EKS-ANC-00110

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ANC-00110

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/LRRK	349.8	8.4E-105	1773	2019	247

Status

Unreviewed

Ensembl Protein

ENSACAP00000008041

UniProt Accession

G1KHH8;

Protein Name

Protein Synonyms/Alias

Gene Name

LRRK2

Gene Synonyms/Alias

LRRK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSACAG00000008207	ENSACAP00000008041	ENSACAT00000008213

Organism

Anolis carolinensis

Functional Description

Protein Length

2416

Protein Sequence
(FASTA)

RHILKMLKIH NANVLLSTVG LKALNLLLSS DEITLLLLEE GTDVFLLVFD AMDTFSDNEE 60

IQKYGCKALH MLLEKEKSVP DEQLMEFVED KDHMIILNVF KKFPEKENLV LPALLSLHSL 120

AGPPSNVEVL MSGNVRCYNI IVEMMKTFPK SEPIQEVSCC LLHKLTLENF FNILVLNDVH 180

EVIVEAIEKY PANAKLQAAG LSCLALLTET IFLNRDLEEN EEEEEEEEEE EKTCWFKACY 240

KALKLHRKNT DVQEAACWAL NNLLMYQRNL HERIGDEEKK FPIHREMMLA MLMHSSSKEV 300

FQAAANALAT LLEQNVNIRT ILLAKGIHMN VLDMMKKHSS SAEVAESACK LLNRAFEGSF 360

LPLDIMTVTA SRVVKAMRKH KTLASVQLEA LQVMLHFMTP GEKTHEESSH CSETLKVIKN 420

QCLLEGTHAL VLDALNTFIG HPGIQKCGFQ ILSSVVECSG ALEMLSQQGM TDTVLHTLQM 480

YPDDQEIQCL GLGLLGSLIT KKTLCIATIH VLAVILVSTL RRFKDAVEIQ AQGFQTITTI 540

LDLSPCFAKL LIQESFDTAI FYQMSMCFTE QRDQQFQSLC CKCFAKMAEN DDLKNLMLEK 600

ACAEYNSIMV ECLLLLGADV NKKTKANSLI YQVCEKGSNA KLVELLLNSG AREQDIRSAL 660

AVSIKKGDSQ IISLLLKKLS LDIANSSICL GGFCIGKIEP AWLSPLFPDK RASLRKQTNA 720

GSALARMVLR YQRTSSYDDQ SRSSSDVNTS EDTMEKNEDW AFLPDPLVDN VFRLSDDIDS 780

EGSESSYLVK RKSNSVATAD LHKDIALQKY SPPLQRQWNS IGAGSQYEPL RNQRRKAMSL 840

EESNKAISKF QPKVKRSDSS SSSISDKEYI KSLDLSSNEL ENIDGLSQSS DLTAHLEHLE 900

KLELHQNALS SIPGQLCETL KCLSYLDLHS NRFTTFPPYL LKMPCIAHLD VSRNDIGPSL 960

ILESKIVCPT LKLLNLSYNQ LSCIPECLAN VAEKLEHLVL EGNKLSGIFS PICLKELKVL 1020

