EKS-ANC-00149

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ANC-00149

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/RSK	359.5	1.1E-107	65	326	262

Status

Unreviewed

Ensembl Protein

ENSACAP00000008180

UniProt Accession

G1KHN2;

Protein Name

Protein Synonyms/Alias

Gene Name

RPS6KB2

Gene Synonyms/Alias

RPS6KB2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSACAG00000008242	ENSACAP00000008180	ENSACAT00000008356

Organism

Anolis carolinensis

Functional Description

Protein Length

475

Protein Sequence
(FASTA)

MAGVFDLDLE TEEGSDGEEP ELGGLDVDPD LRCSGPDQVP GYYEEIEISE NIVNNGPERI 60

GPHCFELLRV LGKGGYGKVF QVRKVQGTNA GKIFAMKVLR KAKIACNAKD TAHTKAERNI 120

LEAIKHPFIV DLMYAFQTGG KLYLILECLS GGELFMQLER EGIFLEDTAC FYLGEITLAL 180

GHLHSNGIIY RDLKPENIML NSQGHIKLTD FGLCKESIHD GAVTHTFCGT IEYMAPEILM 240

RSGHNRAVDW WSLGALMYDM LTGSPPFTAE NRKKTIDKIL KGKLVFPPYL TPDARDLIKK 300

FLKRNPSQRI GGGPGDAADV QRHPFFRHIN WEDLLAKTID PPFRPSLQSD DDVSQFDTRF 360

TRQTPVDSPD DGSLSESANQ AFLGFTYVAP SVLESIKEGF SFQPKLRSPR RLNSSPRTPV 420

SPLKFSPFEA FKPSTAVELM ELSAPPLVPV PEVTAPLPIK TPSGNKKKKG RGRAR 475

Nucleotide Sequence
(FASTA)

