EKS-ANC-00264

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ANC-00264

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	465.9	4.5E-140	205	492	288

Status

Unreviewed

Ensembl Protein

ENSACAP00000009037

UniProt Accession

G1KIM7;

Protein Name

Protein Synonyms/Alias

Gene Name

TGFBR1

Gene Synonyms/Alias

TGFBR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSACAG00000009195	ENSACAP00000009037	ENSACAT00000009230

Organism

Anolis carolinensis

Functional Description

Protein Length

503

Protein Sequence
(FASTA)

MEAVSERSSL VKWLPLLCVP ILPHLTALQC YCLLCQQDNY TCTTDGLCIT SITRSREKTI 60

PNSMCIAEVD LIPKDRPFIC ATSTSEGVTT VPYCCDQDFC NKIDLPIPTP GPIPGKLSSN 120

LGPVELAAVI AGPVCFVCIS LMLVLYICHN RTVIHHRVPN EEDPSMDRPF ISEGTTLKDL 180

IYDMTTSGSG SGLPLLVQRT IARTIVLQES IGKGRFGEVW RGKWRGEEVA VKIFSSREER 240

SWFREAEIYQ TVMLRHENIL GFIAADNKDN GTWTQLWLVS DYHEHGSLFD YLNRYTVTVE 300

GMIKLSLSTA SGLAHLHMEI VGTQGKPAIA HRDLKSKNIL VKKNGTCCIA DLGLAVRHDS 360

ATDTIDIAPN HRVGTKRYMA PEVLDDSINM KHFESFKRAD IYAMGLVFWE IARRCSIGGI 420

HEDYQLPYYD LVPSDPSVEE MRKVVCEQKL RPNIPNRWQS CEALRVMAKI MRECWYANGA 480

ARLTALRIKK TLSQLSQQEG IKM 503

Nucleotide Sequence
(FASTA)

