00000000239	ENSACAT00000000245

Organism

Anolis carolinensis

Functional Description

Protein Length

1397

Protein Sequence
(FASTA)

DSLNSLVLDL DYPALRKNKN IDNFLNRYEK VVGKIRGLQM KAEDYEVVKV IGRGAFGEVQ 60

LVRHKVTQKA YAMKLLSKFE MLKRSDSAFF WEERDIMAFA NSPWVVQLFS AFQDDRYLYM 120

VMEYMPGGDL VNLMSNYDVP EKWAKFYTAE VVLALDAIHS MGLIHRDVKP DNMLLDKYGH 180

LKLADFGTCM KMDETGMVRC DTAVGTPDYI SPEVLRSQGG DGYYGRECDW WSVGVFLFEM 240

LVGDTPFYAD SLVGTYSKIM DHKNSLHFPE DVEISKHAKD LICAFLTDRE VRLGRNGVEE 300

IKSHLFFKND QWDWGNIRDT AAPVVPELSS DIDSSNFEDV EDDKGDVETF PVPKAFVGNQ 360

LPFIGFTYFR DNLYVSREAE PCNNNGARKN EDNEEFQEKI NKLEDQLHNE VQTKEELEQK 420

CRTINNRLEK IIKELDEEAT SRKNLESALR QLEREKALLQ HKNAEYQRKA EHEADKKRNL 480

ENDVNSLKDQ LEDLKKRNHN SQISNEKIIQ LQRQLDEANV LLRTESDTAA RLRKNQTESA 540

KQIQQLEANN RDLQDKNCAL ENTKLRLEKD FLNLQSVLES ERRDRNHGSE IISDLQGRIS 600

SLEEEVKNGK IALAKMETEK RQLQDMFTDL EKEKSNMEID MTYKLKVMQQ NLEQEEVEHK 660

ATKARLADKN KIYKSIEEAK SEAMKEMEKK LSEERVSKQK VENCLLEVEK RCSMLDCDLK 720

QSQQKINELL KQKDKLNEDV ENLTLKIEQE TQKRSLTQND LKMQTQHVNA LKMTEKQLKQ 780

ENNHLLEIKL SLEKQNNELR KERQDADGQM KELQDQLEAE QYFSTLYKTQ VRELKEECEE 840

KTKHCKEMQQ KIQELQDERD SLAAQLEITL TKADSEQLAR SIAEEQYSDL EKEKIMKELE 900

IKEMMARHKQ ELSEKDATIG SLEEANRTLT SDVANLANEK EELNNKLKEV QERIVRINED 960

ENDIDLLKTQ YEKQLAYERT MKTQAVNKLA EVMNRKNPIQ RGADTDVRRK EKENRKLHME 1020

LKSEREKLTQ MMIKYQREIN EMQAQIADES QIRIELQMAL DSKDSDIEQL RSQLQSIHIG 1080

LDSTSIGCGP GEAEADDGFP VRITQSHTSE SMSFTYEHSS TSVSIATKPS SSRVFLSSDS 1140

DSEEEPLPPA QVPSEPDNPE SRLEGWLSLP ARNNTKKFGW VRKYVVVSSK KVLFYHSEQD 1200

KEQSNPYMVL DIDKLFHVRP VTQTDVYRAD SKDIPRIFQI LYDNEGESKK ELEFQAELAG 1260

DKSNYTCHKG HEFIPTLYHF PTNCEACMKP LWHMFKPPPA LECRRCHIKC HKDHMDKKEE 1320

IIAPCKVNYD ISTAKNLLLL ANSMEDQQKW VSRLGKRIPK KPPAPDPFAR SSPRTSMKVQ 1380

PNQSIRRPSK QLPPNKK 1397

Nucleotide Sequence
(FASTA)

