EKS-ANC-00111

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ANC-00111

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Met	472.8	2.5E-142	1082	1342	261

Status

Unreviewed

Ensembl Protein

ENSACAP00000008564

UniProt Accession

G1KI46;

Protein Name

Protein Synonyms/Alias

Gene Name

MET

Gene Synonyms/Alias

MET;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSACAG00000008309	ENSACAP00000008564	ENSACAT00000008747

Organism

Anolis carolinensis

Functional Description

Protein Length

1385

Protein Sequence
(FASTA)

MKAFATPASG IILFLLAFIQ RSDGKCKEAV SRLEMNWNVK YHLPNFTAET PIQNIVLYKN 60

HFYVGAINKI YVLNESLHSV SVYKTGPVLE NPDCVPCTEC APRLNQSENI WKDNKNMALF 120

LETYYDHQLI SCGSAAKGTC QRHVIHPSNP ADIQSDVHCM YSKQVDEESD QCPDCVVSPL 180

GSKVLVTEKE RFVYFYVGNT VNNSSQQDHL LHSVSVRRLK ETLDGFEFLT LYSYIDVLPE 240

FRNSYPIKYI HAFEKDHFVY FLTVQRESLD SQAFHTRIIR FCSFDSELRS YMEMPLECIY 300

TEKRKKRSTK QSNEVFNLLQ AAYIGKPGAA LAQEMGLDVN DDVLFGAFAQ SKPDSSEPTH 360

KSAVCAVAIK TINEFFGKIV DKQNMKCLQH LYEKNSKYCL NRTFSRNTTY CGEQDEEYRV 420

EVTTALQRID LFPEQFNTVL LTSISVFTKG HLTIANLGTS GGRFMQIVIS RSERTTPHVN 480

FHLDFQPVSP EVIIENLPGK DGYMLAITGK RITKIPLNGP GCSHFSTCSQ CLLSPPFMNC 540

GWCGNRCAYS WECSSGGWTQ ETCSPQISQI IPSSATFDGV TRLTLCGWDF GFNKNNKFNL 600

KTMTVLIGRD QCILDVKASD KNKLECTVGP VKKASFNVSS TVSNGQVNAS FSTFSFVNPV 660

IRSISPTYGP RYGGTLLTLT GEYLSSGNSR EVYVGRKQCS IIRVSDHVIE CYTPPQREVS 720

ECPVRMKIDS AFRPAGQFTY REDSSVAKIY PAKSFLSGGS TITAQGINLN SAFSPKMVVT 780

VPKLGRNFTV ACNHRSNSEI ICCPTPSLKS SNLTLPFVTK VFFIFDGVIP SGFNFDYVND 840

PVFSSSEKPV LISKKNRNIM IKGNNLDSEA VKGEVLKVGN KSCENITLKL QSIFCTVPKE 900

LLDTNSELNI VWKKEVAPAV IGKVMIQPDP NSTALIVGVV STTIFFSLLL FGLFLWRKKR 960

KQIKDEDLGR EIVRYDGRVH TPHLDRLVSA RSVSPTTEMV SSESVDYRST FLEDQFPTFS 1020

QNGSCRPAQY PHGDLSPIMS TGDSDLASPL LQTNVHIDIS ALNPDLVKEV EHVVIGPDSL 1080

IVHFNEVIGR GHFGCVYHGT LLDTDDRKIH CAVKSLNRIT DLDEVAQFLK EGIIMKDFTH 1140

PNVLSLLGIC LPSEGSPLVV LPYMKHGDLR NFIRNESHNP TVKDLIGFGL QVAKGMKYLA 1200

SKKFVHRDLA ARNCMLDEKF TVKVADFGLA RDVYDKEYYS VHNKTGAKLP VKWMALESLQ 1260

TQKFTTKSDV WSFGVLLWEL MTRGAPPYPD VNSFDITVYL LQGRRLLQPE YCPDALYEVM 1320

LKCWHPKPEL RPAFSELVSD ISMIFSTFVG EHYVHVNTTY VNVKCVAPYP SLLSSQDNID 1380

RDADT 1385

Nucleotide Sequence
(FASTA)

