EKS-ANC-00266

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ANC-00266

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	452.2	6.5E-136	205	492	288

Status

Unreviewed

Ensembl Protein

ENSACAP00000007502

UniProt Accession

H9GCW2;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR1

Gene Synonyms/Alias

ACVR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSACAG00000007562	ENSACAP00000007502	ENSACAT00000007662

Organism

Anolis carolinensis

Functional Description

Protein Length

506

Protein Sequence
(FASTA)

SVDSAKILSC QMQDSLEFPK PADDELKLIT DYECVCEGMS CGHGVRCRGH QCFASLSINN 60

GAKVSQKGCF RVYEQGKMTC KTPPSPDQAV ECCQGDLCNM NITAQLPTKG KDFPFHGSDH 120

LLVGLLLTLC PTICCVGLVL LIVRKVRQRY IERFNSRDAE YGTIEGLIAS NVGDSTLADL 180

LDHSCTSGSG SGLPFLVQRT VARQITLLEC VGKGRYGEVW RGHWQGENVA VKIFSSRDEK 240

SWFRETELYN TVLLRHENIL GFVASDMTSR NSSTQLWLIT HYHEMGSLYD YLQLTTLDTV 300

SCLRIVLSIA SGLAHLHIEI FGTQGKPAIA HRDLKSKNIL VKKNGQCCIA DLGLAVMHSQ 360

STNQLDVGNN PRVGTKRYMA PEVLDETIQV DCFDSYKRVD IWAFGLVLWE VARRMVSNGI 420

VEDYKPPFYD VVPNDPSFED MRKVVCVDQQ RPNIPNRWFS DPTLTSLAKL MKECWYHNPS 480

ARLTALRIKK TLTKIDNSLD KLKADC 506

Nucleotide Sequence
(FASTA)

TCTGTTGACT CCGCAAAGAT TCTCTCGTGT CAGATGCAAG ACTCCTTAGA ATTTCCCAAG 60

CCTGCAGATG ATGAGCTCAA ACTAATAACA GACTATGAAT GTGTGTGTGA AGGGATGTCA 120

TGTGGACATG GGGTCCGCTG CAGGGGCCAC CAGTGCTTTG CGTCCCTGAG CATCAATAAT 180

GGTGCTAAAG TGTCCCAGAA GGGATGCTTC CGAGTCTACG AGCAAGGGAA GATGACCTGC 240

AAAACTCCTC CATCCCCTGA TCAAGCAGTG GAGTGCTGTC AGGGAGACCT GTGTAACATG 300

AACATCACAG CACAGCTGCC AACAAAAGGC AAAGATTTTC CATTTCACGG ATCTGATCAT 360

CTACTTGTTG GATTACTGCT TACATTGTGT CCCACCATTT GCTGTGTTGG ACTAGTGCTG 420

CTGATTGTCC GGAAAGTGCG GCAGCGCTAT ATAGAAAGGT TCAATTCAAG GGATGCAGAA 480

TATGGAACCA TCGAGGGACT CATAGCCTCA AACGTTGGTG ACAGCACACT GGCAGACTTG 540

TTGGACCATT CCTGTACATC TGGGAGTGGT TCTGGCCTTC CTTTTCTGGT ACAAAGAACA 600

GTCGCTCGCC AGATCACGCT GCTGGAGTGT GTAGGGAAAG GCCGATATGG AGAGGTCTGG 660

CGAGGACATT GGCAAGGAGA AAATGTGGCT GTCAAGATCT TCTCTTCCCG AGATGAAAAG 720

TCCTGGTTCA GGGAAACAGA GTTATACAAT ACAGTGTTGC TGAGGCATGA AAATATTTTA 780

GGCTTTGTTG CTTCAGATAT GACTTCTAGG AACTCGAGTA CTCAGCTATG GCTAATTACA 840

CACTACCATG AAATGGGCTC TTTATACGAC TACCTACAAC TCACTACTCT GGATACCGTG 900

AGCTGCTTAC GAATAGTTTT GTCCATAGCT AGCGGCCTTG CGCATTTGCA CATAGAGATA 960

TTTGGGACCC AAGGAAAGCC TGCCATCGCC CATCGAGATT TGAAGAGTAA AAATATCCTG 1020

GTGAAGAAAA ATGGACAGTG TTGCATAGCA GATCTAGGCC TTGCAGTCAT GCACTCCCAA 1080

AGCACCAACC AGTTGGATGT GGGGAACAAC CCTCGTGTAG GTACCAAGCG CTACATGGCT 1140

CCAGAGGTCT TGGACGAGAC CATCCAGGTG GACTGCTTTG ACTCATACAA AAGGGTTGAC 1200

ATTTGGGCAT TTGGACTCGT CCTTTGGGAG GTGGCCAGGC GCATGGTTAG CAATGGTATT 1260

GTTGAAGATT ACAAACCTCC GTTTTATGAT GTCGTTCCTA ATGACCCTAG TTTTGAAGAT 1320

ATGAGAAAAG TCGTCTGCGT GGATCAGCAA AGGCCAAACA TTCCCAACAG ATGGTTTTCA 1380

GATCCTACAC TAACTTCCCT TGCCAAGTTG ATGAAAGAAT GCTGGTATCA TAATCCATCT 1440

GCCAGATTAA CAGCTCTACG CATCAAAAAG ACCTTGACCA AAATTGACAA TTCCCTAGAT 1500

AAGCTCAAAG CTGACTGTTG A 1521

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         ++lle++gkGrygeVw+++++ge+vAvKifs++de+sw+rE+e+y+tvllrhenil+f+a

Q: 205   ITLLECVGKGRYGEVWRGHWQGENVAVKIFSSRDEKSWFRETELYNTVLLRHENILGFVA  264

         789*********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         +d+++++s+t+l+l+t+yhe+gsL+dyL+ +tld+ ++lr++ls+asGlahLH ei+gt+

Q: 265   SDMTSRNSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQ  324

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNilvkk+++cciaDlGLa+++++++++ld+ +n +vGtkRYmaPE

Q: 325   G--KPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPE  382

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e++++++f+++kr+D++++gLvlWEva+R+ + +++ve+yk+pf++vv++dPs+e+m

Q: 383   VLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVS-NGIVEDYKPPFYDVVPNDPSFEDM  441

         **********************************9.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+++++rP+ip++w ++++l++l+kl++ecW+++p+aRltalr+kk+l

Q: 442   RKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYHNPSARLTALRIKKTL  492

         *************************************************97

Domain Sequence
(FASTA)

ITLLECVGKG RYGEVWRGHW QGENVAVKIF SSRDEKSWFR ETELYNTVLL RHENILGFVA 60

SDMTSRNSST QLWLITHYHE MGSLYDYLQL TTLDTVSCLR IVLSIASGLA HLHIEIFGTQ 120

GKPAIAHRDL KSKNILVKKN GQCCIADLGL AVMHSQSTNQ LDVGNNPRVG TKRYMAPEVL 180

DETIQVDCFD SYKRVDIWAF GLVLWEVARR MVSNGIVEDY KPPFYDVVPN DPSFEDMRKV 240

VCVDQQRPNI PNRWFSDPTL TSLAKLMKEC WYHNPSARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0023014	; P:signal transduction by phosphorylation

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013