EKS-ANC-00385

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ANC-00385

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Axl	513.9	8.0E-155	526	793	268

Status

Unreviewed

Ensembl Protein

ENSACAP00000003898

UniProt Accession

H9G8C7;

Protein Name

Protein Synonyms/Alias

Gene Name

AXL

Gene Synonyms/Alias

AXL;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSACAG00000003874	ENSACAP00000003898	ENSACAT00000003990

Organism

Anolis carolinensis

Functional Description

Protein Length

892

Protein Sequence
(FASTA)

LMWPSMKMGL IPLTFLLCNA ILILHCFLPL AIYFLENPSN LTSSLGKDVK FSCSVHALGG 60

PPELSWLRDG TALEFADSNQ VQVPLDDEEW MATSELSIPS VQLSDMGNYQ CVTWLNGSEI 120

FSDEAYLLLE GLPFFTEEPQ DLEVAANTPF NLSCQAQGPP DPVMVIWLQD SIPPPTDKSF 180

SHPGHSPQRY AFLPCLNHSA SFSCEANNAK GVSSSRTAVV KVVPGRPRNL SVMYRSDRSL 240

EVSWEPRSSG AYALELCTIQ AVRSSEDLST VSDRQLYNQN LRVPPFRHTL KDLIPFTTYK 300

VRVSCRSREG NSPWTHWVAM ETLEGVPTAA PANIMATQNG TCTVIQWEEP RGNINGILRG 360

YKLVCQSDDS PEVVVDVGLT NETVLTLNST GQNLTVRVAA YTQAGDGPWS RAIMISSPGF 420

GENLPEPLSG ISTPAFSWHW WYVVIAIAAT IAAATFVTFF LARMRRKETR YGEAFEPSME 480

QGELVVHYRV RKSYSRRTTE ATLNGLGISE ELKEKLRDVM IDRHKVALGK TLGEDTTGEF 540

GSVMEGQLSQ DGAVLKVAVK TMKIAICTRS EMEDFLSEAV CMKDFDHPNV MKLIAGVCLQ 600

NTESEGYPSP VVILPFMKHG DLHSFLLYSR LGDSPVYLPT QTLVKFMTDI ASGMEYLSSK 660

NFIHRDLAAR NCMLNESMTA CVADFGLSKK IYNGDYYRQG RISKMPVKWI AIESLADRVY 720

TIKSDVWSFG VTMWEIATRG QTPYPGVENS EIYDYLRQGN RLKQPIDCLD GLYELMLSCW 780

ALNPRDRPSF EILHNELEKI LKSLPPAKDP EEILYVNMDD GVAPEESELG AVGGSGSDEA 840

PMKDSQSLKP TVTAAEVHPP QGMGRYVVCP TPHENSRLLT ESPSCAATEE GA 892

Nucleotide Sequence
(FASTA)

