EKS-ANC-00099
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ANC-00099
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Tec434.11.3E-130403652250
StatusUnreviewed
Ensembl ProteinENSACAP00000003742
UniProt AccessionH9G851;
Protein Name
Protein Synonyms/Alias
Gene NameITK
Gene Synonyms/Alias ITK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSACAG00000003690ENSACAP00000003742ENSACAT00000003833
OrganismAnolis carolinensis
Functional Description
Protein Length659
Protein Sequence
(FASTA)
SVLLEEELIK KSQQKRRTSP SNFKVRFFIL TKSRLAYFER RPGKKNILKG SIELSKIKCV 60
EIVNSDITIP CHYKYPFQNN DIRVMVNGLE IPRDVFPQIF HDSYLLYVFA PSQASCQKWV 120
MTLKEETRNN NILVTKFHPN FWIDGRWRCC TQSEKLATGC MFLQCSSMAC LDWKQHHVSK 180
KPLPPTPNDN WVMKKNIAVE FGAKFVNTDS KESPVIAIYD YAAQNPQELT LQCNEEYYVI 240
DNSEVHWWLV QDKNGHEGYV PSSYVVEKSP ENLHAYEWYN KSISRSKAET LLKEEDKEGA 300
FMVRDSRQPG TYTVSVFTKA LSNDNNPVIK HYHIKETSDN PKKYYLAEKH LFNGIPEMIN 360
YHQHNAGGLV TRLRYAVSCW RQKGPVTAGL SYGKWMINPQ ELSFGQEIGV GQFGVVHIGY 420
WLGQMKVAIK TIRTQAMSEE DFLEEAQVMM KLSHPKLVQL HGVCMQPAPM CLVFEFMENG 480
CLSDYLKRQR GSFSKEDLLG MCQDVCEGMA YLEQASVIHR DLAARNCLVG EFQVVKVSDF 540
GMSRYVLDDQ YTSSMGTKFP VRWSAPEVFS YNRYSTKSDV WSFGVLMWEI FSEGKIPYEN 600
KTNGEVVEDL RAGGRLYKPR LSSNTIYKLM RSCWSEKQED RPPFSVLLHQ LSEISESDF 659
Nucleotide Sequence
(FASTA)
TCTGTTCTGC TTGAAGAAGA ACTGATCAAA AAGTCCCAGC AAAAGCGAAG GACCTCTCCC 60
TCAAATTTTA AAGTTCGATT CTTCATTTTA ACAAAATCAA GGCTGGCTTA TTTTGAACGT 120
CGCCCTGGGA AAAAAAACAT TCTAAAAGGT TCAATTGAAC TGTCCAAGAT TAAATGTGTG 180
GAAATTGTGA ATAGTGACAT TACAATTCCA TGTCATTACA AATATCCTTT CCAGAATAAT 240
GATATTAGAG TAATGGTGAA CGGCCTAGAA ATTCCTAGAG ATGTATTCCC TCAGATTTTT 300
CATGACAGCT ACCTCTTGTA CGTGTTCGCT CCCAGCCAAG CAAGCTGTCA GAAATGGGTT 360
ATGACTCTGA AAGAAGAAAC TAGAAACAAT AACATTCTGG TGACAAAGTT TCACCCCAAT 420
TTCTGGATAG ACGGAAGATG GAGATGCTGC ACTCAGTCAG AGAAGCTGGC GACAGGATGT 480
ATGTTTCTCC AGTGCAGCTC TATGGCATGC TTGGACTGGA AGCAGCACCA TGTCTCCAAG 540
AAACCTCTTC CTCCAACTCC AAATGATAAC TGGGTAATGA AAAAGAACAT TGCTGTAGAG 600
TTTGGTGCTA AATTCGTAAA TACTGACTCC AAAGAATCCC CAGTGATCGC CATTTATGAC 660
TATGCTGCCC AGAATCCACA GGAGCTGACA TTACAGTGCA ATGAAGAATA TTATGTTATA 720
GATAATTCAG AGGTCCACTG GTGGTTGGTT CAGGATAAGA ATGGTCATGA AGGATATGTG 780
CCAAGCAGCT ATGTGGTAGA GAAATCACCA GAAAATCTGC ATGCATATGA GTGGTACAAT 840
AAGAGTATCA GCCGAAGCAA AGCAGAGACA CTGCTCAAAG AAGAGGATAA AGAAGGAGCC 900
TTCATGGTAA GAGACTCACG GCAGCCTGGC ACTTATACTG TCTCTGTTTT CACAAAAGCT 960
TTGAGTAATG ACAATAACCC AGTCATAAAG CATTATCACA TCAAGGAAAC AAGTGACAAT 1020
CCCAAAAAGT ACTACCTGGC AGAGAAGCAT CTTTTTAATG GTATCCCAGA AATGATCAAC 1080
TATCACCAGC ACAATGCAGG AGGTCTTGTT ACGCGTTTGC GGTATGCTGT TTCCTGCTGG 1140
AGACAAAAGG GTCCTGTTAC TGCTGGGCTA AGCTATGGGA AATGGATGAT TAACCCCCAA 1200
GAACTATCCT TTGGCCAGGA GATTGGTGTG GGCCAATTTG GAGTGGTACA TATTGGCTAT 1260
TGGCTTGGTC AGATGAAAGT TGCTATAAAG ACCATTCGCA CACAAGCAAT GTCAGAAGAA 1320
GACTTCCTTG AGGAGGCCCA AGTCATGATG AAACTGTCGC ATCCCAAATT AGTCCAGCTG 1380
CATGGGGTCT GCATGCAACC AGCTCCCATG TGCCTTGTGT TTGAGTTCAT GGAGAATGGA 1440
TGCCTGTCTG ATTACCTCAA GAGGCAGCGA GGGAGCTTCT CAAAGGAAGA CCTTCTGGGA 1500
ATGTGCCAAG ATGTGTGTGA AGGGATGGCT TATCTAGAAC AGGCGTCTGT CATCCACAGG 1560
GACCTGGCTG CTCGAAATTG TTTGGTAGGA GAATTCCAAG TGGTCAAAGT TTCAGATTTT 1620
GGAATGTCAC GGTATGTTCT TGATGACCAA TATACCAGCT CTATGGGCAC CAAATTCCCT 1680
