EKS-ANC-00026

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ANC-00026

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Jak	328.0	4.6E-98	872	1146	275

Status

Unreviewed

Ensembl Protein

ENSACAP00000008587

UniProt Accession

G1KI54;

Protein Name

Protein Synonyms/Alias

Gene Name

JAK1

Gene Synonyms/Alias

JAK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSACAG00000008478	ENSACAP00000008587	ENSACAT00000008770

Organism

Anolis carolinensis

Functional Description

Protein Length

1155

Protein Sequence
(FASTA)

LQYFNVKEDC KAMAFCAKMR SSKRNEVYIE NQEQGLELAF YLQEKPSLLY TSGKYTAEEL 60

CIEAAQKCSI SPLCHNLFAL FDESRSLWYA PNHIFQIDDK TALRVHYRMR FYFSNWHGTN 120

ENETPVWRHS SKKSKNSYEK KLVQEGTPLL DAFSLEYLFA QGQNDLVRCF APVRDSKNDQ 180

ETQEIQNECL GMAVLAITHY AIKKNLRLPE LLRDISYKRY IPESLNKTIK QKNLLTRIRI 240

NNVFKDFLKE FNKRTICDSS VSPHDLKVKY LSTMETLTKH YGAELFETTS LLISSENEKS 300

FNMDDCNIIP HYEVIVTGNQ GIQWRVKPYV TQTEKEKHKT KRKKSDGKVK KNEEKSKRED 360

WNNFSYFPEI THLVIKESTV SVYKQDNKRM ELKLSSHGEA LSFAALVDGY FRLTTDAHHY 420

LCTDVAPPLI EHNIKNGCHG PICTDYAVNK LKQEGNEEGM YVLRWSCTDF NNILLTVVCT 480

EGSQQFLNPL KQYKNFQIEM KKNGCLLHGS DKFFSSLKEL MDHLKGQILR TDNIEFTLKQ 540

CCQPKPKEIS NLLVATKLSQ ECKPIYPLSQ LSFHQIRKEE IIQGEHLGRG TKTQIYSGIL 600

NYKDDESYQS EKEIKVLLKV LDPNHRDISL AFFETASMMR QISHKHIVLL HGICVRDVEN 660

IMVEEYVEFG PLDLFMRRKS VLLTTPWKFK VAKQLASALS YLEDKDLVHG NVCTKNILLA 720

REGIDNEYGP FIKLSDPGIS VTVLSKQECV ERIPWLAPEC VKDSKNLSVA ADKWSFGTTL 780

WEICYNGEIP LKDKTLAEKE RFYDGHFTLR TPSCKELADL MKQCMHYDPN QRPFFRAIMR 840

DINKLEEQNP EIVSEKKPND DVDPTVFEKR FLKRIRDLGE NQGHFGKVEL CRYDPEGDNT 900

GEQVAVKSLK PDCGGNHIAD LKKEIEILRN LYHENIVKYK GICTEDGGNG IKLIMEFLPS 960

GSLKEYLPRN RNKICLKQQL KYAVQICKGM DYLGSRQYVH RDLAARNVLV ENEQRVKIGD 1020

FGLTKTIETD KEYYKVNDDR DSPVFWYAPE CLLQSKFYIA SDVWSFGVTL YELLTYCDSE 1080

CSPMAEFLKM IGPTQGQMTV TRLVRILGEG KRLPCPKSCP EEVNHLMRRC WVHDPGERTT 1140

FHNLIQGFEE FMKKM 1155

Nucleotide Sequence
(FASTA)

