EKS-ANC-00100
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ANC-00100
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Tec428.37.7E-129403652250
StatusUnreviewed
Ensembl ProteinENSACAP00000008312
UniProt AccessionH9GDX7;
Protein Name
Protein Synonyms/Alias
Gene NameBTK
Gene Synonyms/Alias BTK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSACAG00000008298ENSACAP00000008312ENSACAT00000008491
OrganismAnolis carolinensis
Functional Description
Protein Length659
Protein Sequence
(FASTA)
MSNVLLESIF LKRSQQKKKT SPLNFKKRFF LLTESKLSYY EYDFERGRRG SKKGSVDVEK 60
VTCVETVTPE SNPPPERRIP EKKGDDLNEP EQISIIERFP YPFQVVYDEG PLYVFSPTEE 120
LRSRWIHQLK GVIRYNSNLA QKYHPCFWTD GQYLCCLQTA KTAMGCQIVG DKRRKGSRSG 180
GSIQKADKPL PPTPEENQMM KKQLPPTPTA STPSKTWKVV ALYDYTPMNE QDLQLQKGEE 240
YLVLEESNES WWRAQDQAGK QGYIPSNYVT EARDSLEIFE WYSKNITRRQ AEQLLKQEGK 300
DGGFIVRDST RNMGKYTVSV FAKSSGEPQG TIRHYVVCST PQNQYFLAEK HLFSTIPELI 360
IYHQHNSAGL ISRLKYPVSS QQKTAPSTAG LGYGAWEIDP KDLTFLKELG TGQFGVVKHG 420
KWRGQHDVAV KMIKEGSMSE DAFIDEAKVM MNLSHEKLVQ LFGVCTKERP ILIVTEYLSK 480
GCLLNYLRDS RQSFQASELL EMCKDVCEAM EYLESKQFLH RDLAARNCLV NEQGVVKVSD 540
FGLSRYVLDD DYISSMGSKF PVRWSPPEVL LYSKFSSKSD VWAFEALLWM ITLSSSRFPT 600
FSNSETTDHV TKGLRLYRPQ LASDRVYSIM YSCWHEKPEE RPTFHVLLGH IVDLTNEDP 659
Nucleotide Sequence
(FASTA)
ATGTCGAATG TCCTCCTGGA AAGCATCTTC CTCAAACGCT CTCAGCAGAA GAAGAAGACA 60
TCTCCGCTCA ACTTCAAGAA GCGCTTCTTC CTGCTGACAG AGAGCAAGCT CTCTTATTAC 120
GAGTATGACT TTGAGCGTGG ACGACGAGGA AGCAAGAAGG GCTCTGTGGA TGTTGAGAAA 180
GTCACCTGTG TGGAAACTGT GACGCCAGAG AGCAACCCTC CTCCAGAACG GCGGATCCCA 240
GAAAAAAAAG GAGATGATTT AAATGAGCCA GAACAGATTT CCATTATAGA GCGGTTCCCC 300
TACCCTTTCC AGGTTGTGTA TGATGAAGGT CCACTCTATG TATTCTCACC AACTGAAGAA 360
TTACGGAGCC GTTGGATCCA CCAGTTAAAG GGTGTGATTC GCTACAACAG CAACCTGGCA 420
CAGAAGTATC ACCCCTGCTT CTGGACTGAT GGTCAGTACC TCTGTTGCCT CCAGACCGCT 480
AAAACGGCCA TGGGTTGCCA AATCGTGGGA GACAAGAGAA GAAAAGGTTC CAGAAGTGGC 540
GGTTCTATTC AAAAGGCCGA CAAACCCCTA CCTCCAACTC CAGAGGAGAA CCAGATGATG 600
AAGAAGCAGC TGCCCCCCAC GCCAACAGCC AGCACCCCAT CTAAGACATG GAAGGTTGTG 660
GCTCTCTATG ACTACACACC TATGAATGAG CAGGATTTGC AGCTGCAGAA AGGTGAAGAG 720
TACCTGGTCC TTGAGGAGAG CAATGAGTCT TGGTGGAGAG CCCAAGACCA AGCGGGGAAA 780
CAAGGTTATA TTCCTAGCAA CTATGTCACT GAAGCAAGAG ATTCGCTGGA AATATTTGAG 840
TGGTATTCGA AAAACATCAC CAGAAGGCAA GCAGAGCAGC TGCTAAAGCA AGAGGGCAAA 900
GATGGTGGAT TCATTGTCCG AGATTCCACC AGGAACATGG GGAAATATAC TGTCTCTGTA 960
TTTGCCAAAT CATCTGGGGA ACCCCAAGGA ACCATCCGCC ATTATGTAGT TTGCTCCACA 1020
CCTCAGAACC AGTATTTCCT GGCAGAAAAG CACCTCTTCA GCACCATCCC AGAGCTCATC 1080
ATCTACCATC AACACAACTC AGCAGGGCTT ATATCCAGAT TGAAGTATCC TGTGTCATCG 1140
CAGCAAAAAA CGGCTCCTTC CACAGCAGGA CTTGGATATG GTGCATGGGA GATTGATCCA 1200
AAGGACTTGA CCTTCCTAAA AGAGCTTGGG ACAGGGCAGT TTGGAGTGGT GAAGCATGGG 1260
AAATGGAGAG GCCAGCATGA TGTGGCAGTC AAAATGATCA AGGAAGGCTC CATGTCGGAA 1320
GATGCATTTA TCGACGAAGC CAAAGTCATG ATGAACCTCT CTCATGAAAA ACTTGTGCAG 1380
TTGTTTGGGG TCTGCACCAA GGAGAGGCCT ATCCTGATTG TCACAGAATA CTTGTCCAAA 1440
GGGTGCCTCT TGAACTACCT GCGAGACAGT CGGCAGTCCT TCCAAGCCAG TGAGCTTCTA 1500
GAAATGTGCA AAGATGTTTG TGAGGCCATG GAGTACTTGG AGTCCAAGCA GTTCCTGCAC 1560
AGGGACTTGG CTGCCCGCAA TTGCTTGGTC AATGAACAAG GTGTTGTCAA AGTCTCTGAT 1620
