EKS-ANC-00395

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ANC-00395

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/IRAK	326.4	1.4E-97	193	459	267

Status

Unreviewed

Ensembl Protein

ENSACAP00000002933

UniProt Accession

G1KBF6;

Protein Name

Protein Synonyms/Alias

Gene Name

IRAK4

Gene Synonyms/Alias

IRAK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSACAG00000002988	ENSACAP00000002933	ENSACAT00000003009

Organism

Anolis carolinensis

Functional Description

Protein Length

465

Protein Sequence
(FASTA)

MNKPITPSTY VRCLGYGMVK QLADFIDPQE GWKKLAVDIK NPSGDNRYNQ MHLRRFEARQ 60

QVGKSPTCEL LHDWGTLNCT VSDLVDLLVK NQFLAPARLL LPDAVQAKEN ISVPLPFQET 120

MCLNEKEAPL GEKQVASVSP LPAPDRELEM PVSCGLSTEE SASLLNSTRL QIFLFHELKS 180

FTNNFDDRTV SAGGNKIGEG GFGVVYKGCT NGRTVAVKKL TVLADVSIDD LKKQFEQEIT 240

IMAKCQHENL VELLGFSNDF DQPCLVSDYM PNGSLLDRLA CLDDTPPIPW KTRCNIAQGA 300

SNGICFLHEN NHIHRDVKSA NILLTEKFVP KLSDFGLARA SVKFTHTILT ERIVGTAAYM 360

APEALRGEIT PKSDIFSFGV VLLEIITGLP PVDENRDPQL LLTIKEEIED EEKTLEDYID 420

EKMSSWSMAS VEQMYSIACQ CLNEKKNRRP DIKMVKQHLE EMAFE 465

Nucleotide Sequence
(FASTA)

