EKS-ANC-00252

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ANC-00252

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	382.0	1.3E-114	12	265	254

Status

Unreviewed

Ensembl Protein

ENSACAP00000011365

UniProt Accession

G1KLA0;

Protein Name

Protein Synonyms/Alias

Gene Name

PLK4

Gene Synonyms/Alias

PLK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSACAG00000011556	ENSACAP00000011365	ENSACAT00000011604

Organism

Anolis carolinensis

Functional Description

Protein Length

967

Protein Sequence
(FASTA)

MATCIGEKIE DFKVGNLLGK GSFAGVYRAV SLKTGLEVAI KMIDKKAMHK VGMVQRVQNE 60

VKIHCQLKHP SILELYNYFE DSNYVYLILE MCHNGELSRY LKNRKKPFSE EEVRHFMHQI 120

ITGMLYLHSH GILHRDLTLS NLLLTNNMNI KIADFGLATQ LNMPHEKHYT MCGTPNYISP 180

EIATRSAHGL ESDVWSLGCM FYTLLVGKPP FDTDTVKNTL NKVVLADYEM PVFLSSEAQD 240

LIHKLLRKNP VDRLSLSSVL DHPFMLKCSS GRSKDLGNVE DSMDSGNATI STAFTSSPSV 300

STSGCLKEKK RLLVGQPLPN KMTILPKNKN SSDVSSGCES TSHSNWGVPA KEIATGRGRA 360

MHLMEERPHS RYLRRAHSSD RSGTNYSRGE AHHVERCHSL EVLSKARGGP IENMKDFSPA 420

NSHGDIPSIF KEKLPTSSGS MEKELSPPVK DQIRSNYLCP MKPSVGLLGM KSQTETMEQW 480

LGNMQLNGHT AQISESSYNT NGNFQFHLNV PQDTLKNTWN GLKGKRPPGY TQSTVTPGGP 540

LDTKKYTVGL LCEGETALPS SAFDHHLVSE IANRAKEPQY GHPKPTLRSI VSPLSAHRLK 600

PIRQKTKNAV VSILDTGEVC MEFLKEYNLQ EFVKEVLRIS CEGSVITVYH PNEGRGIPLN 660

DRPPLPPKDI SVYTFDNLPE KYWKKYQYAA KFVQLVRSKT PKVTFYTRYA KCMLMENSPP 720

ADVEICFYDG AKIHKTAGII RVIEKSGKAY TIKEENEVGL QKDMQIYVDH ANEGHRICLA 780

LESAILAEEK SESVLFFPII VGRKPGNPES PKALVSPPPL QDTCSVVQTT SMKRGPAARS 840

DSSSEVSSIH PPMSSYGGSA FTADVTESKS STGLPNERTG NSPQLLKSIF VKNVGWASQL 900

TSGAVWVQFN DGSQLVAQAG ISSITYTSPA GDTVKYGENE KLPEYIKEKL HCLSSILVMF 960

ANPVGPH 967

Nucleotide Sequence
(FASTA)

