EKS-ANC-00388
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ANC-00388
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR602.23.0E-181593950358
StatusUnreviewed
Ensembl ProteinENSACAP00000010286
UniProt AccessionG1KK54;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NamePDGFRA
Gene Synonyms/Alias PDGFRA;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSACAG00000010297ENSACAP00000010286ENSACAT00000010498
OrganismAnolis carolinensis
Functional Description
Protein Length1087
Protein Sequence
(FASTA)
MGPSQRTYLI LGCFLTGPWL ASCQTLFPTI FPNKDEMEVH LNSPFTLKCS GDSEVNWQHP 60
IPEDNDTIDI RNEENNSGLF VTVLEVKNAS ASHTGLYTCY YNHSQEEEGE VEGKDIYIFV 120
PDPAVPFVPT SPEDSIIVIT EEDETSTIPC RTSDPHAQVT LTNSEGKVVY TFYDNRQGFI 180
GNFSAGSYTC RTTVKAVEFL SGEFFVYVYK ATSHLQVEVG SLKTVYKTGE TIVVTCVVLD 240
NEVVNLEWKY PGKVRNRGII SLEDIKVPAQ KLIYNLTIHD ASVSDSGDYE CAAHHVTKEL 300
KKTKRTIITV HDKGFIRLEP HFNPMETVNL HEVKKFVVGV HAYPEPRIFW LKDNITLMEN 360
LTEIVTSFKQ IQETRYQSVL KLIRAKEEDS GYYTLVAQNE DEIQRYTFSL LIQVPALIRD 420
LVDNHHGSAG QTVKCLAEGT PLPDVEWLIC KDIKRCSNDT SWTPLTNNIS DITMETHLDE 480
RNMVESQVTF QKVQETLAVR CLARNDLGTV ARELKLVAPT LRSELTLAAA ILVLLVFVII 540
SLIVLVIIWK QKPRYEIRWR VIESISPDGH EYIYVDPMQL PYDSRWEFPR DGLVLGRILG 600
SGAFGKVVEG TAYGLSRSQP VMKVAVKMLK PTARTSEKQA LMSELKIMTH LGPHLNIVNL 660
LGACTKSGPI YIITEYCFYG DLVNYLHKNR DNFLNRNPEK TKKDLDIFGM NSADESTRSY 720
VILSFENNGE YMDMKQAETT QYVPMLERRD RSKYSDIQRS LYDRPASYKK KYLSEQDVLN 780
LLSDDNSEGL SLLDLLSFTY QVARGMEFLA SKNCVHRDLA ARNVLLAQGK IVKICDFGLA 840
RDIMHDSNYV SKGSTFLPVK WMAPESIFDN LYTTLSDVWS YGILLWEIFS LGGTPYPGMM 900
VDSTFYNKIK SGYRMTKPDH ATSEVYDIMV KCWNSEPEKR PSFYHLSEIV ENLLPGEYKK 960
SYERIHLDFL KSDHPAVTRM RADCDNTYIG VTYKNEDKLK DRESGFDEQR LSADSGYIIP 1020
LPDIDPVSED ELGKRNRHSS QTSEESAIET GSSSSTFVKR EDETIDDIDI IDDIGMDSSE 1080
LVEDSFL 1087
Nucleotide Sequence
(FASTA)
ATGGGTCCTT CTCAAAGGAC ATACCTGATC CTGGGCTGCT TCTTGACAGG TCCATGGTTA 60
GCCTCCTGCC AGACTTTGTT TCCTACTATT TTTCCAAACA AAGATGAAAT GGAGGTGCAT 120
CTGAATTCCC CCTTCACCTT GAAATGTTCC GGAGACAGTG AAGTAAACTG GCAGCACCCA 180
ATACCTGAAG ACAATGATAC TATAGACATC AGAAATGAAG AAAACAATAG CGGCCTTTTT 240
GTCACTGTGC TGGAAGTCAA AAACGCATCT GCTTCCCATA CTGGACTGTA TACTTGCTAC 300
TACAATCATT CCCAAGAAGA AGAAGGGGAG GTTGAGGGAA AGGATATCTA TATCTTTGTG 360
CCAGATCCAG CTGTCCCCTT TGTCCCTACA TCTCCTGAAG ATTCAATCAT TGTTATTACT 420
GAAGAAGATG AGACCTCCAC CATTCCTTGC CGCACGAGTG ATCCTCATGC TCAAGTAACT 480
TTAACAAACA GCGAAGGGAA AGTCGTGTAC ACCTTTTATG ACAACAGGCA AGGCTTCATT 540
GGAAACTTCT CTGCAGGCTC CTATACATGC AGGACCACTG TGAAGGCCGT GGAGTTCCTG 600
