EKS-ANC-00381

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ANC-00381

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	351.2	3.9E-105	1278	1536	259

Status

Unreviewed

Ensembl Protein

ENSACAP00000003105

UniProt Accession

G1KBM9;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K4

Gene Synonyms/Alias

MAP3K4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSACAG00000003094	ENSACAP00000003105	ENSACAT00000003184

Organism

Anolis carolinensis

Functional Description

Protein Length

1543

Protein Sequence
(FASTA)

RQENRPENVA WKISESDPEE LSDETSTETF YGTSPPSTPR QMKRLSTKHL KSNVGRPTSR 60

SALKEKMSSP NQLPNKESFK PVENSEEHSY KQGKKIRATL RTTERDHKKN VQCSFMLESV 120

GGSLPKKSIL DVDLNKPYLS LGCSNAKPPV SVPVPIAKTT RQTSRTDYPA DRLKFFETLR 180

LLLKLTSVSK KKDKEQKGQE STSSVELNRS NELIWLELQA WHAGRTINDQ DFYLYTARQA 240

IPDIVNEILT FKVNYGNLSC IGNGASLNGT SGRLCKAAYG ASAVGYSSYH EHLHRQRVSF 300

EQVKRIMELL EYVEALYPSL KALQSDYEKY AAKDFQDRVQ ALCLWLNITK DLNQKLRIMG 360

TVLGIKDLSD IGWPVFEIPS PGPFRDMDPE DEDRETSGAC TEESEDEEEI SEESMEELRQ 420

AIQNNFPSRP NFDFEAQDHL SRKLDRLESE DDSTSWVVTE CSGEAGCSRH CLTSIYRPFV 480

DKALKQMGLR KLILRLHKLM HGSLQRARMA LIKNDQQLEF SEYPDPILCS DYVQLSNSPP 540

SSDQKCSTVS WEELKAMDLP SFEPAFLVLC RVLLNVIHEC LKLRLEQRPA GEPSLLSIKQ 600

LVRECKEVLK GGLLMKQYYQ FMLREVLDDL QKNNCNIDSF EEDLHKMLMV YFDYMRSWIQ 660

MLQQLPQASH SLKNLLEEEW NFTKEITPYI RGGEAQAGKL FCDIAGVLLK STGIFLDAGL 720

QVSCAEFWAS ADDSAASDEI RRSVIETSRA LKELFHEARE RASKALGFAK RLRKDLEIAA 780

EFTLSASVRE FLSALKAQQY MKVQIPGLEN LQIFVPDNLV GEKPIILQLL NTAAGKDCSK 840

DSDEVASEPF LLMTKYSEKD HEVIDSWSIW EGQPIKIVPQ VETIDTLRSV QVDNLLLVVM 900

QPVHLVNQRK AFQQVFEGLI SLHQEQTSSQ PVIAKALQQL KSDALQLCNK ISSALDRVER 960

MFTSEFDAEI DESESVTLQQ YYREAMIQCY NFGFEYHKEV IRLMSGDFRQ KIGDQYISFA 1020

RKWMNYVLTK CESGRGTRPR WATQGFDFLQ AIEPAFISAL PEDDFLSLQA LMNECIGHVI 1080

GKPHSPVTAL HRNSPRPVKV PRCHSDPPNP HLIIPTPEAF STRNVPCDVR NHCSPALSRP 1140

APFGGDSAQP KPVSCANDIR GSSVPENDRL ASIAAELQFR SLSRHSSPTE EREEPSYPKG 1200

DSSGSARRSW ELRTLISQTK DTASRQGPME AVQKSVQLFE EKRYREMRRK NIIGQVCDTP 1260

KSYDNVMHVG LRKVTFKWQR GNKIGEGQYG KVYTCISVDT GELMAMKEIR FQPNDHKTIK 1320

ETADELKIFE GIKHPNLVRY FGVELHREEM YIFMEYCDEG TLEEVSRLGL QEHVIRLYTK 1380

QITTAINVLH EHGIVHRDIK GANIFLTSSG LIKLGDFGCS VKLKNNTQTM PGEVNSTLGT 1440

AAYMAPEVIT RAKGEGHGRA ADIWSLGCVV IEMVTGKRPW HEFEHNFQIM YRVGMGHKPP 1500

IPERISPEGK DFLSHCLESD PKMRWTASQL LDHPFVKVCT DEE 1543

Nucleotide Sequence
(FASTA)

