EKS-ANC-00289
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ANC-00289
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR496.91.0E-149710966257
StatusUnreviewed
Ensembl ProteinENSACAP00000003644
UniProt AccessionG1KC71;
Protein Name
Protein Synonyms/Alias
Gene NameERBB2
Gene Synonyms/Alias ERBB2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSACAG00000003496ENSACAP00000003644ENSACAT00000003733
OrganismAnolis carolinensis
Functional Description
Protein Length1249
Protein Sequence
(FASTA)
IGVFSFCSWI KLKSLSSPVI CSHSVCTGTD MKLQRPSSPE NHHATLRRLY EYCQVVQGNL 60
EITHLPASAD TSFLKDIREV QGYVLIAKNN VSNLHLENLI IIRGTQLYED KYALAILDNA 120
DHSGNVGLRE LGMLKLTEIL KGSVIVKRNP QLCFQETIYW DAIFHKDNKQ NDTEISSQRL 180
RQCLDCNQIC PNGHCWGEAK GSCQTLTSTI CASSCARCKG RRPTDCCHER CAAGCTGPKH 240
SDCLACLNFN HSGVCELHCP PLIIYNPDTY ESIPNKHGRY TFGATCVTEC PYNYLAAEVG 300
SCTLVCPQNS QEVCVDNMQK CEKCTKPCPE GCYGLGMGSL KGVRAVNASN IHHFAGCTKI 360
FGSLAFLPET FAGDPDTNTP PLDLQQLKIF ENLKDLTGYL YIESWPGTFS DLTPFQNLQM 420
IRGRALYNGA YSLTLQHLNI TSLGLRSLQE ISSGMVLIHH NPNLCFIQSV PWGDIFKNPR 480
QTLFQNDNSP VEQCELQGQV CFPLCSEGHC WGPGATQCRT CNGFLRGKEC VETCNILDGD 540
IREYVSGTRC FPCHPECMPQ NGTESCNGSE ADQCMACAHY KDGLSCVERC PSGVKMDNSF 600
VPIWKYADDE AICQFCPINC THSCAARDEL GCPVDQKPGQ ATSIIAGVVG AALALVLLLI 660
IIVCINRRKQ QERKHTMRRL LQETELVEPL TPSGALPNQA QMRILKETEL KKVKVLGSGA 720
FGTVYKGVWI PDGENVKIPV AIKVLRENTS PKANKEILDE AYVMAGVGSP YVSRLLGICL 780
TSTVQLVTQL MPYGCLLDYV RENKDRIGSQ DLLNWCVQIA KGMNYLEEVR LVHRDLAARN 840
VLVKSPNHVK ITDFGLARLL DIDETEYHAD GGKVPIKWMA LESILRRRFT HQSDVWSYGV 900
TVWELMTFGA KPYDGIPARE IPDLLEKGER LPQPPICTID VYMIMVKCWM IDSECRPKFR 960
ELVTEFTRMA RDPQRFVVIQ NDDKMGLASP IDSTFYRTLL EEEDMQDLVD AEEYLVPHQG 1020
FFSSEASPDY RPRIPSTRSA TETQPDAEET DESAQSPYLG PLLPEQPDTV LTNLMLDGDC 1080
AASKALQDSL PESSPLQRYS EDPTSPSTNE HEDLDAQNYN SPSGFIPEYV NQPENNLPSC 1140
KIVRPPGTTL DKPKGHFGKN GLIKDPKNTF PSSFTNVVEN PEYLTPCNLP VAGPLSQAFD 1200
NLYYWNQDPS KSNPVEFFAT SVAPVATTNG FTTTPTAENL EYLGLAESV 1249
Nucleotide Sequence
(FASTA)
ATTGGTGTAT TCAGTTTTTG TTCATGGATC AAATTGAAGA GCCTATCTAG TCCAGTGATC 60
TGTTCCCACA GTGTCTGCAC AGGAACTGAT ATGAAGTTGC AACGTCCCTC CAGCCCAGAA 120
AACCACCATG CCACCCTCCG CCGGCTCTAT GAATACTGTC AAGTTGTGCA AGGCAACCTG 180
GAGATCACAC ACTTACCAGC ATCTGCAGAT ACGTCCTTCC TCAAGGACAT CAGAGAGGTC 240
CAGGGATATG TGCTGATTGC CAAGAATAAT GTGAGTAACT TGCATCTGGA GAACCTCATC 300
ATCATTCGTG GGACCCAGCT ATATGAGGAC AAGTATGCAC TAGCCATCCT TGACAATGCC 360
