EKS-ANC-00389
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ANC-00389
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR560.12.0E-168564895332
StatusUnreviewed
Ensembl ProteinENSACAP00000010084
UniProt AccessionG1KJX6;
Protein Name
Protein Synonyms/Alias
Gene NameKIT
Gene Synonyms/Alias KIT;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSACAG00000009902ENSACAP00000010084ENSACAT00000010291
OrganismAnolis carolinensis
Functional Description
Protein Length946
Protein Sequence
(FASTA)
PSITPEESPL VVNSGQELRL FCRDDSAVTW HIQNADPSAL PKHLRSQELY INAVGPRDTG 60
TYTCKDKEGL NDSIYVFVKD PKVLFFHESV AYAVEDSDAL IQCPVTDPEI SNFTLKRCKN 120
AKSLPENIVL KPDPQKGITI KNVQRSFLGC YQCVAQHNGV EKQSEAINLF VRPVHKSLPV 180
ITLSKADQLL KEGEEFEVMC TIRDVDSTLR ANWIVQTNVQ ATSVPEELKQ NLTSKSKNVG 240
DYGYEQKLTL SIRSVGVNDS GAFTCQGSNP FGTSNVTITL TVLGKGYVSL STSTDSTVHV 300
NDGENLALIV TYEAYPKPEE EIWMYMNETL QNSSDHYVRV TNIDRNRHSS ELHLTRLKGT 360
EGGIYTFFVS NSDANSSIAF NVYVNTKPEI VTSERLSNGM LHCVASGYPA PTINWYICPG 420
TEQRCSDSSN ISPVDVKTSY NDSPFPSFGK VVVESTIDAS MFKNNGTITC EASNSIDRRT 480
AYFNFAVKEQ ISTHTLFTPL LIGFGVAAGL MCITVIVLVY KYLQKPKYEI QWKVVDEING 540
NNYVYIDPTQ LPYDDKWEFP RNRLIFGKTL GAGAFGKVVE ATAYGLFKPD GGLRVAVKML 600
KPSAHFTEKE ALMSELKVLS YLGNHINIVN LLGACTIGGP TLVITEYCCY GDLLNFLRRK 660
RDSFICPKHE ETAVYKNLLH QKEHMYDATN EYMDMKPGVS KVVHAKTAKR SPGRTGSFVN 720
QDVTIAILED DELALDIEDL LSFSYQVAKG MSFLSSKNCI HRDLAARNIL LTHGRITKIC 780
DFGLARDIRN DSNYVVKGNA RLPVKWMAPE SIFECVYTFE SDVWSYGILL WELFSLGGSP 840
YPGMPVDSKF YKRIKEGYRM FSPEFAPAEM YEIMKSCWDV DPVKRPTFKQ VVQLIEQQIS 900
DTTNHIYSNV TSGICSQGNG TDHSARINSV GSSASFTQPL LTHEDV 946
Nucleotide Sequence
(FASTA)
CCTTCGATCA CTCCAGAAGA ATCCCCTTTA GTTGTCAATA GTGGGCAAGA ATTAAGGCTG 60
TTTTGTAGGG ATGATAGCGC TGTGACCTGG CATATCCAGA ATGCAGACCC ATCCGCACTG 120
CCCAAGCATC TAAGATCCCA GGAGCTTTAC ATAAATGCAG TTGGACCCAG AGACACAGGG 180
ACATATACGT GCAAGGACAA AGAGGGCTTG AATGACTCCA TTTACGTCTT TGTTAAAGAT 240
CCAAAGGTTC TGTTCTTTCA CGAATCTGTT GCGTATGCAG TTGAAGACAG TGATGCTCTT 300
ATTCAATGCC CAGTGACAGA CCCAGAGATT TCAAATTTCA CATTGAAAAG ATGTAAAAAT 360
GCCAAGTCTC TACCTGAGAA TATTGTGTTA AAACCTGACC CTCAGAAAGG AATTACCATA 420
AAAAATGTAC AAAGATCATT TTTGGGCTGT TACCAATGTG TAGCACAACA CAACGGAGTG 480
GAAAAACAGT CAGAAGCCAT CAACCTTTTT GTGCGGCCAG TTCACAAATC CCTTCCAGTC 540
ATCACCTTAT CCAAAGCCGA CCAACTTCTT AAAGAAGGTG AAGAATTTGA AGTTATGTGC 600
ACAATCAGGG ATGTTGATAG CACTCTGCGA GCTAATTGGA TTGTTCAAAC TAATGTGCAA 660
GCAACAAGTG TGCCAGAGGA ACTGAAGCAG AATCTTACAA GCAAAAGCAA GAATGTGGGT 720
GATTATGGAT ATGAACAAAA ATTAACTCTG AGCATCCGTT CAGTGGGAGT TAATGATTCT 780
GGAGCATTCA CGTGCCAAGG AAGCAACCCT TTTGGAACAT CCAATGTCAC TATAACCTTG 840
ACAGTACTAG GTAAAGGATA TGTCAGTTTA TCAACTTCTA CAGATTCAAC GGTACATGTC 900
AATGATGGAG AAAATCTGGC TTTAATAGTG ACCTATGAAG CATATCCCAA ACCAGAAGAA 960
GAAATATGGA TGTATATGAA TGAAACCTTG CAAAATTCAT CTGATCATTA CGTCAGAGTC 1020
ACAAATATAG ACCGAAACAG ACACTCCAGT GAGCTTCACC TTACTCGACT GAAAGGAACA 1080
GAAGGAGGCA TTTACACATT TTTTGTGTCC AATTCAGATG CTAACTCCTC TATAGCGTTC 1140
AACGTCTATG TCAACACCAA ACCAGAGATT GTCACTTCAG AAAGACTTAG CAACGGCATG 1200
