EKS-ANC-00027

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ANC-00027

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Jak	314.6	5.5E-94	925	1194	270

Status

Unreviewed

Ensembl Protein

ENSACAP00000008443

UniProt Accession

G1KHZ7;

Protein Name

Tyrosine-protein kinase

Protein Synonyms/Alias

Gene Name

TYK2

Gene Synonyms/Alias

TYK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSACAG00000008421	ENSACAP00000008443	ENSACAT00000008625

Organism

Anolis carolinensis

Functional Description

Protein Length

1215

Protein Sequence
(FASTA)

NADRMPLCHC AVQHSESDME GCRFSLAGGL RVYLHWKGEE EEPYQTYMQG TLCAEEICID 60

IAQKIGITPI CYSLFALCDP QAKIWFPPNH VFEVDSGIKL LLHFRMRYYF RNWHGTNDKE 120

PAVYRNAPRS NDSEDKSQRG EQGSAILDKS SFEYLFEQGM SSCPTPKCSH ISVFFILCNF 180

QGKYDFINDV ASLKDLRTEQ EIHQFKNESL GMAVLHLCHI ALKSGLSLEE VAQRTSFKEC 240

IPRSFCRQIQ QNNYLTKFRI RNVFRRFLQR FQRHTMSTGK LTEQDIMHKY LATLENLAPN 300

FGSELFAILS LETVSEGEKL PLYINGGHTH LENSHTSPPS DKPATHEVLV TGTDGIQWRP 360

ISPERLQSYH HRGYLSRKVK IKDYKSKGPN QSAEHHDPKW VHFCDFQEIT HIVVKDCKVS 420

IHRQDNKCLE LALFSHDVAL SLVSLVDGYF RLTADSSHYL CHEVAPPRLV MSIQNGIHGP 480

MHEEFILTKL KREKQEDGLY ILRWSVLDYS RLILSVMRRD QSSQTHDATS YRQFRIQKKE 540

NSYVLEGWEQ EFSSVQELIN ALKGCTLRSG NEIFTMRRCC VPKPGEISDL LITRKIKDST 600

RQILNLTQLS FHQIRKNEIT QRAHLGQGTL TNIYDGVLHV CGGASGDDET EYFSTEQNNN 660

NREVHVVLKM LDPSHRDIAL AFFETASLMS QVSHIHLAFV HGVCVWGSEN IMVEEYVEHG 720

PLDVFLRKNK GRIMVGWKFT VAAQLASALS YLEGKNLVHG SVCAKNILLA RKGLEDGMLP 780

FIKLSDPGVS FTVLSREGKE RVDRIPWIAP ECVRDVSNLS TAADKWSFGT TLLEICFDAD 840

VPLKERTPSE KERFYEKKHR LPEPSFKELA TLISQCLNYA PAERPSFRTI LRDLTQLQPH 900

NPLDISSVNP EFPESDPTVF QKRYLKKIRD LGEGHFGKVS LYCYDPTNDG TGEMVAVKSL 960

KSGCSQQLLT SWKKEIEILK TLYHENIVKY KGCCSEQGEK VVQLIMEYVP LGSLRDYLPK 1020

HNVSLAHILL FAQQICEGMA YLHSSRYIHR DLAARNVLLE NENVVKIGDF GLAKAIPEGH 1080

EYYRVCEDGD SPVFWYAVEC LKDCKFYYTS DVWSFGVTLY ELLTRCDSSQ SPPTKFIEMI 1140

GAIHGQMTVL RLIELLDRGK RLPIPKDCPF EIYRLMKNCW ELESSFRPSF ANLVPILKAF 1200

HEKYKAQDPS VFNVC 1215

Nucleotide Sequence
(FASTA)

