EKS-ANC-00318
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ANC-00318
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE20318.62.9E-9536278243
StatusUnreviewed
Ensembl ProteinENSACAP00000002105
UniProt AccessionH9G604;
Protein NameMitogen-activated protein kinase kinase kinase kinase
Protein Synonyms/Alias
Gene NameMAP4K5
Gene Synonyms/Alias MAP4K5;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSACAG00000001889ENSACAP00000002105ENSACAT00000002162
OrganismAnolis carolinensis
Functional Description
Protein Length847
Protein Sequence
(FASTA)
FEKPLFLYIN IILAMGPSQP CELFRRILAF KIPDKFQARN VHSGEMAAVK IIKLEPGDDF 60
SLIQQEIYMV KECKHCNIVA YFGSYLSREK LWICMEYCGG GSLQDIYHVT GPLSELQIAY 120
VCRETLQGLA YLHMKGKMHR DIKGANILLT DHGDIKLADF GVAAKITATI AKRKSFIGTP 180
YWMAPEVAAV EKNGGYNQLC DIWAVGITAI ELGELQPPMF ELHPMRALFL MSKSNFQPPK 240
LKEKTKWSST FHNFVKVALT KNPKKRPTAE RLLTHSFVGQ PGLSRSLAVE LLDKVNNPDN 300
HPHYSETDDD DFEPHPIIRH TIRSTNRNVR AERTASEINF DKLQFEPPLR KETEARDEMV 360
VAGGAHFASH WSPFVDGSSC AKSTLKRAGP PPLPPKPRLS IYQEEGLVDD EKIQTIKYCP 420
DSQGQVPPAH RRQSIPVCGP QTEPTPIGNG DSGPKHLEEN ADGLGHMPQL PRKKEKREFP 480
KPAINGLPPT PKVLMGACFS KVFDGCPLKI NCATSWIHPD TKDQYIIFGT EDGIYTLNLN 540
ELHEATMEQL FPRRCTWLYV INNTLMSLSE GKTFQLYSHN LIALFEQAKK TGLAAHIQTH 600
RFPDRILPRK FALTTKIPDT KGCHKCCIVR NPYTGHKYLC GALQLGIVLL QWYEPMQKFM 660
LIKHFDFPLP TPLHVFEMLV IPEQEYPMVC VAISKGIEPN QVVQFETINL NSASSWFTEI 720
GAGCQQLDAI HVTQLERDTV LVCLDRFVKI VNLHGKLKSS KKLASELSFD FCIESVVCLQ 780
DSVLAFWKHG MQGKSFKSNE VTQEISDETR VFRLLGSDRV VVLESRPTDN PTAHSNLYIL 840
AGHENSY 847
Nucleotide Sequence
(FASTA)
TTTGAAAAGC CTCTATTTCT ATATATCAAC ATAATCTTGG CGATGGGACC CAGCCAACCC 60
TGTGAACTAT TTCGAAGGAT TTTGGCTTTC AAAATCCCAG ATAAGTTTCA GGCCAGAAAC 120
GTACACTCCG GAGAAATGGC TGCAGTGAAA ATTATCAAGT TAGAACCTGG AGACGACTTT 180
TCATTGATCC AGCAAGAAAT CTACATGGTC AAGGAATGCA AACATTGCAA CATCGTCGCT 240
TACTTTGGAA GCTATCTCAG CCGCGAGAAG CTCTGGATCT GTATGGAATA CTGTGGAGGC 300
GGATCCCTTC AGGACATTTA TCACGTGACG GGGCCCCTGT CAGAGTTGCA AATTGCGTAT 360
GTTTGCAGAG AAACATTGCA GGGACTTGCG TATTTGCACA TGAAAGGGAA AATGCATCGG 420
GACATTAAGG GTGCAAACAT TTTGCTGACG GATCACGGGG ACATCAAGTT AGCTGACTTC 480
GGCGTAGCGG CAAAAATAAC CGCCACCATT GCGAAGAGGA AGTCGTTCAT TGGCACGCCT 540
TACTGGATGG CCCCAGAAGT AGCTGCAGTC GAAAAGAACG GGGGCTACAA CCAGCTCTGC 600
GACATCTGGG CTGTGGGCAT CACGGCCATT GAGCTGGGAG AGCTCCAGCC ACCCATGTTT 660
GAGCTTCACC CCATGAGGGC CCTCTTTCTC ATGTCCAAAA GCAACTTTCA ACCTCCAAAG 720
