EKS-ANC-00288
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ANC-00288
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR499.71.5E-150471728258
StatusUnreviewed
Ensembl ProteinENSACAP00000009958
UniProt AccessionG1KJS5;
Protein Name
Protein Synonyms/Alias
Gene NameERBB4
Gene Synonyms/Alias ERBB4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSACAG00000009921ENSACAP00000009958ENSACAT00000010163
OrganismAnolis carolinensis
Functional Description
Protein Length1046
Protein Sequence
(FASTA)
ACMNFNDSGA CVTQCPQTSV YNPATFQMEN NRDGKYTYGA FCVKKCPHNF VVDISSCVRA 60
CPSPKMEVEE NGIKTCKPCT DICPKACDGI GTGSLMYAQT VDSSNIDKFV NCTKINGNLI 120
FLVTGIHGDP YHTIEAIDPQ NLNIFQTVRE ITGFLNIQSW PENMTDFSVF SNLVTIGGRA 180
LYSGLSLLIL KQHGIRSLQF QSLKHISAGN VYITDNSNLC YYHTINWTSL FSTPNQKTVI 240
HRNKKAENCT TEGMVCSPLC SRNGCWGPGP DQCLSCRHFI RGRTCVKACN LYDGEYREFA 300
NGSVCVECDP QCEKMDNNRI TCRGPGPDHC TKCFHFKDGP NCVEKCPDGV QGTNSFIFKY 360
ADEDRECHSC HPNCTQGCRG PTSHDCIYYP WTRQSTLLQH ARTPLIAAGV IGGLFIIVIL 420
GLTFAVYVRR KSIKKKRALR RFLETELVEP LTPSGTAPNQ AQLRILKETE LKRVKVLGSG 480
AFGTVYKGVW VPEGESVKIP VAIKILNETT GPKANVEFMD EALIMASMDH PHLVRLLGVC 540
LSPTIQLVTQ LMPHGCLLDY VHEHKDNIGS QLLLNWCVQI AKGMMYLEER RLVHRDLAAR 600
NVLVKSPNHV KITDFGLARL LEGDEKEYSA DGGKMPIKWM ALECIHYRKF THQTDVWSYG 660
VTIWELMTFG GKPYDGIPTR EIPDLLEKGE RLPQPPICTI DVYMVMVKCW MIDADSRPKF 720
KELAAEFSRM ARDPQRYLVI QGDDRMKLPS PNDSKFFQNL LDEGDLEDMM DAEEYLVPQA 780
FNIPPPIYTS RARMDSNRNQ FIYRDGTLAA EQGVPLPYRA AIPSIAPEPP ILQGAAEICD 840
DTCCNGTLRK QVASLSQEDS ITQRYSADPT GFISERGPRN ELDEDGYMTP MPEKAKADHL 900
HPVEENPFVS RRKNGDLQAL DNPEYHNNSQ NGPPKVEDEY VNEPWYLNTF ASTFENSEYL 960
KKNGLPLPEK PKKAFDNPGY WNHSLPPRST LQHPDYLQEY GTKYFYKQNG RIQPIVAENP 1020
EYLSEFTLKP GTMLPPPPYR HRNTVV 1046
Nucleotide Sequence
(FASTA)
GCATGTATGA ATTTTAATGA CAGTGGGGCT TGCGTCACAC AGTGTCCCCA AACTTCAGTT 60
TACAATCCTG CCACTTTCCA GATGGAAAAC AACCGGGATG GGAAATACAC CTATGGAGCG 120
TTTTGTGTCA AAAAGTGCCC ACATAACTTT GTGGTTGATA TCAGCTCTTG TGTGCGTGCC 180
TGTCCCAGCC CCAAAATGGA AGTGGAAGAA AATGGCATTA AGACATGCAA ACCGTGCACT 240
GACATTTGCC CTAAAGCATG CGATGGCATA GGAACAGGAA GTCTGATGTA TGCTCAGACT 300
GTAGACTCCA GTAACATTGA CAAATTTGTC AACTGCACCA AGATCAATGG GAACCTGATC 360
TTCCTTGTCA CAGGGATTCA TGGGGACCCT TATCATACTA TTGAAGCAAT CGACCCACAG 420
AATTTAAACA TCTTCCAGAC AGTAAGAGAG ATAACAGGGT TCCTGAATAT ACAATCATGG 480
CCTGAAAATA TGACAGATTT CAGTGTGTTT TCTAATCTGG TGACTATAGG TGGGAGAGCC 540
TTATACAGCG GCTTGTCTTT GCTCATTCTC AAGCAGCATG GCATTAGATC TCTGCAGTTT 600
CAATCCCTGA AGCATATCAG CGCTGGTAAT GTCTACATAA CAGATAATAG TAACCTGTGC 660
TACTATCATA CCATCAACTG GACCAGCCTC TTCAGCACTC CCAACCAAAA GACTGTGATC 720
CATAGAAACA AGAAAGCAGA AAACTGCACT ACAGAGGGGA TGGTATGCAG TCCTTTGTGC 780
TCGAGAAATG GATGTTGGGG ACCAGGGCCA GACCAGTGTT TGTCCTGTAG GCATTTCATC 840
AGAGGAAGGA CCTGTGTGAA GGCTTGTAAT CTTTATGATG GAGAATACAG AGAGTTTGCA 900
