EKS-ANC-00316

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ANC-00316

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	321.4	4.1E-96	1	241	241

Status

Unreviewed

Ensembl Protein

ENSACAP00000006489

UniProt Accession

G1KFJ7;

Protein Name

Mitogen-activated protein kinase kinase kinase kinase

Protein Synonyms/Alias

Gene Name

MAP4K3

Gene Synonyms/Alias

MAP4K3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSACAG00000006417	ENSACAP00000006489	ENSACAT00000006634

Organism

Anolis carolinensis

Functional Description

Protein Length

861

Protein Sequence
(FASTA)

ARNVNSSELA AIKVIKLEPG EDFAVVQQEI IMMKDCKHPN IVAYFGSYLR RDKLWICMEF 60

CGGGSLQDIY HVTGPLSEMQ IAYVSRETLQ GLYYLHSKGK MHRDIKGANI LLTDNGHVKL 120

ADFGVAAQIT ATIAKRKSFI GTPYWMAPEV AAVERKGGYN QLCDLWAVGI TAIELAELQP 180

PMFDLHPMRA LFLMTKSNFQ PPKLKDKMKW SNSFHHFVKM ALTKNPKKRP TAEKLLQHPF 240

VTQPLNRTLA IELLDKMNNP DHSTYHDFDD DDPEPLLVLH RIHSTSRNVR EEKTRSEINF 300

GQVKFDPPLR KETEPHHEFP DSNDFLDSSE EIYYTARSNL DLQLEYGQGP QGSYLLGANK 360

SLLKSVEEEL HQRGHVAHLE DEEEVDSDDS KHSTMKAKVP PPLPPKPKSI CMPQEVNSSE 420

DDNQGTIKRC PVSESPARSN TQVPPRPPPP RLPSQKSLGN GLNSVQINGD REGSPHQEPN 480

ENRHTNVSRK EKKEVPKPIS NGLPPTPKVH MGACFSKVFN GCPLKIHCAT SWINPDTRDQ 540

YLIFGAEEGI YTLNLNELHE TSMEQLFPRR CTWLYVMNNC LLSISGKASQ LYSHNLPGLF 600

DYARQMQKLP VAIPAHKLPD RILPRKFAVS TKIPDTKWCQ KCCVVRNPYT GHKYLCGALQ 660

SSIVLLEWVE PMQKFMLIKH IDFPVPCPLR LFEMLVVPEQ EFPLVCVGVS KGRDFNQVVK 720

FETVNPNSTS SWFTETDTTQ TNVVHVTQLE RDTILVCLDC CIKIVNLQGR LKSSRKLSSE 780

LTFDFQIESI VCLQDSVLAF WKHGMQGRSF RSNEITQEIS DNTRIFRLLG SDRVVVLESR 840

PTDNPTANSN LYILAGHENS Y 861

Nucleotide Sequence
(FASTA)