CTAAAGGAAA AAACAAAATG GTCATCGACA TTCCATAATT TTGTCAAAGT GGCACTTACA 780
AAAAACCCAA AGAAGAGGCC GACAGCAGAA AGGCTTCTCA CACATAGCTT TGTGGGGCAG 840
CCTGGTCTTT CTCGCTCTCT GGCCGTTGAA CTGTTGGACA AAGTGAACAA TCCCGACAAC 900
CACCCCCACT ACAGCGAGAC AGACGATGAT GACTTTGAGC CTCATCCCAT TATCCGCCAC 960
ACCATTCGCT CCACCAACCG AAATGTTCGA GCAGAACGAA CAGCGTCTGA AATAAACTTT 1020
GACAAGTTGC AGTTTGAGCC GCCTCTCAGG AAAGAGACCG AAGCCCGGGA CGAAATGGTG 1080
GTTGCTGGTG GTGCTCACTT TGCCTCACAC TGGAGTCCTT TTGTGGATGG CAGCAGCTGT 1140
GCCAAATCAA CGCTGAAGCG GGCAGGACCT CCTCCTCTAC CTCCAAAGCC CAGGCTCAGT 1200
ATTTATCAAG AGGAAGGCCT TGTGGACGAT GAGAAGATCC AGACGATCAA GTATTGCCCC 1260
GATTCTCAGG GTCAGGTCCC GCCGGCACAT AGGAGGCAAA GCATCCCGGT TTGTGGGCCT 1320
CAGACGGAGC CCACTCCCAT AGGCAACGGC GACAGCGGGC CCAAACACCT GGAGGAAAAT 1380
GCAGATGGCC TGGGACACAT GCCCCAGTTG CCGCGCAAGA AGGAGAAGCG GGAATTCCCG 1440
AAGCCAGCCA TCAACGGTTT GCCGCCGACG CCAAAAGTGC TGATGGGAGC GTGCTTCTCC 1500
AAAGTGTTTG ACGGCTGCCC TTTGAAGATC AACTGTGCCA CCTCGTGGAT CCATCCCGAC 1560
ACAAAAGATC AGTATATTAT ATTTGGGACC GAAGACGGCA TCTACACCCT GAACCTCAAC 1620
GAGCTGCACG AAGCCACCAT GGAGCAGCTC TTTCCGCGCA GGTGCACCTG GCTCTATGTC 1680
ATCAACAACA CCCTCATGTC GCTCTCAGAA GGGAAGACCT TCCAGCTTTA CTCCCACAAC 1740
CTCATCGCTT TGTTTGAACA AGCCAAAAAG ACCGGGCTCG CCGCCCACAT CCAGACCCAT 1800
CGCTTCCCAG ATAGGATATT ACCAAGGAAA TTTGCCTTAA CGACAAAGAT CCCGGATACA 1860
AAAGGGTGCC ATAAATGTTG TATAGTAAGG AATCCGTACA CGGGCCATAA ATACCTCTGT 1920
GGAGCTTTGC AGTTGGGGAT CGTTCTGCTT CAGTGGTATG AACCCATGCA GAAATTCATG 1980
TTAATAAAGC ACTTTGACTT CCCTTTGCCA ACCCCGCTGC ACGTCTTTGA AATGCTGGTG 2040
ATCCCGGAGC AGGAGTACCC CATGGTCTGC GTGGCCATCA GCAAAGGCAT CGAGCCAAAT 2100
CAGGTGGTCC AGTTTGAGAC CATCAACTTG AACTCCGCTT CTTCCTGGTT TACAGAAATT 2160
GGTGCAGGTT GCCAACAGCT TGATGCCATC CATGTTACAC AGCTGGAGAG AGACACAGTT 2220
TTGGTTTGCT TGGACAGATT TGTGAAAATT GTGAATCTGC ACGGGAAACT GAAGTCGAGC 2280
AAGAAGCTGG CCTCGGAGCT GAGTTTTGAT TTCTGCATTG AATCTGTAGT GTGCCTTCAA 2340
GACAGCGTCT TAGCCTTCTG GAAACACGGG ATGCAGGGCA AGAGCTTTAA GTCCAACGAA 2400
GTAACCCAGG AGATCTCCGA TGAAACCAGG GTCTTCCGCT TATTGGGCTC CGACAGGGTG 2460
GTGGTGCTGG AGAGCCGGCC GACCGACAAC CCGACCGCGC ACAGCAACCT CTACATTTTG 2520
GCCGGCCACG AAAACAGTTA CTAG 2544
Domain Profile
S: 16    ylarekktgelvaikkinlekqekleelqkeisvlkklkhpniveylesflkeeelwlvm  75
         ++ar++++ge++a+k+i+le  ++ +++q+ei ++k++kh niv+y++s+l +e+lw++m
Q: 36    FQARNVHSGEMAAVKIIKLEPGDDFSLIQQEIYMVKECKHCNIVAYFGSYLSREKLWICM  95