GATAGTTTGA ACTCTTTAGT TCTTGATCTG GATTATCCAG CACTGAGGAA GAACAAGAAT 60

ATTGACAACT TCTTAAACAG ATATGAGAAA GTTGTCGGAA AGATCCGTGG TCTCCAGATG 120

AAAGCAGAAG ATTATGAAGT TGTTAAAGTG ATTGGAAGAG GTGCATTTGG TGAAGTACAG 180

TTGGTTCGTC ATAAAGTAAC ACAGAAAGCT TACGCCATGA AACTTCTTAG TAAATTTGAA 240

ATGCTCAAAA GATCAGACTC AGCCTTTTTC TGGGAGGAGA GAGATATTAT GGCCTTCGCC 300

AACAGTCCAT GGGTAGTTCA GCTTTTTAGT GCCTTTCAAG ATGACCGATA CCTATACATG 360

GTAATGGAAT ACATGCCAGG TGGAGATCTT GTCAACCTCA TGAGCAATTA TGATGTGCCT 420

GAGAAGTGGG CCAAATTTTA CACTGCTGAA GTTGTTCTTG CCCTTGATGC AATTCATTCC 480

ATGGGCTTGA TACACAGAGA TGTGAAACCT GACAACATGC TTTTGGATAA ATATGGACAT 540

CTGAAGCTTG CAGATTTTGG TACCTGTATG AAAATGGATG AAACAGGAAT GGTGCGTTGT 600

GATACAGCTG TTGGAACACC AGACTACATA TCACCCGAAG TATTGAGGTC ACAAGGTGGT 660

GATGGTTATT ATGGAAGGGA ATGTGACTGG TGGTCTGTAG GAGTCTTTCT GTTTGAGATG 720

CTAGTTGGAG ATACTCCATT TTATGCTGAT TCATTGGTTG GAACATACAG TAAAATAATG 780

GATCACAAAA ATTCATTGCA CTTTCCAGAA GATGTGGAAA TCTCAAAGCA TGCAAAGGAT 840

CTTATCTGTG CCTTTTTAAC AGACAGGGAG GTGCGTCTCG GAAGGAATGG AGTTGAAGAA 900

ATTAAATCGC ATCTGTTCTT TAAAAATGAT CAATGGGATT GGGGTAACAT TCGAGACACT 960

GCAGCACCAG TTGTCCCTGA GCTGAGTAGT GACATAGATA GCAGCAATTT TGAAGATGTT 1020

GAAGATGATA AAGGAGATGT CGAAACTTTT CCCGTCCCTA AAGCCTTCGT TGGAAACCAG 1080

TTGCCTTTCA TAGGATTTAC TTACTTTAGA GACAACCTGT ATGTCTCTAG AGAAGCCGAA 1140

CCCTGCAATA ACAATGGAGC AAGGAAAAAT GAAGACAACG AAGAGTTTCA GGAAAAAATA 1200

AACAAATTAG AAGATCAGCT TCATAATGAA GTACAGACCA AAGAGGAGCT TGAGCAAAAA 1260

TGCAGAACTA TTAATAATCG CCTAGAGAAG ATAATAAAGG AGTTGGATGA AGAGGCAACC 1320

TCACGAAAAA ATCTAGAATC TGCCTTAAGA CAATTGGAAA GGGAGAAAGC TCTTCTTCAG 1380

CACAAAAATG CAGAATACCA GCGGAAAGCA GAACACGAAG CAGATAAAAA GCGCAATCTG 1440

GAAAATGATG TTAACAGTTT GAAGGACCAG CTAGAAGATT TGAAAAAGAG AAATCACAAC 1500

TCTCAAATAT CAAATGAAAA AATCATTCAG CTACAAAGAC AGCTGGATGA AGCCAATGTT 1560

CTGCTGCGCA CAGAGTCTGA TACAGCAGCC AGGCTGAGGA AGAACCAAAC TGAAAGTGCA 1620

AAGCAGATCC AACAGCTGGA AGCTAATAAC CGAGATCTGC AAGATAAAAA CTGTGCCCTG 1680

GAGAATACTA AGCTTAGGCT TGAGAAGGAC TTCCTCAATC TGCAGTCAGT TCTAGAATCA 1740

GAAAGAAGAG ATCGGAATCA CGGGTCAGAG ATTATCAGTG ATCTACAAGG CCGCATATCT 1800

AGTTTAGAAG AAGAAGTAAA AAATGGAAAG ATTGCATTAG CTAAAATGGA GACCGAGAAA 1860

AGGCAATTAC AGGACATGTT CACAGATCTG GAAAAGGAGA AGAGCAACAT GGAAATTGAC 1920

ATGACATACA AGCTCAAAGT CATGCAGCAG AACTTGGAAC AAGAAGAGGT TGAACACAAG 1980

GCAACAAAAG CCCGGCTAGC AGACAAAAAC AAAATCTATA AATCCATTGA GGAAGCCAAA 2040

TCTGAGGCCA TGAAAGAAAT GGAGAAGAAG CTTTCAGAGG AGAGAGTTTC CAAACAAAAA 2100

GTGGAAAACT GCTTGTTGGA AGTTGAAAAG CGATGTTCGA TGTTGGACTG TGATCTGAAA 2160

