EKS-ANC-00457

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ANC-00457

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	342.7	1.4E-102	20	316	297

Status

Unreviewed

Ensembl Protein

ENSACAP00000001865

UniProt Accession

H9G5S7;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK6

Gene Synonyms/Alias

MAPK6;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSACAG00000001922	ENSACAP00000001865	ENSACAT00000001911

Organism

Anolis carolinensis

Functional Description

Protein Length

718

Protein Sequence
(FASTA)

MAEKFESLMN IHGFDVGSRY MDLKPLGCGG NGLVFSAVDN DCDKRVAVKK IVLTDPQSVK 60

HALREIKIIR RLDHDNIVKV FEILGPSGSQ LTDDVGSLTE LNCVYIVQEY METDLAKLVE 120

QGPLPEEHAR LFMYQLLRGL KYIHSANVLH RDLKPANLFI NTEDLVLKIG DFGLARIMDP 180

HYSHKGHLSE GLVTKWYRSP RLLLSPNNYT KAIDMWAAGC IFAEMLTGKT LFAGAHELEQ 240

MQLILESIPV VHEEDRQELL SVIPVYIKSD MTEPHKPLTQ LLPGISPEAL DFLEQILTFS 300

PMDRMTAEEA LSHPYMSIYS FPTDEPISSH PFHIEDEVDD ILLMDESHSH IYNWERYHDS 360

QFSDQEWSAH NTFEADEVQR DPRALSDGTD EEEVQVDPRK YLDGDREKYL EDPAFDTHFS 420

TEPCWPYPDH HENKYCDLEC SHTCNYKMRS SSYLDNLVWR ESEVNHYYEP KLIIDLSNWK 480

EQSKEKSDKK GKSKCERNGL VKARLALEEA SQQLTEKEKN QGFDFDSFIA GTIQLSLQHE 540

STDIDKLNDL NSSVSLLESK GISKSVSREK QEKGMANLAQ LEALYQNSWD GQLVSGGEEC 600

FLIDQFCCEV RKDEQIEKEN PYTSYLDRFF SKKEDTEMLE TEPVEDGKPV EKEREGGFLS 660

HSGEFLFNKH LEAIGIPQFH SPVGSPLKSI QATLAPSAMK SSPQIPHKAY SSILKHLN 718

Nucleotide Sequence
(FASTA)