AATGGTTCAG TCTGTGTGGA ATGTGACCCT CAGTGTGAGA AGATGGATAA CAACAGGATC 960
ACATGTAGGG GACCGGGACC AGATCATTGC ACAAAATGTT TCCATTTTAA AGATGGCCCA 1020
AATTGTGTGG AAAAGTGTCC TGATGGTGTA CAAGGGACAA ACAGCTTCAT TTTCAAGTAT 1080
GCTGATGAAG ACCGTGAATG CCACTCTTGC CATCCAAACT GTACTCAAGG GTGTAGAGGT 1140
CCCACTAGTC ATGACTGCAT TTACTATCCG TGGACACGCC AGTCCACTTT ACTACAACAT 1200
GCTAGAACTC CCCTGATTGC TGCTGGAGTG ATTGGCGGAC TCTTCATCAT CGTCATTTTG 1260
GGCTTGACCT TTGCAGTCTA TGTGAGGCGC AAGAGCATCA AAAAGAAGAG GGCCTTACGA 1320
AGATTCTTAG AGACTGAGTT GGTTGAACCC TTGACACCTA GTGGCACAGC TCCCAACCAA 1380
GCACAGCTCC GCATTTTAAA GGAAACTGAA CTAAAACGTG TGAAAGTCCT TGGATCTGGA 1440
GCCTTTGGAA CTGTGTATAA GGGTGTCTGG GTTCCAGAGG GAGAGAGCGT GAAGATACCC 1500
GTGGCTATTA AAATCCTAAA TGAGACAACT GGCCCCAAAG CCAATGTGGA ATTCATGGAT 1560
GAAGCTCTTA TAATGGCAAG CATGGACCAT CCCCATCTTG TACGACTCTT AGGTGTCTGT 1620
TTAAGCCCAA CGATCCAGCT AGTTACTCAG CTTATGCCTC ATGGCTGCCT ACTGGACTAT 1680
GTCCATGAAC ATAAGGATAA CATTGGTTCG CAGCTTCTGC TAAATTGGTG TGTCCAGATA 1740
GCCAAGGGTA TGATGTACTT AGAAGAAAGA AGACTGGTTC ATCGAGACTT GGCAGCTCGA 1800
AATGTCCTGG TAAAATCACC AAACCACGTG AAGATCACGG ACTTTGGCCT GGCCCGACTA 1860
TTGGAAGGGG ATGAAAAGGA ATACAGTGCA GATGGTGGGA AGATGCCGAT TAAATGGATG 1920
GCTCTTGAGT GTATACATTA CAGGAAATTC ACACATCAAA CTGACGTTTG GAGCTACGGT 1980
GTCACTATTT GGGAGCTCAT GACCTTTGGT GGAAAGCCCT ATGATGGAAT CCCAACAAGA 2040
GAAATCCCTG ATTTGCTTGA GAAAGGGGAG CGCTTGCCAC AGCCTCCTAT CTGCACCATT 2100
GATGTTTACA TGGTGATGGT GAAATGTTGG ATGATTGATG CTGACAGTCG ACCTAAGTTC 2160
AAAGAGCTAG CTGCTGAATT TTCAAGAATG GCTCGAGATC CTCAGAGATA TCTGGTCATT 2220
CAGGGTGATG ATCGTATGAA GCTCCCAAGC CCAAATGACA GCAAGTTTTT CCAAAATCTG 2280
CTGGATGAGG GAGACCTGGA AGACATGATG GATGCTGAGG AATACCTGGT TCCTCAGGCA 2340
TTTAACATTC CACCACCCAT CTACACTTCC AGAGCAAGAA TGGACTCCAA CAGGAACCAG 2400
TTCATCTACA GAGATGGGAC GCTGGCTGCA GAACAAGGAG TTCCTTTGCC ATACCGAGCT 2460
GCCATACCAA GCATAGCACC TGAACCTCCC ATTTTGCAAG GTGCTGCAGA AATCTGTGAT 2520
GATACTTGTT GCAATGGCAC TTTACGGAAA CAGGTAGCTA GTCTTTCACA GGAAGACAGT 2580
ATCACTCAGA GGTACAGTGC TGACCCAACT GGCTTCATAT CAGAGCGGGG GCCAAGAAAT 2640
GAGCTGGATG AAGATGGCTA CATGACTCCA ATGCCAGAAA AGGCAAAAGC AGATCATCTA 2700
CATCCAGTGG AGGAGAACCC ATTTGTGTCT CGGAGGAAGA ATGGTGACCT GCAAGCCCTG 2760
GACAACCCAG AATATCACAA CAACAGCCAA AATGGGCCAC CCAAAGTGGA GGATGAATAT 2820
GTGAATGAGC CATGGTACCT CAACACTTTT GCCAGCACCT TTGAGAATTC TGAATATCTG 2880
AAGAAAAATG GGCTTCCATT GCCTGAGAAG CCCAAGAAGG CTTTTGATAA CCCAGGTTAC 2940
TGGAATCACA GCCTGCCTCC ACGAAGTACC CTACAGCACC CGGACTACCT GCAGGAATAT 3000
GGCACAAAAT ATTTTTACAA ACAGAATGGA AGGATCCAGC CCATTGTGGC AGAGAATCCC 3060
GAATACCTCT CAGAGTTCAC CCTGAAGCCC GGCACTATGC TGCCTCCTCC ACCCTACAGA 3120
CACCGAAACA CAGTGGTGTA A 3141
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         lk++kvlGsGafGtvykG+w+pege+vkipvaik+l+e+tg+kan e++deal++as+dh
Q: 471   LKRVKVLGSGAFGTVYKGVWVPEGESVKIPVAIKILNETTGPKANVEFMDEALIMASMDH  530
