EKS-ANC-00330
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ANC-00330
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Other/PEK387.92.6E-116491957467
StatusUnreviewed
Ensembl ProteinENSACAP00000002180
UniProt AccessionG1KAG9;
Protein Name
Protein Synonyms/Alias
Gene NameEIF2AK3
Gene Synonyms/Alias EIF2AK3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSACAG00000002119ENSACAP00000002180ENSACAT00000002239
OrganismAnolis carolinensis
Functional Description
Protein Length996
Protein Sequence
(FASTA)
RSLVIISTLD GRIAALDPEN GGRKQWDLDV GSGSLVSSSL SKPEVFGNKM IIPSLDGDLF 60
QWDRDRGSME AVPFTIESLL ESSYRFGDDL VLVGGKSLTT YGLSSRSGKV KYICSAMGCH 120
RWDDDEIEQE DILLLHRTQK TVRAVGPRSG NEKWNFSVGH FELRYVPDTE TRTGFIEGHL 180
KPNLNKGDSK IISDVEEQQE AIMKDTVIKV SVADWKVMAF NKKGGHLEWE YQFCNPVASA 240
WLVKDGKVIP ISLFDDTSYT SGNDVLEDDE DLMEARGAME SSVYLGMFGG QLYLQSSVRI 300
SDKFPTNPKA LESRNDNAVT PLPVIRWKPL IHSPSRTPVI VGSDEFDKCL SNDKFSHEEY 360
SNGALSVLQY PYVIDNGYFL PYYSRERNRR STQITVRFSE SMSYKNIRKK DPVLLLHWWK 420
EIVSTILFCI VATTFVVRRL FHPNAHNRQR KESETQCQTD TKYETSAGQA KDNTWSDIKN 480
SGYVSRYLTD FEPIQCLGRG GFGVVFEARN KVDDCNYAIK RIRLPNRDQA REKVMREVKA 540
LAKLDHPCIV RYFNAWLEAP PESWQERMDK QWLKDESIDW AISSPSPAEA PSFKIRTEPF 600
SSKEQIEVST TPGERRTLLS VGISCDQSHS SECQFYPLEF SSVDNRDLSQ MAEPVSNIKD 660
SLLSDCDIEG SCSFELCPPA KPKVRMRERT SSSIVFEDSG CDNASSKKDS HSGDKETSTK 720
GSSSKISSSA TPLSVSPPRP TTLSLDLSKN SVPKAMPTTP KVYLYIQMQL CRKENLKDWM 780
NTRCIMEERE RTECLLIFLQ IAEAVQFLHS KGLMHRDLKP SNIFFTMDDI VKVGDFGLVT 840
AMDQDEEEES VLTPMPTYDR HTGQVGTKLY MSPEQVHGNV YSHKVDIFSL GLILFELLYP 900
FSTQMERVRT LSEVRHLTFP DLFIEKYPEE YAMVKHMLSP SPTERPEAAD IIENPLFEDL 960
EFPSKPVLRQ RSRTMSLSGL KHSTSLEYSY SQLYGV 996
Nucleotide Sequence
(FASTA)
AGATCATTAG TAATTATAAG TACTTTGGAT GGACGGATTG CTGCTCTAGA TCCAGAAAAT 60
GGTGGCAGAA AACAGTGGGA CCTAGATGTG GGATCTGGTT CTCTTGTCTC ATCTAGTCTC 120
AGTAAACCAG AGGTATTTGG GAATAAAATG ATTATTCCTT CTTTGGATGG AGACCTTTTC 180
CAGTGGGATC GTGATAGAGG AAGCATGGAA GCTGTTCCTT TCACCATTGA ATCTCTTCTT 240
GAATCATCCT ATAGATTTGG TGATGATCTT GTTCTGGTTG GAGGGAAATC TTTGACAACT 300
TATGGACTGA GTTCACGTTC AGGAAAGGTG AAATACATTT GCTCAGCTAT GGGCTGTCAT 360
CGCTGGGATG ATGATGAGAT AGAACAGGAA GATATTCTTC TTCTTCATCG GACCCAGAAA 420
ACAGTTCGTG CTGTTGGACC TCGCAGTGGC AATGAAAAGT GGAATTTTAG TGTTGGTCAC 480
TTTGAGCTGC GCTATGTTCC AGACACTGAA ACAAGAACAG GATTTATTGA AGGCCATTTA 540
AAACCAAATC TAAACAAAGG TGATTCAAAA ATCATTTCGG ATGTGGAAGA ACAGCAGGAG 600
GCTATAATGA AGGATACAGT GATAAAGGTC TCGGTAGCTG ATTGGAAGGT TATGGCATTT 660
