EKS-ANC-00086

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ANC-00086

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/PIKK	382.2	2.1E-114	2	316	315

Status

Unreviewed

Ensembl Protein

ENSACAP00000005205

UniProt Accession

G1KDX5;

Protein Name

Protein Synonyms/Alias

Gene Name

ATM

Gene Synonyms/Alias

ATM;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSACAG00000005322	ENSACAP00000005205	ENSACAT00000005322

Organism

Anolis carolinensis

Functional Description

Protein Length

358

Protein Sequence
(FASTA)

LPKIIDCVGS DGIERRQLVK GRDDLRQDAV MQQVFQMCNT LLQENTETRK RKLTIRRYKV 60

VPLSQRSGVL EWCSGTIPLG DFLVNTDRSA HKRYRPKDYS NLDCQSKMVQ AQKKSFEEKY 120

AIFIDVCQKF QPVFRYFCME KFLDPAVWFE KRLAYTRSVA TSSIVGYILG LGDRHVQNIL 180

LDEQSAELVH IDLGVAFEQG KILPTPETVP FRLTRDIVDG MGITGVEGVF RRCCEKTMAV 240

MRNSQEALLT IVEVLLYDPL FDWTMNPLKA LYLQQRPEDE ADVGSSLNAA DQSCSKKAND 300

NQTFNKVAER VLMRLQEKLK GVEEGTVLSV GGQVNLLIQQ AMDPKNLSRL FPGWKAWV 358

Nucleotide Sequence
(FASTA)