         6899********************************************************
S: 76    eylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkviHrdikakniLlteeg  135
         ey+ gGsl+d+++  ++ +l+E qiay++re+l++L+ylH k+++Hrdik++niLlt++g
Q: 96    EYCGGGSLQDIYH--VTGPLSELQIAYVCRETLQGLAYLHMKGKMHRDIKGANILLTDHG  153
         *************..*********************************************
S: 136   eVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe.ekgYdekaDiwslGItaiela  194
         ++kL+dfgvaa++++t +krk+++gtpywmAPEv a+e + gY++ +Diw++GItaiel 
Q: 154   DIKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEkNGGYNQLCDIWAVGITAIELG  213
         *************************************98889******************
S: 195   egepPfkdleplkallkilkne..ppklkskkkfskefkefvekclqknpekRpsasell  252
         e +pP+++l+p++al++++k++  ppklk+k+k+s++f++fv+ +l+knp+kRp+a++ll
Q: 214   ELQPPMFELHPMRALFLMSKSNfqPPKLKEKTKWSSTFHNFVKVALTKNPKKRPTAERLL  273
         *****************9999988************************************
S: 253   khkFl  257
         +h+F+
Q: 274   THSFV  278
         ****7
Domain Sequence
(FASTA)
FQARNVHSGE MAAVKIIKLE PGDDFSLIQQ EIYMVKECKH CNIVAYFGSY LSREKLWICM 60
EYCGGGSLQD IYHVTGPLSE LQIAYVCRET LQGLAYLHMK GKMHRDIKGA NILLTDHGDI 120
KLADFGVAAK ITATIAKRKS FIGTPYWMAP EVAAVEKNGG YNQLCDIWAV GITAIELGEL 180
QPPMFELHPM RALFLMSKSN FQPPKLKEKT KWSSTFHNFV KVALTKNPKK RPTAERLLTH 240
SFV 243
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00313
EKS-BOT-00318
EKS-CAJ-00326
EKS-CAF-00321
EKS-CII-00179
EKS-CIS-00081
EKS-DAR-00675
EKS-EQC-00321
EKS-FEC-00319
EKS-GAG-00269
EKS-GAA-00398
EKS-GOG-00313
EKS-HOS-00327
EKS-LAC-00327
EKS-LOA-00327
EKS-MAM-00321
EKS-MEG-00270
EKS-MOD-00326
EKS-MUM-00351
EKS-MUP-00312
EKS-MYL-00315
EKS-NOL-00293
EKS-ORN-00412
EKS-ORA-00274
EKS-ORC-00315
EKS-OTG-00338
EKS-PAT-00301
EKS-POA-00307
EKS-PTV-00074
EKS-RAN-00334
EKS-SAH-00311
EKS-SUS-00279
EKS-TAG-00332
EKS-TAR-00413
EKS-TEN-00411
EKS-XET-00396
EKS-XIM-00409
Gene Ontology
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0005083; F:small GTPase regulator activity
KEGG
InterPros
IPR001180; Citron.
IPR011009; Kinase-like_dom.
IPR021160; MAPKKKK.
IPR000719; Prot_kinase_cat_dom.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
Pfam
PF00780; CNH; 1.
PF00069; Pkinase; 1.
SMARTs
SM00036; CNH; 1.
SM00220; S_TKc; 1.
Prosites
PS50219; CNH; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
Created Date20-Feb-2013