AATAAAAAGG GAGGACATCT GGAATGGGAA TATCAGTTTT GCAACCCAGT TGCTTCTGCC 720
TGGCTTGTTA AAGATGGCAA GGTGATTCCA ATCAGTCTCT TTGATGATAC AAGCTACACT 780
TCTGGCAATG ATGTCTTAGA AGATGATGAA GATCTTATGG AAGCCAGAGG AGCTATGGAG 840
TCCAGTGTTT ATTTAGGTAT GTTTGGAGGC CAACTGTACC TTCAATCTTC AGTCAGAATT 900
TCTGATAAGT TTCCAACCAA CCCTAAAGCT TTGGAGTCCA GGAATGATAA TGCAGTCACC 960
CCTTTACCTG TAATCAGGTG GAAGCCCTTG ATTCACTCTC CTTCTAGAAC TCCTGTTATA 1020
GTGGGATCTG ATGAATTTGA CAAATGCCTC AGCAATGACA AATTTTCTCA CGAAGAATAC 1080
AGTAATGGTG CCCTTTCAGT CCTGCAGTAT CCTTATGTCA TAGATAATGG CTATTTCTTG 1140
CCATACTACT CACGAGAGAG GAACAGGCGG AGCACTCAGA TCACAGTCCG GTTTTCTGAG 1200
AGCATGAGCT ATAAGAATAT CCGTAAAAAA GATCCTGTTC TGTTACTTCA CTGGTGGAAA 1260
GAAATTGTTA GCACCATCTT ATTCTGCATT GTGGCTACTA CATTTGTTGT ACGCAGACTA 1320
TTCCATCCCA ATGCTCACAA CCGACAGCGA AAGGAGTCGG AAACCCAGTG TCAGACAGAT 1380
ACGAAATATG AAACTTCTGC TGGACAGGCT AAAGATAACA CCTGGTCTGA CATTAAGAAC 1440
TCTGGATATG TATCGAGATA TCTAACAGAT TTTGAGCCAA TTCAGTGCTT GGGCCGTGGG 1500
GGATTTGGAG TAGTGTTTGA AGCCAGAAAC AAAGTTGATG ATTGTAATTA CGCTATTAAA 1560
AGAATACGTT TACCAAACAG GGATCAGGCT CGTGAGAAGG TGATGCGTGA AGTTAAGGCC 1620
TTGGCAAAGC TTGACCATCC TTGTATTGTT CGTTACTTCA ATGCTTGGCT AGAAGCACCA 1680
CCCGAGAGTT GGCAGGAAAG AATGGACAAA CAGTGGCTAA AAGATGAAAG TATTGATTGG 1740
GCAATCAGTT CTCCCAGTCC AGCGGAAGCA CCATCATTTA AAATTAGAAC TGAGCCATTT 1800
TCTTCAAAGG AACAGATTGA AGTTAGTACT ACACCTGGAG AAAGGAGGAC CTTGCTCTCT 1860
GTTGGGATAT CTTGTGACCA ATCACATTCG TCAGAGTGCC AGTTTTACCC TCTGGAGTTC 1920
TCTTCTGTTG ATAACAGAGA CTTGAGCCAA ATGGCGGAAC CTGTGTCAAA CATTAAGGAT 1980
AGCCTTCTCT CCGATTGTGA TATAGAAGGT AGCTGTTCCT TTGAACTTTG TCCTCCAGCT 2040
AAGCCAAAAG TAAGGATGAG GGAGAGGACC TCTTCATCTA TTGTTTTTGA AGACTCTGGC 2100
TGTGACAATG CTTCTAGTAA AAAGGATAGC CACTCTGGAG ATAAAGAAAC AAGCACAAAA 2160
GGGTCTAGTA GTAAAATATC ATCGTCAGCA ACTCCTTTGT CTGTTTCTCC ACCAAGACCT 2220
ACAACCTTAA GTTTGGACCT CTCTAAGAAC TCTGTACCAA AAGCCATGCC TACCACACCA 2280
AAAGTGTACC TTTACATCCA GATGCAACTC TGTAGGAAGG AAAACCTCAA AGACTGGATG 2340
AATACACGAT GTATCATGGA GGAGAGGGAA AGGACAGAGT GCCTGCTAAT ATTCTTACAG 2400
ATAGCAGAAG CTGTTCAGTT CTTACATAGC AAAGGATTGA TGCATCGGGA CCTCAAGCCT 2460
TCCAACATAT TTTTCACAAT GGATGATATA GTAAAAGTCG GGGATTTTGG CCTAGTGACT 2520
GCAATGGACC AAGATGAGGA GGAAGAATCT GTTCTAACAC CAATGCCAAC TTATGACAGG 2580
CACACTGGGC AAGTTGGGAC CAAGCTCTAC ATGAGCCCAG AACAGGTCCA TGGAAATGTT 2640
TATTCACACA AAGTGGATAT CTTCTCTTTG GGCCTGATTT TGTTTGAGCT CCTTTATCCT 2700
TTCAGCACGC AAATGGAGAG AGTCAGGACA TTGAGTGAAG TAAGGCATTT GACGTTTCCT 2760
GATCTGTTCA TTGAGAAGTA TCCAGAGGAG TATGCAATGG TAAAGCACAT GCTCTCTCCA 2820
