EKS-ANC-00025

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ANC-00025

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Jak	328.9	2.5E-98	847	1120	274

Status

Unreviewed

Ensembl Protein

ENSACAP00000003850

UniProt Accession

G1KCE0;

Protein Name

Tyrosine-protein kinase

Protein Synonyms/Alias

Gene Name

JAK2

Gene Synonyms/Alias

JAK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSACAG00000003673	ENSACAP00000003850	ENSACAT00000003942

Organism

Anolis carolinensis

Functional Description

Protein Length

1132

Protein Sequence
(FASTA)

MACLTMTEME GTASSPIHQN GGVVGNSTIS RQTEPLLRVY LYHSLGKTEG DYLEFRAGDY 60

IAEEICIAAC KACGILPVYH NMFALMNQAD RCWYPPNHAF QIEGSATLTV LYRIRFYFPH 120

WYCNDTTRAY RYGVSRGAET PVLDDIIMSY LFAQWREDFV HGWVKMAVTH ETQEECLGMA 180

VLDIMRMAKE KDQTPLSIYN SVSYKMFLPK CIREKIQDYH ILTRKRIRYR FRRFIQRFGQ 240

CNASARNLKL KYLINLETLQ SAFYSEVFEV KEPGREPSGE ERCATIIISA NGGIQCSRGK 300

HKESETLVEQ DIQTYCDFPD IIDVSIKQAN QEGSGENRIV TIHKQDSKNL EAEFHSLKDA 360

LSFVSLIDGY YRLTADAHHY LCKEVAPPSV LESIQSNCHG PISMDFAINK LKKAGNQPGY 420

YVLRCSPKEF NKYFLTFAVQ QDSMADYKHC LITKNENGEY NLTGTRRSFT NLVDLLNCYR 480

TETVRSDSII FQFTRCCPPK PKDKSNLLIL RSNAASDVPT SPTLHRHNNI NQMVFHKIRN 540

EDLIFNESLG QGTFTKIFKG VRKEVGDYGK LYQTEVLLKV LDKVHRNYSE SFFEAASMMS 600

QLSYKHLVLN YGVCVCGEEN ILVQEYVKFG ALDTYLKKNK NSINILWKLE VAKQLAMAMH 660

FLEDKNLVHG NVCAKNILLI REEDRKSGNL PFIKLSDPGI GITVLPKDIL LERIPWVPPE 720

CIENPKRLSL ATDKWSFGTT LWEICSGGDK PLGALDLQRK LQFYEDRHQL PAPNWTELAN 780

LINNCMDYEP DFRPSFRAII RDLNSLFTPD YELLTENDML PNMRTSGLGL SGAFENKDPT 840

YFEERHLKFL QQLGKGNFGS VEMCRYDPLQ DNTGEVVAVK KLQHSTEEHL RDFEREIEIL 900

KSLQHDNIVK YKGVCYSAAW KGRRNLKLIM EYLPYGSLRD YLQKHKDRLD HKKLLQYASQ 960

ICKGMEYLGS KRYIHRDLAT RNILVEHENR VKIGDFGLTK VLPQDKEYYK VKEPGESPIF 1020

WYAPESLTDN KFSVASDMWS FGVVLYELFT YTDKNKSPPV EFMRMIGDDK QNQIAFHLIV 1080

LLKNNVRLSR PDGCPDEVYA IMTECWNSNP SVRPIFRDLT LRVDVLRENM GG 1132

Nucleotide Sequence
(FASTA)