NISKNAVSFL VENFLKECLK LETLNAGMNL LDAVPDLSSN ITTLKLSQNN FSDIPEAILL 1080

LPHLRSVDLS SNKIVSLPGP LHWKSSNLRE LLLNHNEISV LDLNEKPLSW SRLEKLHLSN 1140

NKLKEIPPQI GFLDNLTSFD VSHNPELRCF PDEMGKLSKI WDLPLEGLQL NLDFKHVGWK 1200

ARDIIRFLQQ RLKKAVPYNR MKLMLVGNTG SGKTTLLQQL MKCRRPDLGL QNATIGIDVN 1260

DWKIPVRGKV KKDVVLNVWD FAGQEEFYSA HPHFMTQRAL YLAVYDLSKG EAEVDAMKPW 1320

LFNIKARASS SPVILIGTHL DISNDKQRKA CVSKITKELM NQRGFPAIQD YHFVNATEES 1380

DAMAKLRKTI IKESLNFKIR DQPVVGQLIP DSYLELEKRI LEERTHVPVE FPVIDQKRLF 1440

ELVRENKLQL DENELPHAVH FLNESGVLLH FQDPALQLRD LYFVDPKWLC KIMAQILTVK 1500

VEGFPKYPKG IIKRSDVEKF LLKKSKFPKI YMSQYFKLLE KFQIALPLGE DQLLVPSSLS 1560

DHRPVIELPH CENSEIIIRL YEMPYFPMGF WSRLINRLLE VSSYMLSGRE CALRPNRMYW 1620

RQGIYLNWSP EAYCLVESAI FENNPNSFLK ITVPSCRKGC ILLGQVVDHI DSLMEEWFPG 1680

LLEVDVCGEG ETLLKKWVLY SFEDGEEHQK ILLDDLLKKA EEGDLLINPK EPKSTIPIAQ 1740

IAPDLILADL PRNIMLNNDE LEFDQTSEFL LGKGDGGFGS VYRASYGGED VAVKIFNKHT 1800

SLRLLRQELA VLCHLHHPSL VFLLAAAVRP RMLVMELAPK GSLDRLLQQD NASLTRTLQH 1860

RIALHVADGL RYLHSAMIIY RDLKPHNVLL FTLYPNSAVI AKIADYGIAQ YCCRMGIKTS 1920

EGTPGFRAPE VARGNVIYNQ QADIYSFGLL LYDILTAGGR ILEGMKFPNE FDELAIHGKL 1980

PDPVKEYNCS PWPEVEDLIK KCLKENPQER PTSAQVYEIL NSAELVCLMR YISLSCASAS 2040

ECMVATHQSC KKMGIWLGSG NQEGSQLSFI DLNADGHTCQ DIADTRILCL VLVTLVTEKE 2100

NWVVAGTQSG SLWAFHTQDE KRKHQLQKMS DSVTCLYCNS FAKQNKQKNF FLVGTANGQL 2160

VIFEDRAVKC KGAVPLKILP VGNISTPFMC LTESNYSSEK NLIWGGCGTK IVSLSNDLSV 2220

QKLIETKTSQ LLCHKAYSDA NIISIAVDKS IYLAKKNSYF VEIWDKKTEK LCELIDCVHF 2280

LKEEVPKLNK ESKQKLAYPG RVKSICLQKN TALWIGTGGG HILLLDLSTR RPIRIISDFC 2340

DSVRFMVTAQ LGSLKNVVLV LGYCHRGDSK DNKYAKGIQS CVSVWDINLP HEVQNMKKHI 2400

EIRRELAEKM KTVSLD 2416

Nucleotide Sequence
(FASTA)