CTTCATTGTG TGGCTTCAGG GTACCCTGCC CCTACAATAA ACTGGTACAT TTGCCCAGGA 1260
ACTGAGCAGA GGTGTTCAGA TTCATCAAAT ATTTCTCCAG TGGACGTGAA GACCAGCTAT 1320
AATGATTCAC CCTTTCCTTC CTTTGGAAAG GTAGTCGTTG AAAGCACCAT TGATGCCAGC 1380
ATGTTCAAGA ACAACGGCAC AATCACATGT GAGGCTTCCA ACTCCATTGA CAGGCGCACA 1440
GCTTATTTCA ACTTTGCAGT CAAAGAACAA ATCAGCACTC ATACCCTTTT CACCCCTTTG 1500
CTAATTGGCT TTGGAGTCGC AGCAGGTCTC ATGTGCATCA CAGTTATAGT TCTTGTGTAC 1560
AAATATCTTC AGAAACCCAA GTATGAGATT CAGTGGAAAG TGGTTGATGA AATAAATGGA 1620
AACAACTATG TTTACATAGA CCCAACACAG CTTCCATATG ATGACAAATG GGAGTTTCCA 1680
AGAAACCGGC TAATTTTTGG CAAGACTCTA GGAGCTGGAG CTTTTGGGAA AGTTGTTGAA 1740
GCAACTGCCT ATGGTCTGTT CAAACCTGAT GGAGGATTGA GAGTAGCTGT AAAAATGCTC 1800
AAGCCCAGTG CCCATTTCAC TGAAAAGGAA GCCTTGATGT CAGAACTGAA AGTGTTGAGT 1860
TACCTTGGCA ACCATATTAA CATTGTGAAT TTACTAGGAG CCTGCACAAT TGGAGGTCCT 1920
ACCCTGGTCA TCACGGAATA TTGCTGTTAT GGCGACCTTT TGAATTTCCT GAGGAGAAAA 1980
CGTGATTCTT TTATTTGCCC AAAGCATGAA GAAACAGCTG TTTACAAGAA CCTCCTCCAT 2040
CAAAAAGAAC ACATGTATGA TGCCACCAAT GAATATATGG ATATGAAACC TGGAGTTTCT 2100
AAGGTTGTCC ATGCCAAAAC TGCTAAAAGA AGTCCAGGAA GGACAGGATC GTTTGTTAAT 2160
CAGGATGTCA CCATTGCCAT CTTAGAAGAT GATGAACTGG CTCTGGATAT TGAAGACCTA 2220
TTAAGTTTTT CTTACCAGGT GGCAAAGGGA ATGAGCTTTC TGTCCTCGAA AAATTGCATC 2280
CATAGAGACT TGGCAGCACG CAACATCCTG CTCACTCATG GACGGATCAC AAAAATCTGT 2340
GACTTTGGTC TTGCAAGAGA CATTAGGAAT GACTCAAACT ATGTTGTCAA AGGAAATGCA 2400
CGACTTCCTG TCAAGTGGAT GGCACCTGAA AGCATTTTTG AGTGTGTATA CACATTTGAG 2460
AGTGATGTCT GGTCTTATGG AATTTTGCTT TGGGAACTCT TCTCTCTAGG AGGCAGCCCC 2520
TATCCTGGAA TGCCTGTGGA TTCCAAGTTC TATAAAAGGA TTAAGGAAGG ATACAGGATG 2580
TTTAGCCCAG AATTTGCACC TGCTGAAATG TATGAGATAA TGAAGAGTTG TTGGGATGTT 2640
GATCCTGTAA AGAGACCAAC CTTTAAGCAA GTTGTACAAC TGATTGAACA ACAGATTTCA 2700
GATACTACAA ACCATATTTA CTCAAATGTT ACAAGCGGCA TTTGCAGTCA AGGAAATGGT 2760
ACAGATCATT CTGCAAGAAT CAACTCAGTG GGCAGCAGTG CTTCGTTTAC TCAGCCTCTC 2820
CTCACACATG AAGATGTTTG A 2841
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l +Gk+lG+GafGkvveatayGl k d  l+vavkmlk++a+ +ekealmselk+ls+lG
Q: 564   LIFGKTLGAGAFGKVVEATAYGLFKPDGGLRVAVKMLKPSAHFTEKEALMSELKVLSYLG  623
         679*********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h nivnllGact gGp++viteyccyGdlln+lrrkr+sf+     k   +ee + +k+
Q: 624   NHINIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFIC---PK---HEETAVYKN  677
         ******************************************3...33...455667777
S: 121   lladkslrsksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaaleeed  180
         l     l++k+    ++++ey+d+k++vs+v ++k+ k++  ++ s+++++v+ a+ e+d
Q: 678   L-----LHQKE-HMYDATNEYMDMKPGVSKVVHAKTAKRSPGRTGSFVNQDVTIAILEDD  731
         7.....44444.456999******************************************
S: 181   sevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimkd  240
         + +l++edllsfsyqvakGm fl+sknc+hrdlaarn+llt+G+++kicdfGlardi++d
Q: 732   ELALDIEDLLSFSYQVAKGMSFLSSKNCIHRDLAARNILLTHGRITKICDFGLARDIRND  791
         ************************************************************