TTTGGTCTCT CCAGGTATGT CTTGGATGAT GACTATATTA GCTCCATGGG ATCCAAGTTT 1680
CCAGTGCGGT GGTCCCCTCC AGAAGTCCTT CTCTACAGCA AGTTCAGTAG CAAATCGGAT 1740
GTCTGGGCTT TTGAAGCCCT ACTTTGGATG ATCACCCTCT CCTCAAGCAG ATTCCCAACG 1800
TTCAGCAACA GTGAGACAAC GGACCACGTA ACCAAAGGTC TGCGTCTCTA CCGTCCTCAG 1860
TTGGCTTCGG ACAGAGTCTA CAGCATCATG TATAGTTGCT GGCATGAGAA ACCAGAGGAG 1920
CGCCCCACCT TCCACGTTCT CCTGGGTCAT ATTGTGGATT TAACCAACGA AGACCCTTGA 1980
Domain Profile
S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60
         lt+lkelg+gqfgvvk gkwr+++dva+k+ikeg+mse+ fi+eakvmm+lsh+klvql+
Q: 403   LTFLKELGTGQFGVVKHGKWRGQHDVAVKMIKEGSMSEDAFIDEAKVMMNLSHEKLVQLF  462
         79**********************************************************
S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120
         gvc+k++pi+ivteyl++gcllnylr+++++++++ llemckdvce+meyle+k+f+hrd
Q: 463   GVCTKERPILIVTEYLSKGCLLNYLRDSRQSFQASELLEMCKDVCEAMEYLESKQFLHRD  522
         ************************************************************
S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180
         laarnclv+e+ vvkvsdfgl+ryvldd+y+ss+g+kfpv+wsppevl ysk+ssksdvw
Q: 523   LAARNCLVNEQGVVKVSDFGLSRYVLDDDYISSMGSKFPVRWSPPEVLLYSKFSSKSDVW  582
         ************************************************************
S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240
         af  l+w + ++    +  +snse+ ++v++glrlyrp+las++vy++m+scw+ekpeer
Q: 583   AFEALLWMI-TLSSSRFPTFSNSETTDHVTKGLRLYRPQLASDRVYSIMYSCWHEKPEER  641
         *******87.677788999*****************************************
S: 241   ptfkellsale  251
         ptf+ ll +++
Q: 642   PTFHVLLGHIV  652
         *******9885
Domain Sequence
(FASTA)
LTFLKELGTG QFGVVKHGKW RGQHDVAVKM IKEGSMSEDA FIDEAKVMMN LSHEKLVQLF 60
GVCTKERPIL IVTEYLSKGC LLNYLRDSRQ SFQASELLEM CKDVCEAMEY LESKQFLHRD 120
LAARNCLVNE QGVVKVSDFG LSRYVLDDDY ISSMGSKFPV RWSPPEVLLY SKFSSKSDVW 180
AFEALLWMIT LSSSRFPTFS NSETTDHVTK GLRLYRPQLA SDRVYSIMYS CWHEKPEERP 240
TFHVLLGHIV 250
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00098
EKS-BOT-00108
EKS-CAJ-00109
EKS-CAF-00109
EKS-CAP-00103
EKS-DAR-00355
EKS-EQC-00104
EKS-FEC-00102
EKS-GAM-00052
EKS-GAG-00088
EKS-GAA-00127
EKS-GOG-00108
EKS-HOS-00110
EKS-ICT-00102
EKS-LAC-00112
EKS-LOA-00102
EKS-MAM-00103
EKS-MEG-00083
EKS-MOD-00109
EKS-MUM-00109
EKS-MUP-00110
EKS-MYL-00121
EKS-NOL-00100
EKS-ORN-00132
EKS-ORA-00087
EKS-ORC-00099
EKS-ORL-00124
EKS-OTG-00109
EKS-PAT-00098
EKS-PES-00092
EKS-PEM-00054
EKS-POA-00100
EKS-PTV-00097
EKS-RAN-00109
EKS-SAH-00100
EKS-SOA-00057
EKS-SUS-00094
EKS-TAR-00136
EKS-TEN-00126
EKS-XET-00090
EKS-XIM-00130
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0005543; F:phospholipid binding
GO:0004713; F:protein tyrosine kinase activity
GO:0035556; P:intracellular signal transduction
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR001849; Pleckstrin_homology.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR001562; Znf_Btk_motif.
Pfam
PF00779; BTK; 1.
PF00169; PH; 1.
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00107; BTK; 1.
SM00233; PH; 1.
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS50003; PH_DOMAIN; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
PS51113; ZF_BTK; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013