AGGCACATTC TTAAGATGCT TAAGATCCAC AATGCAAATG TACTTCTTTC AACAGTTGGC 60

CTCAAAGCAT TAAATCTGCT TCTTTCTTCA GATGAAATAA CACTTCTTCT CTTGGAAGAA 120

GGGACTGATG TATTTTTATT GGTTTTTGAT GCTATGGATA CATTTTCTGA TAATGAAGAG 180

ATCCAGAAAT ATGGATGCAA AGCTTTGCAC ATGCTTCTGG AAAAAGAAAA ATCAGTTCCA 240

GATGAGCAGC TGATGGAATT TGTTGAAGAC AAAGACCACA TGATTATACT CAATGTGTTT 300

AAAAAATTCC CAGAGAAAGA GAACCTAGTC CTTCCTGCAC TTTTATCTCT ACATTCATTA 360

GCCGGGCCGC CTAGCAATGT GGAAGTTCTT ATGTCTGGAA ATGTAAGGTG TTACAATATC 420

ATAGTTGAGA TGATGAAAAC CTTCCCCAAG AGTGAGCCAA TTCAGGAAGT GAGCTGCTGC 480

TTGTTGCACA AACTTACCCT GGAAAACTTC TTCAATATAC TGGTATTGAA TGATGTACAT 540

GAAGTCATTG TGGAGGCTAT TGAAAAATAT CCTGCAAATG CAAAGCTACA GGCTGCAGGC 600

CTCAGCTGCC TGGCTCTTCT CACAGAAACA ATATTTTTAA ATAGAGATTT GGAAGAAAAC 660

GAGGAAGAAG AGGAAGAGGA AGAGGAAGAA GAAAAAACAT GCTGGTTTAA AGCATGTTAT 720

AAAGCATTAA AACTGCACCG GAAAAATACA GATGTGCAGG AGGCTGCATG TTGGGCTTTG 780

AACAACCTGC TTATGTATCA ACGTAATCTT CACGAGAGGA TTGGAGATGA AGAGAAAAAG 840

TTTCCCATTC ATAGGGAAAT GATGTTGGCC ATGCTGATGC ATTCCTCTTC AAAGGAAGTG 900

TTTCAGGCAG CTGCAAATGC CTTGGCGACT CTACTGGAAC AAAATGTAAA TATTAGAACA 960

ATTCTGTTGG CAAAAGGAAT ACACATGAAT GTCTTGGACA TGATGAAGAA ACATTCAAGT 1020

TCTGCCGAAG TTGCAGAAAG TGCCTGCAAA TTGCTGAATC GTGCTTTTGA AGGAAGTTTT 1080

CTCCCTTTGG ATATAATGAC AGTAACTGCA TCCAGAGTTG TGAAGGCAAT GAGGAAACAT 1140

AAAACGTTGG CATCTGTTCA ATTAGAGGCC CTTCAAGTTA TGTTACATTT TATGACTCCA 1200

GGTGAGAAAA CTCATGAAGA ATCTTCTCAT TGTAGTGAAA CATTGAAAGT GATTAAAAAC 1260

CAGTGTTTGT TAGAAGGGAC TCACGCATTG GTCCTCGATG CTCTCAACAC GTTCATTGGC 1320

CATCCCGGAA TTCAGAAGTG TGGATTTCAG ATACTTTCAT CTGTGGTAGA GTGTTCAGGA 1380

GCCTTAGAAA TGTTGTCTCA GCAAGGGATG ACAGACACTG TACTTCATAC GCTACAGATG 1440

TATCCTGATG ATCAAGAAAT ACAGTGCTTA GGTTTAGGGC TTCTGGGATC CTTGATTACG 1500

AAAAAAACCT TGTGTATTGC AACAATACAC GTACTGGCTG TAATCTTGGT TTCGACTTTA 1560

CGACGCTTTA AGGATGCTGT GGAAATACAG GCCCAAGGAT TTCAAACAAT TACGACAATA 1620

CTCGATCTGT CACCTTGTTT TGCGAAGCTG TTAATACAGG AGTCATTTGA TACAGCCATT 1680

TTTTATCAGA TGTCCATGTG TTTTACTGAA CAAAGAGACC AGCAGTTTCA GAGTCTTTGT 1740

TGTAAATGCT TTGCCAAAAT GGCTGAGAAC GATGATTTAA AAAACCTGAT GTTGGAGAAA 1800

GCTTGTGCCG AATATAATAG CATTATGGTG GAATGTTTGC TGTTGCTTGG AGCCGATGTG 1860

AATAAGAAGA CAAAAGCAAA CTCTTTAATT TATCAGGTTT GTGAGAAAGG AAGCAATGCT 1920

AAATTGGTAG AACTGCTGCT CAATAGTGGA GCTCGAGAGC AGGATATTCG GAGTGCTCTG 1980

