EKS-ANC-00271

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ANC-00271

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	411.2	2.1E-123	188	477	290

Status

Unreviewed

Ensembl Protein

ENSACAP00000008927

UniProt Accession

H9GET5;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR2B

Gene Synonyms/Alias

ACVR2B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSACAG00000009033	ENSACAP00000008927	ENSACAT00000009118

Organism

Anolis carolinensis

Functional Description

Protein Length

511

Protein Sequence
(FASTA)

LVLSWLQPSI LCLPTGPGHG EAETRECIYY NANWELEKTN QSGVERCEGE KDKRLHCYAS 60

WRNNSGSIEL VKKGCWLDDF NCYDRQECVA TEESPQVFFC CCEGNYCNEK FTHLPEVSGP 120

EVVYEPPPPT PSLLNILVYS LLPIIALSIA ILLAFWMYRH RKPPYGHVDI SEDPGLPPPS 180

PLVGLKPLQL LEIKARGRFG CVWKAQLMND YVAVKIFPIQ DKQSWQSERE IFNTPGMKHE 240

NLLQFIAAEK RGTNLETELW LITAFHDKGS LTDYLKGNII SWNELCHMAE TMAHGLSYLH 300

EDVPWCKGGH KPAIAHRDFK SKNVLLKSDL TAVLADFGLA VRFEPGKPPG DTHGQVGTRR 360

YMAPEVLEGA INFQRDAFLR IDMYAMGLVL WELVSRCRAA DDSGPVDEYM LPFEEEIGQH 420

PSLEDLQEVV VHKKMRPAFK DHWLKHPGLA QLCVTIEECW DHDAEARLSA GCVEERISQI 480

RKAVNGTTSD CLVSIVTSVT NMDLLPKESS I 511

Nucleotide Sequence
(FASTA)