AATGCTGACA GAATGCCACT GTGTCATTGT GCAGTACAAC ATAGTGAATC AGACATGGAG 60

GGATGCCGTT TTTCACTTGC TGGAGGGCTG AGGGTGTATC TCCACTGGAA GGGTGAGGAG 120

GAAGAACCCT ATCAGACTTA TATGCAAGGG ACTCTTTGTG CTGAAGAAAT CTGCATTGAT 180

ATTGCACAGA AGATTGGTAT CACACCAATC TGCTACAGCT TGTTTGCCCT CTGTGATCCC 240

CAAGCCAAAA TATGGTTTCC TCCCAATCAT GTGTTTGAAG TTGACAGTGG CATCAAGTTG 300

CTCCTGCATT TTCGAATGAG GTATTATTTC CGAAACTGGC ATGGAACAAA TGACAAGGAG 360

CCAGCTGTAT ATCGCAACGC TCCTCGATCA AATGACTCAG AGGATAAGTC TCAAAGGGGT 420

GAACAAGGCA GTGCCATACT GGATAAATCA TCATTTGAGT ATCTCTTTGA GCAAGGCATG 480

TCAAGTTGCC CCACCCCTAA ATGTAGCCAT ATTTCAGTGT TCTTTATCTT GTGCAATTTC 540

CAAGGGAAAT ATGACTTCAT TAATGATGTT GCCTCCCTAA AAGATCTTCG GACAGAGCAG 600

GAGATTCACC AATTTAAAAA TGAGAGCCTT GGGATGGCTG TCCTCCACCT CTGCCACATT 660

GCCCTCAAGA GTGGCCTCTC CCTTGAAGAA GTGGCTCAGA GAACAAGCTT CAAGGAGTGC 720

ATCCCACGTT CCTTTTGTCG TCAGATTCAG CAGAACAACT ATCTGACAAA GTTCCGCATA 780

AGGAATGTTT TCAGGAGGTT CTTGCAGCGC TTCCAGCGAC ACACAATGAG CACCGGCAAG 840

CTGACAGAGC AGGATATCAT GCACAAGTAC CTGGCCACTT TGGAGAACTT GGCTCCTAAT 900

TTTGGGAGCG AGCTTTTTGC CATCCTCTCC TTGGAGACAG TTTCAGAGGG TGAAAAGCTG 960

CCACTTTATA TCAATGGTGG CCATACGCAC CTGGAGAACT CTCACACCTC ACCTCCCAGT 1020

GACAAGCCTG CCACCCATGA GGTCCTGGTC ACAGGCACAG ATGGCATTCA GTGGAGACCC 1080

ATTTCTCCTG AGAGATTGCA AAGCTATCAT CACAGAGGTT ATTTGAGCAG GAAGGTGAAG 1140

ATAAAAGACT ATAAATCCAA GGGTCCCAAC CAATCAGCGG AGCACCATGA TCCCAAATGG 1200

GTGCACTTTT GTGACTTCCA GGAGATCACA CACATTGTTG TGAAAGACTG CAAAGTCAGC 1260

ATTCACCGTC AAGACAATAA GTGCCTGGAG CTGGCTCTTT TTTCCCATGA TGTTGCCCTC 1320

TCCTTAGTTT CCCTTGTAGA TGGTTATTTT AGATTGACAG CGGACTCTAG CCACTATCTG 1380

TGTCATGAAG TAGCCCCACC ACGGCTGGTA ATGAGCATAC AGAATGGTAT CCATGGACCC 1440

ATGCATGAGG AATTTATTTT GACTAAACTA AAACGGGAGA AGCAGGAAGA TGGTCTGTAC 1500

ATTCTACGTT GGAGTGTCCT TGATTATAGT AGATTGATAT TGTCGGTTAT GAGGAGAGAC 1560

CAGAGTTCCC AGACTCATGA TGCCACAAGT TACAGACAGT TCCGTATCCA GAAGAAAGAA 1620

AATTCCTATG TACTTGAAGG CTGGGAGCAG GAATTCTCTA GTGTCCAAGA ACTGATAAAT 1680

GCTCTGAAAG GCTGTACTCT AAGATCTGGA AACGAGATCT TTACTATGCG GAGGTGCTGT 1740

GTCCCAAAGC CAGGAGAGAT CTCTGACTTG CTGATCACAC GAAAAATAAA GGACAGCACC 1800

CGACAGATTT TGAATTTGAC CCAGCTGAGT TTCCATCAAA TCCGGAAAAA TGAGATCACC 1860

CAGAGAGCAC ACTTGGGACA AGGGACACTT ACGAACATTT ATGATGGTGT GTTACATGTA 1920

