EKS-ANC-00427

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ANC-00427

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/DMPK	485.9	2.8E-146	18	286	269

Status

Unreviewed

Ensembl Protein

ENSACAP00000000310

UniProt Accession

H9G3K5;

Protein Name

Protein Synonyms/Alias

Gene Name

CDC42BPB

Gene Synonyms/Alias

CDC42BPB;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSACAG00000000214	ENSACAP00000000310	ENSACAT00000000321

Organism

Anolis carolinensis

Functional Description

Protein Length

1659

Protein Sequence
(FASTA)

AKPFTQLVKE MQLHRDDFEI IKVIGRGAFG EVAVVKMKCT ERIYAMKILN KWEMLKRAET 60

ACFREERDVL VNGDCQWITT LHYAFQDENY LYLVMDYYVG GDLLTLLSKF EDKLPEDMAR 120

FYIGEMVLAI HSIHQLHYVH RIRDIKPDNV LLDVNGHIRL ADFGSCLKMS EDGTVQSSVA 180

VGTPDYISPE ILQAMEDGMG KYGPECDWWS LGVCMYEMLY GETPFYAESL VETYGKIMNH 240

EERFQFPSHV SDVSEDAKDL IQRLICSRER RLGQNGIEDF KSHAFFEGLN WDNIRNLEAP 300

YIPDVSSPSD TSNFDVDDDV LRNPEMIPPG SHTGFSGLHL PFVGFTYTTE SCFSDRGSFK 360

SVMQSSGITK DEDVQRDLEN SLQIEAYERR IRRLEQEKLE LSRKLQESTQ AVQSLHGSGR 420

ITANTNRDKE IKKLNEEIER LKNKIADSNR IERQLEDAVT LRQEHEDSTH RLKGLEKQCR 480

ILRQEKEDLH KQLVEASERL KAQSKELKDA HQQRKLAMQE YSELNERMAD LRSHKQKLSR 540

QLRDKEEEIE VIMQKIDSMR QEIRKSEKAR KELEAQLDDA IAEASKEHKL REHSEIFCKQ 600

LENELETLKL KQGGRAAGMA MQEHQQELAK MKSELEKKIL FYEEELVRRE ASHVLEVKNV 660

KKEVHDLESH QLALQKEIMM LKDKLDKAKR EKHSEMEEAV GTLKEKYERE RTMLFEDNKK 720

ITSENEKLCS FVDKLTSQNR QLEDELQDLA AKKESVAHWE AQIAEIIQWV SDEKDARGYL 780

QALASKMTEE LESLRSSSLG SRTLDPLWKV RRSQKLDMSA RLELQSALDA EIRAKQLVQD 840

ELRKVKDANL SFESKLKESE VKNQELLEEV EILKKKLEEK YRTDAGLKLS DFQDSIFEYF 900

NTSPLAHDLT FRTNSVSEQE APGSKAEVSP STSMTTEQQQ AEEPIRLQRM PAAPSPTIQS 960

ISLAVPKPKA HQLNIKSFSS PTQCSHCTSL MVGLIRQGYA CDVCSFACHV SCKDSAPQVC 1020

PIPPEQAKRP LGVDVQRGIG TAYKGYVKVP KPTGVKKGWQ RAYAVVCDCK LFLYDVPEGK 1080

STQPGVVASQ VLDLRDEDFC VSSVLASDVI HATRKDIPCI FRVTASLLGS PSKTCSLLIL 1140

TENENEKRKW VGILEGLKSI LHKNKLKNQV VHIPQEAYDS TLPLIKTSLA AAVIDRDRIA 1200

IGSEEGLYVI EVTRDVIVRA ADCKKVYQIE LAPKEKVVIL ICGRNHHVHL YPWSSLDGSE 1260

GSFDIKLPET KGCQFVTTGT LKKTSSTSLF VAVKRQVLCY EVHRTKPFHK KFNEVQAPGN 1320

IQWMAVFKDR LCVGYPSGFS LLNIQGDGQS INLVNPSDPS LAFLSQQSFD ALCAVELSNE 1380

EYLLCFSQFG VYVDAQGRRS RMQELMWPAT PAACSCNSFY LTVYSEYGVD VFNANTMEWV 1440

QTIGLRRIRP LNVTGTLNLL NCELPRLIYF KNKFSAGATL SVPETSDNSK KQMLRTRSKR 1500

RFVFKVPEEE RLQQRRLREM LRDPELRSKM ISNPTNFNHV AHMGPGDGMQ VLMDLPLSVL 1560

PPSQDEKSCP PTTNISRQPP QRNKSYISWP SSSGTDLGAA MPLRSMSDPD QEFDKEPDSD 1620

STKHSTPSNS SNPSGPPSPN SPHRNQLTLD GLDPSACDA 1659

Nucleotide Sequence
(FASTA)