GACCACAGTG GGAATGTAGG ACTGCGGGAG CTGGGCATGT TGAAACTGAC AGAAATCTTG 420
AAAGGCAGCG TGATTGTTAA AAGGAACCCA CAGCTGTGTT TCCAGGAAAC CATCTATTGG 480
GATGCCATCT TCCATAAAGA CAACAAGCAA AATGACACAG AGATCAGTAG CCAGCGACTT 540
CGGCAATGCC TTGACTGCAA CCAAATCTGC CCCAATGGCC ACTGCTGGGG AGAAGCCAAA 600
GGAAGCTGTC AGACATTGAC AAGCACAATC TGTGCCAGCA GCTGTGCCAG GTGCAAGGGC 660
AGGCGACCGA CAGATTGTTG CCATGAGCGG TGTGCGGCGG GCTGCACAGG ACCTAAGCAT 720
TCGGACTGCC TGGCCTGTTT GAACTTCAAT CACAGTGGGG TCTGTGAACT CCATTGCCCA 780
CCGCTCATCA TCTACAATCC AGACACCTAT GAATCCATAC CCAATAAACA TGGGCGCTAT 840
ACCTTTGGAG CAACTTGTGT CACCGAATGC CCTTATAATT ACCTGGCTGC AGAGGTGGGT 900
TCTTGTACTT TGGTATGTCC TCAGAATAGC CAGGAGGTGT GTGTGGACAA CATGCAGAAG 960
TGTGAAAAGT GCACCAAGCC CTGCCCAGAA GGTTGCTATG GCTTGGGGAT GGGCTCCTTA 1020
AAAGGGGTTC GTGCTGTCAA TGCCTCCAAT ATCCATCACT TTGCCGGCTG CACCAAGATT 1080
TTTGGCAGCT TAGCCTTTCT GCCGGAGACC TTCGCAGGGG ATCCTGACAC CAATACTCCA 1140
CCTTTGGATC TTCAGCAGCT TAAAATCTTT GAGAACCTAA AGGATCTCAC TGGCTACCTC 1200
TACATTGAAT CATGGCCGGG GACGTTCTCA GACTTGACTC CCTTCCAGAA CCTTCAGATG 1260
ATCCGGGGTC GAGCCCTCTA CAACGGAGCG TATTCCCTAA CATTGCAGCA CCTCAACATC 1320
ACTTCTCTTG GCCTGCGTTC ACTGCAGGAG ATCAGCAGCG GGATGGTCCT TATCCACCAC 1380
AACCCTAATC TGTGTTTCAT CCAAAGCGTG CCGTGGGGAG ATATCTTCAA AAATCCCCGG 1440
CAGACGCTGT TCCAGAATGA TAACAGCCCA GTTGAGCAGT GTGAACTCCA AGGTCAGGTG 1500
TGCTTCCCAT TGTGCTCCGA GGGACATTGC TGGGGACCAG GAGCAACCCA GTGCAGGACC 1560
TGTAATGGCT TTCTGCGTGG AAAGGAATGT GTAGAGACCT GCAACATTCT GGATGGAGAT 1620
ATCAGAGAAT ATGTCAGTGG GACACGGTGC TTTCCCTGTC ATCCAGAGTG CATGCCCCAA 1680
AATGGAACGG AGTCCTGCAA TGGCTCGGAA GCAGATCAAT GTATGGCTTG TGCTCATTAC 1740
AAAGATGGCC TTTCTTGTGT GGAGCGGTGT CCCAGTGGTG TGAAGATGGA TAACTCTTTT 1800
GTTCCCATCT GGAAATATGC TGATGATGAA GCCATTTGTC AGTTTTGTCC AATCAACTGC 1860
ACACATTCTT GCGCAGCCCG AGATGAATTA GGCTGCCCCG TGGATCAGAA ACCTGGCCAG 1920
GCTACCTCCA TCATAGCTGG GGTGGTGGGA GCTGCCCTTG CCCTGGTCCT CTTGCTTATC 1980
ATCATTGTTT GCATCAACCG GCGGAAGCAG CAAGAAAGGA AACACACAAT GCGCCGTCTT 2040
CTTCAGGAGA CTGAGTTGGT GGAGCCATTG ACACCGAGTG GAGCTCTGCC AAACCAGGCT 2100
CAGATGCGTA TTCTCAAGGA GACGGAATTG AAAAAAGTCA AGGTGTTGGG GTCCGGTGCT 2160
TTTGGAACAG TGTACAAGGG TGTTTGGATT CCAGATGGTG AGAACGTGAA GATCCCAGTG 2220
GCCATCAAAG TCTTGCGAGA AAACACCTCG CCCAAAGCAA ACAAGGAGAT ATTGGATGAG 2280
GCATATGTCA TGGCAGGTGT GGGCAGCCCA TATGTTTCTC GGCTTCTGGG AATCTGCCTC 2340
ACTTCCACGG TGCAGCTGGT GACTCAGCTC ATGCCCTACG GCTGCCTGCT GGACTATGTG 2400
CGGGAGAACA AGGACCGTAT TGGTTCCCAG GACCTTCTGA ACTGGTGTGT GCAGATAGCA 2460