TGTGGTGGAG CCAGTGGTGA TGATGAAACA GAGTACTTCT CCACTGAACA GAACAATAAC 1980

AACCGTGAAG TGCACGTGGT GCTGAAGATG CTGGATCCCA GTCACAGGGA CATTGCCCTG 2040

GCATTCTTTG AAACAGCCAG CTTGATGAGC CAGGTCTCCC ACATCCACTT GGCCTTTGTA 2100

CATGGAGTCT GTGTATGGGG CTCAGAGAAT ATAATGGTGG AGGAGTACGT CGAGCATGGC 2160

CCCCTGGACG TCTTCCTAAG GAAAAACAAA GGGCGGATAA TGGTGGGCTG GAAATTCACA 2220

GTCGCTGCAC AGTTAGCCAG TGCCTTGAGT TACTTGGAAG GCAAAAATCT GGTACATGGC 2280

AGTGTATGTG CCAAAAACAT CTTGTTGGCG AGGAAAGGCT TGGAAGATGG CATGCTGCCC 2340

TTCATTAAAC TCAGTGACCC TGGGGTCAGC TTCACTGTGC TCTCCCGGGA AGGCAAAGAG 2400

CGAGTGGATC GGATCCCCTG GATTGCTCCA GAGTGTGTCA GAGATGTAAG CAACCTTAGT 2460

ACAGCAGCTG ACAAGTGGAG CTTTGGTACC ACATTGCTAG AAATATGCTT TGATGCCGAT 2520

GTGCCACTAA AAGAACGCAC TCCTTCTGAG AAAGAGCGCT TCTATGAGAA AAAACATCGC 2580

CTTCCAGAAC CATCCTTTAA AGAACTAGCT ACCTTAATCA GCCAGTGCCT GAACTATGCC 2640

CCCGCGGAGC GTCCTTCTTT CCGGACCATC CTGAGAGATC TTACCCAACT GCAACCACAT 2700

AACCCTCTAG ACATCAGCTC TGTGAACCCT GAATTTCCTG AATCTGACCC AACTGTCTTC 2760

CAGAAGCGCT ACCTGAAGAA GATCAGAGAT CTGGGTGAGG GTCACTTTGG CAAAGTGAGC 2820

CTGTACTGCT ATGATCCCAC CAACGATGGC ACGGGTGAGA TGGTGGCAGT GAAGTCATTG 2880

AAATCAGGCT GCAGCCAACA GCTGCTGACT AGTTGGAAAA AGGAAATTGA GATCCTAAAA 2940

ACCCTCTACC ATGAAAACAT TGTCAAGTAC AAGGGCTGCT GTAGTGAACA AGGAGAAAAG 3000

GTTGTGCAAC TTATCATGGA ATATGTGCCT TTGGGGAGCC TGAGGGACTA CCTACCCAAG 3060

CACAATGTCA GCCTGGCCCA CATTCTTCTC TTTGCCCAGC AGATTTGTGA GGGAATGGCT 3120

TACCTCCACT CCTCACGCTA TATCCATAGG GATCTTGCAG CCAGGAATGT CCTTTTGGAG 3180

AATGAGAATG TGGTGAAGAT AGGAGACTTT GGACTTGCCA AAGCCATCCC TGAAGGACAT 3240

GAATATTATC GTGTCTGTGA AGATGGTGAT AGTCCTGTCT TTTGGTATGC TGTGGAATGC 3300

CTGAAAGACT GTAAATTCTA CTACACCTCT GATGTCTGGT CCTTTGGTGT AACGTTGTAT 3360

GAACTCTTGA CACGCTGTGA TTCTAGTCAG AGCCCTCCCA CGAAATTCAT TGAAATGATT 3420

GGGGCAATCC ATGGTCAAAT GACAGTGCTG AGGCTTATAG AGTTGCTGGA CCGAGGGAAA 3480

AGGTTGCCCA TCCCAAAAGA CTGTCCTTTT GAGATTTACC GCCTTATGAA GAACTGTTGG 3540

GAGCTGGAGT CTTCATTCCG CCCATCCTTC GCAAACCTTG TACCCATCCT GAAAGCCTTC 3600

CATGAAAAGT ACAAGGCCCA GGACCCCTCT GTTTTCAATG TGTGTTGA 3648

Domain Profile

S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLk.esgedisrdfkreaeilsqlsh  59

         lk+i++Lg+g+f+kv ++++d+++d t+e+va+k Lk  ++++  +++k+e+eil++l+h

