EKS-ANC-00168

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ANC-00168

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKC	433.3	3.3E-130	358	612	255

Status

Unreviewed

Ensembl Protein

ENSACAP00000008435

UniProt Accession

G1KHZ5;

Protein Name

Protein Synonyms/Alias

Gene Name

PRKCD

Gene Synonyms/Alias

PRKCD;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSACAG00000008408	ENSACAP00000008435	ENSACAT00000008617

Organism

Anolis carolinensis

Functional Description

Protein Length

685

Protein Sequence
(FASTA)

MAPFLRISFN SFELGPVQNQ GEQLQPFCAI KMKEALTTER GKTLIQKKPT MYPDWKSSFD 60

AHIYEGRVIQ IVLMKAAEEP LSEVTVGVSV LAERCKKGNG KAEFWLDLQP QGKVLMAVQY 120

FLEDGVCRLD SKSMQDEGTV TINRRGAIKQ AKIHYIKNHE FIATFFGQPT FCSVCKEFVW 180

GLNKQGYKCR QCNAAIHKKC IDKIIGRCTG TAANSRDTMF QKERFHIDMP HRFKVYNYMS 240

PTFCDHCGSL LWGLVKQGLK CEECGMNVHH KCQRKVANLC GINQKLLAEA LTQVSQRSSR 300

KSDSGSVESV GIYQDFDKQP KALGGDTTVF TDNSEYDKLW EGRSLSRPSR RNFNIDSFVF 360

HKVLGKGSFG KVLLAELKGK NEFFAVKALK KDVVLIDDDV ECTMVEKRVL ALAWENPFLT 420

HLYCTFQTKD HLFFVMEFLN GGDLMFHIQD KGRFDLYRAT FYGAEIVCGL QFLHSKGIIY 480

RDLKLDNVML DKEGHIKIAD FGMCKENVFG DNKATTFCGT PDYIAPEIVQ GLKYTFSVDW 540

WSFGVLLYEM LIGQSPYHGD DEDELFESIR VDTPHYPRWI TKESKDLLEK LFERDPTKRL 600

GITGNIRDHN FFKAINWTAL EKREMDPPFK PKVKSANDYS NFDREFLSEK PRLSYSDKNL 660

IDSMDQSAFA GFSFVNPKFE RILEK 685

Nucleotide Sequence
(FASTA)

