EKS-ANC-00013

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ANC-00013

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/InsR	536.5	9.1E-162	1003	1270	268

Status

Unreviewed

Ensembl Protein

ENSACAP00000008063

UniProt Accession

H9GDM3;

Protein Name

Tyrosine-protein kinase receptor

Protein Synonyms/Alias

Gene Name

IGF1R

Gene Synonyms/Alias

IGF1R;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSACAG00000008089	ENSACAP00000008063	ENSACAT00000008235

Organism

Anolis carolinensis

Functional Description

Protein Length

1366

Protein Sequence
(FASTA)

SKQAVVSTNP EKCWMATQFL SLSFPSFPQF SMAPVCGPNI DLRNSIEQLK ELEDCTVVEG 60

YLRILLINQG EDFSNIRFPK LTMITDYLLL FRVAGLETLS DLFPNLTVIR GRNLFYNYAL 120

VIFEMANLKE IGLYNLRNIT RGAIRIEKNS DLCYLSTIDW SLILDAVSNN YIVGNKPAKE 180

CGDLCPGTAE QNPLCEKTSI NNEYSYRCWT SNHCQKKCPR SCGKYACTEQ NECCHPECLG 240

SCTVPNNNTA CVACRNYYHD GACVPTCPPN TYKFEGWRCI TKENCSRILL SPESLEYESF 300

VIHEDECVQE CPSGFIRNDT QSMFCSPCEG PCPKVCADEK TITIDSVTSA QSLKGCTEIK 360

GNLLINIRRG NNIASELENF MGLIETVTGY VKIRHSHALV SLSFLKNLRY INGEDQLEGN 420

YSFYVLDNQN LQQLWDWSHH NLTVKEGKMY FAFNPRLCVS EIYRMEEVTG TKDRQNKGDI 480

NPRNNGDRAS CESHILKFVS NTTMKNRIKL TWEQYRPKDY RDLISFTVYY KEAPFQNVTE 540

YDGQDACGSN SWNMVDVDLP PNKEDNPGIL LQALKPWTQY AIYVKAVTLT MMENNHVHGA 600

KSEIVYIRTK AAVPSIPLDV ISASNSSSQL IVKWNPPTYP NGNLSYYIVR WQQQPQDNYL 660

YRHSYCSKER VPIRRYADGT IDTEEATEPT KPEGSGGEKG PCCGCPKTEA EKQAEKEEAE 720

YRKVFENFLH NAIFLPRPDR KRRDLFRIAN TTFASKNRTA AAPEHVTNAS DAEESEMEFP 780

FSERKVEGRE RTLISHLLPF TLYRIDIHSC NHEAALLGCS ASNFVFARTM PAEGADDIPG 840

PVTWEGKEEN TIFLKWREPV SPNGLILMYE IKYKQSEEKG LCVSRQEYKK LGGAKLTNLN 900

PGNVTVRVQA TSLAGNGSWT EPISFYVQPK PVNYGNFLHL IIALPIAVLL IVGGLLIMLY 960

VCNKKRNSDR LGNGVLYASV NPEYFSASDV YVPDEWEVPR EKITMCRELG QGSFGMVYEG 1020

IAKGVVKDEP ETRVAIKTVN ESASMRERIE FLNEASVMKE FNCHHVVRLL GVVSQGQPTL 1080

VIMELMTRGD LKSYLRSLRP DTENNPAHTL PALKKMIQMA GEIADGMAYL NANKFVHRDL 1140

AARNCMVAED FTVKIGDFGM TRDIYETDYY RKGGKGLLPV RWMSPESLKD GVFTTHSDVW 1200

SFGVVLWEIA TLAEQPYQGM SNEQVLRFVM EGGLLEKPDN CPDMLFELMR MCWQYNPKMR 1260

PSFLEIIGSI KDELDPAFKE VSFFYSDENK PPDTEELDLE AENMESIPLD PSSTLQPSDK 1320

HSGHKAENGP GVVVLRASFE ERQPYAHMNG GRKNERALPL PQSSAC 1366

Nucleotide Sequence
(FASTA)