GTTAGGTGGT CAGCACCAGA GGTGTTTTCT TATAACCGGT ATAGCACCAA ATCTGATGTC 1740
TGGTCATTTG GGGTATTGAT GTGGGAGATA TTCAGTGAAG GTAAAATACC TTATGAAAAC 1800
AAGACCAATG GTGAAGTGGT AGAAGACCTC AGGGCTGGTG GCCGTTTGTA TAAGCCCAGG 1860
CTGTCTTCCA ACACTATTTA CAAGCTCATG AGAAGTTGCT GGAGTGAGAA GCAAGAAGAC 1920
AGACCACCTT TTTCAGTCCT GCTGCATCAG CTCAGTGAGA TCTCAGAATC AGACTTTTAA 1980
Domain Profile
S: 2     tllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqlyg  61
         ++ +e+g gqfgvv++g+w ++++vaik+i+  amseedf+eea+vmmklshpklvql+g
Q: 403   SFGQEIGVGQFGVVHIGYWLGQMKVAIKTIRTQAMSEEDFLEEAQVMMKLSHPKLVQLHG  462
         6789********************************************************
S: 62    vclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrdl  121
         vc++ +p+++v+e++engcl++yl++++++++ke ll mc+dvcegm+yle++s+ihrdl
Q: 463   VCMQPAPMCLVFEFMENGCLSDYLKRQRGSFSKEDLLGMCQDVCEGMAYLEQASVIHRDL  522
         ************************************************************
S: 122   aarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvwa  181
         aarnclv+e +vvkvsdfg++ryvlddqy+ss+g+kfpv+ws+pev+sy++ys+ksdvw+
Q: 523   AARNCLVGEFQVVKVSDFGMSRYVLDDQYTSSMGTKFPVRWSAPEVFSYNRYSTKSDVWS  582
         ************************************************************
S: 182   fgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeerp  241
         fgvlmwe+fsegk+pye+k+n evve++  g rly+p+l+s+++y++m+scw+ek e+rp
Q: 583   FGVLMWEIFSEGKIPYENKTNGEVVEDLRAGGRLYKPRLSSNTIYKLMRSCWSEKQEDRP  642
         ************************************************************
S: 242   tfkellsale  251
          f+ ll++l+
Q: 643   PFSVLLHQLS  652
         ******9986
Domain Sequence
(FASTA)
SFGQEIGVGQ FGVVHIGYWL GQMKVAIKTI RTQAMSEEDF LEEAQVMMKL SHPKLVQLHG 60
VCMQPAPMCL VFEFMENGCL SDYLKRQRGS FSKEDLLGMC QDVCEGMAYL EQASVIHRDL 120
AARNCLVGEF QVVKVSDFGM SRYVLDDQYT SSMGTKFPVR WSAPEVFSYN RYSTKSDVWS 180
FGVLMWEIFS EGKIPYENKT NGEVVEDLRA GGRLYKPRLS SNTIYKLMRS CWSEKQEDRP 240
PFSVLLHQLS 250
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00101
EKS-BOT-00110
EKS-CAJ-00111
EKS-CAF-00112
EKS-CAP-00105
EKS-CIS-00119
EKS-DAR-00357
EKS-DRM-00050
EKS-EQC-00108
EKS-ERE-00053
EKS-FEC-00105
EKS-GAG-00090
EKS-GAA-00128
EKS-GOG-00111
EKS-HOS-00113
EKS-ICT-00105
EKS-LAC-00114
EKS-LOA-00106
EKS-MAM-00105
EKS-MEG-00085
EKS-MIM-00047
EKS-MOD-00106
EKS-MUM-00112
EKS-MUP-00113
EKS-MYL-00124
EKS-NOL-00103
EKS-OCP-00072
EKS-ORA-00089
EKS-ORC-00102
EKS-ORL-00125
EKS-OTG-00112
EKS-PAT-00100
EKS-PES-00093
EKS-POA-00103
EKS-RAN-00108
EKS-SAH-00102
EKS-TAG-00138
EKS-TAR-00137
EKS-TEN-00127
EKS-TUT-00096
EKS-XET-00091
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0005543; F:phospholipid binding
GO:0004713; F:protein tyrosine kinase activity
GO:0035556; P:intracellular signal transduction
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR001849; Pleckstrin_homology.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR001562; Znf_Btk_motif.
Pfam
PF00779; BTK; 1.
PF00169; PH; 1.
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00107; BTK; 1.
SM00233; PH; 1.
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS50003; PH_DOMAIN; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
PS51113; ZF_BTK; 1.
Prints
PR00401; SH2DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013