EKS-ANC-00151
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ANC-00151
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/RSK342.02.5E-10224293270
StatusUnreviewed
Ensembl ProteinENSACAP00000009834
UniProt AccessionG1KJL7;
Protein NameRibosomal protein S6 kinase
Protein Synonyms/Alias
Gene NameRPS6KA5
Gene Synonyms/Alias RPS6KA5;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSACAG00000009878ENSACAP00000009834ENSACAT00000010035
OrganismAnolis carolinensis
Functional Description
Protein Length838
Protein Sequence
(FASTA)
LTVKSFCVSA NLTGHVEKVG IENFELLKVL GTGAYGKVFL VRKISGHNSG KLYAMKVLKK 60
ATIIQKAKTT EHTKTERQVL EHIRQSPFLV TLHYAFQTDT KLHLILDYIN GGELFTHLSQ 120
REKFTEDEVR IYIGEIVLAL EHLHKLGIIY RDIKLENILL DSDGHVVLTD FGLSKEFVGD 180
ENKRAYSFCG TIEYMAPDIV KGGETGHDKA VDWWSLGVLT YELLTGASPF TVDGERNSQT 240
DISRRILKSE PPYPQEITNL AKDFIQCLLI KDPKKRLGCG QGGADEVKQH PFFQTINWND 300
LAAKKVTAPF KPIIRDELDV SNFAEEFTEM DPTYSPATTP QAADKLFQGY SFVAPSILFK 360
RNAATMDPVH FLTEFDRPGV TSIARSAMMK DSAFYLHYEL DLKEKPLGEG SFSICRKCMH 420
KKTSQEYAVK IISKRLETNT QREITALKLC EGHPNIVKLH EVYHDQVFLK VKILQLNLII 480
VYILNFILTS GSQPVGHGPT VDRENENPVC EPPSSLFFIL LIFISTPFRR ADLHTFVVME 540
LLKGGELLER IQKKKHFSET EASYIMRRLV SAVSHMHDVG VVHRDLKPEN LLFTDESDNS 600
EIKIIDFGFA RLKPPDNQPL KTPCFTLHYA APELLNHSGY DESCDLWSLG VILYTMLSGQ 660
VPFQSQDKNI TCTSALEIMK NIKRGEFSFE GDAWKNVSQE AKDLIKGLLT VDPNKRIKMT 720
SLRYNEWLQD GSQLSSNPLM TPDNLGSSGA AVHTYVKATF NAFNKYKREG FCLQNVDKAP 780
LAKRRKMKKT STSTETRSSS SESSHSSSSH SHGKTTPTKT LQPANPTDSN NPGNLPVF 838
Nucleotide Sequence
(FASTA)
TTGACAGTCA AATCTTTTTG TGTTTCAGCT AATTTGACAG GCCATGTAGA GAAGGTTGGG 60
ATTGAAAACT TTGAGCTTTT GAAGGTTCTT GGGACAGGAG CTTATGGAAA GGTATTTCTA 120
GTAAGGAAAA TAAGTGGTCA TAATTCTGGC AAGTTGTACG CTATGAAGGT ATTGAAAAAA 180
GCAACAATAA TTCAAAAAGC AAAAACAACT GAACATACAA AGACAGAACG ACAAGTACTA 240
GAACACATTC GACAGTCTCC ATTTTTGGTC ACTTTGCATT ATGCTTTCCA GACAGACACA 300
AAGCTTCATC TCATTTTGGA TTACATAAAT GGTGGAGAAC TTTTTACCCA TCTTTCACAA 360
AGAGAGAAAT TTACTGAAGA TGAGGTGCGA ATATACATTG GGGAAATTGT ATTGGCTCTT 420
GAACACCTAC ATAAGTTAGG AATTATCTAT CGTGATATAA AACTTGAGAA CATTCTTCTT 480
GATTCTGATG GTCATGTGGT ACTGACTGAC TTTGGCTTGA GTAAGGAGTT TGTTGGTGAT 540
GAGAATAAGA GAGCATATTC CTTCTGTGGA ACAATAGAAT ACATGGCTCC AGATATTGTC 600
AAAGGAGGGG AGACAGGACA CGATAAAGCT GTTGATTGGT GGAGTCTGGG TGTTCTTACA 660
TATGAATTAT TGACTGGAGC CTCACCGTTT ACAGTTGATG GAGAAAGAAA TTCACAAACC 720
GATATATCTA GGAGAATATT AAAAAGTGAA CCTCCATATC CTCAAGAAAT TACAAATTTA 780