CAATCGCAGC AGAAAATAAA TGAACTTCTT AAGCAGAAAG ATAAACTAAA CGAGGATGTT 2220

GAAAACTTGA CATTGAAAAT AGAACAGGAA ACACAAAAAC GTAGCCTCAC ACAAAACGAC 2280

CTTAAGATGC AAACCCAGCA TGTCAATGCA TTGAAAATGA CAGAGAAGCA GCTCAAACAG 2340

GAGAATAACC ATCTTTTGGA AATCAAATTG AGTTTGGAAA AGCAAAATAA TGAACTTCGC 2400

AAAGAACGTC AGGATGCTGA CGGCCAGATG AAAGAACTTC AAGACCAACT TGAGGCAGAA 2460

CAGTATTTTT CAACGCTGTA TAAAACCCAA GTTCGGGAAC TTAAGGAAGA ATGTGAAGAA 2520

AAGACCAAAC ATTGTAAAGA AATGCAGCAG AAGATACAAG AATTGCAAGA CGAGAGGGAT 2580

TCTTTGGCAG CCCAACTTGA AATTACCTTA ACCAAAGCAG ATTCGGAACA GCTTGCTCGT 2640

TCTATTGCTG AGGAGCAATA TTCGGATTTG GAAAAAGAAA AGATCATGAA AGAGCTGGAG 2700

ATTAAAGAAA TGATGGCCAG GCACAAACAA GAGCTTTCTG AAAAAGATGC CACCATAGGA 2760

TCATTGGAAG AAGCAAATAG GACTTTAACA AGTGATGTGG CAAATCTGGC AAATGAAAAA 2820

GAAGAGCTCA ATAATAAACT TAAAGAAGTC CAAGAAAGAA TTGTTCGTAT TAATGAGGAT 2880

GAAAATGATA TAGATCTGCT TAAGACTCAG TATGAGAAAC AGTTGGCTTA TGAAAGAACC 2940

ATGAAGACCC AGGCTGTAAA CAAGCTGGCT GAAGTCATGA ATCGCAAGAA CCCAATCCAA 3000

CGAGGAGCTG ACACTGATGT CAGAAGGAAA GAAAAAGAGA ATCGTAAACT GCACATGGAA 3060

CTCAAGTCTG AACGTGAAAA GTTAACTCAG ATGATGATCA AATATCAGAG GGAGATCAAT 3120

GAAATGCAAG CGCAAATAGC CGATGAGAGC CAGATAAGAA TCGAACTGCA GATGGCTCTG 3180

GACAGCAAAG ATAGTGACAT CGAGCAGCTT CGCTCTCAAC TTCAATCAAT ACACATTGGT 3240

TTAGACAGCA CTAGTATAGG CTGTGGCCCA GGGGAAGCAG AGGCGGATGA TGGATTTCCG 3300

GTCCGTATCA CTCAGTCCCA CACTTCGGAG TCTATGTCCT TTACCTACGA ACACTCTTCT 3360

ACTTCTGTCA GTATTGCCAC TAAGCCCTCT AGTTCTCGAG TGTTTCTCAG CTCTGATTCT 3420

GACTCAGAGG AAGAACCGTT GCCTCCTGCA CAAGTCCCTT CAGAGCCTGA TAATCCAGAG 3480

TCAAGATTGG AGGGTTGGCT ATCGTTGCCT GCCAGAAACA ACACAAAGAA ATTTGGATGG 3540

GTCAGAAAGT ATGTGGTTGT TAGCAGCAAG AAGGTCCTGT TCTACCATAG TGAGCAAGAT 3600

AAAGAACAAT CAAACCCTTA CATGGTCTTA GACATTGACA AACTATTTCA TGTCCGGCCT 3660

GTCACGCAAA CAGATGTATA CAGAGCGGAT TCAAAGGATA TTCCCAGGAT TTTCCAGATC 3720

CTATATGATA ACGAAGGGGA AAGCAAGAAG GAGCTGGAAT TCCAAGCGGA ATTAGCAGGA 3780

GATAAATCCA ACTATACTTG CCACAAGGGA CACGAATTCA TACCTACACT GTATCACTTC 3840

CCAACCAACT GTGAGGCCTG TATGAAGCCC TTGTGGCACA TGTTTAAGCC TCCTCCTGCC 3900

CTGGAGTGCC GTCGCTGCCA CATCAAATGC CATAAAGATC ACATGGATAA AAAAGAAGAG 3960

ATCATAGCAC CTTGCAAAGT GAATTATGAT ATATCAACTG CAAAGAACCT ACTGCTGTTA 4020

GCCAATTCCA TGGAGGATCA ACAGAAATGG GTGAGCCGCC TGGGGAAAAG GATCCCCAAG 4080

AAACCCCCGG CACCAGATCC ATTTGCACGC TCTTCACCAA GAACTTCCAT GAAGGTACAG 4140

CCAAACCAGT CTATTAGACG GCCAAGCAAA CAGCTTCCTC CAAATAAAAA G 4191

Domain Profile

S: 1     feilkviGrGafgevavvrekatekvyamkilkklellkraesaffreerdvlvkadsew  60