ATGGCCTGCC TTACGATGAC AGAGATGGAA GGGACAGCGT CATCTCCAAT TCACCAGAAT 60

GGTGGCGTCG TTGGGAATTC AACCATTTCT AGACAGACAG AACCACTTCT TCGAGTTTAC 120

CTTTATCATT CCCTGGGAAA GACTGAAGGC GATTATTTGG AGTTTCGAGC TGGAGATTAT 180

ATTGCAGAAG AGATCTGTAT TGCTGCTTGT AAGGCTTGTG GTATCTTGCC TGTGTACCAC 240

AACATGTTTG CACTCATGAA CCAGGCAGAC CGATGCTGGT ATCCTCCAAA CCACGCCTTC 300

CAAATAGAGG GATCAGCCAC ACTGACGGTA CTCTACCGAA TAAGGTTTTA TTTCCCACAC 360

TGGTATTGCA ATGACACTAC ACGGGCATAT CGCTATGGTG TCTCCCGAGG TGCTGAGACT 420

CCTGTGCTTG ATGATATCAT CATGTCTTAT TTGTTTGCTC AGTGGCGAGA AGACTTTGTC 480

CATGGGTGGG TAAAAATGGC TGTTACTCAT GAAACACAAG AAGAATGTCT TGGCATGGCT 540

GTTCTGGATA TAATGAGAAT GGCCAAAGAA AAGGACCAAA CCCCACTATC CATTTACAAT 600

TCTGTTAGCT ATAAAATGTT TTTGCCTAAG TGTATCAGAG AAAAAATCCA GGATTATCAC 660

ATTCTAACCC GCAAGAGAAT AAGGTACAGG TTCCGCAGAT TCATTCAGAG GTTTGGCCAG 720

TGCAACGCAA GTGCCAGAAA CTTGAAACTG AAATATCTCA TAAATCTGGA AACCCTCCAG 780

TCTGCCTTCT ACTCTGAAGT ATTTGAAGTC AAGGAGCCTG GCAGAGAGCC TTCCGGTGAA 840

GAACGCTGTG CAACTATTAT TATAAGTGCA AATGGTGGAA TTCAGTGCTC CAGAGGGAAA 900

CATAAAGAGA GTGAAACACT GGTAGAACAG GACATACAGA CCTACTGTGA TTTCCCAGAC 960

ATTATTGACG TCAGTATTAA GCAAGCAAAC CAGGAAGGTT CTGGAGAGAA TAGAATTGTA 1020

ACCATTCACA AGCAGGACAG CAAGAATTTG GAAGCTGAAT TTCATTCATT AAAAGATGCC 1080

CTTTCTTTTG TATCATTAAT TGATGGGTAT TACAGATTAA CGGCTGATGC CCACCATTAT 1140

CTCTGTAAAG AAGTAGCACC TCCTTCAGTT CTTGAAAGCA TCCAGAGCAA CTGCCATGGG 1200

CCAATTTCGA TGGACTTTGC AATCAATAAA TTGAAAAAAG CTGGCAATCA GCCTGGTTAT 1260

TATGTTCTTC GTTGCAGCCC AAAGGAGTTT AATAAGTACT TCCTTACCTT CGCTGTTCAG 1320

CAAGATAGTA TGGCTGATTA TAAGCATTGC TTGATAACAA AAAATGAGAA TGGAGAATAT 1380

AATCTCACTG GGACACGAAG AAGTTTTACA AACCTTGTGG ATCTTTTGAA TTGCTATCGG 1440

ACAGAAACTG TCCGGTCGGA TAGTATAATT TTCCAGTTTA CCAGATGCTG CCCTCCAAAA 1500

CCAAAAGATA AGTCAAACTT ACTAATCTTG AGGAGCAACG CAGCCTCCGA TGTGCCCACA 1560

TCACCCACAC TGCATAGACA CAATAATATC AACCAGATGG TCTTCCACAA AATCCGGAAT 1620

GAAGACCTGA TTTTCAATGA AAGCCTTGGC CAAGGCACCT TCACCAAGAT TTTCAAAGGT 1680

GTGAGGAAAG AAGTGGGAGA CTACGGTAAA CTGTATCAGA CAGAAGTCCT GCTGAAGGTT 1740