ATGAAGGCTT TTGCTACTCC TGCTTCTGGG ATTATTTTAT TTCTGCTCGC CTTCATACAG 60

AGGAGTGATG GCAAATGTAA AGAAGCAGTT TCAAGGCTGG AGATGAATTG GAATGTGAAA 120

TATCACCTCC CTAATTTCAC TGCAGAAACA CCAATACAAA ACATAGTCCT ATACAAGAAT 180

CACTTCTATG TAGGAGCCAT CAACAAGATA TATGTTTTAA ATGAAAGCCT TCACAGTGTC 240

TCTGTGTACA AGACTGGACC TGTTTTGGAG AACCCAGATT GTGTTCCCTG TACAGAGTGT 300

GCACCTAGAT TAAACCAATC TGAAAACATT TGGAAGGATA ACAAGAATAT GGCTCTGTTC 360

CTAGAAACAT ACTACGATCA TCAACTCATC AGCTGCGGGA GCGCTGCAAA AGGAACCTGC 420

CAACGTCATG TCATTCATCC TAGCAATCCC GCTGACATTC AAAGTGACGT ACACTGTATG 480

TATTCCAAGC AAGTGGATGA AGAATCAGAC CAGTGTCCTG ACTGTGTTGT AAGCCCTTTA 540

GGCAGCAAAG TTCTGGTGAC AGAAAAGGAA AGATTTGTGT ACTTCTATGT TGGAAATACT 600

GTAAATAATT CATCTCAGCA AGACCATTTG CTACATTCAG TATCAGTCCG GAGATTAAAA 660

GAAACCTTGG ATGGTTTTGA GTTTCTCACG CTTTACTCTT ATATTGACGT CCTTCCAGAA 720

TTCAGGAATT CATACCCCAT TAAGTACATT CATGCATTTG AAAAGGACCA CTTTGTGTAC 780

TTTCTCACTG TCCAGAGAGA ATCTCTAGAC TCCCAGGCTT TTCACACAAG GATCATACGG 840

TTCTGTTCTT TTGATTCTGA GCTGCGTTCA TACATGGAAA TGCCCCTTGA ATGTATTTAT 900

ACTGAAAAAC GTAAAAAGAG GTCAACCAAG CAGTCAAATG AGGTGTTTAA TCTTCTACAG 960

GCTGCCTATA TTGGCAAGCC GGGTGCAGCC TTAGCCCAGG AAATGGGGCT TGATGTTAAT 1020

GATGATGTTT TGTTTGGTGC ATTTGCCCAA AGTAAACCAG ACTCTTCAGA ACCAACTCAC 1080

AAATCTGCTG TCTGTGCAGT CGCCATCAAA ACCATAAATG AATTCTTTGG CAAGATTGTG 1140

GACAAACAAA ACATGAAATG TCTTCAGCAT CTTTATGAAA AGAACAGCAA GTACTGTCTG 1200

AACAGGACTT TTTCAAGAAA TACTACCTAT TGTGGAGAAC AAGATGAGGA ATATCGGGTG 1260

GAAGTCACAA CAGCTTTGCA ACGGATTGAC TTATTCCCGG AGCAGTTCAA CACAGTTTTG 1320

TTAACGTCTA TATCTGTGTT CACAAAAGGG CATCTTACAA TAGCAAACCT TGGGACATCA 1380

GGAGGCCGCT TCATGCAGAT AGTGATTTCC CGTTCAGAGC GCACAACACC ACATGTGAAC 1440

TTTCACCTGG ATTTCCAACC TGTTTCTCCA GAGGTTATAA TTGAGAATTT ACCTGGCAAA 1500

GATGGTTATA TGCTGGCGAT CACTGGAAAG AGGATAACCA AGATCCCACT AAATGGACCA 1560

GGATGCTCTC ACTTCAGTAC CTGCAGTCAG TGTCTTCTGT CACCTCCCTT CATGAACTGT 1620

GGCTGGTGTG GGAATCGGTG TGCATATTCT TGGGAGTGCA GCAGCGGAGG GTGGACACAG 1680

GAGACATGCT CACCCCAGAT ATCTCAGATT ATTCCAAGCA GTGCCACTTT TGATGGTGTA 1740

ACAAGACTGA CACTGTGTGG ATGGGACTTT GGATTCAACA AAAATAACAA GTTCAATTTA 1800

AAGACAATGA CAGTTCTTAT AGGGAGAGAC CAGTGCATTC TGGATGTCAA AGCTAGTGAC 1860

AAAAACAAAT TGGAGTGCAC AGTTGGTCCT GTCAAAAAAG CAAGTTTTAA TGTTTCAAGC 1920

ACTGTTTCAA ATGGACAAGT GAATGCATCA TTCAGTACGT TCTCTTTCGT GAATCCTGTA 1980

ATAAGGAGCA TCTCCCCCAC TTATGGTCCA AGATATGGTG GTACCTTGCT GACGTTAACT 2040

GGGGAGTACC TAAGTAGTGG GAATTCTCGA GAGGTTTATG TTGGTAGGAA GCAATGCAGC 2100

ATAATCAGAG TGTCTGATCA TGTAATAGAA TGCTACACCC CTCCACAAAG AGAAGTGTCA 2160

GAGTGTCCTG TCAGAATGAA AATCGATTCA GCCTTTCGCC CAGCAGGTCA ATTTACATAC 2220