ATGGCGACCT GCATCGGCGA GAAGATTGAG GATTTCAAGG TGGGGAACCT GCTGGGTAAG 60

GGCTCCTTTG CAGGAGTCTA TAGAGCGGTA TCCCTGAAAA CAGGCCTGGA GGTGGCCATC 120

AAAATGATTG ATAAAAAGGC AATGCACAAA GTTGGAATGG TACAGAGAGT TCAAAATGAA 180

GTAAAGATAC ATTGTCAGTT AAAACATCCC TCTATACTTG AGTTGTACAA TTACTTTGAA 240

GATAGTAACT ATGTGTACCT CATATTAGAA ATGTGCCATA ATGGAGAATT GAGCAGATAT 300

TTAAAGAACA GAAAGAAGCC TTTCTCTGAA GAAGAAGTTC GGCATTTCAT GCATCAGATT 360

ATTACAGGAA TGTTGTATCT TCATTCCCAT GGAATATTGC ATCGAGACCT CACACTCTCT 420

AATCTGTTAC TCACCAACAA TATGAATATC AAGATTGCCG ACTTTGGACT TGCAACCCAA 480

TTGAATATGC CACATGAAAA ACATTACACA ATGTGTGGGA CTCCTAATTA CATTTCTCCA 540

GAAATAGCAA CAAGAAGTGC ACATGGCCTT GAGTCCGATG TCTGGTCTTT AGGCTGTATG 600

TTTTATACTC TCCTGGTTGG GAAACCACCT TTTGATACGG ATACAGTAAA GAACACCTTG 660

AACAAAGTGG TGTTAGCAGA CTATGAAATG CCAGTATTTT TATCCAGTGA AGCTCAAGAT 720

CTTATTCACA AATTACTTCG CAAAAACCCA GTAGATCGTT TAAGCCTTTC ATCTGTGTTG 780

GATCATCCTT TTATGTTAAA GTGCAGCTCA GGAAGAAGTA AAGACCTGGG AAATGTAGAA 840

GACTCAATGG ACAGTGGAAA TGCCACAATT TCTACAGCTT TTACTTCCTC CCCCAGTGTC 900

AGCACAAGTG GCTGTTTAAA GGAAAAGAAA AGACTTTTAG TGGGGCAGCC ACTTCCCAAC 960

AAAATGACAA TTCTTCCTAA AAATAAGAAT TCTAGTGATG TCTCATCTGG TTGTGAAAGT 1020

ACATCTCATA GTAACTGGGG AGTTCCTGCA AAAGAAATTG CTACTGGTAG GGGAAGAGCA 1080

ATGCATCTGA TGGAGGAAAG ACCACATTCA CGCTACCTCA GGAGGGCACA CTCCTCTGAC 1140

AGATCAGGCA CAAACTACAG TCGAGGGGAA GCACATCATG TGGAAAGATG CCATTCTCTG 1200

GAGGTCCTTT CAAAAGCCAG AGGAGGGCCA ATAGAAAACA TGAAGGATTT CTCACCTGCA 1260

AATAGTCATG GTGACATTCC TTCCATATTT AAAGAAAAAC TCCCTACTAG TTCTGGCTCG 1320

ATGGAAAAAG AACTTTCTCC ACCTGTAAAG GATCAAATTC GTTCAAATTA TCTCTGCCCA 1380

ATGAAACCCA GTGTTGGTTT ATTAGGGATG AAGTCCCAAA CTGAAACAAT GGAGCAGTGG 1440

CTTGGAAATA TGCAACTGAA TGGACATACA GCTCAGATTT CGGAATCTTC ATATAACACA 1500

AATGGAAATT TTCAGTTCCA TCTTAATGTG CCTCAAGATA CACTGAAAAA TACATGGAAT 1560

GGCTTAAAAG GGAAAAGGCC TCCTGGGTAT ACACAGTCAA CGGTGACGCC AGGGGGACCA 1620

CTGGACACAA AAAAATACAC TGTTGGACTT CTATGTGAAG GTGAAACGGC TCTGCCATCA 1680

TCCGCATTTG ATCACCACCT TGTGTCAGAA ATTGCAAACA GGGCCAAAGA GCCACAATAT 1740

GGACACCCAA AACCTACTCT GCGAAGTATT GTATCTCCCC TGAGTGCTCA CAGATTAAAA 1800

CCAATCAGGC AGAAAACAAA AAATGCTGTG GTGAGTATTC TAGATACAGG AGAAGTTTGC 1860

ATGGAATTTC TGAAAGAATA TAATTTGCAG GAGTTTGTAA AAGAAGTTCT GAGGATTTCT 1920

TGTGAGGGAA GTGTGATCAC TGTTTACCAC CCAAATGAAG GTAGAGGCAT TCCTCTTAAT 1980

GATAGACCAC CACTACCTCC TAAAGACATC AGCGTATATA CATTTGACAA CTTGCCAGAG 2040

AAGTACTGGA AGAAGTATCA GTATGCTGCC AAATTTGTGC AGTTGGTAAG ATCCAAAACT 2100

CCCAAAGTTA CTTTCTATAC AAGATACGCC AAATGTATGT TGATGGAAAA TTCTCCCCCT 2160

GCAGATGTGG AAATATGCTT TTATGATGGA GCAAAAATCC ATAAGACAGC AGGTATAATT 2220

CGAGTCATAG AAAAATCTGG CAAAGCCTAC ACAATAAAGG AAGAAAATGA AGTGGGATTA 2280

CAGAAGGATA TGCAGATATA TGTGGATCAT GCAAATGAGG GGCATCGCAT TTGCCTTGCA 2340

