EKS-ANC-00109
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ANC-00109
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/LRRK401.31.6E-120668943276
StatusUnreviewed
Ensembl ProteinENSACAP00000011850
UniProt AccessionH9GIH1;
Protein Name
Protein Synonyms/Alias
Gene NameLRRK1
Gene Synonyms/Alias LRRK1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSACAG00000012028ENSACAP00000011850ENSACAT00000012094
OrganismAnolis carolinensis
Functional Description
Protein Length1435
Protein Sequence
(FASTA)
IFSDSNAGIH ELPPELGQLA NLWQLDLEEL NIGNLPAEIR KESPKAILAY LRAQLRKAEK 60
CNLMKVIVVG PPRQGKSTLI EVLQTGKASP AMPNDATIRT SKWELQKPSG FKAKMDSVVF 120
NAWDIGGPAS MSTVNQCFFT DKALYVVVWN LALGEEAVAN LQFWLLNIEA KAPNSVVLVV 180
GTHLDLIETK FRVERIATLR AYVLAVCRSP SGSRATGFPD ITMKHLHEIS CKTLEGLEGL 240
RHLIYHITIN MKDIGSSIGS QKLVGRLIPR SYLSFQAAVI AEQQRRSQSD DVQYLTDKEI 300
EQIIEKNPGN DIKDYEDLQS AINFLIETGT LLHFPDTSHG LRNLYFLDPV WLSECLQRIF 360
NIKSSKSVAK NGVIRAEDLR MLLVGTGFTQ QSEEQYFQFL AKFEIALPVA NNSYLLPHLL 420
PAKPALDVHG LRHQTTNAIQ RVFKMSFVPV GFWQRFIARM LISLAEMDLQ FLENKKNTKS 480
RNKRAAIYSF AGTQRNRCST FRVKRNHTIY WQEGLFVTFD GGYLSVESSD VNWKKKKSGG 540
IKIICQSEAR DFSAMAFITD HVNSLIDQWF PALTATESDG SLLMEQYVPC PVCSTPKTKD 600
GKGSLEMEGV QYFNMEDCVL AAIESDTIVC DRHPDIPVPL QELVPELFMT DFPARLFLEN 660
SRLEYTENES NVLGQGGSGT VIYQAQYQGK LVAVKRFQIK KCQSSACSAT DTMLRHLRAM 720
DAMKTFSEFR QEACMLHSLQ HPCIVSLVGI SIHPLCLALE LAPLGSLTTV LAENAKGASF 780
VPLGRMLTLK AAYQIAAGLA YLHKKSIIFC DLKSDNILVW SLAVEESINI KLSDYGISRQ 840
SFHEGALGVE GTPGYQAPEI RPRIVYDEKV DMFSYGMVLY ELLSGQRPVL GQHQLQIAKK 900
LSKGIRPVLG RSEEVQFHRM QALMVECWDT KPEKRPLATA VVGRMKDPAF ATFLYLLPCG 960
EQSSFFSSQG EENTVVFWDG KEDIRNYTVV NTEKGLIEVA KMSCPGMKLC CQLKVQSSLW 1020
TATEDQKIYV FGLHGMCPLK DPQKGVDTPA VVTCFLAVPI AKKNSYLVLA GLSDGLIAIF 1080
HESQGVPEES CRYLCSHTAN RSRFRISDDD PRQNPYPVRV METANNGTEV WYSNGPGLLV 1140
IDCAAMEITR RLEPYCPPSV VVSIACSSEC SGEEVAWCLD EATNFLVMYH TASYQLCARY 1200
FCGDQSPLRD MFTLQPLPDS IPSALAPESS SLAGMDILQS QELGIQILNH QDSLTDYCSV 1260
SSHSSLPSPA NQTARSFSSL PSSPTSSSGV PFSTDGEEPD KTQEQNLLPL GRPGEDLAPT 1320