GCAAAACCAT TTACACAATT GGTGAAGGAG ATGCAGCTTC ATCGAGATGA CTTTGAAATC 60

ATAAAAGTCA TTGGTAGGGG TGCATTTGGT GAGGTTGCAG TTGTTAAAAT GAAGTGCACG 120

GAGCGCATTT ACGCAATGAA AATCCTAAAT AAATGGGAAA TGCTTAAAAG GGCAGAGACT 180

GCTTGCTTTC GAGAAGAGAG AGATGTTTTG GTGAATGGAG ATTGCCAGTG GATTACTACA 240

TTGCACTATG CCTTTCAGGA TGAAAACTAT TTGTACTTAG TGATGGACTA CTATGTGGGT 300

GGTGATTTGC TGACACTACT TAGCAAGTTT GAAGACAAGC TTCCTGAAGA TATGGCAAGG 360

TTCTACATTG GTGAAATGGT TCTTGCTATA CATTCCATTC ATCAACTACA TTATGTGCAC 420

AGAATCAGAG ATATAAAACC TGATAATGTT CTGTTGGATG TGAATGGCCA TATACGCCTG 480

GCGGACTTCG GATCATGTTT GAAGATGAGT GAGGATGGCA CTGTGCAATC TTCAGTTGCA 540

GTGGGCACAC CTGATTATAT TTCCCCCGAG ATACTTCAAG CAATGGAAGA TGGCATGGGG 600

AAATATGGAC CTGAATGTGA CTGGTGGTCT CTGGGTGTCT GCATGTATGA AATGTTGTAT 660

GGCGAAACTC CATTTTATGC AGAATCACTG GTGGAAACCT ATGGGAAGAT TATGAATCAT 720

GAAGAGAGAT TCCAGTTTCC ATCACATGTT AGTGACGTTT CTGAAGATGC AAAAGACCTA 780

ATCCAGCGTC TTATCTGCAG CAGGGAACGT CGTCTGGGGC AGAATGGAAT AGAAGATTTC 840

AAGTCACATG CCTTTTTTGA AGGACTCAAT TGGGATAATA TCCGAAATCT AGAAGCACCT 900

TACATTCCAG ATGTTAGCAG TCCTTCTGAC ACATCAAACT TTGATGTGGA TGATGATGTT 960

TTAAGAAACC CTGAAATGAT ACCACCTGGT TCTCACACTG GCTTTTCAGG ATTGCATTTG 1020

CCTTTTGTTG GTTTTACCTA CACAACTGAA AGCTGTTTTT CAGATAGAGG TTCATTCAAG 1080

AGTGTGATGC AGTCCAGCGG TATAACCAAA GATGAGGACG TTCAGCGTGA CTTGGAAAAC 1140

AGCTTGCAAA TAGAAGCATA TGAAAGGAGA ATACGAAGAC TGGAGCAGGA GAAGCTAGAA 1200

CTGAGCAGGA AGTTGCAAGA ATCCACTCAG GCTGTTCAGT CCCTTCATGG TTCTGGTCGC 1260

ATAACAGCAA ACACAAACCG GGATAAAGAA ATAAAAAAGT TAAATGAGGA AATTGAACGC 1320

TTGAAAAACA AAATAGCAGA TTCAAATAGG ATAGAACGGC AGCTTGAAGA TGCAGTGACG 1380

CTGCGGCAAG AACATGAAGA TTCCACTCAC AGGTTAAAAG GCCTTGAAAA GCAATGCAGG 1440

ATACTGAGGC AAGAGAAAGA AGACCTTCAT AAGCAACTTG TTGAGGCATC TGAAAGATTA 1500

AAGGCACAGT CCAAAGAACT GAAGGATGCC CATCAACAAA GAAAGCTAGC AATGCAAGAG 1560

TACTCAGAGC TGAATGAAAG GATGGCAGAC TTACGCTCTC ACAAGCAGAA ACTCTCTCGA 1620

CAGCTCCGTG ACAAGGAGGA AGAAATAGAA GTGATCATGC AGAAAATTGA CTCCATGAGA 1680

CAGGAAATTC GTAAATCTGA GAAAGCGAGG AAAGAGCTAG AAGCCCAACT TGATGATGCA 1740