CTGGAATCTG CCATTTTGGC AGAAGAAAAG AGTGAAAGTG TTCTATTTTT CCCCATTATT 2400

GTTGGAAGGA AACCAGGAAA CCCTGAGTCT CCAAAGGCTT TGGTATCACC ACCTCCTTTA 2460

CAAGATACAT GTTCGGTGGT GCAAACAACC TCCATGAAGA GAGGTCCTGC TGCCAGATCA 2520

GACTCTTCAA GTGAGGTATC CAGCATTCAT CCACCTATGT CTTCATATGG AGGTTCTGCA 2580

TTCACAGCAG ATGTGACTGA ATCAAAGAGC TCAACTGGAC TCCCAAATGA GCGTACTGGA 2640

AATTCACCTC AACTATTGAA GTCGATCTTT GTCAAGAATG TTGGCTGGGC TTCTCAGCTA 2700

ACTAGTGGAG CTGTATGGGT TCAATTCAAT GACGGATCCC AGTTGGTAGC TCAGGCTGGC 2760

ATTTCATCCA TCACATACAC ATCTCCAGCA GGTGACACAG TCAAGTATGG TGAAAATGAG 2820

AAATTGCCAG AGTACATCAA AGAGAAATTG CATTGTTTAT CTTCCATTCT GGTGATGTTT 2880

GCCAATCCAG TTGGCCCTCA CTGA 2904

Domain Profile

S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60

         +++g+llGkG+fa +y++ +l+t+ ++a+k+++k++++k  + ++v++e++ih++lkh++

Q: 12    FKVGNLLGKGSFAGVYRAVSLKTGLEVAIKMIDKKAMHKVGMVQRVQNEVKIHCQLKHPS  71

         6899********************************************************

S: 61    ivklyeffedkenvylvlelcsrrslaellkrr.kaltepevryylrqivsglkylhekr  119

         i++ly++fed+++vyl+le+c++++l ++lk+r k+++e+evr++++qi++g++ylh++

Q: 72    ILELYNYFEDSNYVYLILEMCHNGELSRYLKNRkKPFSEEEVRHFMHQIITGMLYLHSHG  131

         *******************************99899************************

S: 120   ilhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghsle  179

         ilhrdl+l+nl+l++++++ki+dfGlat+l++++e+++t+cGtPnyi+Pe++++++h+le

Q: 132   ILHRDLTLSNLLLTNNMNIKIADFGLATQLNMPHEKHYTMCGTPNYISPEIATRSAHGLE  191

         ************************************************************

S: 180   vdiWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePe  239

         +d+WslGc++ytllvGkPPf+t+++k+t++k++ a+y++P  ls+ea++li+kll+k+P

Q: 192   SDVWSLGCMFYTLLVGKPPFDTDTVKNTLNKVVLADYEMPVFLSSEAQDLIHKLLRKNPV  251

         ************************************************************

S: 240   erpsleevlkdefl  253

         +r+sl++vl+++f+

Q: 252   DRLSLSSVLDHPFM  265

         ************98

Domain Sequence
(FASTA)

FKVGNLLGKG SFAGVYRAVS LKTGLEVAIK MIDKKAMHKV GMVQRVQNEV KIHCQLKHPS 60

ILELYNYFED SNYVYLILEM CHNGELSRYL KNRKKPFSEE EVRHFMHQII TGMLYLHSHG 120

ILHRDLTLSN LLLTNNMNIK IADFGLATQL NMPHEKHYTM CGTPNYISPE IATRSAHGLE 180

SDVWSLGCMF YTLLVGKPPF DTDTVKNTLN KVVLADYEMP VFLSSEAQDL IHKLLRKNPV 240

DRLSLSSVLD HPFM 254

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005814	; C:centriole
GO:0005730	; C:nucleolus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0004713	; F:protein tyrosine kinase activity
GO:0007099	; P:centriole replication
GO:0046601	; P:positive regulation of centriole replication

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008266	; Tyr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

Created Date

20-Feb-2013