GDGISSLQAV RILPVKDLIW IPRRGGDIIV IGLEKEATSQ RGRVIAVLKA AELAAYGSLV 1380
DAAVLAKERV VCCFQNEAKE CCLAAWSGWG AQDFDTFYHS YEELGRLEAC MRKRR 1435
Nucleotide Sequence
(FASTA)
ATATTTTCTG ACAGCAATGC AGGCATTCAC GAGCTTCCTC CCGAACTTGG GCAACTGGCT 60
AATCTCTGGC AGCTGGATCT GGAGGAGCTG AATATTGGCA ACCTTCCCGC TGAAATCAGG 120
AAAGAGAGTC CCAAAGCCAT CTTAGCCTAC CTTCGAGCGC AGCTGCGCAA AGCGGAGAAA 180
TGCAACCTGA TGAAGGTGAT TGTCGTGGGG CCCCCGCGGC AAGGGAAATC CACCCTGATA 240
GAGGTCCTGC AGACAGGGAA GGCTTCCCCG GCCATGCCCA ACGATGCCAC CATCCGGACC 300
TCCAAGTGGG AGCTGCAGAA ACCCTCTGGG TTCAAGGCAA AGATGGATTC GGTCGTGTTT 360
AACGCCTGGG ATATTGGGGG TCCCGCCAGC ATGTCGACAG TCAATCAGTG TTTCTTCACA 420
GATAAAGCAT TATACGTTGT CGTCTGGAAC TTGGCATTGG GGGAGGAAGC AGTGGCAAAT 480
CTTCAGTTCT GGTTACTGAA TATTGAGGCC AAAGCACCAA ATTCGGTTGT GTTGGTGGTG 540
GGAACTCACC TTGACTTGAT TGAAACCAAA TTCCGCGTTG AAAGGATCGC CACCCTGAGA 600
GCCTATGTCC TGGCTGTTTG CCGATCCCCA TCCGGCTCGA GAGCAACCGG CTTCCCAGAT 660
ATCACAATGA AACACTTACA CGAAATCTCA TGTAAGACGC TCGAAGGCCT GGAAGGTCTG 720
CGGCATCTGA TCTATCACAT CACCATCAAC ATGAAGGACA TTGGGAGTTC GATTGGCTCA 780
CAAAAGCTTG TTGGGAGATT GATACCAAGG AGTTACTTGA GTTTCCAAGC GGCCGTCATA 840
GCTGAACAAC AGAGGAGAAG CCAAAGTGAC GATGTACAAT ACCTAACAGA CAAGGAAATA 900
GAGCAAATCA TAGAGAAAAA CCCTGGCAAT GACATCAAGG ACTATGAGGA TTTGCAATCT 960
GCCATCAATT TCCTGATTGA AACGGGCACG CTGCTGCACT TCCCAGACAC CAGCCACGGG 1020
CTCCGGAACC TCTATTTCCT TGACCCAGTT TGGTTGTCGG AATGCCTGCA GCGCATCTTC 1080
AACATCAAGA GCTCCAAGTC GGTTGCGAAG AACGGGGTGA TCAGAGCCGA GGACCTGCGG 1140
ATGCTCCTGG TGGGGACAGG GTTCACCCAA CAGAGCGAAG AGCAGTACTT CCAGTTCCTG 1200
GCCAAGTTTG AAATTGCGCT GCCGGTAGCC AACAACAGTT ACCTTCTGCC CCACCTGCTT 1260
CCTGCCAAAC CGGCTCTTGA TGTCCATGGC TTGCGTCACC AGACCACAAA CGCCATCCAA 1320
AGGGTGTTCA AGATGAGTTT CGTCCCTGTT GGCTTTTGGC AGAGATTTAT CGCCCGGATG 1380
CTCATCAGTC TTGCAGAGAT GGACCTGCAG TTCCTTGAAA ACAAGAAGAA CACCAAGAGT 1440
AGGAACAAGA GAGCGGCTAT CTACAGCTTT GCCGGCACTC AGCGAAACAG ATGCAGCACT 1500
TTCCGGGTTA AAAGAAATCA CACCATTTAC TGGCAAGAAG GGCTGTTTGT CACTTTCGAT 1560