AGAGAAGATT CTTCTGTTGC TAAAATTTAT CCTGCCAAGT CTTTTCTCAG TGGCGGAAGT 2280

ACAATTACAG CCCAGGGGAT CAACCTGAAT TCAGCATTCT CTCCAAAGAT GGTGGTAACA 2340

GTCCCTAAAC TAGGCAGAAA CTTTACTGTG GCATGTAACC ATCGCTCAAA TTCAGAAATA 2400

ATCTGTTGCC CAACTCCTTC ACTGAAATCC TCTAATCTGA CACTGCCTTT TGTGACAAAG 2460

GTTTTTTTCA TTTTTGATGG TGTCATCCCA TCTGGTTTCA ACTTTGATTA TGTGAACGAC 2520

CCAGTCTTTT CCTCCTCAGA GAAACCAGTG CTAATCTCAA AGAAAAACAG AAATATAATG 2580

ATTAAGGGAA ATAACCTTGA CTCGGAAGCT GTTAAAGGTG AAGTGCTAAA AGTTGGAAAC 2640

AAAAGCTGTG AGAATATCAC CTTGAAGTTG CAGTCTATTT TTTGTACAGT TCCTAAGGAG 2700

CTCCTGGATA CCAACAGCGA ATTGAATATA GTGTGGAAGA AAGAAGTTGC ACCCGCTGTT 2760

ATTGGGAAAG TAATGATTCA GCCTGATCCG AATTCCACAG CGCTCATTGT AGGTGTTGTG 2820

TCAACCACAA TTTTTTTCTC ACTGTTGCTC TTTGGACTTT TCTTGTGGAG AAAAAAGAGA 2880

AAACAAATCA AAGATGAAGA TTTAGGCAGA GAGATTGTTC GCTATGATGG AAGAGTGCAC 2940

ACTCCTCACT TGGACAGACT TGTGAGTGCA AGGAGTGTGA GCCCTACAAC AGAAATGGTC 3000

TCAAGTGAAT CTGTAGACTA TAGGTCAACT TTCTTAGAAG ATCAGTTTCC AACTTTTTCT 3060

CAGAATGGTT CATGCAGACC AGCCCAGTAT CCTCACGGAG ACTTATCTCC CATTATGTCT 3120

ACGGGAGACT CTGACTTAGC CAGTCCATTG CTACAGACTA ATGTTCACAT TGACATCAGT 3180

GCCTTAAATC CAGACTTGGT CAAGGAAGTT GAGCATGTGG TTATTGGTCC TGATAGCCTG 3240

ATTGTGCATT TTAATGAAGT AATAGGAAGA GGACACTTTG GATGTGTCTA TCATGGAACT 3300

TTGTTGGATA CTGACGACCG GAAAATTCAT TGTGCTGTGA AGTCTTTGAA CAGGATTACA 3360

GACTTGGATG AAGTCGCCCA GTTCCTAAAA GAAGGGATAA TAATGAAAGA TTTCACACAT 3420

CCTAATGTCC TGTCATTACT TGGAATTTGC TTGCCCAGTG AAGGGTCTCC CTTGGTTGTG 3480

CTTCCTTACA TGAAACATGG AGATCTTCGA AACTTTATTA GAAATGAGTC TCATAACCCA 3540

ACAGTAAAGG ATTTGATTGG ATTTGGTCTG CAAGTGGCAA AGGGGATGAA ATACCTTGCA 3600

AGCAAAAAGT TTGTCCACAG GGATTTAGCA GCAAGAAATT GCATGCTGGA TGAAAAATTT 3660

ACTGTCAAGG TTGCTGATTT TGGCCTTGCT AGAGATGTCT ACGATAAGGA GTACTACAGT 3720

GTACACAATA AAACAGGAGC CAAGCTGCCT GTAAAATGGA TGGCTTTAGA AAGTTTGCAA 3780

ACGCAGAAGT TCACTACGAA GTCAGATGTG TGGTCCTTTG GAGTCTTACT TTGGGAGCTG 3840

ATGACAAGAG GGGCCCCTCC CTACCCTGAT GTCAACTCTT TTGATATCAC TGTTTACTTA 3900

CTACAAGGAA GAAGACTCTT ACAACCTGAA TATTGCCCAG ATGCACTATA CGAAGTCATG 3960

CTCAAATGTT GGCATCCAAA ACCTGAACTA CGGCCAGCAT TTTCTGAATT GGTTTCAGAT 4020

ATATCAATGA TCTTCTCCAC TTTTGTTGGG GAGCATTATG TTCATGTGAA CACCACCTAT 4080

GTCAATGTGA AGTGTGTTGC ACCCTATCCA TCTCTTTTGT CATCGCAAGA CAATATAGAT 4140

CGGGATGCTG ACACATGA 4158

Domain Profile

S: 1     vdkeeviGkGhfGvvykgelsdsaskkikvavksleritdiekveeflreglvmkeldhp  60

         v+++eviG+GhfG+vy+g+l+d++++ki++avksl+ritd+++v +fl+eg++mk++ hp

Q: 1082  VHFNEVIGRGHFGCVYHGTLLDTDDRKIHCAVKSLNRITDLDEVAQFLKEGIIMKDFTHP  1141

         799*********************************************************

S: 61    nvlsllGialddeglplvvlpymkkGdlksfirneernltvkdllefalqvakgmeylas  120

