EKS-ANC-00160

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ANC-00160

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKG	478.9	3.0E-144	449	707	259

Status

Unreviewed

Ensembl Protein

ENSACAP00000010068

UniProt Accession

G1KJX1;

Protein Name

cGMP-dependent protein kinase

Protein Synonyms/Alias

Gene Name

PRKG2

Gene Synonyms/Alias

PRKG2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSACAG00000010172	ENSACAP00000010068	ENSACAT00000010275

Organism

Anolis carolinensis

Functional Description

Protein Length

758

Protein Sequence
(FASTA)

MGNGSVKHKY LKRQEGHAGN CPYDILRSKV WELERELKRQ EEELHERNYH ILELQDQLAK 60

QTRTIADLTE ELKCKCIQLN KLQDVVDTQG TNPFLFSPLK EVPKVSPVPC SNRRKGAKEG 120

VSAEPTSRTY DLTEQPRFSF EKARVRKASS EKKLITEALS RNQFLKRLDP QQIRDMVECM 180

YGRTYQQGSY IIKQGEPGNH IFVLAEGKVE VFQQNKLLSS IPVWTAFGEL AILYNCTRTA 240

SVKAVTIVKT WALDREVFQN IMRRTAQARH DQYRNFLRSV SLLKNLPEDK LSKIVDCLEV 300

EYYDKGDYII REGEEGNTFF VIAKGKVKVT QTTDGQPQTQ LIKTLQKGDY FGERALISDD 360

VRSANIIADE NDVECLVVDR ETFNQTVGTF EELQAYLAGY VATLARDDEK RNAHRVSSLE 420

RLPSDVSLEM IQLKEKVAQF PSSCPFQNLE IVATLGVGGF GRVELVKLKN ESIAFAMKCI 480

KKKHIVDTKQ QEHIHSEKRI LEEACSPFIV RLYRTFKDNK YVYMLLEACL GGELWSILRD 540

RGSFDETTTK FCVGCVTEAI EYLHCISVIY RDLKPENLIL DAHGYIKLVD FGFAKKIAIG 600

QKTWTFCGTP EYVAPEVILN KGHDFSVDFW SLGILVYELL TGNPPFSGAD QMTTYNLILK 660

GVERLDFPRI VSKRPEDLIR RLCRQNPTER LGNLKNGIHD IKRHRWLNGF NWEGLKARKL 720

SSPLKRELSG PMDYSYFDRY PPDQGIPPDE LSGWDKDF 758

Nucleotide Sequence
(FASTA)

