EKS-ANC-00141
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ANC-00141
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/FGFR532.02.2E-160435711277
StatusUnreviewed
Ensembl ProteinENSACAP00000005421
UniProt AccessionG1KE82;
Protein NameFibroblast growth factor receptor
Protein Synonyms/Alias
Gene NameFGFR4
Gene Synonyms/Alias FGFR4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSACAG00000005410ENSACAP00000005421ENSACAT00000005539
OrganismAnolis carolinensis
Functional Description
Protein Length769
Protein Sequence
(FASTA)
MMEVEEEHLL LDPGSLLKLY CSTNHSQVIS WYKEAKQLSP SGRIHMRQSM LEIAEVTYED 60
SGLYSCRARS TGETLRNFTI SIVDSLASGD DDEDSDVDSS HIDSNEEPVN TRRAPYWTHP 120
HRMDKKLYAV PAGNTVKFRC PASGSPNPII RWLKNGRDFR GEHRIGGIRL RHQHWSLVME 180
SVVPSDRGNY TCLVENKFGS IRFSYFLDVL ERSPHRPILQ AGLPANTTAV VGSDVEFFCK 240
VYSDAQPHIQ WLKHIEVNGS SYGPDGVPYV QVLKTADINS SEVEVLYLRN VSMEDAGEYT 300
CLAGNSIGLS YQSAWLTVLP DEEEVQELET PEIKYTDIII YTSGGLAIIM AIVIVILCRM 360
QIQPNKQPLE PMAVHKLSKF PLIRQFSLES SSSGKSTTSL MRVTRLSSSC TPMLAGVMEV 420
ELPLDSKWEF PRDRLVLGKP LGEGCFGQVV RAEAYGIDQE RPERPITVAV KMLKDNATDK 480
DLADLISEME MMKLMDQHKN IINLLGVCTQ DGPLYVIVEF AAKGNLREYL RARRPPTPDY 540
TFDITKMPEE QLSFKDLVSC VYQVARGMEY LESKRCIHRD LAARNVLVTE ENVMKIADFG 600
LARGVHDIDY YKKTSNGRLP VKWMAPEALF DRVYTHQSDV WSFGILMWEI FTLGGSPYPG 660
IPVEELFKLL REGHRMDKPS NCTHELYMMM RECWHAVPSQ RPTFKQLVEG LDKVLVAVSE 720
EYLDLSMPFE QYSPSCEDTT STCSSDDSVF THEPLPASPC LFPYHNVRT 769
Nucleotide Sequence
(FASTA)
ATGATGGAGG TAGAGGAAGA ACACCTTCTC CTGGACCCAG GGAGTCTGCT CAAGCTCTAC 60
TGCAGCACCA ATCACAGTCA GGTCATCTCA TGGTATAAAG AAGCAAAACA GCTTTCCCCA 120
AGTGGACGTA TCCATATGCG CCAGAGCATG CTGGAGATTG CAGAAGTAAC CTATGAGGAC 180
TCAGGGCTGT ACTCATGCCG GGCACGGAGC ACTGGGGAGA CACTACGCAA CTTCACGATC 240
TCTATTGTGG ATTCCTTAGC ATCAGGAGAT GATGATGAAG ACAGTGATGT GGACAGTTCT 300
CACATTGACT CTAATGAGGA GCCTGTAAAC ACCCGACGAG CACCCTACTG GACACACCCC 360
CATCGAATGG ATAAGAAGTT GTATGCCGTC CCGGCAGGGA ATACAGTCAA GTTCCGCTGC 420
CCAGCCTCAG GCAGCCCCAA CCCAATTATC CGCTGGCTGA AGAATGGGAG GGACTTCCGT 480
GGGGAGCACC GTATCGGAGG AATCAGGCTG AGACATCAAC ACTGGAGCTT GGTCATGGAG 540
AGTGTGGTAC CCTCGGACCG AGGCAACTAC ACTTGCTTGG TGGAGAACAA GTTTGGCAGC 600
ATCCGCTTCA GCTACTTTTT GGATGTGCTA GAGAGATCCC CGCACAGACC TATCTTGCAA 660
GCTGGGCTGC CTGCGAACAC CACAGCCGTG GTAGGCAGTG ATGTGGAGTT CTTTTGCAAG 720
GTATACAGTG ATGCCCAGCC TCACATACAG TGGCTCAAAC ACATTGAAGT GAATGGGAGC 780
AGTTATGGCC CAGATGGAGT CCCCTATGTG CAAGTTCTTA AGACGGCAGA TATTAACAGT 840
TCAGAGGTAG AAGTGCTGTA CTTACGCAAT GTCTCCATGG AAGATGCTGG TGAATACACC 900