GCAGTCAGCA TCAAGAAAGG AGACAGCCAG ATCATTAGTT TGCTCCTGAA AAAACTTAGC 2040

TTGGATATTG CCAATAGCAG CATATGCCTT GGAGGATTTT GCATTGGCAA AATTGAACCG 2100

GCTTGGCTGA GCCCCTTATT TCCGGATAAA CGGGCATCCC TTAGGAAACA AACAAATGCT 2160

GGTTCTGCAT TGGCCAGAAT GGTGCTCAGA TACCAAAGGA CAAGCAGCTA TGATGACCAG 2220

TCGAGATCCA GCTCTGATGT AAACACTTCT GAAGATACAA TGGAGAAAAA TGAAGACTGG 2280

GCATTCCTGC CTGATCCTTT AGTGGACAAT GTTTTTCGCC TGAGTGATGA TATAGATAGC 2340

GAAGGGAGTG AAAGCTCATA TCTTGTGAAG AGGAAATCCA ACTCTGTGGC AACTGCAGAT 2400

CTCCACAAGG ACATTGCTCT GCAGAAGTAT TCCCCTCCTC TTCAAAGGCA GTGGAACTCA 2460

ATTGGAGCTG GATCACAGTA TGAACCATTA AGGAATCAGA GAAGAAAAGC GATGTCTTTA 2520

GAAGAATCAA ATAAAGCCAT ATCCAAATTC CAGCCAAAGG TAAAGCGCTC AGACAGTTCC 2580

TCTTCATCCA TCTCTGACAA GGAATATATA AAGTCACTAG ACCTTTCATC TAATGAGCTG 2640

GAGAACATCG ATGGTCTTAG TCAAAGCTCT GACTTAACAG CTCATCTGGA ACATTTGGAG 2700

AAATTGGAGC TTCATCAAAA TGCCCTTTCA AGCATCCCAG GACAACTGTG TGAGACATTG 2760

AAATGTTTGA GCTATCTAGA TCTGCACAGC AATCGGTTTA CTACTTTTCC TCCATACCTG 2820

TTGAAAATGC CTTGTATAGC ACACCTCGAT GTTTCACGCA ATGACATTGG TCCATCGTTA 2880

ATTTTGGAGT CAAAGATTGT CTGTCCGACT CTGAAACTAC TGAATTTATC CTACAACCAG 2940

TTGTCATGCA TTCCTGAATG TCTTGCCAAT GTTGCAGAAA AACTGGAGCA CCTTGTATTA 3000

GAAGGTAACA AACTTTCAGG CATATTCTCA CCTATATGCT TAAAAGAACT GAAAGTTTTA 3060

AACATCAGCA AGAACGCAGT ATCATTCTTG GTTGAGAATT TTCTGAAGGA ATGTTTGAAA 3120

CTGGAGACGC TAAATGCTGG GATGAATTTA CTTGATGCCG TTCCTGATTT GTCATCTAAC 3180

ATAACTACAT TAAAATTATC ACAGAATAAT TTTTCAGATA TCCCGGAAGC AATTCTTCTT 3240

CTTCCACATT TACGCTCAGT GGATTTAAGT AGCAATAAGA TCGTAAGTTT ACCTGGACCT 3300

TTGCACTGGA AATCTTCTAA TTTAAGAGAG TTACTTCTGA ACCACAATGA AATAAGTGTC 3360

TTAGATTTGA ATGAAAAACC TTTGTCATGG TCTCGACTTG AGAAGCTACA TCTGTCTAAC 3420

AACAAGTTAA AAGAGATTCC CCCTCAGATT GGGTTTCTTG ATAACTTGAC GTCTTTTGAT 3480

GTCAGTCACA ATCCTGAGTT AAGATGTTTC CCTGATGAAA TGGGGAAGTT GTCCAAAATA 3540

TGGGACCTGC CTTTGGAAGG GTTACAGCTT AATTTGGATT TCAAACATGT TGGATGGAAA 3600

GCAAGGGACA TTATAAGGTT TCTTCAACAG CGCTTAAAGA AAGCTGTCCC TTATAACCGG 3660

ATGAAGCTCA TGCTCGTTGG AAATACTGGC AGTGGTAAAA CGACATTGTT ACAACAGCTA 3720

ATGAAATGCA GGAGACCAGA CCTGGGACTC CAGAATGCTA CAATTGGAAT TGATGTGAAT 3780

GACTGGAAAA TTCCAGTGAG GGGCAAAGTG AAAAAAGACG TTGTCTTAAA TGTCTGGGAC 3840

TTTGCAGGCC AGGAGGAATT CTACAGTGCT CATCCTCACT TTATGACTCA GAGAGCTCTA 3900

TACCTTGCTG TTTATGATCT TAGCAAAGGA GAGGCTGAAG TGGATGCTAT GAAGCCATGG 3960