AGTAAACAGG CAGTTGTCTC AACGAATCCA GAGAAATGTT GGATGGCTAC ACAATTTCTT 60

TCTCTTTCTT TTCCCTCCTT CCCCCAATTT TCGATGGCTC CAGTCTGTGG GCCAAACATC 120

GATCTCCGCA ACAGCATTGA GCAGCTCAAA GAGCTGGAGG ACTGTACGGT GGTGGAAGGG 180

TACCTCCGCA TCCTGTTGAT CAACCAAGGC GAGGATTTCA GCAACATCCG CTTCCCGAAG 240

CTGACCATGA TCACGGACTA CTTGCTGCTC TTCCGGGTGG CCGGCCTGGA GACCCTGAGC 300

GACCTCTTCC CCAACCTGAC CGTCATCCGG GGCCGGAACC TCTTCTACAA CTATGCCTTG 360

GTCATCTTCG AGATGGCCAA CCTCAAGGAG ATCGGGCTGT ACAACTTGAG GAACATCACC 420

CGGGGGGCCA TCCGGATCGA GAAGAACTCG GACCTGTGTT ACCTCTCGAC CATCGACTGG 480

TCCCTCATCT TGGATGCCGT CTCCAACAAC TACATCGTGG GTAATAAGCC GGCGAAAGAG 540

TGTGGAGATT TATGCCCGGG AACGGCGGAG CAGAACCCGC TGTGCGAAAA GACGTCGATT 600

AACAACGAAT ACAGCTACCG CTGCTGGACG TCCAACCACT GCCAGAAAAA GTGTCCCAGG 660

TCTTGCGGCA AATACGCTTG CACCGAACAG AACGAGTGCT GCCATCCCGA ATGCTTAGGG 720

AGCTGCACCG TGCCGAACAA CAACACGGCA TGCGTGGCTT GCCGCAACTA CTACCACGAC 780

GGCGCGTGCG TGCCCACCTG CCCTCCCAAC ACCTACAAGT TTGAGGGCTG GCGCTGCATC 840

ACCAAGGAGA ACTGCTCCCG AATCCTGCTT TCCCCGGAGA GCCTCGAGTA CGAGAGCTTT 900

GTGATCCACG AGGACGAGTG TGTGCAGGAG TGCCCTTCTG GGTTTATACG CAATGATACC 960

CAAAGCATGT TCTGCAGCCC TTGTGAAGGT CCTTGCCCCA AAGTGTGCGC GGACGAGAAA 1020

ACCATCACCA TCGATTCCGT CACGTCAGCA CAGTCCTTGA AAGGATGCAC AGAAATCAAA 1080

GGGAACCTGC TTATCAATAT CCGTCGGGGC AATAACATTG CTTCTGAACT GGAGAACTTC 1140

ATGGGCCTGA TCGAAACCGT GACTGGCTAT GTGAAGATCC GCCACTCGCA TGCTCTGGTG 1200

TCTCTGTCTT TCTTGAAGAA TCTACGGTAT ATTAATGGAG AGGACCAGCT GGAAGGGAAT 1260

TACTCCTTTT ACGTCCTGGA CAACCAAAAC CTGCAGCAAC TGTGGGACTG GAGCCACCAT 1320

AACCTGACCG TCAAGGAGGG GAAGATGTAC TTTGCGTTCA ATCCCAGGCT CTGCGTTTCC 1380

GAGATTTACC GCATGGAGGA GGTGACTGGA ACCAAAGATC GGCAAAACAA AGGCGACATC 1440

AACCCGAGGA ACAACGGGGA CCGGGCCTCC TGCGAAAGCC ACATTCTAAA ATTTGTTTCC 1500

AACACTACAA TGAAGAATCG GATCAAGCTC ACTTGGGAAC AGTATCGCCC TAAGGACTAT 1560

AGAGATCTGA TCAGCTTCAC TGTGTATTAC AAAGAAGCGC CCTTTCAGAA CGTGACGGAA 1620

TATGACGGGC AGGACGCCTG CGGCTCGAAC AGCTGGAACA TGGTGGACGT GGACCTGCCT 1680

CCCAATAAAG AGGACAATCC GGGGATTTTA CTGCAGGCAC TGAAACCATG GACTCAGTAC 1740

GCCATTTATG TCAAAGCCGT CACTCTGACC ATGATGGAGA ACAACCACGT CCACGGAGCA 1800

AAGAGTGAGA TTGTCTACAT CCGAACTAAG GCTGCAGTGC CATCCATCCC TCTGGACGTC 1860

ATATCCGCAT CCAACTCTTC CTCTCAGCTG ATTGTGAAGT GGAACCCTCC CACTTACCCC 1920

AATGGCAACC TCTCGTATTA CATTGTCCGG TGGCAACAGC AGCCCCAGGA CAATTATCTG 1980

TATCGGCACA GTTATTGCTC CAAAGAACGA GTTCCGATCC GGAGGTATGC TGACGGCACC 2040

