EKS-ANC-00292

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ANC-00292

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Alk	528.8	2.4E-159	702	971	270

Status

Unreviewed

Ensembl Protein

ENSACAP00000008904

UniProt Accession

G1KIG5;

Protein Name

Tyrosine-protein kinase receptor

Protein Synonyms/Alias

Gene Name

ALK

Gene Synonyms/Alias

ALK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSACAG00000008958	ENSACAP00000008904	ENSACAT00000009095

Organism

Anolis carolinensis

Functional Description

Protein Length

1188

Protein Sequence
(FASTA)

SAGLPLSSKM ALQSSFNCWN GMTIKLGQVC DFTRDCAEGE DEGQQCKNLP PGFYCSFENG 60

DCGWTQSSPT SQEIHFWHIG NPKNKHFCLL KECALLLNTS ETPVTEAVVM TSAVFPAPMK 120

NSPCELRMAW FLHGILLGDV SLFLVENKTG KEHSRKLWHF ENRKGLGVWQ KMVRPLIDVS 180

DRFWLQIITS WKVGSEAIIA FDNVSLSLDC YLTKRGFISG HSNPYLQNGS NKTSQIHKRN 240

SHNIELDLGR PGIKSPQTRP AMCPQDNWLF TTCGASGPHG PTQTQCNDAY RNVNLSVLLG 300

AEEGFPGVQI WKVPATDTYS ISTYGAAGGK GKNTIMRSNG VNVAGIFKLQ KNESLYILVG 360

QQGEDACPSA NHIIQKVCLG ENNVVEEEIK ANKSIYEWAG GGGGGGGATY IFKMENGKPV 420

PLIIAAGGGG RAYRAKTYTF NFERLENDTS VPGLNGRPGA AGGGGGWNDN TSFLWSGKSL 480

LEGATGGKSC PQAMKKWGWE TRGGFGGGGG GCSSGGGGGG YIGGNAAENN DPEMDGEDGV 540

SFLNIQYGTL FTPALKVTEG HGEVNIKLYV NCSHCAHDLC YRDVKTQEIV CTCLYGYVLA 600

ENGISCSAEM VQPTKNPPLS LVLSVVTSAL VASLILAFSG IMIVYRRKHQ ELQAMQMELQ 660

SPEYKLSKLR TSTIMTDYNP NYCFAGKTTS ISDLKEVPRK NISLIRGLGH GAFGEVYEGQ 720

VVGIPSDPNP LQVAVKTLPE VCSEQDELDF LMEALIISKF NHQNIVRCIG VSLQALPRFI 780

LLELMAGGDL KSFLRETRPR PSHPSSLVML DLLHVARDIA CGCQYLEENH FIHRDIAARN 840

CLLTCKGPGR IAKIGDFGMA RDIYRASYYR KGGCAMLPVK WMPPEAFMEG IFTSKTDTWS 900

FGVLLWEIFS LGYMPYPSKS NQEVLEFVTS GGRMDPPKNC PGPVYRIMTQ CWQHQPEDRP 960

NFAIILERIE YCTQDPDVIH TVLPVEYGPC IEEEEKVPVR PEDPEAVPPL LVLPQQEKRG 1020

AQQLLPSPLS LALAIPPGKP LMKVAGIEQP PVRGNTQAPL EGGHVNMAYA QSNSATELHK 1080

GGGSRNKPTN LWNPTYGSWF SEKPVVKNTS QVEKEATEGE GSGHEGNSTL GSSIVTGRLP 1140

SSSLLLEPSS LTASVKEVPL FRLRHFPCGN VNYGYQQQGL PLEAPAPP 1188

Nucleotide Sequence
(FASTA)