AGTCCCACGG AAAGACCAGA GGCTGCGGAC ATTATAGAAA ACCCTTTATT TGAAGACTTG 2880
GAATTCCCAT CAAAACCAGT GCTGCGACAG AGATCACGGA CAATGAGTTT ATCTGGATTG 2940
AAGCATTCAA CATCTCTGGA ATATTCATAT TCTCAGCTTT ATGGTGTC 2988
Domain Profile
S: 1     feeikvlGkGgfgvVlkaknkldkkeyaikriklnkakkelekverevkaLaklehpniv  60
         fe i++lG+GgfgvV++a+nk+d+++yaikri+l+++++++ekv+revkaLakl+hp iv
Q: 491   FEPIQCLGRGGFGVVFEARNKVDDCNYAIKRIRLPNRDQAREKVMREVKALAKLDHPCIV  550
         799*********************************************************
S: 61    rYfaawleekeesl..............................................  74
         rYf+awle ++es+                                              
Q: 551   RYFNAWLEAPPESWqermdkqwlkdesidwaisspspaeapsfkirtepfsskeqievst  610
         *******************************99999999999999999999999999999
S: 75    ............................................................  74
                                                                     
Q: 611   tpgerrtllsvgiscdqshssecqfyplefssvdnrdlsqmaepvsnikdsllsdcdieg  670
         999999999999999999999999999999999888888888888888888888888888
S: 75    ...................................tdsseveaeaeleesesseesdtk.  98
                                            +                      k 
Q: 671   scsfelcppakpkvrmrertsssivfedsgcdnasS----------------------Kk  708
         888888888888888888766666555555443321......................02
S: 99    ......................................................llyiqm  104
                                                               +lyiqm
Q: 709   dshsgdketstkgssskisssatplsvspprpttlsldlsknsvpkampttpkvYLYIQM  768
         222224444445555566677899************************************
S: 105   elceketLkdwiderkllesrselvm.rlfkqllegleylHskgliHrdLkpsniFldsd  163
         +lc+ke+Lkdw++ r+ +e+r++  +  +f q++e++++lHskgl+HrdLkpsniF+++d
Q: 769   QLCRKENLKDWMNTRCIMEERERTEClLIFLQIAEAVQFLHSKGLMHRDLKPSNIFFTMD  828
         **************************9*********************************
S: 164   dqvKigDFgLatalaealkedvkqdaqskeakhtgqvgtklymsPeqleksqYnkkvDif  223
         d vK+gDFgL+ta++++++e+++ ++++++ +htgqvgtklymsPeq++++ Y++kvDif
Q: 829   DIVKVGDFGLVTAMDQDEEEESVLTPMPTYDRHTGQVGTKLYMSPEQVHGNVYSHKVDIF  888
         ************************************************************
S: 224   sLGlilfeLlypfstemervetltelrdgkipedfddkvpkekkllqkllsrdpkeRpsa  283
         sLGlilfeLlypfst+merv+tl e+r++ +p+ f +k+p+e+ +++++ls +p+eRp+a
Q: 889   SLGLILFELLYPFSTQMERVRTLSEVRHLTFPDLFIEKYPEEYAMVKHMLSPSPTERPEA  948