TTGCAGTATT TTAATGTAAA AGAAGACTGT AAAGCTATGG CTTTCTGTGC GAAAATGAGA 60

AGTAGCAAAC GAAATGAGGT CTACATAGAA AATCAAGAAC AAGGACTGGA ATTAGCATTC 120

TATTTGCAAG AGAAACCTTC TCTTTTATAT ACATCTGGAA AGTACACAGC AGAAGAACTT 180

TGCATTGAAG CTGCCCAGAA ATGCTCTATA TCTCCATTGT GCCATAACCT GTTTGCCCTT 240

TTTGATGAAA GCAGAAGCCT ATGGTATGCG CCAAATCATA TCTTCCAAAT AGATGACAAA 300

ACTGCACTCC GGGTTCACTA TCGTATGAGG TTTTATTTTT CTAATTGGCA TGGGACAAAT 360

GAAAATGAGA CCCCTGTCTG GAGACATTCT TCAAAGAAAT CAAAGAATTC TTATGAAAAG 420

AAACTAGTGC AAGAAGGAAC ACCCCTCCTT GATGCATTTT CACTAGAATA TCTTTTTGCA 480

CAGGGACAGA ATGATTTGGT GAGGTGTTTT GCACCTGTTC GGGACTCAAA AAATGATCAA 540

GAGACTCAGG AAATTCAAAA CGAATGCTTG GGCATGGCTG TTCTTGCTAT CACTCACTAT 600

GCAATTAAAA AAAACTTGAG GTTGCCAGAG CTTCTCAGAG ACATCAGCTA TAAACGTTAT 660

ATTCCTGAAA GTCTGAACAA GACCATCAAA CAGAAAAACC TTTTAACGAG AATACGGATA 720

AACAATGTTT TCAAAGACTT CCTAAAGGAA TTTAACAAAA GGACTATTTG TGACAGCAGC 780

GTTTCCCCAC ATGATCTGAA AGTGAAGTAC TTGTCAACCA TGGAGACGTT GACAAAACAT 840

TATGGAGCAG AATTATTTGA GACCACTTCA TTGTTAATTT CATCAGAAAA TGAGAAGAGT 900

TTTAATATGG ATGATTGTAA CATCATCCCA CATTATGAGG TGATAGTAAC AGGTAATCAA 960

GGAATCCAGT GGCGTGTAAA GCCGTATGTT ACTCAGACAG AGAAAGAAAA ACATAAAACA 1020

AAGAGAAAAA AATCAGATGG CAAAGTTAAG AAAAATGAAG AAAAAAGTAA GAGGGAAGAC 1080

TGGAACAATT TTTCTTACTT TCCTGAAATC ACTCACCTTG TGATCAAGGA GTCCACAGTT 1140

TCTGTCTATA AACAAGATAA TAAAAGGATG GAGCTTAAAC TGTCTTCACA TGGAGAAGCG 1200

TTGTCATTTG CTGCTTTGGT CGATGGCTAT TTCAGACTTA CTACAGATGC CCACCACTAT 1260

CTCTGTACAG ATGTTGCACC GCCCCTCATA GAACACAACA TTAAAAATGG CTGCCATGGA 1320

CCCATTTGCA CAGATTATGC TGTTAACAAG TTGAAGCAAG AAGGTAATGA GGAAGGCATG 1380

TATGTCCTGA GATGGAGCTG TACAGACTTC AACAACATCC TCTTGACTGT GGTATGTACA 1440

GAAGGCTCAC AGCAGTTTTT AAATCCACTC AAACAATACA AGAACTTCCA GATTGAAATG 1500

AAGAAAAATG GCTGTCTCTT ACATGGATCT GATAAGTTTT TTTCATCTTT GAAAGAACTG 1560

ATGGACCACT TAAAAGGGCA GATTCTGAGA ACAGATAATA TAGAATTCAC GCTCAAGCAA 1620

TGCTGTCAGC CAAAGCCAAA AGAAATCTCC AATTTGCTGG TGGCTACCAA ACTGTCACAA 1680

GAATGTAAGC CGATCTATCC TTTAAGTCAG TTGAGCTTCC ATCAGATCCG TAAAGAAGAA 1740

ATAATACAGG GTGAGCATCT TGGAAGAGGA ACAAAAACAC AGATTTACTC TGGGATTCTA 1800

AATTATAAGG ACGATGAAAG TTATCAGAGT GAAAAGGAAA TTAAAGTTCT TCTTAAAGTC 1860

TTGGATCCCA ACCACAGAGA CATTTCTTTA GCATTTTTTG AGACAGCAAG CATGATGAGA 1920

