EKS-ANC-00383

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ANC-00383

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Axl	525.2	2.8E-158	506	769	264

Status

Unreviewed

Ensembl Protein

ENSACAP00000005957

UniProt Accession

H9GAY1;

Protein Name

Protein Synonyms/Alias

Gene Name

MERTK

Gene Synonyms/Alias

MERTK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSACAG00000005886	ENSACAP00000005957	ENSACAT00000006091

Organism

Anolis carolinensis

Functional Description

Protein Length

910

Protein Sequence
(FASTA)

PLQSVKFNPT VGKIPIAEHT DIKFNCSIKV PRSLINQDSA TISLWKNGKE LLHADRMASQ 60

HYQLDDNEHI SMTSAFRINN IQRADNGSYR CKLKVNTTEI VSDPILVLFE GLPYFIKQPQ 120

GLNVTRNTPF NLTCKAVGPP EPVEIRWHWN SSLIATKEIS PSVLTVPGLN ETAIFHCEAH 180

NEKGVTTSTE ARINIKGIPS PPVKVSVQNS TGYMILVSWV PGSDGYSPLS SCSVQVKEVV 240

VGDNASVMVF NTSTPPHQYH IQNLRPLKNY SICVSCVNEV GWSGFSPWIM ASTTEGAPSA 300

PPGNVTLSIN ESSSSVIITW IKPPDTLMNG ELQGYSISYV WQNSVSVYKE LLKEKAGKDA 360

NATHIPIVAT NATYIVRVAA VTNGGVGPFS DPVGIFVPGN GVAPTASLST TESGVTDSLI 420

IILGFIFGVV VVGLIMCVSM IVRRRLTEET KFGYAFGSDE SELTVNYKAK KSYCRRAVEL 480

TLGSLGVSEE LQEKLQDVVI VRTNLSLGKI LGEGEFGSVM EGSLNNPDGT TQKVAVKTMK 540

LDSFSQREIE EFLREAACMK DFDHPNVIKL LGVCIEPSSQ QVPKPMVILP FMKYGDLHSF 600

LLRSRLGMGT QYVPLQTLLK FMIDIALGME YLSNKHFLHR DLAARNCMLR DDMTVCVADF 660

GLSKKIYSGD YYRQGRIAKM PVKWIAIESL ADRVYTTKSD VWAFGVTMWE IATRGMTPYP 720

GVQNHEIYDY LLHGNRLKQP EDCLDELYEI MCSCWRANPV DRPTFSDLKL HLEKLSKTLP 780

DLSEPDSIIY INTSLLEEST DELDEDADFP QIDTDLDPDH IIQSCSHRPE TTVVTVDIHE 840

SNGMEDRYVV SGVSAGQNLT TTEEDIPLLS VTPSQNGILW SEASTLPVGS MLTTELLYAD 900

DSLEDSEILL 910

Nucleotide Sequence
(FASTA)