TCTGGTGAAT TTTTTGTCTA CGTTTACAAA GCAACTTCAC ATCTTCAAGT TGAGGTTGGA 660
TCCCTTAAGA CTGTGTATAA AACAGGAGAA ACGATTGTTG TAACTTGTGT GGTCTTGGAT 720
AATGAAGTTG TGAACTTGGA GTGGAAATAT CCAGGGAAAG TGAGGAACAG AGGTATCATC 780
TCACTCGAAG ACATCAAAGT GCCAGCCCAG AAACTGATTT ATAACTTAAC CATTCATGAT 840
GCTTCAGTAA GCGACAGTGG AGATTACGAA TGTGCAGCTC ATCATGTCAC CAAAGAGTTA 900
AAGAAAACAA AAAGAACCAT CATTACAGTT CATGATAAAG GGTTCATTCG TCTGGAGCCC 960
CATTTTAATC CCATGGAAAC AGTCAATCTG CATGAAGTTA AAAAATTTGT AGTTGGTGTG 1020
CATGCATATC CAGAGCCAAG AATCTTTTGG CTAAAGGACA ATATCACTCT GATGGAGAAT 1080
CTCACCGAGA TTGTCACTAG TTTCAAGCAG ATCCAGGAGA CGAGGTACCA GAGTGTGTTA 1140
AAATTAATTC GTGCCAAGGA AGAAGACAGT GGGTACTACA CTCTTGTAGC ACAGAATGAA 1200
GATGAAATTC AAAGATATAC TTTCTCTCTG CTTATACAAG TGCCAGCTTT AATTCGAGAC 1260
CTAGTAGATA ATCACCATGG CTCTGCTGGG CAAACTGTGA AATGCTTGGC TGAAGGGACA 1320
CCTCTCCCTG ATGTGGAATG GTTGATTTGC AAGGATATAA AAAGGTGCAG CAATGATACT 1380
TCGTGGACTC CCCTGACTAA CAATATCTCT GATATTACTA TGGAGACTCA TCTGGATGAG 1440
AGGAACATGG TAGAGAGCCA GGTGACTTTT CAGAAGGTGC AAGAAACGTT GGCTGTTCGA 1500
TGCCTGGCAA GGAATGACCT TGGAACCGTA GCACGGGAAC TGAAGCTTGT GGCTCCAACT 1560
TTAAGATCAG AATTGACTCT GGCTGCCGCA ATCCTAGTGT TGCTAGTGTT TGTAATAATT 1620
TCGCTGATTG TCCTGGTTAT CATATGGAAA CAGAAGCCAA GATACGAAAT TAGATGGAGA 1680
GTCATCGAGT CTATCAGCCC AGATGGCCAT GAATATATAT ATGTGGATCC CATGCAGCTG 1740
CCTTATGATT CAAGATGGGA ATTTCCTAGA GATGGATTAG TGCTGGGCCG AATTCTTGGC 1800
TCCGGAGCTT TTGGAAAAGT AGTTGAAGGA ACCGCATATG GATTAAGTCG GTCACAGCCT 1860
GTCATGAAGG TGGCTGTGAA AATGCTGAAG CCCACTGCAC GAACCAGTGA AAAGCAGGCT 1920
CTCATGTCTG AATTAAAGAT AATGACCCAT CTTGGACCCC ACTTGAACAT AGTCAACCTG 1980
TTAGGAGCAT GTACAAAATC AGGTCCAATT TACATCATAA CAGAATACTG CTTTTATGGA 2040
GACTTGGTGA ACTATCTGCA TAAAAACAGG GACAACTTTC TGAACCGAAA CCCTGAAAAG 2100
ACAAAGAAAG ATTTGGACAT CTTTGGGATG AACTCGGCTG ATGAAAGCAC TAGGAGCTAT 2160
GTCATCCTGT CATTTGAAAA TAATGGTGAA TACATGGATA TGAAGCAAGC AGAGACCACA 2220
CAGTATGTGC CGATGCTAGA AAGGAGAGAC AGGTCAAAAT ATTCTGACAT CCAGAGATCT 2280
CTGTATGATA GACCTGCTTC ATATAAGAAA AAATATCTGT CTGAACAAGA TGTTCTGAAT 2340
CTTCTTTCAG ATGATAATTC AGAAGGCCTC AGTTTGCTGG ACCTATTGAG CTTTACCTAC 2400
CAAGTTGCCC GGGGAATGGA GTTCTTAGCA TCGAAAAATT GTGTACACCG TGATTTGGCA 2460
GCAAGGAATG TCCTCCTGGC TCAAGGAAAA ATTGTGAAGA TCTGTGACTT TGGTCTGGCT 2520
AGAGATATTA TGCATGATTC AAACTATGTC TCCAAAGGCA GCACCTTCCT TCCAGTGAAG 2580
TGGATGGCAC CTGAGAGCAT TTTTGACAAC CTATATACAA CATTAAGTGA TGTTTGGTCT 2640
TATGGCATTC TGCTCTGGGA AATATTTTCT CTTGGTGGCA CCCCATATCC TGGCATGATG 2700