CAGATTTCCC ACAAACACAT CGTTCTTCTT CATGGAATTT GTGTCCGTGA TGTAGAAAAC 1980

ATTATGGTCG AGGAGTATGT TGAATTTGGA CCTCTGGATC TCTTCATGCG CCGCAAGAGT 2040

GTTTTGCTAA CGACACCTTG GAAATTCAAA GTAGCAAAAC AGTTAGCAAG TGCATTAAGT 2100

TATCTCGAGG ACAAAGATTT GGTACATGGG AATGTGTGCA CCAAAAATAT ATTACTGGCC 2160

AGAGAAGGAA TTGATAATGA ATATGGACCT TTCATAAAAT TAAGTGACCC AGGAATTTCA 2220

GTTACGGTGC TATCTAAACA AGAATGTGTT GAGCGCATCC CTTGGCTTGC ACCTGAATGT 2280

GTTAAAGACT CCAAAAATTT GAGCGTGGCA GCAGATAAAT GGAGTTTTGG TACAACATTA 2340

TGGGAAATTT GCTACAATGG AGAAATACCA CTTAAAGACA AGACGTTAGC AGAGAAGGAA 2400

AGGTTTTATG ACGGACATTT CACACTTAGA ACGCCATCTT GCAAGGAGCT GGCTGATTTG 2460

ATGAAGCAGT GCATGCACTA TGATCCTAAC CAAAGACCCT TCTTTAGAGC CATTATGCGA 2520

GATATCAACA AACTGGAAGA GCAAAATCCC GAAATTGTCT CGGAGAAGAA GCCTAATGAT 2580

GATGTTGACC CTACCGTTTT TGAAAAACGC TTTCTGAAGA GGATTCGTGA CTTAGGCGAG 2640

AACCAGGGAC ATTTTGGCAA AGTTGAACTC TGCAGATATG ATCCTGAAGG CGATAACACC 2700

GGAGAACAAG TGGCAGTGAA GTCCCTAAAA CCTGACTGTG GTGGGAACCA TATCGCTGAC 2760

CTGAAGAAAG AAATTGAAAT CCTTAGGAAT CTTTACCATG AAAACATTGT GAAATACAAA 2820

GGGATCTGCA CAGAAGACGG TGGAAATGGA ATTAAACTTA TCATGGAATT CCTTCCTTCT 2880

GGAAGCCTAA AAGAGTATCT TCCCCGAAAC AGGAATAAGA TCTGCTTGAA ACAGCAACTG 2940

AAATATGCTG TACAAATCTG TAAGGGAATG GACTATTTGG GATCTCGTCA ATATGTTCAT 3000

CGAGACTTGG CCGCACGAAA TGTTCTTGTT GAAAATGAGC AGAGAGTAAA GATTGGGGAC 3060

TTTGGACTGA CCAAAACTAT TGAGACTGAT AAGGAGTACT ACAAAGTCAA CGATGATCGG 3120

GATAGCCCTG TGTTTTGGTA TGCTCCAGAA TGCTTGCTGC AAAGCAAATT TTATATTGCT 3180

TCAGATGTTT GGTCTTTTGG AGTGACCCTC TATGAACTAT TGACATATTG CGACTCTGAG 3240

TGCAGTCCAA TGGCAGAATT CCTAAAGATG ATTGGGCCAA CCCAAGGTCA GATGACAGTC 3300

ACACGGCTTG TGCGTATATT AGGAGAAGGA AAACGTTTGC CATGCCCCAA AAGTTGCCCT 3360

GAAGAGGTTA ATCATCTGAT GAGGAGGTGC TGGGTGCATG ACCCAGGGGA GAGGACAACG 3420

TTCCACAATC TGATTCAAGG ATTTGAAGAA TTTATGAAGA AGATGTAA 3468

Domain Profile

S: 1     lkqiesLg..kgtftkvfevredaegdsteeevalkvLk.esgedisrdfkreaeilsql  57

         lk+i++Lg  +g+f+kv+++r+d+egd+t+e+va+k Lk ++g ++++d+k+e+eil++l

Q: 872   LKRIRDLGenQGHFGKVELCRYDPEGDNTGEQVAVKSLKpDCGGNHIADLKKEIEILRNL  931

         57788898556*************************************************

S: 58    shehivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakame  115

         +he+ivk+kg+c+++g n  +l+me+++sGsL++yL+++++++ l+++l++a q++k+m+