ATCGATACCG AAGAAGCCAC GGAGCCCACC AAACCTGAGG GCTCAGGGGG AGAGAAGGGG 2100

CCTTGCTGCG GCTGCCCAAA GACGGAGGCA GAGAAGCAAG CCGAGAAGGA GGAGGCCGAG 2160

TACCGAAAGG TCTTTGAGAA TTTCCTCCAC AACGCCATAT TCCTGCCCAG ACCGGACCGG 2220

AAACGGAGGG ACTTGTTCCG AATTGCAAAC ACGACTTTTG CCAGTAAGAA CAGGACCGCA 2280

GCCGCCCCGG AGCACGTGAC CAACGCGTCC GATGCCGAGG AGAGCGAAAT GGAGTTTCCT 2340

TTCTCTGAAA GAAAAGTGGA AGGCCGGGAG CGGACTCTCA TCTCCCATCT CCTGCCCTTC 2400

ACGCTCTACC GGATCGACAT CCACAGCTGC AACCACGAAG CCGCGCTCCT GGGCTGCAGC 2460

GCTTCTAACT TTGTGTTCGC ACGAACGATG CCTGCAGAGG GAGCGGATGA CATTCCAGGA 2520

CCAGTAACGT GGGAAGGAAA AGAAGAAAAC ACAATATTTC TGAAGTGGCG GGAACCTGTT 2580

AGCCCCAACG GTTTGATTCT GATGTATGAA ATCAAATATA AGCAAAGTGA GGAGAAAGGG 2640

TTGTGTGTTT CCAGACAAGA GTACAAGAAA CTCGGAGGAG CCAAACTGAC GAATCTGAAC 2700

CCTGGAAATG TCACCGTCCG AGTCCAGGCC ACGTCTTTGG CAGGGAACGG GTCCTGGACA 2760

GAGCCAATCT CATTCTATGT CCAACCCAAG CCCGTGAACT ATGGGAACTT CTTGCATTTA 2820

ATTATCGCTC TGCCCATTGC GGTCCTGTTG ATTGTGGGAG GGCTTCTCAT CATGCTGTAC 2880

GTCTGTAACA AAAAGAGGAA TAGCGACAGG CTTGGAAATG GAGTACTTTA TGCCTCTGTC 2940

AACCCTGAAT ATTTCAGTGC TTCAGATGTG TACGTGCCGG ATGAATGGGA GGTGCCTCGG 3000

GAGAAGATCA CCATGTGCCG TGAATTGGGG CAGGGCTCCT TCGGGATGGT GTATGAAGGG 3060

ATCGCGAAGG GGGTAGTCAA GGACGAGCCC GAAACCAGGG TGGCCATCAA GACGGTCAAC 3120

GAATCGGCCA GCATGCGAGA GCGGATCGAG TTTTTGAACG AAGCTTCGGT GATGAAGGAG 3180

TTCAACTGTC ACCATGTTGT GAGGCTCCTT GGTGTCGTGT CCCAAGGCCA ACCCACATTG 3240

GTCATCATGG AGCTCATGAC ACGCGGAGAC CTGAAGAGTT ACTTGCGCTC CCTTCGGCCG 3300

GACACAGAGA ATAACCCAGC GCATACTCTT CCGGCCCTGA AGAAGATGAT CCAGATGGCT 3360

GGCGAGATTG CTGATGGCAT GGCCTATCTC AATGCCAACA AGTTTGTCCA CAGAGACCTC 3420

GCGGCAAGGA ACTGCATGGT GGCCGAGGAC TTCACTGTGA AAATTGGAGA TTTTGGCATG 3480

ACAAGGGATA TCTATGAGAC CGATTACTAT CGGAAAGGTG GGAAGGGCTT GCTGCCCGTC 3540

CGCTGGATGT CCCCAGAATC GCTGAAGGAT GGCGTCTTCA CAACTCACTC GGACGTTTGG 3600

TCCTTTGGTG TTGTCTTGTG GGAGATAGCC ACACTGGCTG AGCAGCCTTA TCAAGGCATG 3660

TCGAATGAGC AGGTCCTTCG CTTTGTGATG GAGGGTGGCC TTCTGGAGAA GCCAGACAAC 3720

TGTCCCGATA TGCTCTTTGA GCTCATGCGA ATGTGCTGGC AGTACAATCC CAAGATGAGA 3780

CCGTCTTTCT TGGAAATCAT CGGCAGCATT AAAGACGAGC TCGACCCGGC CTTCAAGGAG 3840

GTCTCCTTCT TCTACAGCGA CGAGAACAAG CCGCCCGACA CGGAAGAGCT TGACTTGGAG 3900

GCGGAGAACA TGGAGAGCAT TCCTTTAGAT CCTTCCTCGA CCCTCCAGCC TTCTGACAAA 3960

CACTCAGGAC ATAAAGCGGA GAACGGCCCC GGCGTGGTGG TCTTGCGGGC CAGCTTTGAG 4020