ATGGGAAATG GTTCAGTGAA ACACAAGTAC CTCAAGAGGC AAGAAGGCCA TGCAGGGAAC 60

TGCCCGTACG ATATTCTGAG AAGCAAGGTT TGGGAGCTGG AGCGGGAGCT GAAGAGGCAA 120

GAGGAAGAGT TGCACGAGAG GAACTACCAC ATCCTCGAGC TCCAGGATCA GCTGGCGAAG 180

CAGACCAGGA CCATTGCAGA CCTCACTGAA GAGCTCAAGT GTAAATGCAT CCAGCTGAAT 240

AAGCTGCAGG ATGTGGTCGA CACCCAGGGA ACAAACCCCT TCCTGTTTTC CCCTCTTAAA 300

GAAGTACCCA AGGTCAGCCC AGTGCCATGC AGCAACAGGA GGAAAGGTGC CAAGGAAGGT 360

GTGTCGGCAG AGCCAACAAG CCGGACATAC GACCTGACTG AGCAGCCTCG GTTTTCCTTC 420

GAAAAGGCAA GAGTCAGAAA GGCCTCCAGT GAGAAAAAGC TCATTACCGA GGCTCTGAGC 480

AGAAACCAAT TTCTGAAGAG ACTGGATCCA CAGCAGATCA GAGATATGGT AGAATGTATG 540

TATGGAAGAA CATACCAGCA AGGCAGCTAT ATAATCAAAC AAGGGGAACC TGGCAACCAT 600

ATATTTGTAC TAGCAGAGGG TAAAGTGGAA GTCTTTCAGC AGAACAAGCT TCTCTCATCC 660

ATTCCTGTGT GGACAGCATT TGGGGAGTTG GCTATTTTGT ACAACTGCAC AAGGACAGCC 720

TCAGTGAAGG CTGTCACTAT TGTGAAAACA TGGGCATTAG ACAGAGAGGT TTTCCAAAAT 780

ATAATGAGAA GAACAGCACA AGCAAGACAT GACCAATACA GAAACTTCCT AAGAAGTGTG 840

TCTTTGCTGA AGAATTTACC TGAAGATAAG CTGTCAAAGA TCGTGGACTG CTTGGAAGTG 900

GAATACTATG ATAAGGGTGA TTATATTATT CGTGAAGGAG AAGAAGGAAA TACATTCTTT 960

GTTATAGCCA AAGGGAAGGT TAAGGTCACC CAGACCACGG ATGGACAGCC ACAAACCCAG 1020

TTGATTAAAA CACTACAGAA AGGAGATTAC TTTGGGGAAA GGGCCCTCAT CAGTGACGAT 1080

GTTCGGTCTG CTAATATAAT TGCGGATGAA AATGATGTGG AGTGTCTCGT TGTCGATAGA 1140

GAAACCTTCA ACCAAACCGT TGGGACTTTT GAAGAGCTCC AGGCTTACCT TGCTGGTTAC 1200

GTGGCTACTC TCGCTCGTGA TGATGAAAAA AGGAATGCAC ACAGAGTCTC TTCCTTGGAG 1260

CGATTACCTA GTGATGTCTC TTTGGAGATG ATACAGCTGA AAGAAAAAGT CGCCCAGTTT 1320

CCTTCCTCTT GCCCATTTCA GAACCTGGAA ATTGTTGCTA CTCTGGGCGT TGGTGGATTT 1380

GGAAGAGTTG AGCTTGTGAA ACTTAAGAAT GAAAGCATAG CATTTGCCAT GAAATGTATT 1440

AAGAAAAAGC ACATAGTGGA TACCAAACAG CAGGAACACA TTCATTCTGA AAAGAGAATT 1500

CTAGAAGAGG CTTGCTCTCC ATTCATTGTG AGATTGTACC GAACTTTCAA AGACAACAAA 1560

TACGTTTACA TGCTTTTGGA AGCCTGCCTT GGAGGTGAAC TATGGAGCAT CCTGAGGGAC 1620

AGAGGTAGCT TTGATGAAAC AACTACAAAA TTCTGTGTTG GATGTGTGAC AGAAGCAATT 1680

GAGTATTTAC ATTGCATCAG TGTGATCTAC AGGGATCTGA AGCCAGAAAA TTTAATTTTG 1740

GATGCTCACG GATATATAAA GCTGGTTGAC TTTGGATTTG CTAAGAAGAT TGCAATTGGA 1800

CAAAAGACGT GGACCTTCTG TGGGACTCCC GAATATGTTG CACCTGAAGT GATTCTGAAT 1860

AAAGGCCATG ATTTCAGTGT GGACTTCTGG TCTCTTGGAA TCCTTGTGTA TGAATTGCTT 1920

ACAGGGAATC CTCCATTTTC TGGAGCCGAT CAAATGACGA CCTACAATTT GATTTTAAAA 1980

GGCGTTGAAA GATTGGATTT TCCAAGAATA GTATCAAAAC GGCCGGAAGA TTTGATTCGG 2040

AGGCTCTGCA GACAAAACCC TACTGAGAGA TTGGGAAATC TGAAGAATGG CATCCATGAT 2100

ATTAAGAGGC ACAGGTGGTT GAATGGATTT AATTGGGAAG GACTCAAGGC AAGGAAGTTG 2160

TCCTCACCTT TAAAAAGAGA GCTTTCAGGA CCAATGGATT ACAGCTACTT CGACAGATAC 2220

CCACCTGACC AGGGAATCCC ACCAGATGAA CTTTCAGGCT GGGATAAAGA TTTCTAA 2277

Domain Profile

S: 1     lkviatlgvggfgrvelvkvksdeskafalkilkkkhivdtkqqehvlsekrileeaksd  60

         l+++atlgvggfgrvelvk+k+ es afa+k++kkkhivdtkqqeh+ sekrileea+s+

Q: 449   LEIVATLGVGGFGRVELVKLKN-ESIAFAMKCIKKKHIVDTKQQEHIHSEKRILEEACSP  507

         689******************9.99***********************************

S: 61    fivklyrtfkdekyvyllleaclggelwtilrdrgsfddktakfivacvvealeylhskn  120

         fiv+lyrtfkd+kyvy+lleaclggelw+ilrdrgsfd++t+kf+v+cv+ea+eylh  +

Q: 508   FIVRLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDETTTKFCVGCVTEAIEYLHCIS  567

         ************************************************************

S: 121   iiyrdlkpenllldeegylklvdfgfakklksgkktwtfcgtpeyvapeiilnkghdlsv  180

         +iyrdlkpenl+ld++gy+klvdfgfakk++ g+ktwtfcgtpeyvape+ilnkghd+sv

Q: 568   VIYRDLKPENLILDAHGYIKLVDFGFAKKIAIGQKTWTFCGTPEYVAPEVILNKGHDFSV  627

         ************************************************************

S: 181   dywalgilvyelltgkppfsgvdplktynlilkgidklelprkitkeaedlikklcrdnp  240

         d+w+lgilvyelltg+ppfsg+d+++tynlilkg++ l++pr ++k++edli++lcr+np

Q: 628   DFWSLGILVYELLTGNPPFSGADQMTTYNLILKGVERLDFPRIVSKRPEDLIRRLCRQNP  687

         ************************************************************

S: 241   aerlgylkggikdikkhkwf  260

         +erlg+lk+gi+dik+h+w+

Q: 688   TERLGNLKNGIHDIKRHRWL  707

         *******************7

Domain Sequence
(FASTA)

LEIVATLGVG GFGRVELVKL KNESIAFAMK CIKKKHIVDT KQQEHIHSEK RILEEACSPF 60

IVRLYRTFKD NKYVYMLLEA CLGGELWSIL RDRGSFDETT TKFCVGCVTE AIEYLHCISV 120

IYRDLKPENL ILDAHGYIKL VDFGFAKKIA IGQKTWTFCG TPEYVAPEVI LNKGHDFSVD 180

FWSLGILVYE LLTGNPPFSG ADQMTTYNLI LKGVERLDFP RIVSKRPEDL IRRLCRQNPT 240

ERLGNLKNGI HDIKRHRWL 259

Keyword

ATP-binding; cGMP; cGMP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0030553	; F:cGMP binding
GO:0004692	; F:cGMP-dependent protein kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR016232	; cGMP-dependent_protein_kinase.
IPR002374	; cGMP_dep_kinase.
IPR018490	; cNMP-bd-like.
IPR018488	; cNMP-bd_CS.
IPR000595	; cNMP-bd_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR014710	; RmlC-like_jellyroll.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00027	; cNMP_binding; 2.
PF00069	; Pkinase; 1.

SMARTs

SM00100	; cNMP; 2.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00888	; CNMP_BINDING_1; 2.
PS00889	; CNMP_BINDING_2; 2.
PS50042	; CNMP_BINDING_3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00104

; CGMPKINASE.

Created Date

20-Feb-2013