AAGGGTATGA ACTACCTGGA GGAAGTCCGT CTGGTCCATC GAGACTTGGC TGCCAGGAAT 2520
GTTTTGGTGA AGAGTCCAAA CCATGTGAAG ATCACGGATT TTGGCTTGGC CCGACTGCTG 2580
GACATTGACG AGACAGAATA TCATGCAGAT GGAGGAAAGG TGCCCATCAA ATGGATGGCA 2640
TTGGAGTCCA TCTTGCGCAG GCGATTCACT CACCAAAGTG ATGTGTGGAG CTATGGTGTG 2700
ACTGTATGGG AGCTGATGAC ATTTGGTGCC AAACCATACG ATGGCATCCC AGCCCGAGAG 2760
ATCCCTGATC TGCTAGAGAA AGGAGAGAGG CTGCCGCAGC CCCCCATCTG CACCATTGAT 2820
GTTTACATGA TTATGGTGAA ATGTTGGATG ATTGATTCAG AATGCCGGCC TAAGTTCCGA 2880
GAACTGGTCA CGGAGTTCAC TCGTATGGCC AGAGATCCAC AGCGTTTTGT GGTTATTCAG 2940
AATGATGATA AGATGGGTCT AGCCAGCCCC ATTGACAGCA CTTTCTACCG CACGTTGCTA 3000
GAGGAAGAAG ACATGCAAGA TCTGGTGGAT GCAGAAGAGT ACCTGGTCCC CCACCAGGGG 3060
TTCTTCAGCA GCGAGGCATC ACCTGACTAT CGTCCTCGGA TTCCTTCAAC CAGAAGTGCC 3120
ACAGAGACTC AGCCAGATGC AGAGGAGACT GACGAATCAG CTCAGAGCCC ATATTTGGGC 3180
CCATTGCTCC CGGAACAGCC AGACACTGTA CTCACTAACT TGATGCTCGA TGGAGACTGT 3240
GCAGCAAGCA AGGCATTGCA GGACTCACTG CCGGAGTCCA GCCCTCTTCA GCGCTACAGT 3300
GAAGATCCCA CCAGTCCCTC AACTAATGAA CATGAGGATC TGGATGCCCA AAACTACAAT 3360
TCACCATCTG GTTTCATTCC AGAATATGTT AACCAGCCAG AAAACAATTT GCCTTCCTGC 3420
AAAATTGTTC GACCACCTGG GACTACCCTA GACAAGCCAA AGGGTCATTT TGGCAAGAAT 3480
GGACTCATCA AAGATCCAAA GAATACCTTC CCCAGCAGTT TCACCAATGT GGTGGAAAAC 3540
CCAGAATATC TGACGCCATG CAACCTCCCT GTGGCTGGCC CTTTATCCCA AGCCTTTGAC 3600
AATCTTTATT ATTGGAATCA AGACCCTTCC AAGAGCAACC CAGTAGAATT CTTTGCTACC 3660
TCCGTTGCTC CTGTTGCCAC CACTAATGGC TTCACTACAA CCCCAACTGC GGAGAATCTG 3720
GAGTACCTCG GTCTTGCAGA ATCTGTC 3747
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         lkk+kvlGsGafGtvykG+wip+genvkipvaikvl+e+t++kanke+ldea+v+a + +
Q: 710   LKKVKVLGSGAFGTVYKGVWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGS  769
         69**********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         ++++rllg+cl+st+qlvtql+p+Gclldyvre+kd++Gsq+llnwcvqiakGm+ylee 
Q: 770   PYVSRLLGICLTSTVQLVTQLMPYGCLLDYVRENKDRIGSQDLLNWCVQIAKGMNYLEEV  829
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
         rlvhrdlaarnvlvkspnhvkitdfGla+ll+ de+e++a+ggkvpikw+alesil+r++
Q: 830   RLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRF  889
         ************************************************************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thqsdvwsyGvtvwel+tfGakpydgipa+eipdllekGerl+qppictidvym++vkcw
Q: 890   THQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCW  949