GAGAGACAGC CGTACGCGCA TATGAACGGG GGGCGCAAGA ACGAGCGCGC CTTGCCTTTG 4080

CCCCAGTCTT CGGCCTGCTG A 4101

Domain Profile

S: 1     ivllrelGqGsfGmvyeGvakdvvkgeeetrvaiktvneaassrerieflkeasvmkefk  60

         i++ relGqGsfGmvyeG+ak+vvk+e etrvaiktvne+as+reriefl+easvmkef+

Q: 1003  ITMCRELGQGSFGMVYEGIAKGVVKDEPETRVAIKTVNESASMRERIEFLNEASVMKEFN  1062

         799*********************************************************

S: 61    thhvvrllGvvskgqpalvvmelmkkGdlksylrslrpeeeneaalappaldkliqmaae  120

         +hhvvrllGvvs+gqp+lv+melm++Gdlksylrslrp++en++a + pal+k+iqma+e

Q: 1063  CHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPDTENNPAHTLPALKKMIQMAGE  1122

         ************************************************************

S: 121   iadGmayleakkfvhrdlaarncmvaedltvkiGdfGmtrdiyetdyyrkggkgllpvrw  180

         iadGmayl+a+kfvhrdlaarncmvaed+tvkiGdfGmtrdiyetdyyrkggkgllpvrw

Q: 1123  IADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRW  1182

         ************************************************************

S: 181   mspeslkdGvftsksdvwsfGvvlweivtlaeqpyqGlsneqvlkfvldggvlekpencp  240

         mspeslkdGvft++sdvwsfGvvlwei+tlaeqpyqG+sneqvl+fv++gg+lekp+ncp

Q: 1183  MSPESLKDGVFTTHSDVWSFGVVLWEIATLAEQPYQGMSNEQVLRFVMEGGLLEKPDNCP  1242

         ************************************************************

S: 241   elltelmrlcwqynpklrpsfleivell  268

         ++l+elmr+cwqynpk+rpsflei+ ++

Q: 1243  DMLFELMRMCWQYNPKMRPSFLEIIGSI  1270

         ************************9875

Domain Sequence
(FASTA)

ITMCRELGQG SFGMVYEGIA KGVVKDEPET RVAIKTVNES ASMRERIEFL NEASVMKEFN 60

CHHVVRLLGV VSQGQPTLVI MELMTRGDLK SYLRSLRPDT ENNPAHTLPA LKKMIQMAGE 120

IADGMAYLNA NKFVHRDLAA RNCMVAEDFT VKIGDFGMTR DIYETDYYRK GGKGLLPVRW 180

MSPESLKDGV FTTHSDVWSF GVVLWEIATL AEQPYQGMSN EQVLRFVMEG GLLEKPDNCP 240

DMLFELMRMC WQYNPKMRPS FLEIIGSI 268

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0046777	; P:protein autophosphorylation
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR000494	; EGF_rcpt_L.
IPR003961	; Fibronectin_type3.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016246	; Tyr_kinase_insulin-like_rcpt.
IPR002011	; Tyr_kinase_rcpt_2_CS.

Pfam

PF00041	; fn3; 1.
PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00060	; FN3; 3.
SM00261	; FU; 1.
SM00219	; TyrKc; 1.

Prosites

PS50853	; FN3; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00239	; RECEPTOR_TYR_KIN_II; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013