TCTGCAGGAC TTCCTTTGAG TTCTAAAATG GCTCTGCAGA GTTCTTTCAA CTGCTGGAAT 60

GGAATGACAA TCAAGCTGGG ACAGGTGTGT GACTTCACCA GAGATTGTGC TGAAGGAGAG 120

GATGAGGGAC AGCAATGCAA AAATCTGCCC CCTGGCTTCT ACTGCTCCTT TGAGAATGGA 180

GACTGTGGAT GGACTCAGAG TTCACCAACC TCTCAAGAGA TCCATTTCTG GCATATTGGA 240

AACCCAAAGA ATAAGCATTT TTGTTTACTG AAAGAATGTG CACTTTTGCT TAACACCAGT 300

GAAACACCAG TTACAGAAGC AGTGGTGATG ACCAGTGCAG TGTTTCCAGC TCCAATGAAA 360

AACTCTCCCT GTGAGCTTCG TATGGCATGG TTCCTCCATG GTATCTTGCT TGGAGATGTT 420

TCCCTCTTCC TTGTTGAGAA CAAGACTGGG AAGGAACACA GCAGAAAGCT GTGGCATTTT 480

GAGAACAGAA AAGGATTGGG AGTCTGGCAG AAGATGGTCA GGCCTCTCAT TGATGTGTCA 540

GACAGGTTTT GGCTTCAAAT TATTACATCC TGGAAAGTTG GGTCAGAAGC CATCATTGCT 600

TTTGATAATG TATCACTCAG CCTGGACTGT TACCTAACAA AGAGGGGATT CATAAGTGGC 660

CACTCAAATC CATATCTCCA AAATGGTTCA AACAAAACCA GCCAAATACA CAAGAGAAAC 720

TCACATAATA TTGAACTAGA TCTGGGGAGA CCAGGCATCA AATCTCCACA AACCCGGCCA 780

GCAATGTGTC CCCAAGATAA TTGGCTGTTT ACCACTTGTG GTGCCAGTGG ACCTCATGGG 840

CCCACTCAGA CCCAATGTAA TGATGCCTAT AGGAATGTCA ACCTCAGTGT ACTCTTAGGG 900

GCAGAAGAAG GTTTCCCAGG TGTACAGATC TGGAAAGTAC CTGCAACAGA TACATACAGC 960

ATCTCTACTT ATGGGGCAGC TGGTGGCAAA GGGAAGAACA CCATAATGAG GTCAAATGGT 1020

GTGAATGTAG CAGGAATATT TAAACTCCAG AAGAATGAAT CCTTGTATAT TTTGGTGGGG 1080

CAACAAGGAG AAGATGCCTG TCCTAGTGCC AATCACATCA TTCAGAAAGT CTGCCTTGGA 1140

GAGAATAATG TGGTTGAAGA GGAAATTAAA GCAAACAAGA GCATCTATGA ATGGGCAGGA 1200

GGAGGTGGCG GAGGTGGAGG AGCAACCTAC ATATTTAAGA TGGAGAATGG AAAGCCAGTT 1260

CCTTTGATCA TTGCAGCAGG GGGAGGTGGT AGGGCCTATA GAGCCAAAAC ATATACATTC 1320

AACTTTGAAA GACTGGAGAA TGATACTTCT GTACCAGGGC TCAATGGGAG ACCAGGAGCT 1380

GCAGGTGGTG GAGGTGGCTG GAATGATAAC ACTTCCTTCC TCTGGTCGGG AAAGTCTTTG 1440

CTGGAAGGCG CTACCGGAGG AAAATCCTGC CCCCAGGCCA TGAAGAAGTG GGGGTGGGAG 1500

ACAAGAGGGG GTTTCGGAGG GGGTGGCGGG GGGTGCTCCT CAGGTGGAGG AGGCGGAGGA 1560

TATATAGGTG GCAATGCAGC AGAAAACAAT GATCCAGAGA TGGATGGAGA GGATGGTGTT 1620

TCTTTTCTAA ATATCCAATA TGGAACATTA TTTACCCCTG CATTAAAAGT GACTGAGGGG 1680

CATGGGGAAG TCAACATCAA GTTGTATGTG AACTGTAGCC ACTGTGCCCA TGACTTATGC 1740

TATAGGGACG TGAAGACACA GGAAATTGTT TGCACTTGTC TCTATGGATA TGTCTTGGCT 1800

GAAAATGGTA TCTCTTGCTC AGCTGAAATG GTGCAGCCAA CGAAGAACCC TCCTCTCTCC 1860