GCCAAAGATT TTATTCAGTG TCTTCTGATA AAAGATCCGA AGAAGAGACT GGGCTGTGGA 840
CAAGGTGGTG CTGATGAAGT CAAACAACAT CCCTTTTTCC AGACAATAAA TTGGAATGAC 900
TTGGCTGCCA AAAAAGTTAC GGCTCCATTT AAACCAATAA TACGTGATGA ATTAGACGTT 960
AGTAACTTTG CAGAGGAGTT TACAGAAATG GACCCAACAT ATTCTCCAGC GACCACCCCA 1020
CAGGCTGCAG ACAAGCTTTT TCAGGGATAT TCCTTTGTTG CCCCTTCTAT TTTATTCAAA 1080
CGCAATGCAG CTACTATGGA TCCTGTTCAC TTTTTGACAG AGTTTGATCG ACCTGGAGTT 1140
ACAAGTATTG CCAGAAGTGC AATGATGAAG GATTCTGCAT TTTATCTTCA CTATGAACTG 1200
GATCTGAAAG AAAAGCCACT TGGGGAAGGA AGTTTCTCCA TATGTCGAAA ATGCATGCAC 1260
AAGAAAACTA GCCAAGAATA TGCAGTAAAA ATAATTAGCA AAAGGCTTGA AACAAATACT 1320
CAGAGAGAAA TAACAGCATT AAAACTCTGC GAAGGACATC CAAATATTGT GAAGCTGCAT 1380
GAAGTTTATC ATGATCAGGT ATTTTTAAAA GTAAAGATAC TACAGTTGAA CTTAATAATA 1440
GTCTACATAC TAAACTTTAT TTTGACCAGT GGTTCTCAAC CTGTGGGCCA CGGCCCAACA 1500
GTGGACCGCG AGAACGAAAA TCCAGTCTGC GAACCACCTT CCTCTTTATT TTTTATTTTA 1560
TTAATTTTTA TTTCCACTCC TTTCCGCAGA GCTGACCTTC ACACATTTGT AGTAATGGAA 1620
CTACTGAAAG GGGGTGAATT ACTTGAACGC ATTCAGAAAA AGAAACACTT CAGTGAAACC 1680
GAAGCTAGTT ACATCATGCG AAGACTTGTT TCAGCAGTTA GCCATATGCA TGATGTAGGA 1740
GTTGTCCACA GAGACTTGAA ACCTGAGAAC CTATTGTTCA CAGATGAAAG TGATAATTCA 1800
GAAATAAAAA TAATTGATTT TGGATTTGCC CGGTTAAAAC CACCTGACAA CCAGCCTCTT 1860
AAGACTCCAT GCTTTACCTT GCATTATGCT GCTCCAGAGC TCTTGAATCA TAGTGGTTAT 1920
GATGAATCGT GTGACCTCTG GAGTTTGGGA GTCATTTTGT ATACAATGCT CTCAGGACAA 1980
GTGCCCTTCC AATCTCAAGA TAAAAATATA ACCTGCACAA GTGCATTGGA AATCATGAAG 2040
AATATTAAAC GAGGGGAATT TTCTTTTGAA GGGGATGCTT GGAAGAATGT TTCTCAGGAA 2100
GCCAAAGATT TGATTAAAGG ACTTCTTACA GTGGATCCAA ATAAGAGAAT TAAAATGACG 2160
AGTCTGAGAT ACAATGAATG GCTTCAAGAT GGTAGCCAGC TGTCATCCAA CCCATTAATG 2220
ACTCCGGACA ATTTAGGATC TTCAGGAGCT GCTGTCCACA CCTATGTCAA AGCAACCTTT 2280
AATGCCTTTA ACAAGTACAA AAGAGAAGGA TTTTGTCTCC AGAATGTGGA CAAGGCACCT 2340
CTTGCAAAAA GAAGAAAAAT GAAAAAGACA AGCACAAGTA CAGAGACTCG CAGCAGTTCT 2400
AGTGAAAGTT CTCATTCTTC TTCCTCTCAT TCGCATGGTA AAACTACCCC TACAAAGACA 2460
CTGCAGCCAG CAAATCCCAC AGACAGCAAT AATCCAGGGA ATCTTCCAGT TTTCTGA 2517
Domain Profile
S: 1     fellkvlgkGaygkvflvrkvekkdtgklyavKvlkkaelvk..kkkertkeereiLeev  58
         fellkvlg+Gaygkvflvrk++++++gklya+Kvlkka++++  k++e+tk+er++Le++
Q: 24    FELLKVLGTGAYGKVFLVRKISGHNSGKLYAMKVLKKATIIQkaKTTEHTKTERQVLEHI  83
         89***************************************988999*************
S: 59    eh.pfivklheafqdekklylvlellkGgeLlerlkkkklfseeeasfilaelvlaleyl  117