CTACCAAAAA TAATAGATTG TGTGGGATCA GATGGGATTG AGAGGAGGCA GCTTGTCAAG 60

GGCCGTGATG ACCTGAGGCA GGATGCTGTT ATGCAGCAGG TTTTCCAGAT GTGCAATACC 120

CTGCTCCAGG AAAACACCGA AACTAGAAAG AGAAAATTGA CTATCCGCAG ATACAAGGTG 180

GTCCCCCTCT CTCAGAGAAG CGGTGTCTTA GAGTGGTGTT CAGGGACAAT TCCCTTGGGT 240

GACTTTCTTG TCAATACTGA CAGAAGTGCT CACAAGCGAT ACAGACCAAA GGACTATAGT 300

AACTTAGACT GCCAAAGCAA AATGGTGCAA GCACAAAAGA AAAGTTTTGA AGAGAAATAT 360

GCCATCTTCA TTGATGTATG CCAGAAGTTT CAACCTGTAT TTCGCTATTT CTGTATGGAG 420

AAATTTCTGG ATCCAGCAGT GTGGTTTGAG AAACGTTTGG CATATACTCG CAGTGTTGCC 480

ACTTCATCAA TAGTTGGCTA CATACTTGGT CTTGGAGACA GACATGTACA GAATATTCTG 540

TTAGATGAGC AAAGTGCAGA GCTTGTTCAC ATTGATCTAG GTGTTGCTTT TGAGCAGGGC 600

AAAATCCTTC CTACCCCAGA AACTGTGCCA TTTAGGCTAA CAAGAGATAT AGTAGATGGG 660

ATGGGAATCA CTGGCGTAGA GGGAGTCTTC AGGAGATGCT GTGAAAAAAC TATGGCTGTT 720

ATGCGCAACT CCCAAGAAGC TTTACTAACT ATTGTAGAAG TACTTCTCTA TGACCCCCTT 780

TTTGACTGGA CCATGAACCC TTTAAAAGCC TTGTATTTGC AGCAAAGGCC AGAGGATGAG 840

GCCGATGTTG GCTCCAGCCT CAATGCTGCT GATCAAAGTT GCAGCAAAAA AGCAAATGAT 900

AACCAGACAT TTAATAAAGT GGCAGAGCGG GTCTTGATGC GACTCCAGGA GAAACTCAAA 960

GGAGTGGAGG AGGGGACCGT GCTCAGTGTG GGAGGCCAGG TGAATCTTCT CATTCAGCAA 1020

GCTATGGACC CAAAGAATCT CAGCCGCCTC TTCCCAGGAT GGAAAGCATG GGTC 1074

Domain Profile

S: 17    pkklllrGsdgkeypyLvkgkeDlrqdervlqlfslvNtlLakdketsrrkLkirtykVv  76

         pk +   Gsdg e+++Lvkg++Dlrqd++++q+f+++NtlL++++et++rkL+ir+ykVv

Q: 2     PKIIDCVGSDGIERRQLVKGRDDLRQDAVMQQVFQMCNTLLQENTETRKRKLTIRRYKVV  61

         6778889*****************************************************

S: 77    plstrsgliewventvsLkellkklvekkavlldqpisyrykdlstvqarkpklkhlkls  136

         pls+rsg++ew+ +t++L+++l   v+    +++   +yr+kd s+  ++ ++++++k+s

Q: 62    PLSQRSGVLEWCSGTIPLGDFL---VNTDRSAHK---RYRPKDYSNLDCQSKMVQAQKKS  115

         **********************...577777887...9**********************

S: 137   ....levfkevlenlvpkdllkklllekfpspeewfelrkaytrslAvislvgyiLgLgd  192

             +++f +v+++++p  +++++++ekf++p++wfe+r aytrs+A++s+vgyiLgLgd

Q: 116   feekYAIFIDVCQKFQP--VFRYFCMEKFLDPAVWFEKRLAYTRSVATSSIVGYILGLGD  173

         *****************..9****************************************

S: 193   rhlenllidqetgevvhidfgvafekaktqlkvpekvPFRLTrnivnalgvtgveGvfra  252

         rh++n+l+d++++e+vhid+gvafe++k+ l++pe+vPFRLTr+iv+++g+tgveGvfr+

Q: 174   RHVQNILLDEQSAELVHIDLGVAFEQGKI-LPTPETVPFRLTRDIVDGMGITGVEGVFRR  232

         *****************************.******************************

S: 253   sceavlrvlreskeklltiLevflydplvdwkk......kkktsketeeelaekakaeal  306

         +ce+++ v+r+s+e llti+ev+lydpl+dw++      + ++++e+e ++ +  +a ++

Q: 233   CCEKTMAVMRNSQEALLTIVEVLLYDPLFDWTMnplkalYLQQRPEDEADVGSSLNAADQ  292

         ***************************************9****************9999

S: 307   kikkllskvekaenavatrdlllle  331

          + k+  + ++++n+va+r+l++l+

Q: 293   SCSKKA-NDNQTFNKVAERVLMRLQ  316

         888877.5689********999887

Domain Sequence
(FASTA)

PKIIDCVGSD GIERRQLVKG RDDLRQDAVM QQVFQMCNTL LQENTETRKR KLTIRRYKVV 60

PLSQRSGVLE WCSGTIPLGD FLVNTDRSAH KRYRPKDYSN LDCQSKMVQA QKKSFEEKYA 120

IFIDVCQKFQ PVFRYFCMEK FLDPAVWFEK RLAYTRSVAT SSIVGYILGL GDRHVQNILL 180

DEQSAELVHI DLGVAFEQGK ILPTPETVPF RLTRDIVDGM GITGVEGVFR RCCEKTMAVM 240

RNSQEALLTI VEVLLYDPLF DWTMNPLKAL YLQQRPEDEA DVGSSLNAAD QSCSKKANDN 300

QTFNKVAERV LMRLQ 315

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0000077	; P:DNA damage checkpoint
GO:0006281	; P:DNA repair
GO:0016572	; P:histone phosphorylation
GO:0090399	; P:replicative senescence
GO:0010212	; P:response to ionizing radiation
GO:0000723	; P:telomere maintenance

KEGG

InterPros

IPR015519	; ATM/Tel1.
IPR003152	; FATC.
IPR011009	; Kinase-like_dom.
IPR000403	; PI3/4_kinase_cat_dom.
IPR018936	; PI3/4_kinase_CS.

Pfam

PF02260	; FATC; 1.
PF00454	; PI3_PI4_kinase; 1.

SMARTs

SM00146

; PI3Kc; 1.

Prosites

PS51190	; FATC; 1.
PS00915	; PI3_4_KINASE_1; 1.
PS00916	; PI3_4_KINASE_2; 1.
PS50290	; PI3_4_KINASE_3; 1.

Prints

Created Date

20-Feb-2013