TTGGTCTTGT CTGTAGTGAC TTCTGCCCTT GTTGCATCTC TCATTCTGGC CTTCTCAGGG 1920

ATCATGATAG TGTACCGCCG GAAACACCAG GAACTGCAAG CCATGCAGAT GGAGTTACAG 1980

AGCCCTGAGT ATAAACTGAG CAAGTTGCGC ACCTCCACCA TTATGACCGA CTACAACCCC 2040

AATTATTGCT TTGCAGGGAA GACCACTTCC ATTAGCGACC TTAAAGAGGT GCCCCGGAAA 2100

AATATCTCTC TAATAAGAGG TTTAGGCCAT GGAGCCTTTG GGGAGGTGTA TGAAGGTCAA 2160

GTGGTTGGGA TCCCAAGTGA CCCCAATCCC TTGCAAGTGG CTGTAAAAAC TTTGCCAGAG 2220

GTTTGTTCTG AGCAAGATGA ACTGGATTTC CTCATGGAAG CTCTTATAAT CAGCAAGTTC 2280

AACCATCAGA ATATTGTGCG TTGCATTGGG GTGAGCTTGC AGGCCCTGCC ACGCTTTATT 2340

CTGCTGGAGC TTATGGCTGG AGGAGACCTG AAATCTTTCC TGAGGGAGAC TCGACCAAGA 2400

CCAAGCCATC CCTCCTCCCT GGTCATGCTG GACCTGCTAC ACGTGGCTCG TGACATTGCT 2460

TGTGGCTGTC AGTATTTGGA AGAAAACCAT TTCATTCACA GAGACATTGC TGCTCGAAAT 2520

TGCCTACTTA CTTGTAAAGG CCCTGGAAGA ATAGCTAAAA TTGGAGATTT CGGAATGGCT 2580

CGAGACATAT ACAGGGCCAG CTACTACAGA AAAGGAGGGT GTGCAATGCT CCCCGTCAAG 2640

TGGATGCCAC CTGAGGCCTT TATGGAAGGA ATATTTACAT CCAAAACAGA CACTTGGTCA 2700

TTTGGAGTGC TGCTATGGGA AATATTCTCT CTTGGATATA TGCCTTACCC CAGCAAAAGT 2760

AACCAGGAGG TCCTAGAGTT TGTAACAAGT GGAGGAAGAA TGGATCCACC AAAAAACTGC 2820

CCTGGCCCAG TGTATCGGAT AATGACCCAG TGCTGGCAAC ACCAGCCTGA AGACAGGCCA 2880

AATTTTGCCA TAATACTGGA GAGGATTGAA TACTGCACCC AGGATCCTGA TGTCATTCAT 2940

ACTGTTCTGC CTGTGGAATA TGGCCCGTGC ATTGAAGAAG AAGAAAAGGT TCCAGTTCGT 3000

CCCGAAGACC CTGAGGCAGT TCCTCCTCTG CTAGTCCTGC CACAGCAAGA GAAAAGGGGT 3060

GCTCAACAGC TCTTGCCATC CCCTCTCTCG TTGGCCTTAG CCATCCCTCC TGGAAAGCCT 3120

CTTATGAAAG TGGCTGGCAT TGAGCAGCCG CCAGTCCGTG GCAACACGCA GGCACCCCTG 3180

GAAGGAGGAC ATGTCAACAT GGCGTATGCT CAGTCCAACT CTGCAACTGA GCTCCACAAA 3240

GGTGGCGGGT CCAGAAACAA ACCCACCAAT CTCTGGAACC CGACGTATGG CTCTTGGTTT 3300

TCAGAGAAGC CAGTTGTCAA AAACACTTCA CAGGTGGAAA AAGAGGCAAC TGAAGGGGAA 3360

GGTTCTGGGC ATGAAGGGAA CAGTACTTTG GGATCCAGCA TTGTGACTGG AAGGCTGCCA 3420

AGCTCCTCCC TTCTTCTAGA ACCATCTTCA CTGACAGCCA GTGTTAAAGA AGTGCCTCTG 3480

TTCAGGCTCC GCCATTTCCC GTGTGGGAAC GTTAACTATG GATACCAACA GCAGGGCTTG 3540

CCTTTGGAAG CCCCTGCTCC ACCC 3564

Domain Profile

S: 1     ielvralGkGafGevyeglvsglpgdasklavavktlpesaseqdeldflkealiiskfn  60

         i l+r+lG+GafGevyeg+v g+p+d+ +l+vavktlpe++seqdeldfl+ealiiskfn