TTGATGTGGC CCTCAATGAA AATGGGTTTG ATACCCCTGA CTTTTCTCCT TTGCAATGCC 60

ATCCTAATTC TCCACTGTTT TCTCCCTTTA GCCATCTATT TTCTAGAGAA TCCATCGAAC 120

CTGACGTCCT CCTTGGGCAA AGATGTGAAG TTCTCCTGTT CAGTCCATGC TCTGGGAGGG 180

CCGCCGGAGC TGAGCTGGTT GCGAGATGGC ACAGCACTGG AGTTTGCGGA CAGCAACCAG 240

GTGCAGGTGC CCTTGGATGA TGAAGAATGG ATGGCCACCA GTGAGTTGAG CATCCCATCG 300

GTACAACTTT CCGACATGGG AAACTACCAG TGTGTGACCT GGCTCAACGG ATCTGAAATC 360

TTCTCGGATG AAGCTTACCT GCTATTAGAA GGTCTCCCCT TTTTCACGGA GGAGCCCCAA 420

GACCTCGAGG TGGCCGCCAA CACTCCCTTC AACCTCAGCT GCCAGGCGCA AGGGCCTCCG 480

GACCCGGTAA TGGTGATTTG GCTTCAAGAC AGCATCCCGC CTCCAACTGA CAAGAGTTTC 540

TCCCACCCTG GACATTCTCC TCAGAGGTAT GCTTTTCTCC CATGTCTCAA TCACAGTGCC 600

TCCTTCTCAT GCGAAGCCAA CAATGCGAAA GGCGTGAGCT CGTCTCGAAC AGCAGTGGTG 660

AAAGTGGTAC CTGGACGGCC GCGCAACCTG TCTGTTATGT ATCGCAGCGA CCGCAGCTTG 720

GAAGTGTCGT GGGAACCCAG GTCCAGCGGA GCGTATGCTT TGGAGCTTTG CACCATCCAG 780

GCTGTGCGCT CCAGTGAAGA CCTCAGCACT GTGTCGGACA GGCAGCTCTA TAACCAGAAC 840

CTCCGTGTGC CCCCCTTCCG GCACACCCTG AAAGACCTGA TCCCCTTCAC CACGTACAAG 900

GTCCGTGTCT CTTGTCGCTC CAGGGAAGGC AACTCCCCAT GGACTCACTG GGTGGCTATG 960

GAGACTCTGG AAGGAGTGCC CACAGCCGCA CCAGCAAATA TCATGGCCAC ACAAAATGGC 1020

ACCTGTACCG TTATCCAGTG GGAAGAACCA CGGGGCAACA TCAATGGGAT CTTGCGGGGA 1080

TACAAGCTGG TTTGTCAGAG TGACGACTCA CCAGAGGTGG TTGTGGACGT GGGTCTGACC 1140

AATGAGACCG TCCTGACACT CAACTCAACA GGACAGAACC TGACAGTGCG AGTTGCAGCC 1200

TACACACAAG CAGGCGATGG GCCGTGGAGC AGGGCTATCA TGATTTCTTC CCCTGGTTTT 1260

GGTGAAAATC TTCCGGAACC TTTGTCAGGG ATCTCCACGC CTGCCTTCTC CTGGCACTGG 1320

TGGTATGTGG TGATTGCCAT AGCTGCCACC ATCGCTGCTG CCACCTTCGT CACCTTCTTC 1380

TTGGCACGGA TGAGGAGGAA GGAAACCCGC TATGGGGAAG CCTTCGAACC AAGTATGGAG 1440

CAAGGGGAGC TGGTGGTTCA CTACCGAGTC CGCAAATCCT ATAGCCGCCG TACCACCGAA 1500

GCTACCCTGA ATGGTCTGGG CATCAGTGAA GAGCTAAAGG AGAAACTACG AGATGTGATG 1560

ATTGACCGCC ACAAAGTGGC CCTTGGGAAG ACACTTGGGG AAGACACTAC AGGAGAATTT 1620

GGCTCAGTCA TGGAAGGGCA ACTTAGTCAA GATGGGGCCG TGCTTAAGGT TGCTGTGAAG 1680

ACCATGAAAA TCGCCATTTG CACCCGCAGC GAGATGGAGG ATTTCCTCAG TGAAGCTGTT 1740

TGCATGAAGG ACTTCGACCA TCCAAATGTC ATGAAGCTGA TCGCAGGAGT CTGCTTACAG 1800

AACACAGAGA GTGAAGGCTA TCCCTCTCCA GTTGTTATCT TGCCCTTCAT GAAGCACGGC 1860

GACCTCCACA GCTTCCTCCT ATATTCCCGT CTTGGAGACA GTCCGGTGTA CCTACCAACA 1920

CAAACGCTGG TCAAGTTCAT GACCGACATT GCTAGCGGGA TGGAGTATCT CAGTAGCAAG 1980

AACTTCATCC ATCGTGACCT TGCAGCCCGT AACTGCATGC TGAACGAGAG CATGACCGCT 2040

TGCGTGGCTG ATTTTGGCCT CTCCAAGAAG ATCTACAATG GGGATTATTA CCGGCAAGGC 2100

CGCATCTCCA AGATGCCCGT CAAGTGGATC GCCATTGAGA GTTTAGCGGA TCGCGTCTAT 2160

ACCATCAAGA GCGATGTGTG GTCATTTGGT GTTACTATGT GGGAGATTGC AACCCGAGGC 2220

CAAACGCCGT ACCCAGGTGT GGAAAACAGT GAAATTTATG ATTACCTGCG CCAAGGCAAC 2280

CGCCTTAAGC AGCCCATCGA CTGCCTAGAT GGCTTATATG AGCTGATGCT GAGCTGCTGG 2340