CTGGATAAAG TGCACAGAAA CTACTCTGAG TCTTTCTTTG AAGCCGCCAG CATGATGAGC 1800

CAGCTTTCTT ACAAGCACTT GGTATTAAAT TATGGAGTTT GTGTCTGTGG AGAGGAAAAC 1860

ATTCTGGTAC AAGAATATGT AAAATTTGGA GCACTTGACA CCTATTTGAA GAAGAATAAA 1920

AATTCTATAA ATATCTTATG GAAACTGGAA GTTGCAAAGC AGCTGGCAAT GGCAATGCAT 1980

TTTCTGGAGG ATAAAAACCT TGTTCATGGG AACGTATGTG CAAAAAATAT CTTGCTTATC 2040

AGAGAAGAAG ATAGGAAGTC TGGGAATCTT CCTTTTATCA AGCTCAGTGA TCCTGGTATC 2100

GGCATTACAG TGTTGCCAAA AGACATTCTT CTAGAGAGAA TCCCATGGGT TCCACCTGAG 2160

TGCATCGAAA ATCCCAAGCG GCTGAGTTTG GCGACGGACA AGTGGAGTTT TGGGACCACC 2220

TTATGGGAGA TCTGCAGCGG GGGAGACAAG CCCCTCGGGG CACTGGATTT GCAGAGAAAA 2280

CTACAGTTTT ATGAAGATAG GCACCAACTT CCTGCTCCAA ATTGGACTGA ACTGGCAAAT 2340

CTTATAAATA ACTGTATGGA TTATGAACCA GATTTTAGGC CATCTTTCAG AGCAATTATA 2400

CGTGATCTTA ACAGTTTGTT CACTCCAGAT TATGAACTTT TGACAGAAAA TGACATGTTA 2460

CCAAATATGA GAACTAGTGG CCTTGGACTT TCTGGGGCTT TTGAAAACAA GGACCCTACA 2520

TATTTTGAAG AGAGACACCT CAAGTTCTTA CAGCAACTTG GCAAGGGCAA TTTTGGGAGT 2580

GTGGAGATGT GCCGATACGA TCCACTGCAA GACAACACTG GGGAGGTGGT CGCTGTTAAG 2640

AAGCTTCAGC ACAGCACAGA AGAACACCTG AGAGACTTTG AAAGAGAAAT TGAAATCCTC 2700

AAATCTTTGC AACATGACAA CATTGTCAAG TACAAAGGAG TGTGCTACAG TGCAGCTTGG 2760

AAAGGTCGCA GAAATCTGAA GCTGATAATG GAATATTTGC CCTATGGAAG TTTACGAGAC 2820

TATCTCCAGA AACATAAGGA CAGGTTGGAT CATAAGAAAC TCCTGCAGTA TGCTTCTCAG 2880

ATATGTAAGG GCATGGAGTA TCTGGGATCA AAAAGATACA TTCATAGGGA TCTAGCGACC 2940

AGAAATATCT TGGTGGAGCA TGAAAACAGA GTTAAGATTG GAGACTTCGG CTTGACAAAA 3000

GTCCTGCCGC AGGACAAAGA ATATTACAAA GTCAAGGAAC CAGGAGAGAG TCCAATCTTT 3060

TGGTATGCAC CAGAGTCACT GACAGACAAC AAATTTTCTG TGGCTTCAGA TATGTGGAGT 3120

TTTGGTGTGG TCCTGTATGA ACTTTTCACA TATACAGACA AGAACAAAAG TCCACCTGTG 3180

GAGTTCATGC GCATGATTGG CGATGATAAG CAAAACCAGA TCGCATTCCA TTTAATAGTT 3240

CTTTTGAAAA ACAATGTTAG GCTGTCAAGA CCTGATGGAT GTCCTGATGA GGTTTACGCC 3300

ATCATGACAG AATGCTGGAA CAGTAACCCA AGTGTGCGGC CCATCTTTAG GGACCTCACT 3360

TTGAGAGTTG ATGTCCTAAG GGAGAACATG GGTGGATGA 3399

Domain Profile

S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLkesgedisrdfkreaeilsqlshe  60

