EKS-ANC-00356

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ANC-00356

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	446.9	1.7E-134	266	515	250

Status

Unreviewed

Ensembl Protein

ENSACAP00000011762

UniProt Accession

H9GID5;

Protein Name

Protein Synonyms/Alias

Gene Name

SRC

Gene Synonyms/Alias

SRC;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSACAG00000011859	ENSACAP00000011762	ENSACAT00000012005

Organism

Anolis carolinensis

Functional Description

Protein Length

532

Protein Sequence
(FASTA)

MGSSKSKPKD PSQRRRSLES TENIHGGCSA SQTPNKTTVA DAHRTPSRLF GSTTPEPKLF 60

GGSNTSDTVT SPQRCGALAG GVTTFVALYD YESRTESDLS FKKGERLQIL NNTEGDWWLA 120

HSLTTGQKGY IPSNYVAPSD SIQAEEWYFG KITRRESERL LLNPENPRGT FLARESETTK 180

GAYCLSVSDF DNAKGLNVKH YKIRKLDNGG FYITSRTQFS SLQQLVAYYS KHADGLCHRL 240

TNVCPTSKPQ TQGLAKDAWE IPRESLRLEV KLGQGCFGEV WMGTWNGTTR VAIKTLKPGT 300

MSPEAFLQEA QVMKKLRHEK LVQLYAVVSE EPIYIVTEYM CKGSLLDFLK GEMGKYLRLP 360

QLVDMAAQIA SGMAYVERMN YVHRDLRAAN ILVGENLVCK VADFGLARLI EDNEYTARQG 420

AKFPIKWTAP EAALYGRFTI KSDVWSFGIL LTELATKGRV PYPGMVNREV LDQVERGYRM 480

PCPPECPESL HDLMCQCWRK DPEERPTFEY LQAFLEDYFT STEPQYQPGE NL 532

Nucleotide Sequence
(FASTA)

ATGGGGAGCA GTAAGAGCAA ACCCAAAGAT CCCAGTCAAC GGAGACGCAG CCTCGAATCC 60

ACAGAAAATA TCCATGGTGG TTGCTCTGCC TCTCAAACAC CCAACAAGAC CACAGTCGCA 120

GATGCTCATC GAACCCCCAG CCGTTTATTT GGAAGCACAA CACCAGAGCC AAAACTCTTT 180

GGAGGATCAA ATACATCTGA TACAGTCACC TCTCCTCAGC GTTGTGGAGC TCTAGCTGGA 240

GGAGTCACTA CATTTGTGGC CCTTTATGAT TATGAATCAC GGACAGAATC AGATCTTTCT 300

TTTAAGAAAG GGGAACGCCT CCAAATCCTC AATAACACGG AAGGAGATTG GTGGCTGGCT 360

CACTCTCTCA CAACTGGTCA GAAAGGCTAT ATCCCCAGTA ACTATGTCGC ACCCTCAGAC 420

TCCATCCAGG CTGAAGAGTG GTATTTTGGC AAGATAACCC GCCGAGAGTC TGAACGGCTA 480

CTACTCAATC CTGAAAATCC TCGAGGAACT TTCCTGGCAA GAGAGAGTGA GACAACAAAA 540

GGTGCCTACT GCCTCTCTGT CTCAGATTTT GACAATGCCA AAGGACTCAA TGTGAAGCAC 600

TACAAGATCC GCAAACTGGA CAATGGTGGT TTCTACATCA CCTCTCGCAC CCAATTCAGC 660

AGTCTTCAGC AGCTGGTAGC ATATTATTCC AAACATGCAG ATGGCTTGTG CCACCGTCTC 720

ACCAATGTCT GCCCAACCAG CAAGCCTCAG ACACAAGGCC TTGCCAAGGA TGCTTGGGAA 780

ATTCCCCGGG AATCCCTAAG ATTAGAAGTG AAGCTTGGAC AAGGCTGCTT TGGAGAAGTG 840

TGGATGGGGA CCTGGAATGG CACCACCAGG GTAGCAATAA AGACTCTGAA ACCTGGGACA 900

ATGTCTCCAG AGGCATTTCT ACAGGAAGCT CAGGTCATGA AGAAACTGCG CCACGAGAAG 960

CTGGTGCAGT TGTACGCTGT GGTTTCTGAA GAACCTATTT ACATTGTGAC AGAATACATG 1020

TGCAAAGGAA GCCTCTTGGA TTTCTTGAAG GGTGAAATGG GCAAATATCT AAGGCTGCCC 1080

CAGTTGGTGG ACATGGCTGC ACAGATTGCA TCTGGCATGG CGTACGTGGA GAGAATGAAC 1140

TATGTTCACA GAGATCTCCG AGCTGCCAAT ATCCTTGTCG GGGAGAACCT GGTATGCAAG 1200

GTGGCTGATT TTGGACTGGC TCGCCTGATT GAGGACAACG AATATACGGC AAGGCAAGGT 1260

GCTAAATTCC CTATTAAGTG GACTGCTCCA GAAGCTGCGC TCTATGGCCG GTTCACCATC 1320

AAGTCAGATG TATGGTCCTT TGGAATACTG CTGACTGAAC TAGCCACAAA AGGCCGAGTG 1380

CCATATCCAG GTATGGTGAA CCGTGAAGTG CTTGATCAAG TGGAACGAGG CTACCGGATG 1440

CCCTGCCCAC CTGAATGCCC AGAATCTTTG CATGATCTGA TGTGCCAGTG TTGGAGGAAG 1500

GATCCTGAAG AAAGACCCAC CTTTGAGTAC CTTCAAGCTT TCTTGGAGGA TTACTTCACA 1560

TCAACAGAAC CTCAGTATCA GCCAGGCGAG AACTTATAG 1599

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         l+l+ klG+G+fGevw+g+w+g+++va+ktlk+gt+speafl+eaq++kklrheklv+ly

Q: 266   LRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLY  325

         68999*******************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avvse ePiyivte+m kGslldflk e gk+l+lp+lvd+aaq+a+Gmay+e++n++hr

Q: 326   AVVSE-EPIYIVTEYMCKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHR  384

         ****9.******************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+n+lvge+lv+kvadfGlarlied+eyta++gak+PikWtaPea+ +g+ftiksdv

Q: 385   DLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV  444

         ************************************************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfGillte+ tkG+vPypGm n+evl+qvergyr+p+p ecpe+l++l+++cw+kdpee

Q: 445   WSFGILLTELATKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKDPEE  504

         ************************************************************

S: 241   rPtfetlqevl  251

         rPtfe+lq++l

Q: 505   RPTFEYLQAFL  515

         *******9876

Domain Sequence
(FASTA)

LRLEVKLGQG CFGEVWMGTW NGTTRVAIKT LKPGTMSPEA FLQEAQVMKK LRHEKLVQLY 60

AVVSEEPIYI VTEYMCKGSL LDFLKGEMGK YLRLPQLVDM AAQIASGMAY VERMNYVHRD 120

LRAANILVGE NLVCKVADFG LARLIEDNEY TARQGAKFPI KWTAPEAALY GRFTIKSDVW 180

SFGILLTELA TKGRVPYPGM VNREVLDQVE RGYRMPCPPE CPESLHDLMC QCWRKDPEER 240

PTFEYLQAFL 250

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

acs:100558035

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013