TGTCTGGCGG GGAATTCCAT TGGCCTCTCC TACCAGTCAG CTTGGCTCAC TGTGCTTCCA 960
GATGAAGAAG AAGTGCAAGA GCTGGAAACC CCAGAAATCA AGTATACTGA TATCATCATC 1020
TACACCTCAG GGGGTTTGGC CATTATTATG GCTATTGTCA TCGTCATCTT GTGCCGAATG 1080
CAAATTCAAC CAAACAAGCA GCCCTTGGAG CCCATGGCTG TACACAAACT CTCCAAATTC 1140
CCCCTCATCC GACAGTTCTC ACTGGAATCG AGTTCCTCTG GAAAGTCCAC CACATCTTTG 1200
ATGCGTGTCA CACGCCTTTC ATCAAGTTGT ACCCCCATGC TGGCTGGGGT CATGGAAGTG 1260
GAGCTGCCTC TGGACTCAAA GTGGGAATTC CCACGAGACA GACTGGTGCT GGGCAAGCCG 1320
CTAGGTGAGG GCTGTTTCGG GCAGGTGGTA AGAGCTGAAG CCTATGGGAT TGATCAGGAG 1380
CGACCAGAGC GCCCCATCAC AGTTGCTGTT AAGATGCTGA AAGATAATGC CACTGATAAG 1440
GATTTGGCTG ATCTCATCTC AGAAATGGAA ATGATGAAAC TGATGGACCA GCATAAAAAT 1500
ATCATCAACC TCTTGGGTGT CTGCACACAA GATGGGCCTC TTTATGTGAT TGTGGAGTTT 1560
GCTGCGAAAG GAAACCTGCG GGAATATCTG CGTGCTCGTC GCCCTCCAAC ACCTGATTAC 1620
ACCTTTGATA TCACCAAGAT GCCTGAGGAA CAGCTGTCCT TCAAAGACTT GGTGTCTTGT 1680
GTCTACCAGG TGGCACGTGG CATGGAGTAC TTGGAGTCCA AACGGTGCAT TCACCGGGAC 1740
TTGGCTGCCC GCAATGTTCT TGTCACTGAA GAGAATGTCA TGAAAATTGC TGATTTTGGT 1800
TTGGCCCGTG GGGTTCATGA CATAGACTAC TACAAGAAAA CCAGCAATGG TCGTCTGCCT 1860
GTCAAATGGA TGGCACCAGA GGCCCTCTTC GACAGAGTGT ACACCCACCA GAGTGATGTG 1920
TGGTCCTTTG GCATTCTGAT GTGGGAGATC TTTACATTGG GTGGCTCCCC ATACCCAGGC 1980
ATCCCAGTGG AAGAACTCTT TAAGCTTCTC AGAGAAGGTC ACCGCATGGA CAAGCCTTCC 2040
AACTGCACCC ATGAATTGTA CATGATGATG AGGGAATGCT GGCATGCTGT GCCTTCCCAG 2100
AGGCCCACCT TCAAGCAGCT GGTGGAGGGA TTGGATAAGG TCTTAGTGGC TGTCTCTGAA 2160
GAGTACCTGG ACCTGTCAAT GCCCTTCGAA CAGTATTCCC CATCCTGCGA GGACACGACC 2220
AGCACTTGCT CCTCTGATGA TTCAGTCTTC ACTCATGAGC CCTTGCCTGC TAGCCCTTGC 2280
CTCTTCCCCT ACCACAATGT GAGAACATGA 2310
Domain Profile
S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60
         lvlgk+lGeG+fGqvv+aea g+d++++++ +tvavkmlk++atdkdladl+seme++kl
Q: 435   LVLGKPLGEGCFGQVVRAEAYGIDQERPERPITVAVKMLKDNATDKDLADLISEMEMMKL  494
         79**********************************************************
S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120
         + +hkniinllG+ctq+Gplyvive+aakGnlre+lrarrp++ +++ d +k++eeql++
Q: 495   MDQHKNIINLLGVCTQDGPLYVIVEFAAKGNLREYLRARRPPTPDYTFDITKMPEEQLSF  554
         ************************************************************
S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180
         kdlvs+ yqvarGmeyl+sk+cihrdlaarnvlvte+nv+kiadfGlar+vh+idyykkt
Q: 555   KDLVSCVYQVARGMEYLESKRCIHRDLAARNVLVTEENVMKIADFGLARGVHDIDYYKKT  614
         ************************************************************
S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240