         699*********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         ++lvrllg+cls t+qlvtql+p+Gclldyv+ehkd++Gsq llnwcvqiakGm+ylee+
Q: 531   PHLVRLLGVCLSPTIQLVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEER  590
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
         rlvhrdlaarnvlvkspnhvkitdfGla+lle deke++a+ggk+pikw+ale+i++rk+
Q: 591   RLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYSADGGKMPIKWMALECIHYRKF  650
         ************************************************************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thq+dvwsyGvt+wel+tfG kpydgip++eipdllekGerl+qppictidvymv+vkcw
Q: 651   THQTDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCW  710
         ************************************************************
S: 241   midaesrpkfkelaeefs  258
         mida+srpkfkela+efs
Q: 711   MIDADSRPKFKELAAEFS  728
         ****************96
Domain Sequence
(FASTA)
LKRVKVLGSG AFGTVYKGVW VPEGESVKIP VAIKILNETT GPKANVEFMD EALIMASMDH 60
PHLVRLLGVC LSPTIQLVTQ LMPHGCLLDY VHEHKDNIGS QLLLNWCVQI AKGMMYLEER 120
RLVHRDLAAR NVLVKSPNHV KITDFGLARL LEGDEKEYSA DGGKMPIKWM ALECIHYRKF 180
THQTDVWSYG VTIWELMTFG GKPYDGIPTR EIPDLLEKGE RLPQPPICTI DVYMVMVKCW 240
MIDADSRPKF KELAAEFS 258
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00279
EKS-BOT-00300
EKS-CAE-00255
EKS-CAJ-00303
EKS-CAF-00303
EKS-CAP-00332
EKS-DAR-00650
EKS-DRM-00152
EKS-EQC-00288
EKS-GAG-00250
EKS-GAA-00369
EKS-GOG-00294
EKS-HOS-00303
EKS-LAC-00313
EKS-LOA-00307
EKS-MAM-00300
EKS-MOD-00291
EKS-MUM-00328
EKS-MUP-00294
EKS-MYL-00299
EKS-NOL-00273
EKS-ORN-00387
EKS-ORA-00263
EKS-ORC-00279
EKS-ORL-00356
EKS-OTG-00306
EKS-PAT-00282
EKS-PES-00266
EKS-POA-00290
EKS-RAN-00313
EKS-SUS-00266
EKS-TAG-00313
EKS-TAR-00389
EKS-TEN-00384
EKS-VIP-00031
EKS-XET-00370
EKS-XIM-00377
Gene Ontology
GO:0016323; C:basolateral plasma membrane
GO:0005739; C:mitochondrion
GO:0005524; F:ATP binding
GO:0044212; F:transcription regulatory region DNA binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0006915; P:apoptotic process
GO:0045165; P:cell fate commitment
GO:0016477; P:cell migration
GO:0043066; P:negative regulation of apoptotic process
GO:0008285; P:negative regulation of cell proliferation
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0060045; P:positive regulation of cardiac muscle cell proliferation
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:2000366; P:positive regulation of STAT protein import into nucleus
GO:0045893; P:positive regulation of transcription, DNA-dependent
GO:0042523; P:positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0046777; P:protein autophosphorylation
GO:0030334; P:regulation of cell migration
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 1.
SMARTs
SM00261; FU; 3.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013