EKS-ANC-00360

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ANC-00360

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	423.0	3.4E-127	182	430	249

Status

Unreviewed

Ensembl Protein

ENSACAP00000011257

UniProt Accession

H9GHP3;

Protein Name

Protein Synonyms/Alias

Gene Name

BLK

Gene Synonyms/Alias

BLK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSACAG00000011166	ENSACAP00000011257	ENSACAT00000011493

Organism

Anolis carolinensis

Functional Description

Protein Length

445

Protein Sequence
(FASTA)

KHCVIAQHDF VPSSERDLPL TAGERFEVLC SNGDWWLAKS LTTKKIGYIP SNFVVRFNSL 60

EEEKWFFKGL SRKETERFLM APRNAVGSFL IRESETTPDA FSLSIRDSTS QGDVIKHYKI 120

RKMDNGGYYI CPKAMFFSLP ELVKHYSVHQ GGLCQRLREP CISLTPQIPW ATDEWEIPRS 180

TLKLIKKLGS GQFGEVWMGY YKNNVKVAIK TLKEGSMSPD AFLAEANLMK QLQHSKLVRL 240

HAVVTEQPIY IITEYMANGS LLDYLQTEEG KKLNLPRLID MAAQVAEGMA YIERMNSIHR 300

DLRAANILVS ATLCCKVADF GLARIIEDEY FAQEGTKFPI KWTAPEAINY GVFTIKSDVW 360

SFGILLTEII TYGRCPYAAM TNPEVIQKLE QGYRMPCPDS CPPELYAMML KCWRGKAEER 420

PTFEYLQSTL EDFYTSTEMQ YQPEP 445

Nucleotide Sequence
(FASTA)

AAACACTGTG TAATTGCACA ACATGATTTT GTACCATCAA GTGAACGGGA TCTGCCATTG 60

ACAGCAGGTG AAAGATTTGA AGTCCTTTGC AGCAACGGGG ACTGGTGGCT AGCAAAATCA 120

CTTACCACCA AGAAGATAGG CTACATTCCT AGCAATTTTG TGGTCCGGTT CAACAGCCTA 180

GAAGAAGAAA AGTGGTTTTT TAAAGGCCTC AGCCGAAAAG AAACCGAACG CTTCTTGATG 240

GCGCCGCGCA ATGCGGTGGG TTCGTTTCTG ATCAGGGAAA GTGAGACAAC TCCAGATGCC 300

TTTTCCCTTT CCATCAGAGA CAGCACTTCT CAAGGGGATG TCATCAAGCA TTACAAGATT 360

CGGAAGATGG ACAATGGCGG GTATTACATT TGCCCCAAGG CCATGTTCTT TTCACTGCCA 420

GAGCTTGTGA AGCATTATTC TGTTCATCAA GGTGGTTTAT GCCAGAGACT CAGAGAACCC 480

TGCATCTCTC TGACTCCACA AATCCCTTGG GCCACAGATG AATGGGAAAT CCCTCGGTCG 540

ACCCTGAAGC TGATCAAGAA GTTGGGATCT GGACAGTTTG GAGAGGTGTG GATGGGATAT 600

TACAAGAACA ATGTGAAGGT GGCCATCAAG ACATTGAAAG AAGGCAGCAT GTCTCCAGAT 660

GCCTTCTTGG CCGAGGCCAA CTTGATGAAG CAACTTCAGC ATAGCAAGCT GGTGCGGCTA 720

CATGCAGTTG TGACCGAGCA ACCCATTTAT ATCATCACAG AGTACATGGC CAATGGGAGT 780

TTATTGGATT ACTTGCAAAC CGAAGAAGGA AAGAAACTGA ATCTTCCCAG ACTTATTGAT 840

ATGGCTGCTC AGGTTGCGGA AGGGATGGCG TACATCGAGA GAATGAACTC CATCCACAGA 900

GACCTCAGGG CCGCCAACAT TTTGGTCTCG GCGACGCTTT GCTGCAAAGT TGCCGACTTC 960

GGCCTGGCTA GGATCATAGA GGATGAATAC TTTGCACAAG AAGGTACCAA ATTTCCTATC 1020

AAATGGACGG CTCCGGAAGC AATTAACTAT GGGGTTTTCA CCATTAAATC TGACGTCTGG 1080

TCTTTTGGGA TTCTTCTAAC AGAAATCATC ACTTACGGAA GGTGTCCATA TGCAGCGATG 1140

ACCAATCCTG AAGTTATCCA AAAGCTAGAA CAGGGCTATC GGATGCCGTG CCCAGACTCT 1200

TGCCCACCTG AACTCTATGC CATGATGCTG AAATGCTGGA GAGGCAAGGC GGAAGAAAGG 1260

CCCACCTTTG AGTACCTCCA GTCTACCCTT GAAGACTTTT ATACGTCCAC AGAAATGCAG 1320

TATCAACCAG AGCCT 1335

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         lkl+kklG+GqfGevw+g++k++vkva+ktlkeg++sp+afl+ea+++k+l+h+klv+l+

Q: 182   LKLIKKLGSGQFGEVWMGYYKNNVKVAIKTLKEGSMSPDAFLAEANLMKQLQHSKLVRLH  241

         689*********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avv+e +Piyi+te+ma+Gslld+l++eegkkl+lp+l+d+aaqvaeGmay+e++n ihr

Q: 242   AVVTE-QPIYIITEYMANGSLLDYLQTEEGKKLNLPRLIDMAAQVAEGMAYIERMNSIHR  300

         ****9.******************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+n+lv+ +l++kvadfGlar+i +dey a+eg+k+PikWtaPeai++g+ftiksdv

Q: 301   DLRAANILVSATLCCKVADFGLARII-EDEYFAQEGTKFPIKWTAPEAINYGVFTIKSDV  359

         **************************.57899****************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfGilltei+t+G++Py  mtn ev++++e+gyr+p+p++cp ely ++l+cw+ ++ee

Q: 360   WSFGILLTEIITYGRCPYAAMTNPEVIQKLEQGYRMPCPDSCPPELYAMMLKCWRGKAEE  419

         ************************************************************

S: 241   rPtfetlqevl  251

         rPtfe+lq++l

Q: 420   RPTFEYLQSTL  430

         *******9875

Domain Sequence
(FASTA)

LKLIKKLGSG QFGEVWMGYY KNNVKVAIKT LKEGSMSPDA FLAEANLMKQ LQHSKLVRLH 60

AVVTEQPIYI ITEYMANGSL LDYLQTEEGK KLNLPRLIDM AAQVAEGMAY IERMNSIHRD 120

LRAANILVSA TLCCKVADFG LARIIEDEYF AQEGTKFPIK WTAPEAINYG VFTIKSDVWS 180

FGILLTEIIT YGRCPYAAMT NPEVIQKLEQ GYRMPCPDSC PPELYAMMLK CWRGKAEERP 240

TFEYLQSTL 249

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity
GO:0008270	; F:zinc ion binding

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR020635	; Tyr_kinase_cat_dom.
IPR015880	; Znf_C2H2-like.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.
SM00355	; ZnF_C2H2; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013