EKS-ANC-00254

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ANC-00254

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	472.5	6.4E-142	147	460	314

Status

Unreviewed

Ensembl Protein

ENSACAP00000003789

UniProt Accession

H9G877;

Protein Name

Protein Synonyms/Alias

Gene Name

DYRK2

Gene Synonyms/Alias

DYRK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSACAG00000003898	ENSACAP00000003789	ENSACAT00000003881

Organism

Anolis carolinensis

Functional Description

Protein Length

526

Protein Sequence
(FASTA)

MNEHLHVTSH GQIQVQQLFE ENSNKRTVLT TQPNGLTTVA KSGLPIGQER LFDFVARRQA 60

SASSLKSTDG PGKLKASLMT PEQAMKQYMQ KLTAFEHHEI FSYPEIYFLG PNAKKRQGVI 120

GGPNNNGYDD DQGSYIQVPH DHISYRYEVL KVIGKGSFGQ VVKAYDHKMH QHVALKMVRN 180

EKRFHRQAAE EIRILEHLKK QDKDNNMNVI HMLENFTFRN HICMTFELLS MNLYELIKKN 240

KFQGFSLLLV RKFAHSILQC LDALHKNRII HCDLKPENIL LKQQGRSGIK VIDFGSSCYE 300

HQRVYTYIQS RFYRAPEVIL GARYGMPIDM WSLGCILAEL LTGYPLLPGE DEGDQLACMI 360

ELLGMPSQKL LDSSKRAKNF VSSKGYPRYC TVTTLSDGSV VLNGGRSRRG KLRGPPESRE 420

WGSALKGCDD PHFLDFLKQC LEWDPALRMT PGQALRHPWL RRRLPKPPIG EKTSAKRITE 480

STGAITSISK LPPTSNSASK LRTNLAQMTD ANGNIQQRTV LPKLVS 526

Nucleotide Sequence
(FASTA)

