EKS-ANC-00452

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ANC-00452

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	411.8	1.3E-123	26	321	296

Status

Unreviewed

Ensembl Protein

ENSACAP00000011352

UniProt Accession

H9GHV5;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK8

Gene Synonyms/Alias

MAPK8;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSACAG00000011361	ENSACAP00000011352	ENSACAT00000011591

Organism

Anolis carolinensis

Functional Description

Protein Length

427

Protein Sequence
(FASTA)

MSRSKHENNF YSVEIGDSTF TVLKRYQNLK PIGSGAQGIV CAAYDAILER NVAIKKLSRP 60

FQNQTHAKRA YRELVLMKCV NHKNIIGLLN VFTPQKLLEE FQDVYIVMEL MDANLCQVIQ 120

MELDHERMSY LLYQMLCGIK HLHSAGIIHR DLKPSNIVVK SDCTLKILDF GLARTAGTSF 180

MMTPYVVTRY YRAPEVILGM GYKENVDIWS VGCIMGEMIK GGVLFPGTDH IDQWNKVIEQ 240

LGTPCPEFMK KLQPTVRTYV ENRPKYAGYS FEKLFPDVLF PVDSEHNKFK ASQARDLLSK 300

MLVIDASKRI SVDEALQHPY INVWYDPSEA EAPPPKIPDK QLDEREHTIE EWKELIYNEV 360

IELEEKTKNG IIRGQPSPLG AAMINSSQPQ SSSSSVNDAA SMSTDPTLIS DIDSSLETSA 420

GPLGCCR 427

Nucleotide Sequence
(FASTA)

ATGAGCAGAA GCAAACATGA AAACAACTTC TACAGTGTAG AGATTGGAGA TTCTACCTTC 60

ACTGTACTCA AAAGATACCA GAATTTAAAA CCCATTGGCT CAGGTGCTCA GGGCATAGTA 120

TGTGCAGCCT ATGATGCTAT CCTTGAAAGA AATGTTGCAA TCAAAAAGCT AAGTAGGCCA 180

TTTCAGAACC AAACCCATGC AAAAAGAGCC TACAGAGAAC TTGTTCTCAT GAAGTGTGTA 240

AATCACAAAA ATATTATTGG CCTGTTGAAT GTCTTCACTC CACAGAAGTT GCTAGAAGAA 300

TTTCAAGATG TTTACATAGT GATGGAGCTC ATGGATGCAA ATCTCTGCCA GGTGATTCAG 360

ATGGAGCTTG ACCATGAACG CATGTCCTAT CTCCTCTATC AGATGTTGTG TGGTATTAAG 420

CATCTTCACT CAGCTGGAAT TATACATAGG GATTTGAAAC CTAGCAATAT AGTAGTAAAA 480

TCTGACTGCA CTTTGAAGAT TCTTGACTTT GGACTGGCTA GAACAGCAGG AACCAGTTTT 540

ATGATGACAC CTTATGTAGT GACTCGTTAC TACAGAGCAC CAGAAGTCAT CTTAGGAATG 600

GGATACAAAG AAAATGTTGA TATTTGGTCA GTGGGGTGCA TCATGGGAGA AATGATCAAA 660

GGTGGTGTAT TATTTCCTGG TACAGACCAT ATTGATCAGT GGAATAAAGT TATTGAGCAA 720

CTAGGAACCC CATGCCCTGA ATTCATGAAG AAACTACAAC CAACCGTAAG GACCTATGTG 780

GAGAACAGGC CTAAATATGC TGGCTATAGT TTTGAGAAGC TTTTCCCAGA TGTCCTCTTT 840

CCAGTTGACT CTGAACACAA CAAATTTAAG GCCAGTCAGG CAAGAGATTT GTTATCCAAA 900

ATGCTGGTGA TTGATGCCTC AAAAAGAATC TCAGTAGATG AAGCTCTACA ACACCCTTAT 960

ATCAATGTCT GGTATGACCC TTCAGAAGCA GAAGCGCCTC CTCCAAAGAT ACCAGACAAG 1020

CAGTTAGATG AAAGAGAGCA TACAATAGAA GAATGGAAAG AACTGATTTA CAATGAAGTT 1080

ATAGAGCTGG AGGAGAAAAC CAAGAATGGA ATTATACGCG GACAGCCATC TCCTTTAGGT 1140

GCAGCAATGA TCAATAGCTC CCAACCTCAG TCCTCATCAT CATCTGTCAA TGACGCGGCT 1200

TCAATGTCCA CTGACCCAAC ACTGATCTCC GATATAGACA GCAGTCTAGA AACATCAGCC 1260

GGCCCCCTAG GATGCTGTAG ATGA 1284

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++lkp+g+Ga+g+v++a+d+  e++vaikklsrpfq++t+akr++REl l+k+++h+Ni

Q: 26    YQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI  85

         899*********************************************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120

         i ll+vftp++ lee++dvY+v+elm+++L++vi+++ l++e++++llyq+l+g+k+lHs

Q: 86    IGLLNVFTPQKLLEEFQDVYIVMELMDANLCQVIQME-LDHERMSYLLYQMLCGIKHLHS  144

         ************************************9.**********************

S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslke  180

         a++iHrDlKPsN++v++dc+lkildFGlar+a ++ +  +t+yv+tr+YraPe++l  +

Q: 145   AGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFM--MTPYVVTRYYRAPEVILG-MG  201

         **********************************976..*****************9.99

S: 181   ytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyi  240

         y+++vDiWsvGCI++E+++g +lfpg+d+idq++k++e+lgtp  ef+kk++  ++r+y+

Q: 202   YKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQP-TVRTYV  260

         *****************************************************.5*****

S: 241   kslpkkkkkdfeelfpk............aseealdLleklLvldpdkRisveeaLehpY  288

         +++pk++  +fe+lfp+            + ++a+dLl+k+Lv+d++kRisv+eaL+hpY

Q: 261   ENRPKYAGYSFEKLFPDvlfpvdsehnkfKASQARDLLSKMLVIDASKRISVDEALQHPY  320

         *****************************9******************************

S: 289   l  289

Q: 321   I  321

Domain Sequence
(FASTA)

YQNLKPIGSG AQGIVCAAYD AILERNVAIK KLSRPFQNQT HAKRAYRELV LMKCVNHKNI 60

IGLLNVFTPQ KLLEEFQDVY IVMELMDANL CQVIQMELDH ERMSYLLYQM LCGIKHLHSA 120

GIIHRDLKPS NIVVKSDCTL KILDFGLART AGTSFMMTPY VVTRYYRAPE VILGMGYKEN 180

VDIWSVGCIM GEMIKGGVLF PGTDHIDQWN KVIEQLGTPC PEFMKKLQPT VRTYVENRPK 240

YAGYSFEKLF PDVLFPVDSE HNKFKASQAR DLLSKMLVID ASKRISVDEA LQHPYI 296

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tupaia belangeri"; ?>Vicugna pacos"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008351	; MAPK_JNK.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01772

; JNKMAPKINASE.

Created Date

20-Feb-2013