ATAGCAGAAG CATCCAAGGA ACACAAGCTT CGAGAGCACA GTGAGATTTT CTGTAAGCAG 1800

CTGGAAAATG AACTGGAAAC TCTAAAGTTA AAGCAAGGGG GCCGTGCTGC AGGAATGGCC 1860

ATGCAGGAAC ATCAGCAAGA GCTGGCTAAA ATGAAGTCAG AGCTCGAGAA GAAAATCTTG 1920

TTCTATGAAG AGGAACTGGT CAGGCGAGAA GCATCCCATG TCTTGGAAGT AAAAAATGTG 1980

AAAAAAGAAG TGCATGATTT AGAAAGCCAC CAGCTAGCAT TGCAGAAAGA AATCATGATG 2040

TTGAAAGATA AATTGGATAA GGCAAAACGA GAGAAACATA GTGAAATGGA AGAAGCAGTA 2100

GGAACTCTGA AAGAGAAATA TGAGCGAGAG AGAACCATGC TCTTTGAAGA TAATAAGAAA 2160

ATAACATCTG AAAATGAAAA GCTTTGTTCC TTTGTGGATA AACTTACATC ACAAAACAGA 2220

CAGCTAGAAG ATGAACTTCA GGATTTGGCA GCAAAGAAGG AATCTGTTGC CCACTGGGAA 2280

GCTCAGATTG CAGAAATTAT TCAATGGGTG AGTGATGAAA AAGATGCACG CGGCTATCTT 2340

CAGGCTTTGG CTTCTAAGAT GACAGAAGAA CTTGAGTCTT TGAGAAGCTC CAGTCTGGGA 2400

TCAAGAACAC TGGATCCTCT TTGGAAAGTA AGACGAAGTC AGAAGCTGGA TATGTCTGCA 2460

AGACTAGAAT TGCAGTCTGC TCTAGATGCT GAAATACGTG CCAAGCAGCT AGTCCAGGAC 2520

GAATTAAGGA AAGTCAAAGA TGCCAACCTA TCTTTTGAAA GCAAATTAAA GGAATCTGAA 2580

GTAAAGAATC AAGAACTCTT GGAAGAAGTT GAAATTTTAA AGAAGAAACT GGAAGAAAAA 2640

TACAGGACTG ATGCAGGTCT TAAACTTTCT GACTTCCAAG ATTCCATTTT TGAGTACTTC 2700

AATACCTCTC CACTTGCACA TGATCTGACT TTCAGAACAA ATTCCGTTAG TGAGCAAGAA 2760

GCGCCAGGTT CCAAGGCAGA GGTCTCACCA TCAACATCTA TGACTACAGA ACAGCAGCAA 2820

GCAGAAGAAC CAATTCGGCT TCAGAGGATG CCTGCTGCTC CCTCCCCCAC CATTCAGTCC 2880

ATTTCTCTAG CTGTACCAAA GCCGAAAGCT CATCAACTCA ATATCAAATC CTTTTCAAGT 2940

CCTACGCAGT GCAGCCATTG CACATCCCTC ATGGTGGGAT TGATTAGACA GGGATATGCT 3000

TGTGATGTGT GTTCATTTGC ATGCCATGTT TCCTGCAAGG ATAGTGCACC ACAAGTCTGC 3060

CCTATACCTC CTGAGCAAGC CAAGCGGCCC CTTGGAGTAG ATGTTCAAAG AGGCATAGGA 3120

ACAGCTTACA AAGGCTATGT TAAGGTTCCA AAGCCAACAG GAGTTAAGAA AGGTTGGCAG 3180

AGGGCCTATG CCGTAGTCTG TGACTGTAAA CTCTTCCTCT ATGATGTGCC TGAAGGAAAA 3240

TCCACTCAGC CAGGAGTTGT TGCAAGTCAA GTCTTAGATC TCAGAGATGA AGATTTTTGT 3300

GTGAGTTCTG TCCTAGCATC GGATGTTATA CACGCAACCC GCAAAGATAT CCCTTGTATA 3360

TTCAGGGTGA CAGCTTCTCT CTTAGGCTCA CCTTCAAAGA CTTGCTCTCT GCTGATCCTA 3420

ACAGAAAATG AGAATGAAAA GCGAAAATGG GTTGGAATCT TAGAGGGGCT GAAATCTATT 3480