GTTGATTCTA CATTCTATAA CAAAATCAAG AGTGGATATC GAATGACAAA ACCTGACCAT 2760
GCTACCAGTG AAGTGTATGA CATCATGGTA AAATGCTGGA ACAGCGAACC TGAGAAGAGA 2820
CCCTCTTTTT ACCACTTGAG TGAAATAGTT GAGAATCTTT TGCCTGGAGA ATACAAGAAG 2880
AGCTATGAGA GAATTCACTT GGACTTCCTG AAGAGTGACC ATCCTGCTGT CACACGCATG 2940
CGAGCAGACT GTGACAACAC TTACATTGGT GTTACTTACA AAAATGAAGA CAAACTGAAA 3000
GATAGGGAGA GCGGCTTTGA TGAACAAAGA CTAAGTGCTG ACAGTGGATA CATCATTCCT 3060
CTGCCGGATA TTGACCCTGT CTCAGAAGAT GAACTTGGCA AAAGGAACAG GCATAGTTCC 3120
CAGACCTCTG AAGAAAGTGC CATTGAAACC GGATCCAGCA GTTCGACCTT TGTCAAGCGA 3180
GAGGATGAAA CCATTGATGA CATCGACATT ATTGACGACA TTGGCATGGA TTCCTCCGAA 3240
TTGGTTGAGG ACAGCTTCCT GTAA 3264
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l+lG++lGsGafGkvve+tayGls+s++v+kvavkmlk+tar+sek+almselki++hlG
Q: 593   LVLGRILGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARTSEKQALMSELKIMTHLG  652
         78**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h+nivnllGactk+Gpiy+iteyc+yGdl+nyl+++r++fl++  ek   ++++ld+++
Q: 653   PHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDNFLNRNPEK---TKKDLDIFG  709
         ******************************************999999...667888888
S: 121   l.ladkslrsksslssesseeyvdlkkd................vsdvssskadklasek  163
         +  ad+s+rs+++ls+e+++ey+d+k++                +sd+++s +d++as+k
Q: 710   MnSADESTRSYVILSFENNGEYMDMKQAettqyvpmlerrdrskYSDIQRSLYDRPASYK  769
         8789********************************************************
S: 164   kksalerevkaaleeedsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteG  223
         kk + e++v + l++++se+l+l dllsf+yqva+Gmeflaskncvhrdlaarnvll++G
Q: 770   KKYLSEQDVLNLLSDDNSEGLSLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQG  829
         ************************************************************
S: 224   kvvkicdfGlardimkdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweif  283
         k+vkicdfGlardim+dsnyv+kG+++lpvkwmapesifd+lyt+ sdvwsyGillweif
Q: 830   KIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIF  889
         ************************************************************
S: 284   slGstpypgllvdskfyklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvel  343
         slG+tpypg++vds+fy++ik+Gyrm++p++at+e+y+im+kcw++epekrpsf++l+e+
Q: 890   SLGGTPYPGMMVDSTFYNKIKSGYRMTKPDHATSEVYDIMVKCWNSEPEKRPSFYHLSEI  949
         *********************************************************998
S: 344   l  344
         +
Q: 950   V  950
         6
Domain Sequence
(FASTA)