         ************************************************************
S: 284   sellksell  292
          ++++++l+
Q: 949   ADIIENPLF  957
         *****9876
Domain Sequence
(FASTA)
FEPIQCLGRG GFGVVFEARN KVDDCNYAIK RIRLPNRDQA REKVMREVKA LAKLDHPCIV 60
RYFNAWLEAP PESWQERMDK QWLKDESIDW AISSPSPAEA PSFKIRTEPF SSKEQIEVST 120
TPGERRTLLS VGISCDQSHS SECQFYPLEF SSVDNRDLSQ MAEPVSNIKD SLLSDCDIEG 180
SCSFELCPPA KPKVRMRERT SSSIVFEDSG CDNASSKKDS HSGDKETSTK GSSSKISSSA 240
TPLSVSPPRP TTLSLDLSKN SVPKAMPTTP KVYLYIQMQL CRKENLKDWM NTRCIMEERE 300
RTECLLIFLQ IAEAVQFLHS KGLMHRDLKP SNIFFTMDDI VKVGDFGLVT AMDQDEEEES 360
VLTPMPTYDR HTGQVGTKLY MSPEQVHGNV YSHKVDIFSL GLILFELLYP FSTQMERVRT 420
LSEVRHLTFP DLFIEKYPEE YAMVKHMLSP SPTERPEAAD IIENPLF 467
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00317
EKS-BOT-00338
EKS-CAE-00275
EKS-CAJ-00347
EKS-CAF-00346
EKS-CAP-00372
EKS-CII-00189
EKS-CIS-00091
EKS-DAR-00702
EKS-DRM-00166
EKS-EQC-00330
EKS-FEC-00329
EKS-GAG-00285
EKS-GAA-00421
EKS-GOG-00335
EKS-HOS-00345
EKS-ICT-00322
EKS-LAC-00353
EKS-LOA-00350
EKS-MAM-00344
EKS-MEG-00279
EKS-MOD-00334
EKS-MUM-00373
EKS-MUP-00333
EKS-MYL-00337
EKS-NOL-00309
EKS-ORN-00442
EKS-ORA-00297
EKS-ORC-00317
EKS-ORL-00409
EKS-OTG-00343
EKS-PAT-00321
EKS-PES-00298
EKS-PEM-00179
EKS-POA-00331
EKS-PTV-00079
EKS-RAN-00353
EKS-SAH-00317
EKS-SUS-00302
EKS-TAG-00414
EKS-TAR-00445
EKS-TEN-00441
EKS-VIP-00041
EKS-XET-00434
EKS-XIM-00430
Gene Ontology
GO:0005789; C:endoplasmic reticulum membrane
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0019722; P:calcium-mediated signaling
GO:0007029; P:endoplasmic reticulum organization
GO:0030968; P:endoplasmic reticulum unfolded protein response
GO:0006983; P:ER overload response
GO:0045444; P:fat cell differentiation
GO:0030073; P:insulin secretion
GO:0048009; P:insulin-like growth factor receptor signaling pathway
GO:0031642; P:negative regulation of myelination
GO:0017148; P:negative regulation of translation
GO:0032092; P:positive regulation of protein binding
GO:0009967; P:positive regulation of signal transduction
GO:0046777; P:protein autophosphorylation
GO:0051260; P:protein homooligomerization
GO:0019217; P:regulation of fatty acid metabolic process
GO:0032933; P:SREBP signaling pathway
GO:0006412; P:translation
GO:0006926; P:virus-infected cell apoptotic process
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR011047; Quinonprotein_ADH-like.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
SMARTs
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013