EKS-ANC-00281

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ANC-00281

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/DDR	453.7	2.3E-136	565	851	287

Status

Unreviewed

Ensembl Protein

ENSACAP00000008521

UniProt Accession

H9GE80;

Protein Name

Protein Synonyms/Alias

Gene Name

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSACAG00000008707	ENSACAP00000008521	ENSACAT00000008704

Organism

Anolis carolinensis

Functional Description

Protein Length

857

Protein Sequence
(FASTA)

KWETPRMLCL PILLLAGLSR SSGSEVNPAI NRYHKGMQEA HIPGRVYSWL PATGSDFRGL 60

KYARLLRDEG DEGPVSGQKS AQFLQVDLHK LHFITLVGTQ GRHARATGKE FARAYRIDYS 120

RNGERWLSWK DRQNRQVIQG NIDTYDVVLK DLRPPIIARY IRVIPVTEQP MTVCMRVELY 180

GCVWSDGLEA YSMPEGEVMA APGHPIVYLN DSTYDGFQER RSLHGGLGQL TDGILGLDDF 240

TKSHQYRVWP GYDYVGWRNN SFRNGAVGLE FQFDRQRNFT FMKVHCNNMF SKGVKIFERV 300

ECFFKPQLFA EWETESVGAD TVLDDKNPSA RFVTVPLGHR VGKAILCQFY FADTWMMISE 360

VSFQSVQDAE LRVLKGPLSP KRPLSPWTEP NFKTFQTPQA SAGCPVSIIL DLLAIIVAIL 420

WRQYAQKRLE TAPRRILEED ATVRLSFYSS RMVGGQTQIH QTNPTYERVF PLDLEYHQPI 480

TLLQKLPELS QSAEDSACSG DYAEPDLTKC TPHQGFQNNV PHYAETDIVS LQGVTGNNTY 540

AVPAITVDSL TKKDISVAEF PRQQLRLKEK LGEGQFGEVH LCEADGLLEF LGRSSSDASS 600

RPVLVAVKML RANVTKTARN DFLKEIKIMS RLKDPNIIRL LGVCVRDDPL CMITEYMENG 660

DLHQFLLQRQ SRSTFTLSNN IPCVSCLHLL LMATQIASGM KYLASLNFVH RDLATRNCLV 720

GNNYTIKIAD FGMSRNLYSG DYYRIQGRAV LPIRWMAWES ILLGKFTTAS DAWAFGVTLW 780

EMFTLCKEQP YSWLSDEQVI ENTGEFFRDQ GRQAYLSQPP LCPNLVFSLM MKCWSRDIKD 840

RPAFEAIHLF LVEQMDG 857

Nucleotide Sequence
(FASTA)