ATGGAGGCAG TCAGTGAGAG GAGTTCACTA GTGAAATGGC TGCCTCTCTT GTGTGTACCC 60

ATCTTGCCTC ATTTGACAGC CTTACAGTGT TATTGCCTTC TCTGCCAACA AGATAACTAT 120

ACTTGCACAA CGGATGGGCT CTGCATTACT TCGATAACAC GGAGCCGAGA GAAAACCATA 180

CCTAACAGCA TGTGCATCGC AGAAGTTGAT CTGATTCCTA AGGATAGGCC ATTTATTTGT 240

GCCACCTCAA CAAGTGAAGG AGTTACAACT GTGCCTTATT GCTGTGATCA AGACTTCTGC 300

AATAAAATAG ATCTTCCAAT TCCAACACCA GGTCCTATAC CAGGAAAGCT TTCTTCTAAT 360

CTAGGACCAG TGGAACTGGC TGCTGTCATT GCTGGCCCTG TTTGTTTTGT TTGCATTTCT 420

CTCATGTTGG TTCTGTACAT CTGCCATAAT CGCACAGTCA TCCACCATCG TGTTCCAAAT 480

GAAGAAGATC CTTCAATGGA TCGTCCTTTC ATATCTGAAG GAACTACTTT AAAAGATTTA 540

ATTTATGATA TGACTACATC AGGATCAGGA TCAGGTTTAC CATTACTTGT TCAAAGGACA 600

ATTGCAAGAA CAATTGTATT ACAAGAAAGC ATTGGAAAAG GTCGGTTTGG AGAAGTATGG 660

CGAGGAAAAT GGAGAGGAGA AGAAGTTGCT GTGAAAATTT TTTCTTCAAG AGAAGAGCGT 720

TCTTGGTTTC GTGAGGCAGA AATCTATCAA ACTGTTATGC TACGCCATGA AAATATTCTT 780

GGGTTTATAG CTGCAGACAA CAAAGATAAT GGTACGTGGA CACAGCTCTG GCTGGTGTCA 840

GATTACCATG AGCATGGTTC TCTCTTTGAT TACTTAAACA GATATACAGT CACTGTGGAA 900

GGAATGATAA AACTATCTCT GTCTACTGCC AGCGGACTTG CACATCTTCA TATGGAGATT 960

GTTGGCACCC AGGGGAAACC CGCCATAGCT CACAGAGATT TGAAATCAAA AAATATATTG 1020

GTAAAGAAAA ATGGAACATG CTGTATTGCA GATTTAGGTT TGGCAGTAAG ACATGATTCT 1080

GCTACAGACA CAATAGATAT TGCACCGAAC CACAGAGTGG GAACAAAAAG GTACATGGCT 1140

CCTGAGGTAC TTGATGATTC CATAAATATG AAACATTTTG AGTCTTTCAA AAGAGCCGAT 1200

ATATATGCAA TGGGATTAGT ATTTTGGGAG ATAGCTCGCC GATGTTCCAT TGGTGGAATT 1260

CATGAAGATT ATCAGTTGCC ATATTATGAC TTAGTCCCTT CTGATCCTTC AGTTGAAGAA 1320

ATGAGAAAAG TTGTTTGTGA ACAGAAGCTA CGACCTAATA TTCCAAACAG ATGGCAGAGC 1380

TGTGAGGCCT TACGAGTAAT GGCCAAAATT ATGAGAGAAT GTTGGTATGC CAATGGTGCA 1440

GCAAGGCTAA CAGCTTTACG CATAAAGAAA ACATTATCGC AGCTTAGTCA ACAAGAAGGC 1500

ATAAAAATGT AG 1512

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         + l+e igkGr+geVw++k+rgeevAvKifs+++e+sw+rE+eiyqtv+lrhenil+fia

Q: 205   IVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA  264

         57899*******************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k+++++t+l+lv++yhe+gsL+dyL+r+t++ve +++l ls+asGlahLH+eivgt+

Q: 265   ADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLSLSTASGLAHLHMEIVGTQ  324

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNilvkk++tcciaDlGLa++++++++++d+a n++vGtkRYmaPE

Q: 325   G--KPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPE  382

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl++++n+k+fe+fkraD+Y++gLv+WE+a+Rc+  ++++e+y+lp+++ v+sdPs+eem

Q: 383   VLDDSINMKHFESFKRADIYAMGLVFWEIARRCSI-GGIHEDYQLPYYDLVPSDPSVEEM  441

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+e+klrP+ip++w+++eal++++k+++ecW+a+++aRltalr+kk+l

Q: 442   RKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTL  492

         *************************************************97

Domain Sequence
(FASTA)

IVLQESIGKG RFGEVWRGKW RGEEVAVKIF SSREERSWFR EAEIYQTVML RHENILGFIA 60

ADNKDNGTWT QLWLVSDYHE HGSLFDYLNR YTVTVEGMIK LSLSTASGLA HLHMEIVGTQ 120

GKPAIAHRDL KSKNILVKKN GTCCIADLGL AVRHDSATDT IDIAPNHRVG TKRYMAPEVL 180

DDSINMKHFE SFKRADIYAM GLVFWEIARR CSIGGIHEDY QLPYYDLVPS DPSVEEMRKV 240

VCEQKLRPNI PNRWQSCEAL RVMAKIMREC WYANGAARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0044459	; C:plasma membrane part
GO:0043235	; C:receptor complex
GO:0005923	; C:tight junction
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0000186	; P:activation of MAPKK activity
GO:0071560	; P:cellular response to transforming growth factor beta stimulus
GO:0030199	; P:collagen fibril organization
GO:0043542	; P:endothelial cell migration
GO:0006917	; P:induction of apoptosis
GO:0043066	; P:negative regulation of apoptotic process
GO:0032331	; P:negative regulation of chondrocyte differentiation
GO:0060389	; P:pathway-restricted SMAD protein phosphorylation
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:0030307	; P:positive regulation of cell growth
GO:0008284	; P:positive regulation of cell proliferation
GO:0051272	; P:positive regulation of cellular component movement
GO:0051491	; P:positive regulation of filopodium assembly
GO:0010862	; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0051897	; P:positive regulation of protein kinase B signaling cascade
GO:0060391	; P:positive regulation of SMAD protein import into nucleus
GO:0045893	; P:positive regulation of transcription, DNA-dependent
GO:0043393	; P:regulation of protein binding
GO:0031396	; P:regulation of protein ubiquitination
GO:0023014	; P:signal transduction by phosphorylation
GO:0007179	; P:transforming growth factor beta receptor signaling pathway

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013