CTAGTCCTAT CATGGCTTCA GCCTTCTATT TTGTGTCTTC CTACAGGGCC GGGCCATGGC 60

GAGGCAGAGA CAAGGGAATG CATCTACTAT AATGCCAACT GGGAACTGGA AAAAACCAAC 120

CAGAGTGGAG TGGAGCGCTG CGAAGGGGAG AAGGACAAGC GCCTCCACTG CTATGCTTCC 180

TGGAGAAACA ACTCTGGCTC CATTGAACTG GTGAAGAAAG GATGTTGGCT TGATGACTTC 240

AACTGTTATG ACAGGCAGGA ATGTGTGGCC ACAGAAGAGA GTCCACAAGT GTTCTTCTGC 300

TGCTGTGAGG GGAACTACTG CAATGAGAAA TTCACTCACT TACCTGAAGT CAGCGGTCCG 360

GAAGTCGTAT ATGAGCCTCC TCCACCGACT CCCTCTCTGC TCAACATTCT GGTTTACTCT 420

CTGCTTCCAA TCATTGCCCT CTCCATCGCC ATTCTCCTGG CCTTCTGGAT GTATCGTCAT 480

CGCAAGCCGC CGTACGGACA TGTTGATATT AGTGAGGACC CAGGGCTGCC GCCACCTTCT 540

CCTCTGGTTG GACTTAAGCC ATTGCAATTA CTAGAGATCA AGGCAAGAGG CCGCTTTGGT 600

TGTGTCTGGA AGGCGCAGCT GATGAATGAC TATGTAGCAG TGAAAATCTT CCCCATACAG 660

GATAAGCAGT CCTGGCAGAG CGAGCGGGAG ATTTTCAACA CCCCAGGCAT GAAGCATGAA 720

AACCTCTTGC AGTTTATTGC AGCAGAGAAG CGAGGAACCA ACCTGGAGAC AGAGCTGTGG 780

CTGATCACAG CTTTTCATGA CAAGGGCTCT CTGACTGACT ACCTGAAGGG AAACATTATT 840

AGTTGGAATG AACTCTGTCA TATGGCTGAA ACAATGGCTC ATGGACTCTC CTACCTGCAT 900

GAAGATGTCC CTTGGTGTAA AGGAGGACAC AAACCTGCTA TAGCACACAG GGACTTCAAG 960

AGCAAAAATG TATTGTTGAA GAGTGACTTG ACAGCTGTGC TAGCTGACTT TGGATTGGCT 1020

GTACGGTTTG AACCTGGAAA ACCTCCAGGA GATACCCATG GACAGGTGGG AACAAGGAGG 1080

TACATGGCTC CTGAGGTCTT AGAGGGAGCA ATAAACTTCC AGAGAGACGC TTTCCTAAGA 1140

ATAGACATGT ATGCAATGGG GCTAGTCTTG TGGGAGTTGG TCTCCAGATG CAGAGCAGCT 1200

GACGATTCAG GTCCCGTGGA TGAGTACATG CTGCCCTTTG AAGAAGAGAT AGGACAGCAC 1260

CCATCCCTTG AGGACCTCCA GGAGGTGGTA GTTCACAAGA AGATGCGCCC TGCATTCAAG 1320

GATCACTGGC TTAAACATCC TGGTTTGGCG CAGCTTTGTG TCACGATTGA GGAATGCTGG 1380

GACCATGATG CAGAGGCACG CCTATCTGCA GGTTGTGTAG AGGAAAGGAT TTCTCAGATA 1440

CGCAAAGCAG TAAACGGTAC TACCTCGGAC TGCCTCGTTT CCATCGTGAC CTCCGTCACC 1500

AACATGGACT TGCTGCCCAA AGAATCAAGT ATCTAA 1536

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         l+lle+ ++Gr+g+Vwka+l++++vAvKif+ +d++sw++E+ei++t+ ++hen+lqfia

Q: 188   LQLLEIKARGRFGCVWKAQLMNDYVAVKIFPIQDKQSWQSEREIFNTPGMKHENLLQFIA  247

         6899********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         a+k+ ++++tel+l+t++h+kgsL+dyLk ++++++el+++a+++a+Gl++LHe+++++k

Q: 248   AEKRGTNLETELWLITAFHDKGSLTDYLKGNIISWNELCHMAETMAHGLSYLHEDVPWCK  307

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g +KpaiaHRD+kskN+l+k+dlt+++aD+GLa+++e  k   d  ++ qvGt+RYmaPE

Q: 308   GGHKPAIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGD--THGQVGTRRYMAPE  365

         *****************************************888..79************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRcee..vdeeveeyklpfeevvgsdPsle  238

         vle+a+n+++ +af r+D+Y++gLvlWE++sRc++   ++ v+ey+lpfee++g++Psle

Q: 366   VLEGAINFQR-DAFLRIDMYAMGLVLWELVSRCRAadDSGPVDEYMLPFEEEIGQHPSLE  424

         *********9.9**********************9666779*******************

S: 239   emkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         +++evvv+kk+rP ++++w k++ l++l+ ++eecWd+d+eaRl+a +v++r+

Q: 425   DLQEVVVHKKMRPAFKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERI  477

         **************************************************985

Domain Sequence
(FASTA)

LQLLEIKARG RFGCVWKAQL MNDYVAVKIF PIQDKQSWQS EREIFNTPGM KHENLLQFIA 60

AEKRGTNLET ELWLITAFHD KGSLTDYLKG NIISWNELCH MAETMAHGLS YLHEDVPWCK 120

GGHKPAIAHR DFKSKNVLLK SDLTAVLADF GLAVRFEPGK PPGDTHGQVG TRRYMAPEVL 180

EGAINFQRDA FLRIDMYAMG LVLWELVSRC RAADDSGPVD EYMLPFEEEI GQHPSLEDLQ 240

EVVVHKKMRP AFKDHWLKHP GLAQLCVTIE ECWDHDAEAR LSAGCVEERI 290

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0017002	; F:activin-activated receptor activity
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0023014	; P:signal transduction by phosphorylation

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR015768	; Activin_II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013