Q: 932   YHENIVKYKGICTEDGGNgiKLIMEFLPSGSLKEYLPRNRNKICLKQQLKYAVQICKGMD  991

         ************************************************************

S: 116   YLedkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsrip  174

         YL+++++vhrd+aarnvLve+e++      vk++d+gl+k++++d eYy v ++rds+++

Q: 992   YLGSRQYVHRDLAARNVLVENEQR------VKIGDFGLTKTIETDkEYYKVNDDRDSPVF  1045

         ************************......******************************

S: 175   wlapeclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle.......rkl  222

         w+apecl ++k +++asdvWsFgvtlyellt c++++sp    l++++++       r++

Q: 1046  WYAPECLLQSK-FYIASDVWSFGVTLYELLTyCDSECSPmaefLKMIGPTqgqmtvtRLV  1104

         ***********.*******************************9999999999*******

S: 223   elleekerlpkpk.cpaelaelmtnclsyepsqrpsFraile  263

         ++l e++rlp+pk cp+e+ +lm++c+ ++p +r++F+++++

Q: 1105  RILGEGKRLPCPKsCPEEVNHLMRRCWVHDPGERTTFHNLIQ  1146

         ***************************************986

Domain Sequence
(FASTA)

LKRIRDLGEN QGHFGKVELC RYDPEGDNTG EQVAVKSLKP DCGGNHIADL KKEIEILRNL 60

YHENIVKYKG ICTEDGGNGI KLIMEFLPSG SLKEYLPRNR NKICLKQQLK YAVQICKGMD 120

YLGSRQYVHR DLAARNVLVE NEQRVKIGDF GLTKTIETDK EYYKVNDDRD SPVFWYAPEC 180

LLQSKFYIAS DVWSFGVTLY ELLTYCDSEC SPMAEFLKMI GPTQGQMTVT RLVRILGEGK 240

RLPCPKSCPE EVNHLMRRCW VHDPGERTTF HNLIQ 275

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005856	; C:cytoskeleton
GO:0016020	; C:membrane
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0019221	; P:cytokine-mediated signaling pathway
GO:0007167	; P:enzyme linked receptor protein signaling pathway
GO:0007243	; P:intracellular protein kinase cascade
GO:0018108	; P:peptidyl-tyrosine phosphorylation
GO:0046677	; P:response to antibiotic

KEGG

InterPros

IPR019749	; Band_41_domain.
IPR019748	; FERM_central.
IPR000299	; FERM_domain.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016251	; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020776	; Tyr_kinase_non-rcpt_Jak1.

Pfam

PF07714	; Pkinase_Tyr; 2.
PF00017	; SH2; 1.

SMARTs

SM00295	; B41; 1.
SM00252	; SH2; 1.
SM00219	; TyrKc; 2.

Prosites

PS50057	; FERM_3; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR01823	; JANUSKINASE.
PR01824	; JANUSKINASE1.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013