GCTCGGAATG TTAACTCAAG CGAATTGGCG GCAATTAAAG TAATAAAGTT AGAACCAGGA 60

GAAGATTTTG CTGTTGTGCA GCAGGAAATC ATTATGATGA AAGACTGTAA GCATCCAAAC 120

ATTGTTGCTT ATTTTGGCAG CTATCTCAGA CGTGATAAAC TGTGGATTTG CATGGAGTTC 180

TGTGGAGGAG GTTCATTGCA GGACATTTAC CATGTGACTG GACCTCTGTC AGAAATGCAG 240

ATTGCTTATG TAAGCAGAGA AACACTACAG GGATTATATT ATCTTCACAG TAAAGGAAAA 300

ATGCACAGAG ACATAAAGGG AGCCAATATT CTTTTAACAG ACAATGGCCA TGTGAAATTA 360

GCTGATTTTG GAGTAGCAGC ACAAATAACA GCAACCATTG CCAAAAGGAA ATCTTTCATT 420

GGAACACCAT ATTGGATGGC CCCTGAGGTT GCGGCAGTTG AAAGGAAAGG GGGATATAAC 480

CAACTTTGTG ACCTTTGGGC TGTTGGAATC ACTGCTATAG AACTAGCAGA GCTCCAGCCA 540

CCAATGTTTG ACTTGCATCC AATGAGAGCA CTATTTTTAA TGACTAAAAG CAACTTCCAG 600

CCTCCCAAAC TAAAAGACAA AATGAAGTGG TCAAATAGTT TTCATCATTT TGTGAAAATG 660

GCACTTACAA AGAATCCTAA AAAAAGACCT ACAGCTGAAA AATTATTGCA GCATCCTTTT 720

GTTACCCAGC CATTAAACCG GACCCTTGCT ATTGAACTAT TGGATAAAAT GAACAATCCT 780

GATCATTCAA CCTACCATGA TTTTGATGAT GATGATCCTG AGCCTCTTCT TGTGCTTCAT 840

AGAATTCACT CAACAAGTAG AAATGTGAGA GAAGAAAAAA CACGCTCTGA AATAAACTTT 900

GGCCAAGTAA AATTTGATCC ACCTTTAAGG AAGGAGACAG AGCCTCATCA TGAGTTTCCC 960

GACAGTAACG ATTTTTTGGA CAGTTCAGAA GAAATATACT ACACTGCAAG ATCTAATCTG 1020

GATTTGCAGC TAGAATATGG CCAAGGTCCC CAAGGAAGCT ACTTATTGGG TGCAAATAAG 1080

AGCCTTCTCA AATCAGTTGA AGAAGAGCTG CATCAGCGGG GACATGTGGC ACACCTTGAA 1140

GATGAGGAAG AAGTGGACAG TGATGATTCC AAACATTCAA CTATGAAAGC AAAAGTGCCA 1200

CCTCCTTTGC CGCCAAAGCC TAAATCCATC TGCATGCCAC AAGAAGTTAA TTCTTCTGAG 1260

GATGATAATC AAGGAACCAT AAAAAGATGT CCTGTTTCAG AAAGCCCTGC AAGATCCAAC 1320

ACTCAAGTCC CACCTAGACC ACCACCTCCT CGGTTACCTT CACAGAAATC TTTAGGTAAT 1380

GGATTGAATT CTGTACAAAT AAATGGTGAC AGAGAGGGAT CTCCCCATCA AGAGCCAAAT 1440

GAAAATAGAC ACACTAATGT GTCTAGGAAA GAAAAGAAGG AAGTACCGAA ACCTATTAGT 1500

AATGGTCTTC CTCCTACACC AAAAGTACAT ATGGGTGCCT GCTTTTCAAA GGTTTTCAAT 1560

GGATGCCCCT TAAAAATTCA TTGTGCAACC TCATGGATTA ATCCTGACAC ACGAGACCAA 1620

TACTTAATAT TTGGTGCTGA GGAAGGCATT TATACCTTGA ACCTTAATGA GCTCCATGAA 1680

ACATCAATGG AACAGCTCTT TCCTCGACGA TGTACGTGGC TGTACGTAAT GAACAACTGC 1740

TTACTATCAA TATCTGGTAA AGCTTCTCAA CTTTATTCCC ATAATTTGCC AGGATTGTTT 1800

GACTATGCTC GACAAATGCA GAAGTTGCCA GTTGCTATAC CAGCACACAA GCTTCCCGAC 1860

AGAATACTTC CGAGAAAGTT TGCCGTTTCT ACAAAAATTC CAGACACTAA ATGGTGCCAG 1920

AAGTGTTGTG TGGTGAGGAA TCCTTACACG GGACACAAAT ATCTTTGTGG AGCACTACAG 1980

TCCAGCATTG TTCTGTTAGA GTGGGTTGAA CCAATGCAGA AATTCATGTT AATCAAGCAT 2040

ATAGATTTTC CTGTACCTTG TCCACTGAGA TTATTTGAAA TGCTGGTAGT ACCGGAACAG 2100

GAATTCCCTT TAGTTTGTGT TGGTGTAAGT AAAGGAAGAG ACTTCAATCA GGTGGTGAAG 2160