CTGCACAAAA ATAAACTCAA AAACCAAGTT GTACATATTC CACAGGAAGC CTATGACAGT 3540

ACATTGCCCC TCATTAAAAC CAGCTTGGCT GCTGCTGTTA TAGATCGAGA TCGAATAGCA 3600

ATTGGTTCTG AAGAAGGCCT TTATGTCATT GAGGTAACCC GTGATGTGAT TGTCCGAGCT 3660

GCTGACTGCA AGAAGGTCTA CCAGATAGAG CTTGCTCCCA AAGAGAAAGT CGTTATTCTT 3720

ATCTGTGGTC GGAATCATCA TGTTCATTTG TATCCTTGGT CCTCCCTGGA TGGTTCTGAA 3780

GGCAGCTTCG ATATTAAGCT TCCTGAAACT AAAGGTTGTC AGTTTGTTAC AACTGGGACA 3840

CTGAAGAAGA CTTCTTCAAC TAGTTTATTT GTGGCAGTCA AGCGGCAAGT TCTGTGCTAT 3900

GAAGTTCATA GGACTAAACC TTTCCATAAA AAGTTCAATG AAGTCCAGGC TCCCGGCAAT 3960

ATACAGTGGA TGGCAGTTTT CAAAGACAGG CTTTGTGTAG GCTATCCCTC AGGTTTCTCT 4020

CTGTTGAACA TCCAGGGAGA TGGACAGTCT ATAAACCTGG TAAATCCCAG TGATCCTTCG 4080

CTTGCATTCC TCTCACAACA GTCTTTTGAT GCCCTTTGTG CTGTGGAGCT CAGCAATGAA 4140

GAATACCTGC TTTGCTTCAG CCAGTTCGGA GTATATGTGG ATGCACAAGG TCGAAGGTCT 4200

CGCATGCAGG AACTAATGTG GCCTGCAACG CCTGCTGCCT GTAGTTGCAA TTCATTCTAT 4260

TTAACCGTCT ACAGTGAATA TGGTGTTGAT GTTTTTAATG CAAACACTAT GGAATGGGTG 4320

CAGACTATCG GCTTAAGAAG GATCAGACCC TTAAATGTGA CAGGCACATT GAATCTCCTT 4380

AACTGTGAAC TTCCTCGATT AATCTATTTC AAGAACAAGT TTTCGGCAGG AGCTACCCTT 4440

AGTGTGCCGG AAACATCCGA CAATAGCAAA AAGCAAATGC TTCGTACTAG AAGCAAAAGA 4500

AGATTTGTTT TTAAAGTCCC TGAGGAAGAA AGATTACAGC AAAGACGACT TAGAGAGATG 4560

CTTCGAGATC CTGAGCTCAG ATCCAAGATG ATTTCTAACC CAACCAATTT CAACCATGTG 4620

GCTCATATGG GACCAGGAGA TGGAATGCAA GTTCTCATGG ATCTCCCCTT GAGCGTCTTA 4680

CCTCCGTCAC AAGATGAAAA GTCCTGTCCT CCCACAACCA ACATTTCACG CCAACCCCCT 4740

CAGAGAAACA AAAGCTACAT TTCATGGCCA TCATCAAGTG GCACTGATCT AGGAGCAGCC 4800

ATGCCTTTGC GGAGTATGTC TGATCCAGAC CAGGAGTTTG ACAAAGAGCC TGATTCAGAC 4860

TCTACAAAAC ACTCGACTCC TTCCAACAGC TCTAACCCAA GTGGCCCCCC CAGCCCCAAT 4920

TCACCGCATA GGAATCAGCT GACATTAGAT GGATTGGACC CATCTGCCTG TGATGCATAA 4980

Domain Profile

S: 1     feilkviGrGafgevavvrekatekvyamkilkklellkraesaffreerdvlvkadsew  60

         fei+kviGrGafgevavv++k te++yamkil+k+e+lkrae+a+freerdvlv++d++w

Q: 18    FEIIKVIGRGAFGEVAVVKMKCTERIYAMKILNKWEMLKRAETACFREERDVLVNGDCQW  77

         89**********************************************************