S: 241   snyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskfy  300
         snyvvkGnarlpvkwmapesif+++yt++sdvwsyGillwe+fslG++pypg++vdskfy
Q: 792   SNYVVKGNARLPVKWMAPESIFECVYTFESDVWSYGILLWELFSLGGSPYPGMPVDSKFY  851
         ************************************************************
S: 301   klikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344
         k ikeGyrm +p++a++e+yeim++cw+++p krp+fkq+v+l+
Q: 852   KRIKEGYRMFSPEFAPAEMYEIMKSCWDVDPVKRPTFKQVVQLI  895
         *****************************************996
Domain Sequence
(FASTA)
LIFGKTLGAG AFGKVVEATA YGLFKPDGGL RVAVKMLKPS AHFTEKEALM SELKVLSYLG 60
NHINIVNLLG ACTIGGPTLV ITEYCCYGDL LNFLRRKRDS FICPKHEETA VYKNLLHQKE 120
HMYDATNEYM DMKPGVSKVV HAKTAKRSPG RTGSFVNQDV TIAILEDDEL ALDIEDLLSF 180
SYQVAKGMSF LSSKNCIHRD LAARNILLTH GRITKICDFG LARDIRNDSN YVVKGNARLP 240
VKWMAPESIF ECVYTFESDV WSYGILLWEL FSLGGSPYPG MPVDSKFYKR IKEGYRMFSP 300
EFAPAEMYEI MKSCWDVDPV KRPTFKQVVQ LI 332
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00374
EKS-BOT-00402
EKS-CAJ-00407
EKS-CAF-00402
EKS-CAP-00432
EKS-DAR-00787
EKS-EQC-00394
EKS-FEC-00386
EKS-GAG-00341
EKS-GAA-00515
EKS-GOG-00394
EKS-HOS-00409
EKS-ICT-00381
EKS-LAC-00419
EKS-LOA-00412
EKS-MAM-00402
EKS-MEG-00335
EKS-MOD-00391
EKS-MUM-00435
EKS-MUP-00399
EKS-MYL-00397
EKS-NOL-00368
EKS-ORN-00514
EKS-ORA-00347
EKS-ORC-00378
EKS-ORL-00472
EKS-OTG-00405
EKS-PAT-00381
EKS-PES-00357
EKS-POA-00394
EKS-PTV-00114
EKS-RAN-00418
EKS-SAH-00372
EKS-SUS-00353
EKS-TAG-00473
EKS-TAR-00510
EKS-TEN-00511
EKS-XET-00515
EKS-XIM-00506
Gene Ontology
GO:0005737; C:cytoplasm
GO:0009897; C:external side of plasma membrane
GO:0005615; C:extracellular space
GO:0016021; C:integral to membrane
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0005020; F:stem cell factor receptor activity
GO:0031532; P:actin cytoskeleton reorganization
GO:0000187; P:activation of MAPK activity
GO:0097067; P:cellular response to thyroid hormone stimulus
GO:0048066; P:developmental pigmentation
GO:0038093; P:Fc receptor signaling pathway
GO:0006687; P:glycosphingolipid metabolic process
GO:0007243; P:intracellular protein kinase cascade
GO:0002551; P:mast cell chemotaxis
GO:0043303; P:mast cell degranulation
GO:0043069; P:negative regulation of programmed cell death
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0008284; P:positive regulation of cell proliferation
GO:0010628; P:positive regulation of gene expression
GO:0043410; P:positive regulation of MAPK cascade
GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0042511; P:positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042523; P:positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0046777; P:protein autophosphorylation
GO:0048070; P:regulation of developmental pigmentation
GO:0009314; P:response to radiation
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
Pfam
PF07679; I-set; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 4.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 4.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
Created Date20-Feb-2013