ATGGCAGAGA AGTTTGAAAG CCTCATGAAC ATCCATGGTT TTGATGTAGG TTCTCGGTAT 60

ATGGACTTAA AACCTCTGGG CTGTGGTGGC AACGGCTTAG TTTTTTCTGC TGTCGATAAT 120

GACTGCGACA AAAGAGTAGC AGTCAAGAAA ATTGTCCTTA CAGATCCTCA GAGCGTTAAA 180

CATGCTCTGC GTGAGATCAA AATTATTAGA AGACTTGACC ATGATAACAT TGTCAAAGTG 240

TTTGAAATCC TCGGTCCCAG TGGGAGTCAA TTGACAGATG ATGTAGGCTC TCTTACAGAA 300

CTGAACTGTG TTTACATTGT CCAAGAGTAT ATGGAGACAG ATCTGGCTAA ACTGGTGGAG 360

CAGGGGCCCT TACCTGAAGA ACATGCTAGG CTCTTCATGT ACCAGCTGCT ACGTGGGCTC 420

AAATATATAC ACTCTGCAAA CGTCCTGCAC AGAGATCTCA AACCAGCTAA CTTGTTCATT 480

AATACTGAAG ACTTGGTGCT GAAAATCGGT GACTTTGGCC TTGCACGGAT CATGGATCCT 540

CATTATTCCC ATAAGGGCCA TCTTTCCGAA GGACTGGTAA CTAAATGGTA CAGATCACCT 600

CGCCTCTTGC TTTCACCCAA CAACTATACT AAAGCCATTG ATATGTGGGC TGCAGGTTGC 660

ATCTTTGCTG AAATGCTGAC AGGGAAAACC CTCTTTGCAG GTGCACATGA ACTTGAACAG 720

ATGCAGCTTA TTTTAGAATC TATTCCTGTT GTGCATGAGG AAGATCGTCA GGAACTTCTT 780

AGTGTAATCC CAGTTTACAT TAAAAGCGAT ATGACTGAGC CACACAAACC TTTAACTCAG 840

CTCCTCCCAG GCATTAGCCC TGAAGCACTG GACTTCCTGG AACAAATACT GACCTTTAGT 900

CCCATGGATC GAATGACAGC AGAAGAAGCT TTGTCCCATC CTTACATGAG TATTTATTCC 960

TTTCCAACTG ATGAGCCTAT TTCAAGCCAT CCCTTCCACA TTGAAGACGA GGTCGATGAT 1020

ATTCTGCTCA TGGATGAAAG TCACAGCCAC ATCTATAATT GGGAAAGATA TCATGACAGT 1080

CAGTTTTCAG ACCAGGAGTG GTCTGCTCAT AACACCTTCG AAGCTGACGA GGTTCAGCGT 1140

GACCCAAGGG CTCTTTCTGA CGGGACGGAC GAGGAGGAAG TACAAGTAGA TCCTCGCAAA 1200

TATCTGGACG GTGACCGTGA AAAATACCTA GAGGATCCCG CTTTCGATAC TCACTTCTCC 1260

ACTGAACCTT GCTGGCCATA TCCAGATCAC CATGAAAACA AATATTGTGA TCTAGAATGT 1320

AGCCACACGT GTAATTACAA AATGAGGTCA TCTTCGTACC TAGATAATTT AGTCTGGAGA 1380

GAAAGTGAGG TGAACCATTA CTATGAGCCC AAGCTTATAA TTGATCTTTC TAACTGGAAA 1440

GAGCAGAGTA AAGAGAAGTC AGACAAGAAA GGCAAGTCCA AATGTGAAAG GAATGGGTTG 1500

GTGAAAGCTC GGTTAGCTCT TGAGGAAGCC TCGCAGCAAC TTACAGAAAA GGAGAAGAAT 1560

CAGGGGTTTG ACTTTGATTC TTTTATAGCA GGGACTATTC AGCTTAGTTT ACAGCATGAG 1620

TCAACTGATA TTGATAAATT AAATGATCTG AATAGCTCAG TGTCCCTCTT GGAGTCAAAA 1680

GGCATATCGA AATCAGTAAG CAGAGAGAAA CAGGAGAAAG GAATGGCCAA CTTGGCCCAG 1740

TTGGAAGCAC TCTACCAAAA TTCGTGGGAT GGCCAGCTTG TAAGTGGAGG AGAGGAGTGC 1800

TTTCTCATAG ACCAGTTTTG TTGTGAAGTT AGGAAAGATG AGCAGATAGA GAAGGAGAAT 1860

CCATACACCA GTTACCTGGA TAGATTTTTT AGCAAGAAGG AAGATACCGA AATGCTAGAA 1920

ACTGAGCCAG TTGAAGATGG GAAGCCTGTA GAGAAAGAAA GAGAGGGGGG CTTTTTAAGT 1980

CATAGCGGGG AATTCCTCTT TAACAAGCAC CTCGAAGCGA TAGGTATCCC TCAGTTCCAC 2040

AGCCCCGTTG GCTCACCGCT TAAATCAATA CAGGCCACCC TAGCACCTTC TGCTATGAAA 2100

TCATCTCCTC AGATTCCTCA TAAAGCATAC AGCAGCATTC TGAAACACCT AAACTAA 2157

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++lkplg G +g+v+savd+++++rva+kk++  +++ +s+k++lRE+k++++l+h+Ni

Q: 20    YMDLKPLGCGGNGLVFSAVDNDCDKRVAVKKIV--LTDPQSVKHALREIKIIRRLDHDNI  77

         7899****************************9..9************************

S: 61    iklldvftpee........eleelkdvYlvtelmetdLkkviksqklsdehiklllyqil  112

         +k+++++ p+         +l+el+ vY+v+e+metdL+k++++  l +eh++l++yq+l

Q: 78    VKVFEILGPSGsqltddvgSLTELNCVYIVQEYMETDLAKLVEQGPLPEEHARLFMYQLL  137

         *********998999999999***************************************

S: 113   rglkylHsanviHrDlKPsNllvnedce.lkildFGlarsadkekekk..lteyvatrwY  169

         rglky+Hsanv+HrDlKP+Nl++n++   lki dFGlar++d+++++k  l+e ++t+wY

Q: 138   RGLKYIHSANVLHRDLKPANLFINTEDLvLKIGDFGLARIMDPHYSHKghLSEGLVTKWY  197

         ************************876449**************999999**********

S: 170   raPeillslkeytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflk  229

         r+P++lls ++ytka+D+W++GCI+aE+ltgk+lf+g++e++q+++ile ++ ++ee+ +

Q: 198   RSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQ  257

         ************************************************************

S: 230   kieseearnyikslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

         ++ s  +  yiks +++++k++++l+p  s+eald+le++L+++p++R+++eeaL+hpY+

Q: 258   ELLSV-IPVYIKSDMTEPHKPLTQLLPGISPEALDFLEQILTFSPMDRMTAEEALSHPYM  316

         ****5.*****************************************************7

Domain Sequence
(FASTA)

YMDLKPLGCG GNGLVFSAVD NDCDKRVAVK KIVLTDPQSV KHALREIKII RRLDHDNIVK 60

VFEILGPSGS QLTDDVGSLT ELNCVYIVQE YMETDLAKLV EQGPLPEEHA RLFMYQLLRG 120

LKYIHSANVL HRDLKPANLF INTEDLVLKI GDFGLARIMD PHYSHKGHLS EGLVTKWYRS 180

PRLLLSPNNY TKAIDMWAAG CIFAEMLTGK TLFAGAHELE QMQLILESIP VVHEEDRQEL 240

LSVIPVYIKS DMTEPHKPLT QLLPGISPEA LDFLEQILTF SPMDRMTAEE ALSHPYM 297

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

acs:100561204

;

InterPros

IPR011009	; Kinase-like_dom.
IPR008350	; MAPK_ERK3/4.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01771

; ERK3ERK4MAPK.

Created Date

20-Feb-2013