AGGCAGGAGA ACAGGCCTGA AAATGTTGCG TGGAAGATCT CGGAGTCTGA TCCTGAGGAG 60

TTATCAGATG AAACAAGTAC TGAAACTTTC TATGGAACCT CTCCTCCTAG CACCCCACGG 120

CAGATGAAAC GTTTATCAAC AAAACACCTG AAAAGTAACG TTGGGAGACC TACCAGCCGT 180

TCTGCTCTGA AAGAAAAGAT GAGCTCACCA AACCAGCTGC CTAACAAAGA GAGCTTCAAA 240

CCCGTTGAGA ACTCAGAAGA ACACAGCTAC AAGCAAGGGA AAAAGATCCG AGCCACCTTA 300

AGGACAACAG AGAGGGATCA CAAGAAAAAC GTACAGTGTT CATTCATGCT GGAATCAGTT 360

GGTGGGTCCT TGCCAAAAAA GTCAATTCTA GATGTTGATC TCAATAAGCC TTACCTCAGC 420

CTTGGCTGCA GCAATGCAAA GCCACCAGTA TCTGTACCTG TGCCTATAGC CAAAACCACA 480

CGGCAGACTT CTCGAACTGA TTACCCAGCG GACCGCCTGA AGTTCTTCGA AACCCTACGA 540

CTTTTGTTAA AGCTTACCTC AGTTTCCAAG AAAAAGGACA AGGAGCAAAA AGGCCAAGAA 600

AGCACTTCCT CTGTTGAGTT AAACCGATCC AATGAATTGA TCTGGCTTGA ACTGCAAGCT 660

TGGCATGCAG GCCGGACTAT TAACGACCAA GATTTTTATT TGTACACAGC CCGTCAAGCC 720

ATCCCAGATA TTGTCAATGA AATCCTTACT TTCAAAGTGA ACTATGGGAA CCTTTCCTGT 780

ATAGGAAACG GAGCCAGTCT TAATGGTACA TCGGGAAGAC TGTGTAAAGC AGCCTATGGA 840

GCTAGTGCTG TGGGCTACTC AAGCTACCAT GAACACCTCC ATCGGCAGCG GGTCTCGTTT 900

GAACAGGTAA AGCGGATAAT GGAGCTGCTA GAATATGTAG AAGCACTTTA TCCATCTCTA 960

AAGGCCCTTC AAAGTGACTA TGAAAAATAC GCTGCAAAGG ATTTTCAGGA CAGGGTGCAG 1020

GCACTCTGTC TTTGGTTAAA CATTACAAAA GACTTAAATC AGAAACTAAG GATTATGGGA 1080

ACTGTTTTGG GCATTAAGGA TCTCTCTGAC ATTGGCTGGC CAGTGTTTGA AATCCCCTCT 1140

CCTGGTCCGT TCAGGGACAT GGACCCAGAA GATGAGGATA GGGAAACCTC CGGGGCTTGC 1200

ACAGAGGAAA GTGAAGACGA AGAAGAAATC TCAGAGGAGA GTATGGAGGA ACTCAGGCAA 1260

GCCATCCAGA ATAATTTTCC TAGTAGGCCA AATTTTGACT TTGAGGCACA GGATCATTTG 1320

TCCAGAAAGC TTGACAGGCT TGAATCCGAG GATGACTCAA CCTCCTGGGT TGTCACAGAA 1380

TGCAGTGGTG AGGCCGGCTG CAGCAGACAC TGTTTGACCT CTATTTATAG GCCATTTGTA 1440

GATAAAGCAC TGAAACAAAT GGGGTTACGA AAGCTAATTT TAAGACTGCA CAAGTTAATG 1500

CATGGCTCCT TGCAAAGGGC CCGAATGGCA TTGATAAAGA ATGATCAACA GTTGGAGTTT 1560

TCAGAATATC CAGATCCCAT TTTATGTTCA GATTACGTGC AGTTGTCAAA TTCTCCGCCT 1620

TCTTCAGATC AAAAATGCAG TACTGTGTCA TGGGAAGAAC TGAAAGCCAT GGATTTACCA 1680

TCTTTTGAGC CCGCATTTCT AGTTCTTTGC CGAGTCCTCC TCAATGTTAT CCATGAATGT 1740

CTCAAATTAA GATTGGAACA ACGACCTGCA GGGGAGCCAT CTCTCTTGAG TATTAAGCAG 1800

TTAGTACGAG AATGTAAAGA GGTCTTGAAG GGTGGCCTGC TAATGAAGCA ATATTATCAG 1860

TTTATGTTAC GTGAGGTGTT AGATGATTTA CAGAAGAACA ACTGCAACAT TGACTCTTTT 1920

GAGGAAGATC TGCATAAGAT GTTAATGGTT TATTTTGATT ATATGCGAAG CTGGATCCAA 1980

ATGCTGCAGC AGTTACCTCA AGCATCTCAT AGTTTAAAAA ATCTCTTGGA AGAAGAATGG 2040

AATTTCACTA AAGAAATTAC TCCTTATATA CGAGGGGGTG AAGCTCAAGC TGGAAAGCTG 2100