LVLGRILGSG AFGKVVEGTA YGLSRSQPVM KVAVKMLKPT ARTSEKQALM SELKIMTHLG 60
PHLNIVNLLG ACTKSGPIYI ITEYCFYGDL VNYLHKNRDN FLNRNPEKTK KDLDIFGMNS 120
ADESTRSYVI LSFENNGEYM DMKQAETTQY VPMLERRDRS KYSDIQRSLY DRPASYKKKY 180
LSEQDVLNLL SDDNSEGLSL LDLLSFTYQV ARGMEFLASK NCVHRDLAAR NVLLAQGKIV 240
KICDFGLARD IMHDSNYVSK GSTFLPVKWM APESIFDNLY TTLSDVWSYG ILLWEIFSLG 300
GTPYPGMMVD STFYNKIKSG YRMTKPDHAT SEVYDIMVKC WNSEPEKRPS FYHLSEIV 358
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00373
EKS-BOT-00401
EKS-CAJ-00405
EKS-CAF-00401
EKS-CAP-00430
EKS-EQC-00393
EKS-FEC-00385
EKS-GAG-00339
EKS-GAA-00490
EKS-GOG-00393
EKS-HOS-00407
EKS-ICT-00380
EKS-LAC-00417
EKS-LOA-00410
EKS-MAM-00400
EKS-MEG-00333
EKS-MOD-00390
EKS-MUM-00433
EKS-MUP-00395
EKS-MYL-00396
EKS-NOL-00366
EKS-OCP-00085
EKS-ORN-00512
EKS-ORA-00350
EKS-ORC-00376
EKS-ORL-00470
EKS-OTG-00403
EKS-PAT-00380
EKS-PES-00356
EKS-POA-00392
EKS-RAN-00416
EKS-SAH-00370
EKS-TAG-00476
EKS-TAR-00508
EKS-TEN-00509
EKS-TUT-00117
EKS-XET-00512
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005021; F:vascular endothelial growth factor-activated receptor activity
GO:0060326; P:cell chemotaxis
GO:0071230; P:cellular response to amino acid stimulus
GO:0007204; P:elevation of cytosolic calcium ion concentration
GO:0008210; P:estrogen metabolic process
GO:0030198; P:extracellular matrix organization
GO:0010544; P:negative regulation of platelet activation
GO:0048015; P:phosphatidylinositol-mediated signaling
GO:0035790; P:platelet-derived growth factor receptor-alpha signaling pathway
GO:0030335; P:positive regulation of cell migration
GO:0038091; P:positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
GO:0045740; P:positive regulation of DNA replication
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0048146; P:positive regulation of fibroblast proliferation
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0010863; P:positive regulation of phospholipase C activity
GO:0050920; P:regulation of chemotaxis
GO:2000739; P:regulation of mesenchymal stem cell differentiation
GO:0023019; P:signal transduction involved in regulation of gene expression
GO:0048010; P:vascular endothelial growth factor receptor signaling pathway
GO:0042060; P:wound healing
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
IPR009134; Tyr_kinase_VEGFR_rcpt_N.
Pfam
PF07679; I-set; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 3.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
PR01832; VEGFRECEPTOR.
Created Date20-Feb-2013