ATGGCTCCCT TTTTAAGAAT ATCGTTCAAC TCTTTTGAGC TGGGACCAGT GCAGAATCAA 60

GGGGAGCAAT TGCAGCCCTT CTGTGCAATA AAAATGAAAG AGGCCTTGAC TACAGAGAGA 120

GGCAAAACAC TCATTCAGAA GAAACCTACC ATGTACCCAG ACTGGAAATC ATCTTTTGAT 180

GCCCACATCT ATGAAGGGCG TGTGATTCAG ATTGTTTTAA TGAAGGCAGC AGAAGAGCCA 240

TTATCCGAGG TGACTGTAGG TGTCTCTGTT TTGGCTGAAA GGTGTAAGAA AGGCAATGGG 300

AAGGCAGAAT TCTGGCTTGA TTTACAACCG CAAGGGAAAG TATTAATGGC TGTACAATAT 360

TTCCTTGAAG ATGGAGTTTG TAGACTAGAT TCCAAGTCAA TGCAAGATGA GGGAACAGTG 420

ACTATAAACA GAAGAGGTGC AATCAAACAG GCAAAGATCC ACTACATCAA AAACCATGAA 480

TTTATTGCCA CCTTCTTTGG GCAACCTACA TTTTGCTCAG TCTGTAAAGA ATTTGTTTGG 540

GGTCTAAACA AGCAAGGATA CAAATGTAGA CAATGTAATG CTGCTATTCA CAAAAAATGC 600

ATTGATAAAA TCATTGGGAG ATGTACTGGT ACTGCAGCAA ACAGTAGAGA TACAATGTTT 660

CAGAAAGAGC GCTTCCACAT TGATATGCCC CATAGATTCA AAGTTTACAA TTACATGAGT 720

CCTACCTTCT GCGATCACTG TGGGAGTCTT CTTTGGGGAC TAGTTAAACA AGGACTTAAG 780

TGTGAAGAAT GTGGAATGAA TGTTCATCAC AAATGTCAAA GGAAAGTGGC AAATCTATGT 840

GGGATCAATC AGAAACTACT GGCAGAAGCT TTGACTCAAG TTAGTCAGAG ATCTTCAAGA 900

AAATCTGATT CTGGGTCAGT AGAAAGTGTT GGCATTTACC AGGATTTTGA TAAGCAACCT 960

AAAGCCTTAG GTGGTGATAC AACAGTTTTT ACAGATAATA GTGAGTATGA TAAGCTCTGG 1020

GAAGGAAGAT CATTGTCTCG GCCATCCAGG AGAAATTTCA ACATAGACAG TTTTGTCTTC 1080

CATAAAGTTC TTGGGAAAGG AAGTTTTGGA AAGGTACTAC TTGCTGAACT GAAAGGGAAG 1140

AATGAATTTT TTGCAGTAAA GGCTTTGAAA AAGGATGTGG TGCTAATTGA TGATGATGTG 1200

GAATGTACCA TGGTGGAAAA GCGGGTCTTA GCACTTGCAT GGGAAAATCC ATTTCTTACC 1260

CATTTATACT GCACTTTTCA AACGAAGGAC CATCTGTTCT TTGTTATGGA GTTTCTTAAT 1320

GGTGGAGACC TAATGTTCCA TATACAGGAT AAAGGCCGTT TTGATCTCTA CAGAGCTACG 1380

TTTTATGGAG CTGAAATAGT TTGCGGCTTG CAGTTTCTTC ATAGCAAAGG CATTATTTAT 1440

AGAGACCTCA AACTAGACAA TGTGATGCTT GATAAAGAAG GCCACATCAA AATAGCTGAT 1500

TTTGGGATGT GCAAAGAGAA TGTATTTGGA GATAACAAGG CAACAACGTT CTGTGGTACC 1560

CCTGATTACA TAGCACCTGA AATTGTGCAA GGGCTGAAAT ACACATTTTC TGTGGACTGG 1620

TGGTCATTTG GGGTCTTGTT GTATGAGATG CTTATTGGAC AGTCGCCTTA TCACGGTGAT 1680

GATGAAGACG AGTTGTTTGA GTCAATCCGG GTAGACACTC CACATTACCC ACGCTGGATT 1740

ACCAAGGAAT CGAAGGATCT TCTCGAGAAG TTGTTTGAAA GGGATCCAAC AAAGCGACTG 1800

GGAATAACTG GAAACATCAG GGACCACAAT TTCTTCAAAG CCATAAATTG GACAGCACTA 1860

GAGAAGAGGG AGATGGATCC CCCTTTCAAA CCTAAAGTGA AGTCAGCGAA CGACTACAGC 1920

AACTTTGACC GAGAGTTTTT GAGTGAGAAG CCTCGTCTAT CGTACAGCGA CAAAAACTTA 1980

ATAGACTCTA TGGACCAGTC TGCATTTGCT GGGTTCTCCT TTGTCAACCC GAAGTTTGAA 2040

AGGATCCTGG AGAAATAG 2058

Domain Profile

S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60

         f ++kvlGkGsfgkvllaelk+++e++a+k lkkdvvl dddve+t+vekrvlala+++p

Q: 358   FVFHKVLGKGSFGKVLLAELKGKNEFFAVKALKKDVVLIDDDVECTMVEKRVLALAWENP  417

         889*********************************************************

S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120

         fl++l+++fqt+d+lffv+e++nGGdlmfhiq++++++  ra+fy aei+++l+flh+kg

Q: 418   FLTHLYCTFQTKDHLFFVMEFLNGGDLMFHIQDKGRFDLYRATFYGAEIVCGLQFLHSKG  477

         ************************************************************

S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180

         iiyrdlkldnv+ld+eGhik+adfG+cke+++ +++++tfcGtPdyiaPei+++ +y++s

Q: 478   IIYRDLKLDNVMLDKEGHIKIADFGMCKENVFGDNKATTFCGTPDYIAPEIVQGLKYTFS  537

         ************************************************************

S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240

         vdww++Gvllyeml+gqsP++g+dedelfesi+ ++++yP++++ke++++l++l+++dp+

Q: 538   VDWWSFGVLLYEMLIGQSPYHGDDEDELFESIRVDTPHYPRWITKESKDLLEKLFERDPT  597

         ************************************************************

S: 241   krlGvkeegeedikehaff  259

         krlG+  +g  +i++h+ff

Q: 598   KRLGI--TG--NIRDHNFF  612

         *****..55..79999998

Domain Sequence
(FASTA)

FVFHKVLGKG SFGKVLLAEL KGKNEFFAVK ALKKDVVLID DDVECTMVEK RVLALAWENP 60

FLTHLYCTFQ TKDHLFFVME FLNGGDLMFH IQDKGRFDLY RATFYGAEIV CGLQFLHSKG 120

IIYRDLKLDN VMLDKEGHIK IADFGMCKEN VFGDNKATTF CGTPDYIAPE IVQGLKYTFS 180

VDWWSFGVLL YEMLIGQSPY HGDDEDELFE SIRVDTPHYP RWITKESKDL LEKLFERDPT 240

KRLGITGNIR DHNFF 255

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005911	; C:cell-cell junction
GO:0005829	; C:cytosol
GO:0005783	; C:endoplasmic reticulum
GO:0016363	; C:nuclear matrix
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0008047	; F:enzyme activator activity
GO:0046872	; F:metal ion binding
GO:0004697	; F:protein kinase C activity
GO:0006915	; P:apoptotic process
GO:0042100	; P:B cell proliferation
GO:0090398	; P:cellular senescence
GO:0016064	; P:immunoglobulin mediated immune response
GO:0035556	; P:intracellular signal transduction
GO:0030837	; P:negative regulation of actin filament polymerization
GO:0051490	; P:negative regulation of filopodium assembly
GO:0034351	; P:negative regulation of glial cell apoptotic process
GO:0046627	; P:negative regulation of insulin receptor signaling pathway
GO:0043407	; P:negative regulation of MAP kinase activity
GO:0050732	; P:negative regulation of peptidyl-tyrosine phosphorylation
GO:0090331	; P:negative regulation of platelet aggregation
GO:0042119	; P:neutrophil activation
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:2000304	; P:positive regulation of ceramide biosynthetic process
GO:2000753	; P:positive regulation of glucosylceramide catabolic process
GO:1900163	; P:positive regulation of phospholipid scramblase activity
GO:0035307	; P:positive regulation of protein dephosphorylation
GO:2001022	; P:positive regulation of response to DNA damage stimulus
GO:2000755	; P:positive regulation of sphingomyelin catabolic process
GO:0032930	; P:positive regulation of superoxide anion generation
GO:0023021	; P:termination of signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR014376	; Prot_kin_PKC_delta.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00130	; C1_1; 2.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 2.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 2.
PS50081	; ZF_DAG_PE_2; 2.

Prints

PR00008

; DAGPEDOMAIN.

Created Date

20-Feb-2013