         +e++kviGrGafgev++vr+k t+k yamk+l+k+e+lkr++saff+eerd++++a+s+w

Q: 45    YEVVKVIGRGAFGEVQLVRHKVTQKAYAMKLLSKFEMLKRSDSAFFWEERDIMAFANSPW  104

         89**********************************************************

S: 61    ivqlqyafqdekylylvmeylvGGdlltllskyedklpeelarfylaelvlaldsvhelg  120

         +vql+ afqd++yly+vmey++GGdl++l+s+y+  +pe++a+fy+ae+vlald++h++g

Q: 105   VVQLFSAFQDDRYLYMVMEYMPGGDLVNLMSNYD--VPEKWAKFYTAEVVLALDAIHSMG  162

         **********************************..9***********************

S: 121   yvhrdikpdnilldksGhikladfGsclklnedgtvkssvavGtpdyispevlkaleegk  180

         ++hrd+kpdn+lldk Gh+kladfG+c+k++e+g+v++++avGtpdyispevl++++ g+

Q: 163   LIHRDVKPDNMLLDKYGHLKLADFGTCMKMDETGMVRCDTAVGTPDYISPEVLRSQG-GD  221

         ********************************************************9.**

S: 181   geygkecdwwslGvilyellvgetpfyaeslvetyskilnhkeslkfpedekvseeakdl  240

         g+yg+ecdwws+Gv+l+e+lvg+tpfya+slv tyski++hk+sl+fped+++s++akdl

Q: 222   GYYGRECDWWSVGVFLFEMLVGDTPFYADSLVGTYSKIMDHKNSLHFPEDVEISKHAKDL  281

         ************************************************************

S: 241   ikklltsreerlgregiedlkkhpff  266

         i+++lt+re rlgr+g+e++k+h ff

Q: 282   ICAFLTDREVRLGRNGVEEIKSHLFF  307

         *************************9

Domain Sequence
(FASTA)

YEVVKVIGRG AFGEVQLVRH KVTQKAYAMK LLSKFEMLKR SDSAFFWEER DIMAFANSPW 60

VVQLFSAFQD DRYLYMVMEY MPGGDLVNLM SNYDVPEKWA KFYTAEVVLA LDAIHSMGLI 120

HRDVKPDNML LDKYGHLKLA DFGTCMKMDE TGMVRCDTAV GTPDYISPEV LRSQGGDGYY 180

GRECDWWSVG VFLFEMLVGD TPFYADSLVG TYSKIMDHKN SLHFPEDVEI SKHAKDLICA 240

FLTDREVRLG RNGVEEIKSH LFF 263

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0031616	; C:spindle pole centrosome
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0030036	; P:actin cytoskeleton organization
GO:0051298	; P:centrosome duplication
GO:0000910	; P:cytokinesis
GO:0035556	; P:intracellular signal transduction
GO:0016525	; P:negative regulation of angiogenesis
GO:0010825	; P:positive regulation of centrosome duplication
GO:0045616	; P:regulation of keratinocyte differentiation

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011072	; HR1_rho-bd.
IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR020684	; Rho-assoc_coiled-coil_kin.
IPR015008	; Rho-bd.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF02185	; HR1; 1.
PF00169	; PH; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.
PF08912	; Rho_Binding; 1.

SMARTs

SM00109	; C1; 1.
SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

Created Date

20-Feb-2013