CCTCTTCAAT CCGTTAAATT TAACCCAACA GTAGGAAAGA TACCAATTGC TGAACATACG 60

GACATCAAAT TTAATTGCTC TATCAAAGTT CCTAGATCAC TAATTAACCA GGATTCCGCA 120

ACTATTTCCT TGTGGAAGAA TGGAAAAGAG CTGCTTCATG CTGATAGGAT GGCCAGCCAG 180

CATTACCAAT TAGATGATAA TGAGCATATT TCTATGACAT CTGCCTTCCG TATCAACAAT 240

ATCCAGCGTG CTGATAATGG GTCTTACAGA TGCAAATTGA AAGTCAATAC CACTGAAATA 300

GTATCAGATC CTATTTTGGT TTTGTTCGAA GGACTGCCAT ACTTCATTAA ACAGCCGCAG 360

GGGCTGAATG TGACCCGAAA CACACCGTTC AATCTCACCT GTAAAGCGGT GGGACCTCCT 420

GAGCCTGTTG AGATCCGCTG GCATTGGAAC AGCAGCCTCA TTGCTACGAA AGAAATATCT 480

CCATCGGTCT TGACTGTGCC AGGCCTTAAC GAAACTGCTA TCTTCCATTG TGAAGCTCAT 540

AACGAGAAGG GAGTCACAAC ATCCACCGAA GCTCGAATCA ATATCAAAGG AATTCCATCT 600

CCACCTGTCA AAGTGTCTGT CCAGAACAGC ACAGGTTACA TGATACTAGT ATCTTGGGTC 660

CCAGGTTCAG ATGGCTATTC ACCTTTGAGT AGTTGCAGTG TCCAGGTGAA GGAGGTTGTT 720

GTCGGAGATA ATGCTTCAGT GATGGTTTTC AACACTTCCA CCCCACCTCA TCAGTATCAC 780

ATTCAGAATC TGAGGCCTTT GAAGAATTAT AGCATTTGTG TTTCTTGTGT GAATGAAGTG 840

GGCTGGTCTG GCTTTAGCCC TTGGATAATG GCCAGTACTA CAGAAGGAGC TCCCTCTGCT 900

CCGCCTGGGA ATGTCACTCT CTCCATCAAT GAGTCAAGCT CTTCTGTGAT AATCACCTGG 960

ATTAAGCCCC CTGACACTCT GATGAACGGC GAACTTCAAG GCTACAGTAT CTCATATGTA 1020

TGGCAGAATT CGGTATCTGT GTATAAAGAG TTATTAAAAG AAAAGGCCGG CAAAGATGCC 1080

AATGCCACCC ATATTCCGAT TGTGGCCACG AATGCCACAT ACATAGTGCG GGTAGCTGCA 1140

GTCACAAATG GTGGAGTTGG GCCATTCAGT GACCCAGTTG GGATTTTTGT TCCAGGAAAT 1200

GGTGTGGCAC CCACTGCCTC TTTGTCAACT ACAGAATCTG GAGTCACGGA TTCACTTATA 1260

ATAATCCTTG GGTTCATATT TGGAGTCGTG GTCGTTGGCT TAATCATGTG CGTGTCCATG 1320

ATTGTCAGGA GAAGATTGAC AGAGGAAACC AAGTTTGGGT ACGCTTTCGG CAGTGATGAG 1380

TCAGAACTGA CTGTAAATTA CAAAGCGAAG AAGTCCTACT GCCGCAGAGC GGTTGAACTC 1440

ACATTGGGCA GCCTTGGGGT GAGTGAAGAG CTGCAAGAAA AACTCCAGGA TGTTGTGATT 1500

GTCAGGACGA ACCTGTCCCT GGGGAAGATC TTGGGAGAGG GAGAGTTTGG GTCAGTCATG 1560

GAAGGGAGTC TCAACAATCC TGATGGAACT ACTCAGAAAG TTGCTGTGAA AACTATGAAG 1620

TTGGACAGCT TTTCCCAACG AGAAATTGAG GAGTTCCTTC GGGAAGCTGC ATGCATGAAA 1680

GATTTCGATC ACCCCAATGT CATCAAACTT CTTGGTGTGT GTATAGAGCC AAGTTCTCAA 1740

CAGGTTCCAA AGCCCATGGT GATTCTCCCT TTCATGAAAT ATGGAGATCT GCACAGCTTT 1800

CTTCTTCGCT CAAGACTTGG AATGGGCACT CAGTATGTAC CACTACAAAC TTTATTGAAG 1860

TTTATGATTG ACATTGCTCT GGGAATGGAG TACCTCAGTA ACAAGCACTT CCTCCATAGA 1920

GACCTGGCTG CTCGAAACTG CATGTTACGG GACGACATGA CTGTGTGTGT AGCCGACTTC 1980

GGTTTATCCA AGAAGATTTA CAGTGGAGAT TATTATCGGC AAGGGCGCAT TGCAAAGATG 2040

CCCGTTAAGT GGATTGCGAT AGAAAGTCTT GCCGATCGGG TCTACACAAC AAAAAGTGAT 2100

GTGTGGGCTT TTGGTGTTAC AATGTGGGAG ATAGCGACTC GAGGGATGAC GCCATACCCA 2160

GGAGTGCAGA ACCATGAAAT ATACGACTAC CTCCTCCATG GAAACAGGCT GAAGCAGCCA 2220

GAAGACTGTT TAGATGAATT GTATGAAATA ATGTGCTCTT GCTGGAGAGC AAATCCGGTA 2280