         ************************************************************
S: 241   midaesrpkfkelaeef  257
         mid+e+rpkf+el++ef
Q: 950   MIDSECRPKFRELVTEF  966
         ****************9
Domain Sequence
(FASTA)
LKKVKVLGSG AFGTVYKGVW IPDGENVKIP VAIKVLRENT SPKANKEILD EAYVMAGVGS 60
PYVSRLLGIC LTSTVQLVTQ LMPYGCLLDY VRENKDRIGS QDLLNWCVQI AKGMNYLEEV 120
RLVHRDLAAR NVLVKSPNHV KITDFGLARL LDIDETEYHA DGGKVPIKWM ALESILRRRF 180
THQSDVWSYG VTVWELMTFG AKPYDGIPAR EIPDLLEKGE RLPQPPICTI DVYMIMVKCW 240
MIDSECRPKF RELVTEF 257
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00280
EKS-BOT-00298
EKS-CAJ-00305
EKS-CAF-00305
EKS-CAP-00334
EKS-CII-00175
EKS-DAR-00646
EKS-EQC-00290
EKS-FEC-00284
EKS-GAA-00370
EKS-GOG-00296
EKS-HOS-00305
EKS-ICT-00281
EKS-LAC-00310
EKS-LOA-00309
EKS-MAM-00302
EKS-MOD-00293
EKS-MUM-00330
EKS-MUP-00296
EKS-MYL-00300
EKS-NOL-00275
EKS-ORN-00389
EKS-ORC-00281
EKS-ORL-00360
EKS-OTG-00303
EKS-PAT-00284
EKS-PES-00267
EKS-RAN-00315
EKS-SAH-00280
EKS-SUS-00262
EKS-TAR-00391
EKS-TEN-00386
EKS-XET-00372
EKS-XIM-00379
Gene Ontology
GO:0016324; C:apical plasma membrane
GO:0016323; C:basolateral plasma membrane
GO:0010008; C:endosome membrane
GO:0016021; C:integral to membrane
GO:0043235; C:receptor complex
GO:0005524; F:ATP binding
GO:0004716; F:receptor signaling protein tyrosine kinase activity
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0033088; P:negative regulation of immature T cell proliferation in thymus
GO:0014065; P:phosphatidylinositol 3-kinase cascade
GO:0045785; P:positive regulation of cell adhesion
GO:0030307; P:positive regulation of cell growth
GO:0050679; P:positive regulation of epithelial cell proliferation
GO:0043406; P:positive regulation of MAP kinase activity
GO:0032321; P:positive regulation of Rho GTPase activity
GO:0045943; P:positive regulation of transcription from RNA polymerase I promoter
GO:0045945; P:positive regulation of transcription from RNA polymerase III promoter
GO:0045727; P:positive regulation of translation
GO:0070372; P:regulation of ERK1 and ERK2 cascade
GO:0032886; P:regulation of microtubule-based process
GO:0023014; P:signal transduction by phosphorylation
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
GO:0042060; P:wound healing
KEGG
InterPros
IPR021157; Cyt_c1_TM_anchor_C.
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt.
Pfam
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00261; FU; 3.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013