         +nGrlpvkwmapealfdrvyt+qsdvwsfG+l+wei+tlGgspypgi+veelfkll+eGh
Q: 615   SNGRLPVKWMAPEALFDRVYTHQSDVWSFGILMWEIFTLGGSPYPGIPVEELFKLLREGH  674
         ************************************************************
S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277
         rm+kp++ct+ely++mrecwha++s+rptfkqlve l
Q: 675   RMDKPSNCTHELYMMMRECWHAVPSQRPTFKQLVEGL  711
         **********************************965
Domain Sequence
(FASTA)
LVLGKPLGEG CFGQVVRAEA YGIDQERPER PITVAVKMLK DNATDKDLAD LISEMEMMKL 60
MDQHKNIINL LGVCTQDGPL YVIVEFAAKG NLREYLRARR PPTPDYTFDI TKMPEEQLSF 120
KDLVSCVYQV ARGMEYLESK RCIHRDLAAR NVLVTEENVM KIADFGLARG VHDIDYYKKT 180
SNGRLPVKWM APEALFDRVY THQSDVWSFG ILMWEIFTLG GSPYPGIPVE ELFKLLREGH 240
RMDKPSNCTH ELYMMMRECW HAVPSQRPTF KQLVEGL 277
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00141
EKS-BOT-00149
EKS-CAJ-00153
EKS-CAP-00150
EKS-DAR-00435
EKS-DRM-00072
EKS-EQC-00148
EKS-FEC-00139
EKS-GAM-00077
EKS-GAA-00174
EKS-ICT-00143
EKS-LAC-00159
EKS-LOA-00148
EKS-MAM-00146
EKS-MOD-00149
EKS-MUM-00154
EKS-MUP-00154
EKS-MYL-00158
EKS-ORN-00184
EKS-ORC-00140
EKS-ORL-00172
EKS-POA-00145
EKS-RAN-00148
EKS-SAH-00144
EKS-SUS-00130
EKS-TAG-00178
EKS-TAR-00193
EKS-TEN-00185
EKS-XET-00138
EKS-XIM-00178
Gene Ontology
GO:0005911; C:cell-cell junction
GO:0005783; C:endoplasmic reticulum
GO:0005887; C:integral to plasma membrane
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0005007; F:fibroblast growth factor-activated receptor activity
GO:0008201; F:heparin binding
GO:0016477; P:cell migration
GO:0042593; P:glucose homeostasis
GO:0001759; P:organ induction
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0055062; P:phosphate ion homeostasis
GO:0008284; P:positive regulation of cell proliferation
GO:2000573; P:positive regulation of DNA biosynthetic process
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0048554; P:positive regulation of metalloenzyme activity
GO:0045862; P:positive regulation of proteolysis
GO:0046777; P:protein autophosphorylation
GO:0070857; P:regulation of bile acid biosynthetic process
GO:2000188; P:regulation of cholesterol homeostasis
GO:0010715; P:regulation of extracellular matrix disassembly
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR013151; Immunoglobulin.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016248; Tyr_kinase_fibroblast_GF_rcpt.
Pfam
PF07679; I-set; 2.
PF00047; ig; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00408; IGc2; 3.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013