GATCGGCCCA CCTTTTCAGA CCTGAAGCTT CACCTGGAGA AGCTGTCCAA AACTTTGCCT 2340

GACTTGAGCG AACCTGACAG CATCATTTAC ATCAACACAA GTTTGCTAGA GGAGAGCACA 2400

GATGAACTGG ACGAAGATGC CGATTTCCCC CAGATAGACA CGGATCTTGA TCCTGATCAC 2460

ATCATACAGT CTTGTTCTCA TAGACCAGAG ACTACGGTAG TCACTGTTGA CATCCACGAG 2520

AGCAATGGGA TGGAGGACAG GTATGTTGTA AGTGGAGTGA GTGCGGGACA GAACCTGACG 2580

ACAACAGAAG AAGATATTCC TCTGCTCTCT GTGACTCCTT CGCAGAATGG GATATTGTGG 2640

TCTGAAGCCA GTACCTTACC TGTAGGAAGC ATGTTGACAA CTGAACTACT GTATGCAGAT 2700

GACTCTTTGG AGGACTCTGA AATCCTTCTG TGA 2733

Domain Profile

S: 2     vlgkvlgegefgsvmegqlkqedgsilkvavktlkldiiarseieeflseaacmkefdhp  61

          lgk+lgegefgsvmeg l++ dg+++kvavkt+kld ++++eieefl+eaacmk+fdhp

Q: 506   SLGKILGEGEFGSVMEGSLNNPDGTTQKVAVKTMKLDSFSQREIEEFLREAACMKDFDHP  565

         79**********************************************************

S: 62    nvirlvgvslessekgrlpkpvvilpfmkygdlhafllysrlgenpvylplqtlvkfmvd  121

         nvi+l+gv++e s+++ +pkp+vilpfmkygdlh+fll srlg + +y+plqtl+kfm+d

Q: 566   NVIKLLGVCIEPSSQQ-VPKPMVILPFMKYGDLHSFLLRSRLGMGTQYVPLQTLLKFMID  624

         **************99.*******************************************

S: 122   iasgmeylssrnfihrdlaarncmlaedmtvcvadfglskkiysgdyyrqgriaklpvkw  181

         ia gmeyls+++f+hrdlaarncml++dmtvcvadfglskkiysgdyyrqgriak+pvkw

Q: 625   IALGMEYLSNKHFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKW  684

         ************************************************************

S: 182   iaiesladrvytsksdvwafgvtmweiatrgqtpyagvenaeiydyllqgnrlkqpedcl  241

         iaiesladrvyt+ksdvwafgvtmweiatrg+tpy+gv+n+eiydyll+gnrlkqpedcl

Q: 685   IAIESLADRVYTTKSDVWAFGVTMWEIATRGMTPYPGVQNHEIYDYLLHGNRLKQPEDCL  744

         ************************************************************

S: 242   delydlmyrcweadpkdrpsfsvlr  266

         dely++m +cw+a+p drp+fs+l+

Q: 745   DELYEIMCSCWRANPVDRPTFSDLK  769

         **********************987

Domain Sequence
(FASTA)

SLGKILGEGE FGSVMEGSLN NPDGTTQKVA VKTMKLDSFS QREIEEFLRE AACMKDFDHP 60

NVIKLLGVCI EPSSQQVPKP MVILPFMKYG DLHSFLLRSR LGMGTQYVPL QTLLKFMIDI 120

ALGMEYLSNK HFLHRDLAAR NCMLRDDMTV CVADFGLSKK IYSGDYYRQG RIAKMPVKWI 180

AIESLADRVY TTKSDVWAFG VTMWEIATRG MTPYPGVQNH EIYDYLLHGN RLKQPEDCLD 240

ELYEIMCSCW RANPVDRPTF SDLK 264

Keyword

ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR003961	; Fibronectin_type3.
IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003599	; Ig_sub.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF00041	; fn3; 2.
PF07679	; I-set; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00060	; FN3; 2.
SM00409	; IG; 2.
SM00219	; TyrKc; 1.

Prosites

PS50853	; FN3; 2.
PS50835	; IG_LIKE; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013