AAGTGGGAAA CGCCAAGGAT GCTGTGCTTG CCAATCCTTC TTCTGGCTGG ACTCTCCCGT 60

TCTTCTGGCT CTGAAGTCAA CCCAGCAATA AATCGTTATC ATAAGGGGAT GCAGGAAGCG 120

CACATCCCGG GACGAGTATA TTCCTGGCTT CCAGCCACTG GTTCTGATTT TCGGGGGCTC 180

AAATATGCAC GGCTGCTGCG AGACGAAGGC GACGAGGGCC CGGTGTCCGG ACAAAAGAGC 240

GCCCAGTTCC TCCAGGTTGA TCTCCACAAA CTGCACTTCA TCACACTGGT GGGCACCCAA 300

GGGCGGCACG CCAGGGCCAC CGGCAAGGAG TTTGCCCGCG CCTATCGCAT CGACTACAGC 360

CGCAACGGGG AGCGCTGGCT CTCTTGGAAG GACCGGCAGA ACAGGCAGGT TATTCAGGGC 420

AACATTGACA CATACGACGT GGTCCTTAAA GATCTTCGCC CGCCTATCAT TGCCCGCTAC 480

ATCCGAGTGA TCCCGGTCAC TGAGCAGCCC ATGACCGTCT GCATGCGAGT AGAACTGTAT 540

GGCTGCGTTT GGTCTGATGG TTTGGAGGCC TACAGCATGC CAGAAGGTGA GGTCATGGCA 600

GCTCCAGGAC ATCCCATTGT CTACCTGAAC GATTCGACTT ACGATGGTTT CCAGGAACGC 660

AGGTCTCTCC ATGGCGGCTT GGGCCAGCTG ACTGATGGCA TCTTGGGGTT GGATGATTTC 720

ACCAAGAGCC ACCAATACAG AGTGTGGCCG GGCTACGACT ACGTGGGATG GAGGAACAAC 780

AGCTTCCGGA ACGGCGCCGT TGGGCTGGAG TTCCAGTTTG ACCGGCAAAG GAACTTCACC 840

TTCATGAAGG TCCATTGCAA TAACATGTTC TCCAAAGGCG TGAAGATCTT TGAGCGGGTG 900

GAGTGCTTCT TCAAGCCACA GCTCTTTGCG GAGTGGGAGA CCGAGTCCGT GGGAGCGGAT 960

ACCGTTCTGG ACGACAAGAA CCCCAGTGCG CGGTTTGTGA CCGTCCCCCT CGGCCATCGG 1020

GTCGGCAAAG CCATCCTGTG CCAGTTCTAC TTTGCCGACA CATGGATGAT GATCAGCGAG 1080

GTCTCCTTCC AATCGGTCCA AGATGCAGAG CTGCGAGTCC TAAAAGGCCC TCTCAGTCCT 1140

AAAAGGCCTC TCAGTCCCTG GACTGAGCCC AATTTTAAAA CCTTCCAGAC ACCTCAGGCC 1200

TCCGCCGGCT GCCCTGTGTC CATCATCCTG GACCTCCTAG CCATCATTGT GGCCATCTTG 1260

TGGAGGCAAT ATGCCCAGAA ACGGCTGGAG ACGGCTCCCC GACGGATCCT GGAAGAGGAC 1320

GCCACCGTCC GGCTCTCCTT CTACAGCTCC AGGATGGTTG GTGGTCAGAC GCAGATCCAT 1380

CAAACCAACC CTACCTATGA AAGGGTCTTC CCGTTGGATC TGGAGTATCA CCAGCCCATC 1440

ACCCTCCTCC AGAAACTGCC TGAATTATCC CAAAGTGCCG AAGACTCAGC TTGTAGCGGG 1500

GATTATGCTG AGCCGGACCT CACCAAATGC ACCCCTCACC AAGGATTCCA GAATAACGTT 1560

CCACATTATG CCGAGACGGA TATCGTCAGC CTACAAGGAG TGACCGGCAA TAATACATAC 1620

GCGGTGCCCG CCATTACGGT TGATTCATTG ACCAAGAAGG ATATCTCAGT AGCCGAATTC 1680

CCCAGGCAGC AGCTGCGACT CAAGGAGAAA CTAGGAGAAG GGCAATTTGG GGAGGTCCAC 1740

TTGTGTGAAG CTGATGGTCT CCTGGAATTT CTTGGCCGCT CTTCTTCAGA CGCATCCAGC 1800

CGACCAGTCC TAGTTGCCGT CAAAATGCTG AGAGCCAACG TTACCAAAAC AGCCAGGAAT 1860

GACTTCCTGA AGGAGATCAA GATCATGTCT CGCCTGAAGG ATCCAAACAT CATCCGGCTT 1920

CTGGGAGTCT GCGTGAGGGA CGATCCGCTG TGCATGATCA CCGAATACAT GGAAAATGGG 1980

GATCTCCACC AGTTCTTGTT GCAACGGCAG AGTAGAAGTA CCTTCACCCT CTCCAACAAC 2040

ATTCCCTGTG TGAGCTGCCT CCACCTCCTG CTCATGGCGA CTCAGATTGC GTCCGGCATG 2100

AAGTACTTGG CGTCCCTCAA CTTCGTCCAC CGCGACCTGG CCACCCGCAA CTGCCTGGTT 2160

GGAAACAACT ACACCATCAA GATTGCCGAT TTCGGCATGA GCCGGAACCT GTACAGCGGG 2220

GATTACTATA GGATCCAAGG CAGGGCTGTG TTGCCGATTC GTTGGATGGC CTGGGAGAGC 2280

ATCCTCCTGG GCAAGTTCAC CACAGCGAGC GATGCGTGGG CTTTCGGGGT CACGCTGTGG 2340