TTGTTTAATA TCAAGGCCCG AGCATCATCA TCACCTGTGA TCCTCATTGG TACTCATTTA 4020

GACATCTCTA ATGATAAACA ACGTAAAGCA TGTGTCAGTA AAATTACAAA AGAACTGATG 4080

AATCAGAGAG GATTTCCAGC AATTCAAGAT TATCACTTTG TGAATGCTAC AGAAGAATCC 4140

GATGCAATGG CCAAACTTCG GAAAACCATC ATAAAGGAGA GTCTGAATTT CAAAATCAGA 4200

GACCAGCCTG TTGTTGGACA GTTAATTCCA GACAGCTATT TGGAACTTGA GAAGAGAATC 4260

TTAGAGGAAC GCACACATGT TCCAGTTGAA TTTCCTGTGA TTGATCAGAA GCGATTATTT 4320

GAATTGGTGC GAGAAAACAA GTTGCAGTTG GATGAAAATG AACTCCCTCA TGCCGTTCAC 4380

TTTCTGAATG AATCAGGTGT TCTGCTACAT TTTCAAGATC CAGCTCTTCA GCTCAGAGAC 4440

TTATATTTTG TTGACCCTAA GTGGCTATGT AAAATCATGG CACAGATCTT AACAGTGAAG 4500

GTTGAAGGCT TCCCTAAGTA TCCAAAAGGC ATCATAAAAC GTTCTGATGT AGAAAAATTC 4560

CTGCTAAAGA AAAGCAAATT TCCTAAGATT TACATGTCAC AGTACTTCAA GCTCCTGGAG 4620

AAGTTCCAGA TTGCGTTACC ATTAGGAGAA GATCAGCTCC TTGTTCCAAG CAGCTTGTCA 4680

GATCACCGTC CTGTAATAGA ATTACCCCAC TGTGAAAACT CAGAAATTAT CATAAGGCTG 4740

TATGAGATGC CATATTTTCC TATGGGATTC TGGTCCAGGC TAATCAACAG ATTGCTTGAA 4800

GTGTCTTCTT ATATGCTTTC TGGAAGAGAA TGTGCTCTTC GTCCTAACAG GATGTATTGG 4860

AGGCAAGGCA TATACCTGAA CTGGTCCCCA GAAGCCTACT GCTTGGTGGA GTCTGCCATT 4920

TTCGAAAACA ATCCGAACAG TTTCCTAAAA ATTACTGTGC CTTCTTGCAG GAAAGGTTGT 4980

ATCCTTTTGG GACAAGTCGT TGATCACATC GATTCTCTTA TGGAAGAATG GTTCCCTGGT 5040

TTACTAGAGG TGGATGTGTG TGGCGAAGGA GAAACCCTTT TGAAAAAATG GGTTCTATAT 5100

AGTTTTGAGG ATGGTGAAGA ACATCAGAAA ATATTACTGG ATGATCTACT TAAAAAAGCA 5160

GAGGAAGGTG ACCTCCTGAT TAATCCAAAG GAACCCAAAT CTACCATACC TATAGCTCAG 5220

ATTGCTCCAG ACCTGATCTT GGCTGACTTG CCTAGAAATA TCATGTTGAA CAATGATGAA 5280

TTAGAATTTG ACCAAACTTC AGAATTTCTT TTAGGAAAAG GTGATGGTGG ATTTGGATCT 5340

GTATATCGTG CTTCATATGG TGGAGAAGAT GTGGCTGTAA AGATTTTTAA TAAGCACACT 5400

TCCCTTCGGC TCTTGAGACA AGAACTGGCA GTGCTTTGCC ATCTTCATCA CCCTAGTTTG 5460

GTATTCTTGC TGGCTGCAGC AGTGCGTCCC CGGATGCTTG TCATGGAATT AGCCCCAAAG 5520

GGGTCTCTGG ATCGATTATT GCAACAAGAC AACGCAAGTC TGACGAGAAC ACTCCAGCAC 5580

AGAATAGCAC TACATGTTGC AGATGGATTA AGATATCTTC ATTCAGCAAT GATCATCTAC 5640

CGTGATCTAA AACCCCATAA TGTGCTGCTC TTTACACTGT ATCCAAATTC AGCAGTCATT 5700

GCAAAGATTG CTGATTATGG TATTGCCCAG TATTGTTGCA GGATGGGGAT AAAAACGTCT 5760

GAAGGCACAC CAGGATTTAG AGCACCAGAA GTTGCAAGGG GGAATGTTAT TTACAACCAG 5820

CAAGCTGATA TTTATTCATT TGGCTTGCTC TTGTATGACA TTTTAACAGC TGGTGGGAGG 5880

ATATTGGAAG GCATGAAATT TCCGAATGAA TTTGATGAAC TTGCTATCCA TGGAAAATTG 5940

CCAGATCCTG TCAAAGAATA TAACTGCTCT CCCTGGCCGG AAGTTGAAGA TTTAATTAAG 6000