TTCTGTGACA TTGCAGGTGT GCTATTAAAA TCAACAGGAA TCTTTCTGGA TGCTGGCTTA 2160

CAAGTGAGCT GTGCCGAGTT TTGGGCTAGT GCTGATGATA GTGCTGCTTC AGATGAAATC 2220

AGGAGGTCTG TTATAGAGAC CAGCCGAGCA CTAAAAGAGC TGTTTCATGA AGCTAGAGAA 2280

AGAGCATCCA AAGCTCTTGG TTTTGCCAAG AGGTTAAGAA AGGATCTTGA AATAGCAGCA 2340

GAGTTCACAT TGTCTGCTTC TGTGAGAGAG TTCCTCAGTG CCCTGAAAGC ACAACAGTAT 2400

ATGAAGGTAC AAATCCCTGG ACTTGAAAAC TTACAGATCT TTGTGCCAGA TAACCTTGTG 2460

GGGGAAAAAC CTATTATCTT GCAGTTGCTT AATACAGCTG CAGGAAAAGA CTGTTCAAAA 2520

GACTCTGATG AAGTTGCAAG TGAACCATTT TTACTTATGA CAAAATACAG TGAAAAAGAT 2580

CATGAAGTTA TTGACAGCTG GAGCATTTGG GAAGGACAGC CTATTAAAAT AGTTCCTCAG 2640

GTGGAAACTA TTGACACACT GAGAAGTGTG CAGGTTGATA ACCTACTCCT TGTCGTCATG 2700

CAACCTGTTC ATCTTGTGAA CCAGAGAAAG GCTTTCCAAC AGGTTTTTGA AGGGCTGATC 2760

TCTTTGCATC AGGAGCAAAC ATCCAGCCAG CCAGTCATTG CTAAAGCTCT ACAGCAATTG 2820

AAGAGTGATG CTTTGCAGCT GTGCAATAAG ATAAGCAGTG CACTTGACAG AGTGGAGCGC 2880

ATGTTCACAT CTGAGTTTGA TGCAGAGATT GATGAGTCAG AATCAGTTAC TTTGCAGCAA 2940

TATTATCGGG AAGCCATGAT TCAGTGTTAC AATTTTGGTT TTGAGTATCA TAAAGAAGTC 3000

ATTCGTCTGA TGTCCGGAGA TTTCAGACAG AAAATTGGAG ACCAGTATAT CAGTTTTGCA 3060

AGGAAGTGGA TGAATTATGT CCTTACAAAA TGTGAGAGTG GTCGAGGCAC CAGACCCAGG 3120

TGGGCAACAC AGGGTTTTGA TTTTCTTCAA GCCATTGAGC CAGCCTTTAT TTCTGCTCTG 3180

CCAGAAGATG ACTTCTTGAG CTTACAGGCA CTGATGAATG AATGTATTGG GCATGTCATT 3240

GGAAAGCCTC ATAGTCCTGT AACAGCTCTT CATCGGAATA GTCCCCGTCC TGTTAAAGTA 3300

CCTCGATGTC ATAGTGATCC CCCAAATCCT CACCTCATCA TCCCAACTCC TGAAGCATTC 3360

AGCACAAGGA ATGTCCCATG CGATGTACGG AACCATTGCA GCCCTGCTCT TAGTCGCCCC 3420

GCTCCCTTTG GAGGTGACTC TGCTCAGCCA AAACCTGTCA GCTGTGCAAA TGATATCAGA 3480

GGTTCCAGTG TTCCTGAAAA TGATCGACTA GCTTCAATTG CTGCTGAATT ACAGTTTAGG 3540

TCATTAAGCC GCCACTCAAG TCCCACTGAA GAAAGAGAAG AACCATCTTA TCCAAAAGGG 3600

GATTCAAGCG GATCCGCCCG AAGGAGTTGG GAACTTCGAA CTCTCATCAG TCAGACCAAA 3660

GATACTGCAT CCAGGCAGGG ACCCATGGAA GCAGTTCAGA AATCTGTTCA GCTCTTTGAA 3720

GAGAAGAGGT ATCGAGAAAT GAGGCGGAAA AATATTATTG GCCAAGTTTG TGACACTCCG 3780

AAATCTTATG ACAACGTAAT GCATGTAGGT TTGAGAAAGG TGACATTCAA GTGGCAGAGA 3840

GGAAACAAAA TTGGAGAAGG CCAGTATGGA AAAGTCTATA CCTGTATCAG TGTTGACACT 3900

GGTGAATTGA TGGCCATGAA AGAAATAAGA TTTCAACCAA ATGATCATAA AACCATCAAA 3960

GAAACTGCAG ATGAGCTGAA AATATTTGAA GGCATTAAGC ATCCTAACTT GGTTCGGTAC 4020

TTTGGTGTAG AGCTCCATAG GGAAGAAATG TACATCTTCA TGGAATACTG TGATGAAGGA 4080

ACTCTGGAAG AAGTGTCAAG GCTGGGTCTC CAGGAACACG TCATTAGACT CTACACAAAG 4140