TTTGAAACTG TCAACCCAAA TTCTACCTCT TCATGGTTCA CTGAAACAGA TACTACACAG 2220

ACAAATGTTG TGCACGTAAC ACAGTTGGAG AGAGATACCA TTTTAGTCTG CCTGGATTGC 2280

TGTATAAAGA TAGTAAATTT GCAAGGTAGA TTGAAATCTA GTCGAAAACT ATCTTCAGAA 2340

CTCACATTTG ATTTCCAGAT TGAATCAATA GTTTGTTTAC AAGATAGTGT TTTGGCTTTC 2400

TGGAAGCATG GAATGCAGGG CAGAAGTTTT CGGTCAAATG AGATCACACA GGAAATTTCA 2460

GACAATACAA GAATTTTCAG ACTCCTTGGA TCTGACAGGG TTGTGGTACT GGAGAGTCGG 2520

CCCACAGATA ACCCTACTGC CAACAGCAAC TTGTACATCT TAGCAGGTCA CGAAAACAGT 2580

TACTGA 2586

Domain Profile

S: 18    arekktgelvaikkinlekqekleelqkeisvlkklkhpniveylesflkeeelwlvmey  77

         ar+++++el+aik+i+le  e+ + +q+ei ++k++khpniv+y++s+l++++lw++me+

Q: 1     ARNVNSSELAAIKVIKLEPGEDFAVVQQEIIMMKDCKHPNIVAYFGSYLRRDKLWICMEF  60

         6788999*****************************************************

S: 78    lagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkviHrdikakniLlteegeV  137

         + gGsl+d+++  ++ +l+E qiay+ re+l++L ylHsk+++Hrdik++niLlt++g+V

Q: 61    CGGGSLQDIYH--VTGPLSEMQIAYVSRETLQGLYYLHSKGKMHRDIKGANILLTDNGHV  118

         ***********..***********************************************

S: 138   kLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe.ekgYdekaDiwslGItaielaeg  196

         kL+dfgvaaq+++t +krk+++gtpywmAPEv a+e + gY++ +D+w++GItaielae

Q: 119   KLADFGVAAQITATIAKRKSFIGTPYWMAPEVAAVErKGGYNQLCDLWAVGITAIELAEL  178

         ***********************************98889********************

S: 197   epPfkdleplkallkilkne..ppklkskkkfskefkefvekclqknpekRpsasellkh  254

         +pP++dl+p++al++++k++  ppklk+k k+s++f++fv+ +l+knp+kRp+a++ll+h

Q: 179   QPPMFDLHPMRALFLMTKSNfqPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQH  238

         *************999999888**************************************

S: 255   kFl  257

+F+

Q: 239   PFV  241

**7

Domain Sequence
(FASTA)

ARNVNSSELA AIKVIKLEPG EDFAVVQQEI IMMKDCKHPN IVAYFGSYLR RDKLWICMEF 60

CGGGSLQDIY HVTGPLSEMQ IAYVSRETLQ GLYYLHSKGK MHRDIKGANI LLTDNGHVKL 120

ADFGVAAQIT ATIAKRKSFI GTPYWMAPEV AAVERKGGYN QLCDLWAVGI TAIELAELQP 180

PMFDLHPMRA LFLMTKSNFQ PPKLKDKMKW SNSFHHFVKM ALTKNPKKRP TAEKLLQHPF 240

V 241

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity
GO:0007243	; P:intracellular protein kinase cascade
GO:0006950	; P:response to stress

KEGG

InterPros

IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR021160	; MAPKKKK.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00780	; CNH; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00036	; CNH; 1.
SM00220	; S_TKc; 1.

Prosites

PS50219	; CNH; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013