GCCCTCAACC CGCGGGACCG CCCCAGCTTT GAGATCCTCC ACAACGAGCT GGAGAAGATC 2400

CTCAAGTCCC TCCCACCTGC CAAGGACCCC GAGGAGATCC TCTACGTCAA CATGGATGAC 2460

GGGGTGGCCC CCGAGGAGTC CGAGCTAGGA GCTGTTGGCG GCTCAGGCTC CGATGAGGCA 2520

CCGATGAAGG ACAGCCAGTC GCTGAAGCCC ACAGTGACGG CAGCTGAGGT TCACCCGCCC 2580

CAAGGCATGG GGCGCTACGT GGTGTGCCCC ACTCCCCATG AAAACAGCCG ACTCCTGACA 2640

GAGTCCCCCA GCTGTGCTGC CACAGAGGAA GGAGCCTGA 2679

Domain Profile

S: 1     lvlgkvlge...gefgsvmegqlkqedgsilkvavktlkldiiarseieeflseaacmke  57

         ++lgk+lge   gefgsvmegql q dg++lkvavkt+k++i++rse+e+flsea+cmk+

Q: 526   VALGKTLGEdttGEFGSVMEGQLSQ-DGAVLKVAVKTMKIAICTRSEMEDFLSEAVCMKD  584

         689*****77779**********99.57********************************

S: 58    fdhpnvirlv.gvslessekgrlpkpvvilpfmkygdlhafllysrlgenpvylplqtlv  116

         fdhpnv++l+ gv+l+++e +  p pvvilpfmk+gdlh+fllysrlg++pvylp+qtlv

Q: 585   FDHPNVMKLIaGVCLQNTESEGYPSPVVILPFMKHGDLHSFLLYSRLGDSPVYLPTQTLV  644

         ********9879************************************************

S: 117   kfmvdiasgmeylssrnfihrdlaarncmlaedmtvcvadfglskkiysgdyyrqgriak  176

         kfm diasgmeylss+nfihrdlaarncml+e mt cvadfglskkiy+gdyyrqgri+k

Q: 645   KFMTDIASGMEYLSSKNFIHRDLAARNCMLNESMTACVADFGLSKKIYNGDYYRQGRISK  704

         ************************************************************

S: 177   lpvkwiaiesladrvytsksdvwafgvtmweiatrgqtpyagvenaeiydyllqgnrlkq  236

         +pvkwiaiesladrvyt ksdvw+fgvtmweiatrgqtpy+gven+eiydyl+qgnrlkq

Q: 705   MPVKWIAIESLADRVYTIKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQ  764

         ************************************************************

S: 237   pedcldelydlmyrcweadpkdrpsfsvl  265

         p dcld+ly+lm +cw ++p+drpsf +l

Q: 765   PIDCLDGLYELMLSCWALNPRDRPSFEIL  793

         **************************877

Domain Sequence
(FASTA)

VALGKTLGED TTGEFGSVME GQLSQDGAVL KVAVKTMKIA ICTRSEMEDF LSEAVCMKDF 60

DHPNVMKLIA GVCLQNTESE GYPSPVVILP FMKHGDLHSF LLYSRLGDSP VYLPTQTLVK 120

FMTDIASGME YLSSKNFIHR DLAARNCMLN ESMTACVADF GLSKKIYNGD YYRQGRISKM 180

PVKWIAIESL ADRVYTIKSD VWSFGVTMWE IATRGQTPYP GVENSEIYDY LRQGNRLKQP 240

IDCLDGLYEL MLSCWALNPR DRPSFEIL 268

Keyword

Complete proteome; Disulfide bond; Immunoglobulin domain; Membrane; Receptor; Reference proteome; Repeat; Transmembrane; Transmembrane helix.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Equus caballus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR003961	; Fibronectin_type3.
IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003599	; Ig_sub.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF00041	; fn3; 2.
PF07679	; I-set; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00060	; FN3; 2.
SM00409	; IG; 1.
SM00408	; IGc2; 1.
SM00219	; TyrKc; 1.

Prosites

PS50853	; FN3; 2.
PS50835	; IG_LIKE; 2.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013