ATGAATGAGC ACCTCCACGT CACAAGCCAT GGGCAAATCC AGGTCCAGCA GCTGTTTGAA 60

GAAAACAGCA ACAAAAGGAC GGTCCTGACA ACACAACCAA ATGGGCTTAC AACAGTAGCA 120

AAATCAGGAT TGCCAATTGG GCAAGAGAGA CTATTCGACT TTGTTGCAAG GCGGCAGGCG 180

AGTGCTAGCT CTTTAAAGTC GACTGATGGG CCTGGGAAGC TGAAAGCCTC TCTGATGACA 240

CCTGAGCAAG CCATGAAGCA ATACATGCAA AAGCTAACCG CCTTTGAGCA TCATGAGATC 300

TTCAGTTACC CTGAAATATA CTTTTTGGGT CCAAATGCAA AGAAGAGACA AGGTGTAATT 360

GGTGGTCCAA ACAATAATGG ATATGATGAT GACCAGGGCT CTTATATACA AGTACCCCAC 420

GATCATATAT CGTACAGATA TGAAGTCTTG AAGGTGATAG GAAAAGGGAG CTTTGGGCAA 480

GTGGTGAAGG CCTATGACCA CAAGATGCAT CAACACGTGG CCCTAAAAAT GGTGAGAAAC 540

GAGAAGCGTT TTCACCGCCA GGCTGCCGAA GAAATCAGGA TCCTGGAGCA CCTAAAAAAG 600

CAGGATAAGG ATAACAACAT GAACGTGATA CATATGCTGG AAAATTTCAC ATTCCGCAAC 660

CATATCTGTA TGACCTTTGA GTTGCTGAGC ATGAACCTTT ATGAGCTTAT AAAGAAAAAC 720

AAATTTCAGG GCTTTAGCCT GCTGCTGGTT CGCAAGTTCG CCCACTCCAT TTTGCAGTGC 780

TTGGATGCTT TGCACAAAAA CAGAATCATT CACTGTGACC TTAAGCCAGA GAACATTCTG 840

TTGAAACAAC AGGGTAGGAG TGGGATAAAA GTTATTGATT TTGGCTCTAG CTGTTACGAG 900

CATCAGCGGG TCTACACTTA CATTCAGTCA CGTTTTTACC GTGCTCCAGA AGTCATCCTT 960

GGTGCTCGTT ATGGGATGCC CATAGATATG TGGAGCCTTG GTTGCATTCT AGCTGAGCTC 1020

TTGACAGGTT ATCCTCTCCT CCCGGGAGAA GATGAGGGAG ATCAGCTAGC TTGTATGATA 1080

GAACTGCTGG GCATGCCTTC CCAGAAACTA TTAGATTCAT CCAAAAGAGC AAAAAATTTT 1140

GTGAGCTCAA AGGGTTATCC CCGATACTGT ACCGTTACTA CCTTGTCCGA TGGATCTGTA 1200

GTGCTCAATG GTGGTCGTTC CCGGCGTGGC AAACTGCGTG GCCCACCAGA GAGTCGAGAG 1260

TGGGGGAGTG CACTCAAAGG ATGTGATGAT CCTCACTTCC TTGACTTCTT GAAACAGTGT 1320

TTAGAGTGGG ATCCTGCATT GCGCATGACA CCGGGTCAGG CTTTACGGCA TCCCTGGCTA 1380

AGGAGGCGCT TGCCAAAGCC TCCAATTGGG GAGAAGACGT CAGCAAAAAG AATAACAGAA 1440

AGCACTGGTG CTATCACGTC AATTTCCAAG TTACCTCCAA CCTCAAACTC AGCTTCCAAA 1500

CTGAGGACTA ATCTGGCACA GATGACAGAT GCCAATGGGA ATATTCAGCA AAGGACAGTA 1560

TTGCCAAAAC TGGTTAGC 1578

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         yevl+vigkGsfgqVvka+d+k +++va+k+++n+krf+rqa+eE++iLe+l+k+dk+++

Q: 147   YEVLKVIGKGSFGQVVKAYDHKMHQHVALKMVRNEKRFHRQAAEEIRILEHLKKQDKDNN  206

         9***********************************************************

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120

         +nv+++le f+frnh+c++fells+nLyel+kknkf+g+sl lvrk+a++il++L++L++

Q: 207   MNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLLLVRKFAHSILQCLDALHK  266

         ************************************************************

S: 121   lkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglkyd  180

         ++iiH+DlKPeNill++++rs +kviDFGss++++q+ +ytyiqsrfYraPE+ilg++y

Q: 267   NRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQR-VYTYIQSRFYRAPEVILGARYG  325

         *************************************.**********************

S: 181   eaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftkke  240

         + iDmWSlGc+laEl+tG+pL+pGe+e dqla+++e+lg+p++kll+++k+ak+f+++k+

Q: 326   MPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDSSKRAKNFVSSKG  385

         ************************************************************

S: 241   apkyilktkksdrkkklvlnvkkaakkrkaplskelgealkekedklfkdllkrmleldp  300

         +p+y+++t+ sd +++l+ ++++++k r +p+s+e+g+alk ++d +f d+lk++le+dp

Q: 386   YPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGSALKGCDDPHFLDFLKQCLEWDP  445

         ************************************************************

S: 301   akRitpkealkhpfv  315

         a R+tp +al+hp++

Q: 446   ALRMTPGQALRHPWL  460

         **************6

Domain Sequence
(FASTA)

YEVLKVIGKG SFGQVVKAYD HKMHQHVALK MVRNEKRFHR QAAEEIRILE HLKKQDKDNN 60

MNVIHMLENF TFRNHICMTF ELLSMNLYEL IKKNKFQGFS LLLVRKFAHS ILQCLDALHK 120

NRIIHCDLKP ENILLKQQGR SGIKVIDFGS SCYEHQRVYT YIQSRFYRAP EVILGARYGM 180

PIDMWSLGCI LAELLTGYPL LPGEDEGDQL ACMIELLGMP SQKLLDSSKR AKNFVSSKGY 240

PRYCTVTTLS DGSVVLNGGR SRRGKLRGPP ESREWGSALK GCDDPHFLDF LKQCLEWDPA 300

LRMTPGQALR HPWL 314

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013