EKS-ANC-00359

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ANC-00359

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	432.0	5.9E-130	244	493	250

Status

Unreviewed

Ensembl Protein

ENSACAP00000008770

UniProt Accession

H9GEL5;

Protein Name

Protein Synonyms/Alias

Gene Name

HCK

Gene Synonyms/Alias

HCK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSACAG00000008823	ENSACAP00000008770	ENSACAT00000008958

Organism

Anolis carolinensis

Functional Description

Protein Length

509

Protein Sequence
(FASTA)

LPRMGCIKSK EHGLQRKTSK THSSSSLQGH YVKDPTSKPF ILECRFCEFM PFLVLTGLED 60

FVVLALYDYD AIHTEDLSFR KGDHLKVLEE SGEWWKAKSL SNGKVGFIPS NYVARVDSLE 120

TEEDVDFKGV SRKDAERQLL APGNVIGSSM IRDSETTKGS YSLSVRDFDN ISKVDIVKHY 180

KIRTLDSGGF YISPRNTFNS LQELVAHYKG QSDGLCQVLT IPCVVPKPEK PWEKDAWEIP 240

RESLKLEKKL GAGQFGEVWI ATYNKHTKVA VKTMKPGSMS VEAFLEEANI MKTLQHDKLV 300

KLNAVVTKEE PIYIITEFME KGSLLDFLKS DEGRGVQLPK LIDFSAQIAE GMAFIEQRNY 360

IHRDLRAANI LVSGILVCKI ADFGLARVIE DNEYTAREGA KFPIKWTAPE AINYGSFTIK 420

SDVWSFGILL MEIITYGRTP YPGMSNQEVM RALERGYHMP RPESCPVELY DIMLRCWKKK 480

PEDRPTFESN QSILEDFFTA TESQYQQQP 509

Nucleotide Sequence
(FASTA)

CTTCCCAGGA TGGGCTGCAT CAAGTCTAAA GAGCACGGCC TTCAACGAAA GACATCCAAA 60

ACCCATTCAA GCTCCAGCCT CCAAGGCCAT TATGTCAAAG ATCCGACATC CAAGCCGTTT 120

ATTCTTGAGT GTCGATTTTG TGAATTCATG CCTTTCCTCG TTCTCACAGG ATTGGAAGAC 180

TTCGTTGTCC TGGCTCTTTA CGACTATGAT GCGATCCACA CGGAAGACCT GAGCTTCCGG 240

AAGGGAGACC ACCTCAAAGT CCTAGAGGAG TCAGGCGAGT GGTGGAAAGC CAAGTCACTA 300

TCAAACGGCA AAGTAGGCTT CATCCCAAGC AACTACGTCG CCAGGGTCGA CTCACTGGAG 360

ACAGAAGAAG ATGTGGATTT CAAAGGTGTC AGTCGCAAGG ATGCCGAGCG GCAGCTGCTG 420

GCCCCTGGAA ACGTTATTGG CTCCTCCATG ATTCGAGACA GTGAGACCAC CAAAGGGAGT 480

TACTCCTTAT CTGTGAGAGA TTTTGATAAC ATCAGCAAGG TGGACATCGT GAAACATTAC 540

AAGATCCGGA CGCTGGACAG CGGGGGGTTC TACATCTCCC CTCGGAACAC CTTCAACAGC 600

CTCCAAGAAT TAGTTGCCCA TTATAAAGGC CAAAGCGATG GGCTTTGCCA AGTGCTGACC 660

ATCCCGTGTG TTGTGCCGAA GCCTGAGAAA CCCTGGGAGA AAGACGCTTG GGAAATCCCT 720

CGCGAATCCC TGAAGCTGGA GAAGAAACTG GGAGCTGGGC AATTTGGGGA AGTCTGGATA 780

GCCACATACA ACAAGCACAC AAAAGTCGCC GTGAAGACCA TGAAGCCGGG CAGCATGTCC 840

GTGGAAGCCT TCCTGGAAGA GGCCAACATC ATGAAGACCC TGCAGCATGA CAAACTGGTT 900

AAGTTGAATG CTGTCGTGAC CAAGGAAGAG CCTATTTACA TCATCACTGA ATTCATGGAG 960

AAAGGCAGCT TGCTGGACTT CCTGAAAAGC GATGAAGGAC GTGGTGTGCA GCTGCCCAAA 1020

TTGATAGACT TCTCTGCCCA GATTGCTGAA GGTATGGCTT TCATTGAACA GAGAAATTAC 1080

ATTCATCGGG ACTTGAGGGC TGCCAACATC CTAGTCTCAG GAATATTAGT GTGCAAAATT 1140

GCAGATTTTG GCCTGGCCAG AGTGATTGAG GATAATGAAT ACACAGCCCG AGAAGGTGCC 1200

AAGTTCCCTA TCAAATGGAC TGCACCGGAG GCCATCAATT ACGGCTCCTT CACCATCAAA 1260

TCTGACGTCT GGTCTTTTGG GATTCTGCTG ATGGAAATCA TTACTTACGG ACGGACTCCT 1320

TACCCAGGGA TGTCGAACCA GGAGGTGATG CGTGCCCTCG AGCGGGGCTA CCACATGCCC 1380

CGTCCGGAGA GCTGCCCGGT CGAGCTCTAC GACATCATGC TGCGGTGCTG GAAGAAGAAG 1440

CCGGAGGACC GTCCCACCTT TGAGTCCAAT CAGAGTATCC TGGAGGATTT CTTCACTGCC 1500

ACGGAAAGCC AGTATCAGCA ACAGCCTTAG 1530

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         lkl+kklG+GqfGevw++++++++kvavkt+k+g++s eafleea+i+k+l+h+klvkl

Q: 244   LKLEKKLGAGQFGEVWIATYNKHTKVAVKTMKPGSMSVEAFLEEANIMKTLQHDKLVKLN  303

         689*********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avv++eePiyi+te+m+kGslldflk++eg+ ++lpkl+d++aq+aeGma++e++n+ihr

Q: 304   AVVTKEEPIYIITEFMEKGSLLDFLKSDEGRGVQLPKLIDFSAQIAEGMAFIEQRNYIHR  363

         ************************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+n+lv+  lv+k+adfGlar+ied+eyta+egak+PikWtaPeai++g+ftiksdv

Q: 364   DLRAANILVSGILVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINYGSFTIKSDV  423

         ************************************************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfGill+ei+t+G++PypGm+n+ev++++ergy++prpe+cp ely+++l+cwkk+pe+

Q: 424   WSFGILLMEIITYGRTPYPGMSNQEVMRALERGYHMPRPESCPVELYDIMLRCWKKKPED  483

         ************************************************************

S: 241   rPtfetlqev  250

         rPtfe  q++

Q: 484   RPTFESNQSI  493

         *****87765

Domain Sequence
(FASTA)

LKLEKKLGAG QFGEVWIATY NKHTKVAVKT MKPGSMSVEA FLEEANIMKT LQHDKLVKLN 60

AVVTKEEPIY IITEFMEKGS LLDFLKSDEG RGVQLPKLID FSAQIAEGMA FIEQRNYIHR 120

DLRAANILVS GILVCKIADF GLARVIEDNE YTAREGAKFP IKWTAPEAIN YGSFTIKSDV 180

WSFGILLMEI ITYGRTPYPG MSNQEVMRAL ERGYHMPRPE SCPVELYDIM LRCWKKKPED 240

RPTFESNQSI 250

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013