AAATGTTTGA AAGAAAATCC TCAGGAAAGA CCTACTTCCG CACAGGTTTA TGAGATTTTG 6060

AATTCTGCAG AACTCGTGTG CCTAATGAGA TACATTTCAC TATCATGTGC GTCTGCATCC 6120

GAATGCATGG TTGCTACCCA TCAAAGTTGC AAGAAGATGG GCATTTGGCT GGGTAGTGGG 6180

AACCAAGAAG GATCACAACT CTCATTTATT GACTTGAATG CAGATGGACA TACTTGTCAG 6240

GACATTGCAG ACACTAGAAT ATTGTGTTTG GTCTTGGTGA CCCTTGTTAC AGAAAAGGAA 6300

AACTGGGTGG TCGCGGGAAC ACAGTCTGGT TCCCTGTGGG CCTTTCACAC CCAAGATGAG 6360

AAGCGCAAGC ACCAACTTCA GAAGATGTCC GACTCTGTGA CATGTCTTTA TTGCAACTCT 6420

TTTGCAAAGC AAAACAAGCA GAAGAATTTC TTTCTAGTGG GTACCGCAAA TGGACAGCTA 6480

GTGATTTTTG AAGACAGAGC AGTAAAGTGC AAAGGTGCTG TGCCCTTGAA GATTTTACCC 6540

GTTGGAAACA TCAGTACCCC TTTTATGTGT TTAACCGAAT CGAATTATTC TTCTGAAAAG 6600

AATTTAATTT GGGGAGGCTG TGGAACGAAG ATTGTATCAT TGTCCAATGA TCTGTCTGTC 6660

CAAAAGCTCA TTGAGACAAA GACAAGCCAG CTATTATGCC ACAAAGCATA CAGTGATGCC 6720

AATATTATTT CAATAGCAGT CGATAAATCC ATCTACTTGG CAAAGAAGAA CAGCTACTTT 6780

GTTGAAATTT GGGATAAAAA GACTGAGAAA CTCTGTGAAC TAATTGACTG TGTTCATTTT 6840

CTAAAAGAGG AGGTGCCGAA ACTGAATAAA GAATCAAAGC AAAAACTAGC CTATCCTGGA 6900

AGAGTGAAGA GCATTTGCCT GCAAAAGAAC ACGGCTCTTT GGATCGGCAC AGGAGGAGGA 6960

CACATCCTTT TGCTTGACCT CTCCACACGC CGCCCCATAA GAATAATAAG TGATTTCTGC 7020

GATTCTGTTC GATTCATGGT GACAGCTCAG TTAGGCAGTC TCAAAAATGT TGTACTGGTG 7080

TTGGGATACT GCCATAGAGG GGACAGTAAA GACAACAAAT ATGCCAAAGG AATACAGTCA 7140

TGTGTGTCTG TATGGGACAT CAATCTGCCA CACGAAGTTC AAAACATGAA AAAACATATT 7200

GAAATAAGAC GGGAATTAGC AGAGAAAATG AAGACTGTTT CTTTGGATTA A 7251

Domain Profile

S: 7     lGrGafGsvyraavkGeevavkafkiaadklkrdslelalkayselrqelsvLlalkhPs  66

          G+G+fGsvyra++ Ge+vavk+f+      k++sl+l       lrqel+vL++l+hPs

Q: 1773  KGDGGFGSVYRASYGGEDVAVKIFN------KHTSLRL-------LRQELAVLCHLHHPS  1819

         599**********************......*******.......***************

S: 67    ivsLvgisikPlalvleLaplgsLdrlLsedkksssklgrtltkkialqvargleyLhkk  126

         +v L++++++P++lv+eLap+gsLdrlL++d++s   l+rtl+++ial+va+gl+yLh++

Q: 1820  LVFLLAAAVRPRMLVMELAPKGSLDRLLQQDNAS---LTRTLQHRIALHVADGLRYLHSA  1876

         *******************************999...***********************

S: 127   kiiyrdLksenvLvwslspkeailikladyGisrqslrsGakgveGteGfraPeivrgev  186

         +iiyrdLk++nvL+++l+p++a+++k+adyGi+++++r+G+k++eGt+GfraPe++rg+v

Q: 1877  MIIYRDLKPHNVLLFTLYPNSAVIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNV  1936