Q: 702   ISLIRGLGHGAFGEVYEGQVVGIPSDPNPLQVAVKTLPEVCSEQDELDFLMEALIISKFN  761

         679*********************************************************

S: 61    henivrliGvsleklprlillellaGGdlksflresrpkpeqlsslamkdllkvaldvak  120

         h+nivr+iGvsl++lpr+illel+aGGdlksflre+rp+p+++ssl+m dll+va+d+a+

Q: 762   HQNIVRCIGVSLQALPRFILLELMAGGDLKSFLRETRPRPSHPSSLVMLDLLHVARDIAC  821

         ************************************************************

S: 121   GckyleenkfihrdiaarnillsskGpsrvakiadfGmardiyraeyyrkggrallpvkw  180

         Gc+yleen+fihrdiaarn+ll++kGp+r+aki+dfGmardiyra+yyrkgg+a+lpvkw

Q: 822   GCQYLEENHFIHRDIAARNCLLTCKGPGRIAKIGDFGMARDIYRASYYRKGGCAMLPVKW  881

         ************************************************************

S: 181   mppeafleGiftsktdvwsfGvllwevfslGvvpypgksnqevlelvveGgrldspkeip  240

         mppeaf+eGiftsktd+wsfGvllwe+fslG++pyp+ksnqevle+v++Ggr+d+pk++p

Q: 882   MPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCP  941

         ************************************************************

S: 241   gsvyrimtdcwkhepedrpkfvsilerlqa  270

         g+vyrimt+cw+h+pedrp+f++iler+++

Q: 942   GPVYRIMTQCWQHQPEDRPNFAIILERIEY  971

         ***************************986

Domain Sequence
(FASTA)

ISLIRGLGHG AFGEVYEGQV VGIPSDPNPL QVAVKTLPEV CSEQDELDFL MEALIISKFN 60

HQNIVRCIGV SLQALPRFIL LELMAGGDLK SFLRETRPRP SHPSSLVMLD LLHVARDIAC 120

GCQYLEENHF IHRDIAARNC LLTCKGPGRI AKIGDFGMAR DIYRASYYRK GGCAMLPVKW 180

MPPEAFMEGI FTSKTDTWSF GVLLWEIFSL GYMPYPSKSN QEVLEFVTSG GRMDPPKNCP 240

GPVYRIMTQC WQHQPEDRPN FAIILERIEY 270

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0000187	; P:activation of MAPK activity
GO:0048666	; P:neuron development
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR026830	; ALK.
IPR008985	; ConA-like_lec_gl_sf.
IPR011009	; Kinase-like_dom.
IPR002172	; LDrepeatLR_classA_rpt.
IPR000998	; MAM_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR002011	; Tyr_kinase_rcpt_2_CS.

Pfam

PF00629	; MAM; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00192	; LDLa; 1.
SM00219	; TyrKc; 1.

Prosites

PS50060	; MAM_2; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00239	; RECEPTOR_TYR_KIN_II; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013