ATGAACAAGC CCATAACGCC TTCAACATAC GTGCGCTGCC TTGGCTATGG CATGGTAAAA 60

CAACTAGCAG ATTTTATTGA TCCGCAGGAA GGATGGAAGA AATTAGCAGT AGACATAAAA 120

AATCCCTCTG GAGATAACAG ATACAACCAA ATGCATTTAA GGAGATTTGA AGCACGTCAG 180

CAAGTAGGAA AGAGCCCTAC CTGTGAATTA CTTCATGACT GGGGTACATT AAACTGTACA 240

GTTAGTGATT TGGTGGACTT GCTGGTTAAG AATCAGTTCT TGGCACCCGC CAGACTTCTT 300

CTTCCAGATG CTGTGCAGGC AAAAGAAAAT ATCTCAGTGC CTTTACCTTT CCAAGAAACA 360

ATGTGTCTAA ATGAAAAAGA AGCTCCTTTG GGGGAAAAGC AAGTGGCATC TGTGTCCCCT 420

CTCCCAGCTC CAGACAGAGA GCTTGAAATG CCAGTTTCTT GTGGTCTGAG TACCGAGGAG 480

AGTGCCTCAC TTTTGAACAG CACCAGATTG CAGATTTTTC TCTTTCATGA GCTGAAAAGC 540

TTTACAAATA ACTTTGATGA CAGAACAGTG TCAGCTGGTG GCAACAAGAT TGGCGAAGGA 600

GGCTTTGGAG TGGTATACAA AGGGTGCACC AATGGCAGAA CGGTGGCAGT GAAAAAACTG 660

ACGGTTCTCG CTGATGTAAG TATTGATGAT CTGAAAAAAC AGTTTGAACA AGAAATAACA 720

ATAATGGCAA AGTGTCAGCA TGAGAATCTA GTAGAATTGC TTGGGTTCTC AAATGACTTT 780

GATCAGCCGT GCCTTGTCTC TGACTATATG CCTAATGGCT CATTGCTTGA CAGATTAGCT 840

TGTCTGGATG ACACTCCACC AATTCCATGG AAAACAAGAT GCAATATTGC TCAAGGTGCA 900

TCAAATGGAA TCTGCTTTTT ACATGAAAAT AACCATATTC ACCGTGATGT TAAAAGCGCA 960

AATATCTTAC TAACAGAGAA ATTTGTGCCC AAACTTTCTG ACTTTGGGCT CGCAAGGGCC 1020

TCAGTTAAAT TCACGCACAC CATCCTAACA GAGAGAATAG TGGGAACAGC AGCCTATATG 1080

GCTCCGGAGG CTTTGCGAGG AGAGATCACT CCTAAATCCG ACATCTTCAG CTTTGGAGTG 1140

GTATTACTTG AAATTATAAC TGGGCTTCCT CCTGTGGATG AAAATAGAGA TCCCCAGTTA 1200

CTGCTCACTA TCAAAGAGGA AATTGAAGAT GAAGAGAAGA CACTTGAAGA TTATATTGAT 1260

GAAAAGATGA GTAGTTGGAG TATGGCATCA GTTGAACAGA TGTACTCAAT TGCTTGCCAG 1320

TGTCTGAATG AGAAGAAGAA CCGGAGACCA GATATTAAGA TGGTCAAGCA ACATTTAGAA 1380

GAAATGGCGT TTGAATAA 1398

Domain Profile

S: 3     ednrigeGgfgevyrgelkntavavkklkeeadlslkelkqsfltElkvlarfrHdnile  62

          +n+igeGgfg+vy+g++++ +vavkkl   ad+s++ lk++f++E+ ++a+++H+n++e

Q: 193   GGNKIGEGGFGVVYKGCTNGRTVAVKKLTVLADVSIDDLKKQFEQEITIMAKCQHENLVE  252

         579*********************************************************

S: 63    llgysaeseklcLvYqymknGsLedrLqcqkgsepLsWpqRlsillGtaraiefLHeasp  122

         llg+s + +++cLv  ym+nGsL drL c ++++p++W++R++i++G++++i fLHe+

Q: 253   LLGFSNDFDQPCLVSDYMPNGSLLDRLACLDDTPPIPWKTRCNIAQGASNGICFLHEN--  310

         **********************************************************..

S: 123   slihgdiksaNiLLDekltpKlgDfglarfapesekqsstvlrtskvrgtlaYlpeefir  182

         ++ih+d+ksaNiLL ek+ pKl+Dfglar   +s k ++t+l t++++gt+aY+++e++r

Q: 311   NHIHRDVKSANILLTEKFVPKLSDFGLAR---ASVKFTHTIL-TERIVGTAAYMAPEALR  366

         *****************************...8889999999.*****************

S: 183   vgqltvkvDvySfGiVllEvltGlravdedrktkyLkdllkeeieeekveilekfldkka  242

          g++t k+D++SfG+VllE++tGl+ vde+r+++ L+ + keeie+e+ ++le+++d+k+

Q: 367   -GEITPKSDIFSFGVVLLEIITGLPPVDENRDPQLLLTI-KEEIEDEE-KTLEDYIDEKM  423

         .***********************************998.********.***********

S: 243   gkleeellealielalaclaekakkrPtmsqvlell  278

         ++   +++e+++++a++cl+ek+++rP+++ v ++l

Q: 424   SSWSMASVEQMYSIACQCLNEKKNRRPDIKMVKQHL  459

         *******************************99876

Domain Sequence
(FASTA)

GGNKIGEGGF GVVYKGCTNG RTVAVKKLTV LADVSIDDLK KQFEQEITIM AKCQHENLVE 60

LLGFSNDFDQ PCLVSDYMPN GSLLDRLACL DDTPPIPWKT RCNIAQGASN GICFLHENNH 120

IHRDVKSANI LLTEKFVPKL SDFGLARASV KFTHTILTER IVGTAAYMAP EALRGEITPK 180

SDIFSFGVVL LEIITGLPPV DENRDPQLLL TIKEEIEDEE KTLEDYIDEK MSSWSMASVE 240

QMYSIACQCL NEKKNRRPDI KMVKQHL 267

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0019221	; P:cytokine-mediated signaling pathway

KEGG

acs:100556834

;

InterPros

IPR000488	; Death.
IPR011029	; DEATH-like.
IPR017428	; Interleukin-1_rcpt-assoc_kin4.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.

Pfam

PF00531	; Death; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013