CAGATTACAA CTGCCATCAA TGTGCTGCAT GAACATGGCA TAGTGCACCG AGACATCAAA 4200

GGAGCAAATA TCTTTCTCAC ATCATCAGGA TTAATAAAGC TGGGGGATTT TGGTTGTTCA 4260

GTAAAATTAA AAAATAATAC ACAGACGATG CCTGGTGAAG TGAACAGTAC ACTTGGGACT 4320

GCAGCATACA TGGCTCCTGA AGTGATAACT AGAGCTAAAG GAGAAGGTCA TGGGCGTGCA 4380

GCTGACATCT GGAGTCTAGG CTGTGTTGTG ATTGAAATGG TCACAGGGAA GAGGCCCTGG 4440

CATGAATTTG AGCACAACTT CCAGATCATG TATAGAGTAG GAATGGGGCA TAAACCTCCC 4500

ATACCAGAAA GGATAAGTCC GGAAGGGAAG GACTTTCTTT CTCATTGCCT GGAAAGTGAT 4560

CCAAAGATGA GATGGACTGC TAGCCAGCTC CTCGATCATC CATTTGTCAA GGTGTGCACA 4620

GATGAAGAAT GA 4632

Domain Profile

S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkH  60

         wq+++ ig+G++g+vy++++vdtgel+a+Ke++++p++++   ++k+ ++E+k+++ +kH

Q: 1278  WQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHK---TIKETADELKIFEGIKH  1334

         99********************************999876...799**************

S: 61    enivkyyGveveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLHek  120

         +n+v+y+Gve ++ee++if+Ey+++G+l+++ +    l+e+vi+ ytkqi +++++LHe+

Q: 1335  PNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRL--GLQEHVIRLYTKQITTAINVLHEH  1392

         *******************************884..7***********************

S: 121   kivHRDiKgaNilldssgvvklsDFGaskrlaelntka.aelesltGtlaymaPEvikk.  178

         +ivHRDiKgaNi+l+ssg++kl+DFG+s +l+++++++ +e++s+ Gt+aymaPEvi++

Q: 1393  GIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNTQTMpGEVNSTLGTAAYMAPEVITRa  1452

         ********************************9987762569****************98

S: 179   kekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkd  238

         k +g+gr+aDiWslgcvviem+tgkrP++e++++++im++vg+ + kP+ipe++s+egkd

Q: 1453  KGEGHGRAADIWSLGCVVIEMVTGKRPWHEFEHNFQIMYRVGMGH-KPPIPERISPEGKD  1511

         899******************************************.**************

S: 239   flekcleldpkkrpsaeeLLkhefl  263

         fl++cle+dpk r++a++LL+h+f+

Q: 1512  FLSHCLESDPKMRWTASQLLDHPFV  1536

         ***********************96

Domain Sequence
(FASTA)

WQRGNKIGEG QYGKVYTCIS VDTGELMAMK EIRFQPNDHK TIKETADELK IFEGIKHPNL 60

VRYFGVELHR EEMYIFMEYC DEGTLEEVSR LGLQEHVIRL YTKQITTAIN VLHEHGIVHR 120

DIKGANIFLT SSGLIKLGDF GCSVKLKNNT QTMPGEVNST LGTAAYMAPE VITRAKGEGH 180

GRAADIWSLG CVVIEMVTGK RPWHEFEHNF QIMYRVGMGH KPPIPERISP EGKDFLSHCL 240

ESDPKMRWTA SQLLDHPFV 259

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade
GO:0043507	; P:positive regulation of JUN kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013