EKS-ANC-00454

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ANC-00454

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	401.8	1.4E-120	43	337	295

Status

Unreviewed

Ensembl Protein

ENSACAP00000011801

UniProt Accession

G1KLT0;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK10

Gene Synonyms/Alias

MAPK10;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSACAG00000011795	ENSACAP00000011801	ENSACAT00000012045

Organism

Anolis carolinensis

Functional Description

Protein Length

442

Protein Sequence
(FASTA)

QGFGKQVDVS YIAKYYNMSK SKVDNQFYSV EVGDSTFTVL KRYQNLKPIG SGAQGIVCAA 60

YDAVLDRNVA IKKLSRPFQN QTHAKRAYRE LVLMKCVNHK NIISLLNVFT PQKSLEEFQD 120

VYLVMELMDG NLCQVFKWEL DHERMSYLLY MLCGIKHLHS AGIIHRDLKP SNIVVKSDCT 180

LKILDFGLAR TAGTSFMMTP YVVTRYYRAP EVILGMGYKE NVDIWSVGCI MGEMVRHKIL 240

FPGRDYIDQW NKVIEQLGTP CPEFMKKLQP TVRNYVENRP KYAGLTFPKL FPDSLFPADS 300

EHNKLKASQA RDLLSKMLVI DPAKRISVDE ALQHPYINVW YDPAEVEAPP PQIYDKQLDE 360

REHTIEEWKE LIYKEVMNSE EKTKNGVVKG QPSPSGAAVN SSESLPPSSS VNDISSMSTD 420

QTLASDTDSS LEASAGPLGC CR 442

Nucleotide Sequence
(FASTA)

CAGGGATTCG GGAAACAAGT GGATGTGTCA TATATTGCCA AATATTACAA CATGAGTAAA 60

AGCAAAGTTG ACAACCAGTT CTACAGTGTG GAAGTGGGTG ACTCGACCTT CACAGTTCTC 120

AAGCGCTACC AGAACTTAAA ACCGATTGGC TCTGGAGCTC AGGGAATAGT TTGTGCTGCA 180

TATGATGCTG TTCTCGACAG GAATGTGGCC ATCAAGAAGC TCAGCAGGCC GTTTCAAAAC 240

CAGACACACG CTAAGCGAGC TTACCGAGAA CTAGTCCTCA TGAAATGTGT GAATCACAAA 300

AACATTATCA GTTTATTAAA TGTCTTCACA CCACAGAAAT CTCTGGAGGA GTTCCAGGAT 360

GTTTATTTAG TAATGGAACT GATGGATGGC AACTTGTGCC AGGTTTTCAA ATGGGAACTA 420

GACCATGAAC GGATGTCTTA CCTGCTCTAC ATGCTTTGTG GCATCAAACA TCTTCATTCT 480

GCAGGAATTA TTCACAGGGA TTTAAAACCA AGTAATATTG TGGTAAAATC AGACTGTACG 540

TTGAAGATCC TAGATTTTGG ACTGGCCAGA ACTGCAGGCA CTAGCTTCAT GATGACTCCC 600

TATGTGGTCA CACGGTATTA CAGAGCACCA GAGGTCATCT TGGGAATGGG CTACAAGGAG 660

AACGTGGATA TATGGTCAGT AGGATGCATT ATGGGAGAAA TGGTGCGCCA CAAAATCCTC 720

TTTCCAGGAA GGGATTATAT TGATCAGTGG AATAAGGTAA TTGAACAGCT GGGAACCCCT 780

TGCCCGGAAT TCATGAAGAA ACTGCAACCA ACAGTGCGGA ACTATGTGGA AAACAGACCT 840

AAATATGCCG GCCTCACCTT CCCCAAACTA TTCCCAGATT CTCTCTTTCC CGCCGATTCA 900

GAACACAACA AACTCAAAGC TAGCCAAGCC AGGGACCTTT TGTCAAAGAT GCTAGTGATT 960

GACCCAGCCA AACGGATATC AGTGGATGAA GCCTTACAGC ATCCGTACAT TAATGTCTGG 1020

TATGACCCGG CAGAAGTGGA GGCACCACCT CCACAGATAT ATGATAAGCA GCTGGATGAA 1080

AGAGAACACA CAATCGAAGA GTGGAAAGAA TTAATCTACA AGGAAGTCAT GAACTCTGAA 1140

GAAAAGACTA AAAATGGTGT AGTAAAAGGA CAGCCTTCTC CCTCAGGTGC AGCAGTGAAC 1200

AGCAGCGAAA GCCTCCCTCC ATCCTCATCC GTCAATGACA TTTCCTCCAT GTCCACAGAC 1260

CAGACCCTGG CATCAGACAC TGACAGCAGT TTGGAAGCTT CTGCAGGACC CCTCGGTTGT 1320

TGCAGGTGA 1329

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++lkp+g+Ga+g+v++a+d+  +++vaikklsrpfq++t+akr++REl l+k+++h+Ni

Q: 43    YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI  102

         899*********************************************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120

         i+ll+vftp+++lee++dvYlv+elm+ +L++v k + l++e++++lly +l+g+k+lHs

Q: 103   ISLLNVFTPQKSLEEFQDVYLVMELMDGNLCQVFKWE-LDHERMSYLLY-MLCGIKHLHS  160

         ***********************************98.***********.89********

S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslke  180

         a++iHrDlKPsN++v++dc+lkildFGlar+a ++ +  +t+yv+tr+YraPe++l  +

Q: 161   AGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFM--MTPYVVTRYYRAPEVILG-MG  217

         **********************************976..*****************9.99

S: 181   ytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyi  240

         y+++vDiWsvGCI++E++++k+lfpg+d+idq++k++e+lgtp  ef+kk++  ++rny+

Q: 218   YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQP-TVRNYV  276

         *****************************************************.5*****

S: 241   kslpkkkkkdfeelfpk............aseealdLleklLvldpdkRisveeaLehpY  288

         +++pk++  +f +lfp+            + ++a+dLl+k+Lv+dp kRisv+eaL+hpY

Q: 277   ENRPKYAGLTFPKLFPDslfpadsehnklKASQARDLLSKMLVIDPAKRISVDEALQHPY  336

         *****************************99*****************************

S: 289   l  289

Q: 337   I  337

Domain Sequence
(FASTA)

YQNLKPIGSG AQGIVCAAYD AVLDRNVAIK KLSRPFQNQT HAKRAYRELV LMKCVNHKNI 60

ISLLNVFTPQ KSLEEFQDVY LVMELMDGNL CQVFKWELDH ERMSYLLYML CGIKHLHSAG 120

IIHRDLKPSN IVVKSDCTLK ILDFGLARTA GTSFMMTPYV VTRYYRAPEV ILGMGYKENV 180

DIWSVGCIMG EMVRHKILFP GRDYIDQWNK VIEQLGTPCP EFMKKLQPTV RNYVENRPKY 240

AGLTFPKLFP DSLFPADSEH NKLKASQARD LLSKMLVIDP AKRISVDEAL QHPYI 295

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005739	; C:mitochondrion
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008351	; MAPK_JNK.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01772

; JNKMAPKINASE.

Created Date

20-Feb-2013