S: 61    ivqlqyafqdekylylvmeylvGGdlltllskyedklpeelarfylaelvlaldsvhelg  120

         i++l+yafqde+ylylvm+y+vGGdlltllsk+edklpe++arfy+ e+vla++s+h+l+

Q: 78    ITTLHYAFQDENYLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIHSIHQLH  137

         ************************************************************

S: 121   yvhr..dikpdnilldksGhikladfGsclklnedgtvkssvavGtpdyispevlkalee  178

         yvhr  dikpdn+lld++Ghi+ladfGsclk++edgtv+ssvavGtpdyispe+l+a+e+

Q: 138   YVHRirDIKPDNVLLDVNGHIRLADFGSCLKMSEDGTVQSSVAVGTPDYISPEILQAMED  197

         ***555******************************************************

S: 179   gkgeygkecdwwslGvilyellvgetpfyaeslvetyskilnhkeslkfpede.kvseea  237

         g+g+yg+ecdwwslGv++ye+l+getpfyaeslvety+ki+nh+e+++fp+++ +vse+a

Q: 198   GMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVsDVSEDA  257

         ****************************************************99******

S: 238   kdlikklltsreerlgregiedlkkhpff  266

         kdli++l++sre+rlg++gied+k+h+ff

Q: 258   KDLIQRLICSRERRLGQNGIEDFKSHAFF  286

         ****************************9

Domain Sequence
(FASTA)

FEIIKVIGRG AFGEVAVVKM KCTERIYAMK ILNKWEMLKR AETACFREER DVLVNGDCQW 60

ITTLHYAFQD ENYLYLVMDY YVGGDLLTLL SKFEDKLPED MARFYIGEMV LAIHSIHQLH 120

YVHRIRDIKP DNVLLDVNGH IRLADFGSCL KMSEDGTVQS SVAVGTPDYI SPEILQAMED 180

GMGKYGPECD WWSLGVCMYE MLYGETPFYA ESLVETYGKI MNHEERFQFP SHVSDVSEDA 240

KDLIQRLICS RERRLGQNGI EDFKSHAFF 269

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity
GO:0031532	; P:actin cytoskeleton reorganization
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR014930	; Myotonic_dystrophy_kinase_coil.
IPR000095	; PAK_box_Rho-bd.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR026611	; Ser/Thr_kinase_MRCK.

Pfam

PF00130	; C1_1; 1.
PF00780	; CNH; 1.
PF08826	; DMPK_coil; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 1.
SM00036	; CNH; 1.
SM00285	; PBD; 1.
SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50219	; CNH; 1.
PS50108	; CRIB; 1.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

Created Date

20-Feb-2013