         ************************************************************

S: 187   vydekvdvfsfGlllyell.sgkrpvegeeqlkivekl.lkGkrPvlvkeeevlptplld  244

         +y++++d++sfGllly++l +g r++eg ++++++++l ++Gk+P++vke+++ p+p ++

Q: 1937  IYNQQADIYSFGLLLYDILtAGGRILEGMKFPNEFDELaIHGKLPDPVKEYNCSPWPEVE  1996

         *******************7799*********************************9887

S: 245   .LlveCwkekPekrPtasqvvsi  266

          L+++C+ke+P++rPt++qv +i

Q: 1997  dLIKKCLKENPQERPTSAQVYEI  2019

         7*******************875

Domain Sequence
(FASTA)

KGDGGFGSVY RASYGGEDVA VKIFNKHTSL RLLRQELAVL CHLHHPSLVF LLAAAVRPRM 60

LVMELAPKGS LDRLLQQDNA SLTRTLQHRI ALHVADGLRY LHSAMIIYRD LKPHNVLLFT 120

LYPNSAVIAK IADYGIAQYC CRMGIKTSEG TPGFRAPEVA RGNVIYNQQA DIYSFGLLLY 180

DILTAGGRIL EGMKFPNEFD ELAIHGKLPD PVKEYNCSPW PEVEDLIKKC LKENPQERPT 240

SAQVYEI 247

Keyword

ATP-binding; Complete proteome; GTP-binding; Leucine-rich repeat; Nucleotide-binding; Reference proteome; Repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0032839	; C:dendrite cytoplasm
GO:0032473	; C:external side of mitochondrial outer membrane
GO:0045121	; C:membrane raft
GO:0043025	; C:neuronal cell body
GO:0005886	; C:plasma membrane
GO:0008021	; C:synaptic vesicle
GO:0005802	; C:trans-Golgi network
GO:0005524	; F:ATP binding
GO:0005525	; F:GTP binding
GO:0034211	; F:GTP-dependent protein kinase activity
GO:0005096	; F:GTPase activator activity
GO:0003924	; F:GTPase activity
GO:0004708	; F:MAP kinase kinase activity
GO:0000186	; P:activation of MAPKK activity
GO:0048312	; P:intracellular distribution of mitochondria
GO:2000173	; P:negative regulation of branching morphogenesis of a nerve
GO:0034260	; P:negative regulation of GTPase activity
GO:0070997	; P:neuron death
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:0010508	; P:positive regulation of autophagy
GO:0060161	; P:positive regulation of dopamine receptor signaling pathway
GO:0043068	; P:positive regulation of programmed cell death
GO:0032436	; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0031398	; P:positive regulation of protein ubiquitination
GO:0046777	; P:protein autophosphorylation
GO:0040012	; P:regulation of locomotion
GO:0042391	; P:regulation of membrane potential
GO:0006979	; P:response to oxidative stress
GO:0007264	; P:small GTPase mediated signal transduction

KEGG

InterPros

IPR002110	; Ankyrin_rpt.
IPR020683	; Ankyrin_rpt-contain_dom.
IPR011989	; ARM-like.
IPR016024	; ARM-type_fold.
IPR011009	; Kinase-like_dom.
IPR001611	; Leu-rich_rpt.
IPR025875	; Leu-rich_rpt_4.
IPR013684	; MIRO-like.
IPR000719	; Prot_kinase_cat_dom.
IPR020859	; ROC_GTPase.
IPR008271	; Ser/Thr_kinase_AS.
IPR005225	; Small_GTP-bd_dom.
IPR001806	; Small_GTPase.
IPR015943	; WD40/YVTN_repeat-like_dom.
IPR017986	; WD40_repeat_dom.

Pfam

PF00560	; LRR_1; 1.
PF12799	; LRR_4; 1.
PF08477	; Miro; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00248

; ANK; 2.

Prosites

PS51450	; LRR; 12.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS51424	; ROC; 1.

Prints

PR00449

; RASTRNSFRMNG.

Created Date

20-Feb-2013