         lk++++Lgkg+f++v+++r+d+ +d+t+e va+k L++s+e++ rdf+re+eil++l+h+

Q: 847   LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHD  906

         6899********************************************************

S: 61    hivklkgv....cvaegen.rlVmeyvesGsLdiyLrkkkealslsslldvakqlakame  115

         +ivk+kgv    ++++ +n +l+mey+++GsL++yL+k+k++l++++ll++a+q++k+me

Q: 907   NIVKYKGVcysaAWKGRRNlKLIMEYLPYGSLRDYLQKHKDRLDHKKLLQYASQICKGME  966

         ********33333455666*****************************************

S: 116   YLedkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsrip  174

         YL++k+++hrd+a+rn+Lve+e++      vk++d+gl+k+++qd eYy v+e+++s+i+

Q: 967   YLGSKRYIHRDLATRNILVEHENR------VKIGDFGLTKVLPQDkEYYKVKEPGESPIF  1020

         ************************......******************************

S: 175   wlapeclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle.......rkl  222

         w+ape+l+++k +s+asd+WsFgv+lyel+t  +k++sp    +r+++ +       +++

Q: 1021  WYAPESLTDNK-FSVASDMWSFGVVLYELFTyTDKNKSPpvefMRMIGDDkqnqiafHLI  1079

         ***********.*******************99999999*88877777778889999999

S: 223   elleekerlpkpk.cpaelaelmtnclsyepsqrpsFrail  262

          ll+++ rl +p+ cp+e++ +mt+c++ +ps rp Fr++

Q: 1080  VLLKNNVRLSRPDgCPDEVYAIMTECWNSNPSVRPIFRDLT  1120

         9*************************************985

Domain Sequence
(FASTA)

LKFLQQLGKG NFGSVEMCRY DPLQDNTGEV VAVKKLQHST EEHLRDFERE IEILKSLQHD 60

NIVKYKGVCY SAAWKGRRNL KLIMEYLPYG SLRDYLQKHK DRLDHKKLLQ YASQICKGME 120

YLGSKRYIHR DLATRNILVE HENRVKIGDF GLTKVLPQDK EYYKVKEPGE SPIFWYAPES 180

LTDNKFSVAS DMWSFGVVLY ELFTYTDKNK SPPVEFMRMI GDDKQNQIAF HLIVLLKNNV 240

RLSRPDGCPD EVYAIMTECW NSNPSVRPIF RDLT 274

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005901	; C:caveola
GO:0005737	; C:cytoplasm
GO:0005856	; C:cytoskeleton
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0020037	; F:heme binding
GO:0035401	; F:histone kinase activity (H3-Y41 specific)
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0006915	; P:apoptotic process
GO:0030154	; P:cell differentiation
GO:0060396	; P:growth hormone receptor signaling pathway
GO:0035722	; P:interleukin-12-mediated signaling pathway
GO:0008285	; P:negative regulation of cell proliferation
GO:0043392	; P:negative regulation of DNA binding
GO:0010811	; P:positive regulation of cell-substrate adhesion
GO:0050727	; P:regulation of inflammatory response
GO:0046677	; P:response to antibiotic
GO:0007262	; P:STAT protein import into nucleus
GO:0033209	; P:tumor necrosis factor-mediated signaling pathway
GO:0007260	; P:tyrosine phosphorylation of STAT protein

KEGG

InterPros

IPR019749	; Band_41_domain.
IPR019748	; FERM_central.
IPR000299	; FERM_domain.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016251	; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020693	; Tyr_kinase_non-rcpt_Jak2.

Pfam

PF07714	; Pkinase_Tyr; 2.
PF00017	; SH2; 1.

SMARTs

SM00295	; B41; 1.
SM00252	; SH2; 1.
SM00219	; TyrKc; 2.

Prosites

PS50057	; FERM_3; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.

Prints

PR01823	; JANUSKINASE.
PR01825	; JANUSKINASE2.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013