GAGATGTTCA CCCTGTGCAA GGAGCAACCC TACAGTTGGC TCTCGGATGA GCAGGTCATC 2400

GAGAATACAG GGGAGTTCTT CCGAGACCAA GGACGGCAGG CTTATTTGTC TCAACCGCCG 2460

CTGTGTCCGA ACCTGGTCTT CTCCTTGATG ATGAAGTGCT GGAGCCGAGA CATCAAGGAT 2520

CGCCCAGCCT TTGAAGCCAT TCACTTATTC CTGGTCGAGC AAATGGACGG G 2571

Domain Profile

S: 1     LlikeklGeGkfgevklCevegledl...kekdskgsallvavkslredanknarkdflk  57

         L++keklGeG+fgev+lCe +gl ++    ++d  ++++lvavk+lr++ +k ar+dflk

Q: 565   LRLKEKLGEGQFGEVHLCEADGLLEFlgrSSSDASSRPVLVAVKMLRANVTKTARNDFLK  624

         789*******************99983334677999************************

S: 58    eikilsrlkdPnivrllgvcvrdeplclileyvenGdlnqflseheaedselake..ktl  115

         eiki+srlkdPni+rllgvcvrd+plc+i+ey+enGdl+qfl +++++++ + ++  + +

Q: 625   EIKIMSRLKDPNIIRLLGVCVRDDPLCMITEYMENGDLHQFLLQRQSRSTFTLSNniPCV  684

         ******************************************999988776544422789

S: 116   syellvsiatqiasglkyLeslnfvhrdlatrnclvgeeftvkiadfglsrslyagdyyr  175

         s   l+ +atqiasg+kyL+slnfvhrdlatrnclvg+++t+kiadfg+sr+ly+gdyyr

Q: 685   SCLHLLLMATQIASGMKYLASLNFVHRDLATRNCLVGNNYTIKIADFGMSRNLYSGDYYR  744

         ************************************************************

S: 176   vqGravlPiRwmawesillgkfttasDvWafgvtlweiltlcreqPyeeltdeqvienag  235

         +qGravlPiRwmawesillgkfttasD+Wafgvtlwe++tlc+eqPy+ l+deqvien+g

Q: 745   IQGRAVLPIRWMAWESILLGKFTTASDAWAFGVTLWEMFTLCKEQPYSWLSDEQVIENTG  804

         ************************************************************

S: 236   elfrdqkrkvvlsrPavcpselyelllrCwrrdeseRPsfeelhkll  282

         e+frdq+r+ +ls+P++cp+ ++ l+++Cw+rd ++RP+fe +h++l

Q: 805   EFFRDQGRQAYLSQPPLCPNLVFSLMMKCWSRDIKDRPAFEAIHLFL  851

         ********************************************997

Domain Sequence
(FASTA)

LRLKEKLGEG QFGEVHLCEA DGLLEFLGRS SSDASSRPVL VAVKMLRANV TKTARNDFLK 60

EIKIMSRLKD PNIIRLLGVC VRDDPLCMIT EYMENGDLHQ FLLQRQSRST FTLSNNIPCV 120

SCLHLLLMAT QIASGMKYLA SLNFVHRDLA TRNCLVGNNY TIKIADFGMS RNLYSGDYYR 180

IQGRAVLPIR WMAWESILLG KFTTASDAWA FGVTLWEMFT LCKEQPYSWL SDEQVIENTG 240

EFFRDQGRQA YLSQPPLCPN LVFSLMMKCW SRDIKDRPAF EAIHLFL 287

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ciona intestinalis"; ?>Danio rerio"; ?>Gallus gallus"; ?>Latimeria chalumnae"; ?>Meleagris gallopavo"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0007155	; P:cell adhesion
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR000421	; Coagulation_fac_5/8-C_type_dom.
IPR008979	; Galactose-bd-like.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR002011	; Tyr_kinase_rcpt_2_CS.

Pfam

PF00754	; F5_F8_type_C; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00231	; FA58C; 1.
SM00219	; TyrKc; 1.

Prosites

PS01286	; FA58C_2; 1.
PS50022	; FA58C_3; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00239	; RECEPTOR_TYR_KIN_II; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013