         ++ pf+v+lh+afq+++kl+l+l++++GgeL+++l++++ f+e+e++ ++ e+vlale+l
Q: 84    RQsPFLVTLHYAFQTDTKLHLILDYINGGELFTHLSQREKFTEDEVRIYIGEIVLALEHL  143
         ************************************************************
S: 118   HskgvvyrDLkpeNilldeeghvkltDfglakekiaeneekaysfcgTleyvaPevl..k  175
         H+ g++yrD+k+eNilld++ghv+ltDfgl+ke + +++++aysfcgT+ey+aP+++   
Q: 144   HKLGIIYRDIKLENILLDSDGHVVLTDFGLSKEFVGDENKRAYSFCGTIEYMAPDIVkgG  203
         *********************************************************666
S: 176   rkgydeavDlwslGvllyemLtGktPftgeerketlarilkgkfslklpaweelseeakd  235
         ++g+d+avD+wslGvl ye+LtG++Pft + ++++++ i +  ++ + p  +e+++ akd
Q: 204   ETGHDKAVDWWSLGVLTYELLTGASPFTVDGERNSQTDISRRILKSEPPYPQEITNLAKD  263
         78****************************99988887777666666666677*******
S: 236   lvkklLkkdpakRlga...taeeikehkfl  262
         +++ lL kdp+kRlg+   +a+e+k+h+f+
Q: 264   FIQCLLIKDPKKRLGCgqgGADEVKQHPFF  293
         ****************9999********97
Domain Sequence
(FASTA)
FELLKVLGTG AYGKVFLVRK ISGHNSGKLY AMKVLKKATI IQKAKTTEHT KTERQVLEHI 60
RQSPFLVTLH YAFQTDTKLH LILDYINGGE LFTHLSQREK FTEDEVRIYI GEIVLALEHL 120
HKLGIIYRDI KLENILLDSD GHVVLTDFGL SKEFVGDENK RAYSFCGTIE YMAPDIVKGG 180
ETGHDKAVDW WSLGVLTYEL LTGASPFTVD GERNSQTDIS RRILKSEPPY PQEITNLAKD 240
FIQCLLIKDP KKRLGCGQGG ADEVKQHPFF 270
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Mus musculus"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00149
EKS-MUM-00161
EKS-PES-00139
EKS-RAN-00154
EKS-XET-00152
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0043990; P:histone H2A-S1 phosphorylation
GO:0043987; P:histone H3-S10 phosphorylation
GO:0043988; P:histone H3-S28 phosphorylation
GO:0070498; P:interleukin-1-mediated signaling pathway
GO:0007243; P:intracellular protein kinase cascade
GO:0045892; P:negative regulation of transcription, DNA-dependent
GO:0035066; P:positive regulation of histone acetylation
GO:0033129; P:positive regulation of histone phosphorylation
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
GO:0009605; P:response to external stimulus
GO:0006950; P:response to stress
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR016239; Ribosomal_S6_kinase_II.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 3.
PF00433; Pkinase_C; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 2.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 2.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00108; PROTEIN_KINASE_ST; 2.
Prints
Created Date20-Feb-2013