Q: 925   LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKSLKsGCSQQLLTSWKKEIEILKTLYH  984

         6899*********************************999********************

S: 60    ehivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYL  117

         e+ivk+kg+c ++ge+  +l+meyv+ GsL++yL+k+  ++sl+  l +a+q++++m+YL

Q: 985   ENIVKYKGCCSEQGEKvvQLIMEYVPLGSLRDYLPKH--NVSLAHILLFAQQICEGMAYL  1042

         ************************************9..*********************

S: 118   edkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwl  176

         ++ +++hrd+aarnvL+e+e+       vk++d+glaka++++ eYy v+e++ds+++w+

Q: 1043  HSSRYIHRDLAARNVLLENENV------VKIGDFGLAKAIPEGhEYYRVCEDGDSPVFWY  1096

         *********************9......********************************

S: 177   apeclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle.......rklel  224

         a+ecl+++k +++ sdvWsFgvtlyellt c++++sp    +++++ +       r++el

Q: 1097  AVECLKDCK-FYYTSDVWSFGVTLYELLTrCDSSQSPptkfIEMIGAIhgqmtvlRLIEL  1155

         *********.****************************99988888889999999*****

S: 225   leekerlpkpk.cpaelaelmtnclsyepsqrpsFrail  262

         l +++rlp pk cp e++ lm+nc++ e s+rpsF +++

Q: 1156  LDRGKRLPIPKdCPFEIYRLMKNCWELESSFRPSFANLV  1194

         ***********************************9986

Domain Sequence
(FASTA)

LKKIRDLGEG HFGKVSLYCY DPTNDGTGEM VAVKSLKSGC SQQLLTSWKK EIEILKTLYH 60

ENIVKYKGCC SEQGEKVVQL IMEYVPLGSL RDYLPKHNVS LAHILLFAQQ ICEGMAYLHS 120

SRYIHRDLAA RNVLLENENV VKIGDFGLAK AIPEGHEYYR VCEDGDSPVF WYAVECLKDC 180

KFYYTSDVWS FGVTLYELLT RCDSSQSPPT KFIEMIGAIH GQMTVLRLIE LLDRGKRLPI 240

PKDCPFEIYR LMKNCWELES SFRPSFANLV 270

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005856	; C:cytoskeleton
GO:0016020	; C:membrane
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR019749	; Band_41_domain.
IPR000299	; FERM_domain.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016251	; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR016045	; Tyr_kinase_non-rcpt_TYK2_N.

Pfam

PF07714	; Pkinase_Tyr; 2.
PF00017	; SH2; 1.

SMARTs

SM00295	; B41; 1.
SM00252	; SH2; 1.
SM00219	; TyrKc; 2.

Prosites

PS50057	; FERM_3; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.

Prints

PR01823	; JANUSKINASE.
PR00109	; TYRKINASE.
PR01827	; YKINASETYK2.

Created Date

20-Feb-2013