         nvlsllGi+l++eg+plvvlpymk+Gdl++firne++n+tvkdl++f+lqvakgm+ylas

Q: 1142  NVLSLLGICLPSEGSPLVVLPYMKHGDLRNFIRNESHNPTVKDLIGFGLQVAKGMKYLAS  1201

         ************************************************************

S: 121   kkfvhrdlaarnclldekltvkvadfGlardvldkelyvveeerdarlpvkwlaleslqt  180

         kkfvhrdlaarnc+ldek+tvkvadfGlardv+dke+y+v+++++a+lpvkw+aleslqt

Q: 1202  KKFVHRDLAARNCMLDEKFTVKVADFGLARDVYDKEYYSVHNKTGAKLPVKWMALESLQT  1261

         ************************************************************

S: 181   fkqfttksdvwsfGvllwelltrgatpysevasfdltlylkegrrlrkpeycpdklydvm  240

         +k fttksdvwsfGvllwel+trga+py++v+sfd+t+yl +grrl +peycpd+ly+vm

Q: 1262  QK-FTTKSDVWSFGVLLWELMTRGAPPYPDVNSFDITVYLLQGRRLLQPEYCPDALYEVM  1320

         **.*********************************************************

S: 241   lkcwkakpaerpqfsdlvsiis  262

         lkcw++kp+ rp fs+lvs is

Q: 1321  LKCWHPKPELRPAFSELVSDIS  1342

         *******************986

Domain Sequence
(FASTA)

VHFNEVIGRG HFGCVYHGTL LDTDDRKIHC AVKSLNRITD LDEVAQFLKE GIIMKDFTHP 60

NVLSLLGICL PSEGSPLVVL PYMKHGDLRN FIRNESHNPT VKDLIGFGLQ VAKGMKYLAS 120

KKFVHRDLAA RNCMLDEKFT VKVADFGLAR DVYDKEYYSV HNKTGAKLPV KWMALESLQT 180

QKFTTKSDVW SFGVLLWELM TRGAPPYPDV NSFDITVYLL QGRRLLQPEY CPDALYEVML 240

KCWHPKPELR PAFSELVSDI S 261

Keyword

ATP-binding; Complete proteome; Disulfide bond; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0009925	; C:basal plasma membrane
GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0005008	; F:hepatocyte growth factor-activated receptor activity
GO:0000187	; P:activation of MAPK activity
GO:0042593	; P:glucose homeostasis
GO:0007275	; P:multicellular organismal development
GO:0014812	; P:muscle cell migration
GO:0051450	; P:myoblast proliferation
GO:0010828	; P:positive regulation of glucose transport
GO:0046777	; P:protein autophosphorylation
GO:0060665	; P:regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling

KEGG

InterPros

IPR013783	; Ig-like_fold.
IPR014756	; Ig_E-set.
IPR002909	; IPT_TIG_rcpt.
IPR011009	; Kinase-like_dom.
IPR003659	; Plexin-like.
IPR016201	; Plexin-like_fold.
IPR002165	; Plexin_repeat.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001627	; Semaphorin/CD100_Ag.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016244	; Tyr_kinase_HGF/MSP_rcpt.
IPR015943	; WD40/YVTN_repeat-like_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF01437	; PSI; 1.
PF01403	; Sema; 1.
PF01833	; TIG; 3.

SMARTs

SM00429	; IPT; 4.
SM00423	; PSI; 1.
SM00630	; Sema; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS51004	; SEMA; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013