ATGGCCGGCG TCTTCGACCT CGACCTGGAG ACGGAGGAGG GGAGCGACGG GGAGGAGCCT 60

GAACTGGGGG GCTTGGACGT GGACCCAGAT CTCCGCTGCA GTGGCCCCGA TCAGGTGCCA 120

GGATATTATG AAGAAATTGA AATCTCTGAG AACATTGTCA ACAATGGCCC GGAGCGCATT 180

GGACCCCACT GCTTCGAGCT CCTGCGTGTT TTGGGCAAGG GCGGCTATGG CAAGGTATTC 240

CAAGTACGGA AGGTGCAAGG CACAAATGCT GGGAAAATCT TTGCTATGAA AGTGTTAAGG 300

AAGGCCAAGA TTGCCTGTAA TGCCAAGGAC ACAGCCCACA CAAAGGCTGA GAGAAACATC 360

CTGGAGGCCA TCAAGCACCC ATTCATAGTG GACCTCATGT ATGCCTTCCA GACTGGTGGC 420

AAGCTCTACC TCATCCTGGA ATGCCTCAGC GGCGGGGAAC TGTTCATGCA GCTGGAGCGC 480

GAAGGCATCT TCTTGGAGGA CACAGCCTGT TTCTATCTGG GCGAGATCAC TTTGGCCCTT 540

GGCCACCTCC ATTCTAATGG CATCATCTAC CGAGATCTCA AACCGGAGAA CATAATGTTA 600

AACAGCCAAG GACATATTAA GCTAACGGAC TTTGGTCTCT GCAAGGAGTC TATTCATGAT 660

GGAGCTGTTA CGCACACCTT TTGTGGCACC ATAGAGTACA TGGCCCCAGA GATACTGATG 720

CGCAGTGGTC ACAATCGGGC AGTGGACTGG TGGAGCCTCG GTGCTCTGAT GTACGACATG 780

CTCACTGGCT CGCCTCCATT TACGGCTGAA AACCGCAAGA AAACAATTGA CAAAATCCTG 840

AAGGGGAAGC TGGTGTTTCC ACCCTACTTG ACGCCAGATG CTCGTGACTT GATTAAGAAG 900

TTCCTCAAAA GGAATCCCAG TCAGAGAATT GGAGGTGGAC CAGGTGATGC TGCAGATGTT 960

CAGAGGCACC CATTCTTTCG ACACATTAAC TGGGAAGACT TGCTGGCAAA GACCATTGAT 1020

CCACCCTTCC GACCATCCCT GCAATCGGAT GACGACGTCA GTCAATTTGA CACCCGTTTC 1080

ACCCGTCAGA CCCCTGTGGA TAGTCCAGAT GATGGCTCTC TCAGTGAGAG TGCCAATCAA 1140

GCCTTTTTGG GATTTACTTA TGTAGCCCCA TCGGTGTTGG AGAGCATTAA GGAAGGTTTT 1200

TCCTTTCAGC CCAAGCTGCG ATCACCACGG CGACTCAACA GCAGCCCCCG CACACCTGTC 1260

AGCCCATTAA AGTTCTCACC CTTTGAGGCC TTCAAGCCAA GCACAGCAGT GGAACTCATG 1320

GAGCTGTCTG CACCCCCTCT CGTGCCTGTA CCAGAAGTCA CTGCCCCATT ACCCATCAAA 1380

ACACCTTCTG GCAACAAAAA GAAGAAAGGG CGAGGACGGG CAAGGTAG 1428

Domain Profile

S: 1     fellkvlgkGaygkvflvrkvekkdtgklyavKvlkkaelvk..kkkertkeereiLeev  58

         fell+vlgkG+ygkvf+vrkv+++++gk++a+Kvl+ka+++   k++++tk+er+iLe++

Q: 65    FELLRVLGKGGYGKVFQVRKVQGTNAGKIFAMKVLRKAKIACnaKDTAHTKAERNILEAI  124

         89**************************************9889****************

S: 59    ehpfivklheafqdekklylvlellkGgeLlerlkkkklfseeeasfilaelvlaleylH  118

         +hpfiv+l++afq+  klyl+le+l+GgeL+++l+++++f e++a+f+l e++lal +lH

Q: 125   KHPFIVDLMYAFQTGGKLYLILECLSGGELFMQLEREGIFLEDTACFYLGEITLALGHLH  184

         ************************************************************

S: 119   skgvvyrDLkpeNilldeeghvkltDfglakekiaeneekaysfcgTleyvaPevlkrkg  178

         s+g++yrDLkpeNi+l+++gh+kltDfgl+ke+i +++  +++fcgT+ey+aPe+l+r+g

Q: 185   SNGIIYRDLKPENIMLNSQGHIKLTDFGLCKESI-HDGAVTHTFCGTIEYMAPEILMRSG  243

         *********************************9.9999999******************

S: 179   ydeavDlwslGvllyemLtGktPftgeerketlarilkgkfslklpaweelseeakdlvk  238

         +++avD+wslG+l+y+mLtG++Pft+e+rk+t+++ilkgk  l +p +  l+++a+dl+k

Q: 244   HNRAVDWWSLGALMYDMLTGSPPFTAENRKKTIDKILKGK--LVFPPY--LTPDARDLIK  299

         ****************************************..******..**********

S: 239   klLkkdpakRlga...taeeikehkfl  262

         k+Lk++p++R+g    +a+++++h+f+

Q: 300   KFLKRNPSQRIGGgpgDAADVQRHPFF  326

         ***********99999*********97

Domain Sequence
(FASTA)

FELLRVLGKG GYGKVFQVRK VQGTNAGKIF AMKVLRKAKI ACNAKDTAHT KAERNILEAI 60

KHPFIVDLMY AFQTGGKLYL ILECLSGGEL FMQLEREGIF LEDTACFYLG EITLALGHLH 120

SNGIIYRDLK PENIMLNSQG HIKLTDFGLC KESIHDGAVT HTFCGTIEYM APEILMRSGH 180

NRAVDWWSLG ALMYDMLTGS PPFTAENRKK TIDKILKGKL VFPPYLTPDA RDLIKKFLKR 240

NPSQRIGGGP GDAADVQRHP FF 262

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Tursiops truncatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0045948	; P:positive regulation of translational initiation
GO:0043491	; P:protein kinase B signaling cascade

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016238	; Ribosomal_S6_kinase.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013