GGAGGTTACT TGAGCGTGGA GTCTTCTGAT GTAAACTGGA AGAAGAAGAA AAGTGGTGGA 1620
ATCAAGATTA TTTGCCAGTC GGAAGCCAGG GATTTTTCAG CAATGGCTTT TATTACCGAT 1680
CATGTCAATT CCCTCATAGA TCAGTGGTTT CCTGCCCTGA CGGCCACTGA AAGTGACGGG 1740
AGTTTGCTGA TGGAGCAGTA CGTCCCTTGC CCGGTTTGTT CAACCCCTAA AACCAAAGAC 1800
GGGAAAGGCA GTCTGGAAAT GGAAGGCGTG CAGTACTTCA ACATGGAGGA TTGCGTTCTG 1860
GCCGCCATCG AATCGGACAC CATTGTTTGC GATCGCCACC CAGATATACC GGTGCCTTTG 1920
CAGGAGTTGG TTCCCGAGCT TTTCATGACC GATTTCCCGG CCAGGTTATT TTTGGAAAAC 1980
AGCAGACTGG AATACACTGA AAATGAAAGC AATGTTCTCG GCCAGGGAGG AAGCGGAACC 2040
GTTATATACC AGGCACAGTA CCAAGGCAAA CTGGTGGCGG TGAAGCGGTT TCAGATTAAA 2100
AAATGCCAGA GTTCTGCCTG CTCCGCTACA GACACGATGC TGAGGCACCT GCGAGCCATG 2160
GATGCCATGA AGACCTTCTC CGAGTTCCGC CAGGAAGCCT GCATGCTCCA CTCCCTTCAG 2220
CATCCGTGCA TCGTCTCCTT GGTCGGGATC AGCATCCACC CGCTCTGCTT GGCCTTAGAG 2280
CTGGCCCCGT TGGGCAGCCT CACCACGGTG CTTGCCGAAA ATGCCAAAGG AGCATCTTTT 2340
GTGCCGCTAG GGCGCATGTT GACCCTGAAA GCAGCATACC AGATTGCAGC TGGCCTGGCC 2400
TACCTCCATA AGAAGAGCAT CATTTTCTGT GACTTGAAGT CCGACAACAT CCTGGTGTGG 2460
TCTCTGGCGG TGGAGGAGAG CATCAATATC AAACTGTCGG ACTATGGGAT TTCCCGGCAG 2520
TCCTTCCACG AAGGGGCGCT CGGCGTGGAG GGGACGCCCG GCTACCAAGC CCCGGAAATA 2580
CGGCCCCGGA TTGTCTATGA TGAAAAGGTT GACATGTTTT CCTATGGCAT GGTGCTCTAT 2640
GAGCTGTTGT CTGGGCAGCG ACCTGTCCTT GGGCAGCATC AGCTCCAGAT CGCAAAGAAG 2700
CTCTCCAAGG GGATCCGGCC TGTCCTGGGC CGTTCGGAAG AGGTCCAGTT CCACCGAATG 2760
CAGGCCTTGA TGGTGGAGTG CTGGGACACC AAGCCCGAAA AGCGCCCACT GGCCACTGCT 2820
GTGGTAGGAA GGATGAAAGA CCCTGCCTTT GCGACCTTCC TGTACCTGCT GCCATGTGGG 2880
GAACAGTCGT CCTTCTTCTC TTCCCAAGGA GAAGAGAACA CCGTTGTGTT CTGGGATGGG 2940
AAGGAAGACA TCAGAAACTA TACTGTTGTG AATACAGAGA AAGGACTGAT AGAAGTTGCA 3000
AAGATGAGCT GCCCGGGAAT GAAGCTGTGC TGCCAGCTGA AAGTCCAGAG CTCCCTATGG 3060
ACAGCCACAG AGGATCAGAA GATTTACGTG TTTGGTTTAC ACGGCATGTG TCCTCTGAAG 3120
GATCCTCAAA AAGGTGTCGA CACTCCAGCA GTTGTCACCT GTTTCCTTGC AGTACCCATT 3180
GCAAAAAAGA ACTCTTATCT GGTGTTGGCT GGCTTGTCAG ATGGTCTCAT AGCTATTTTC 3240
CACGAGTCGC AAGGCGTCCC GGAGGAGAGC TGTCGCTACC TGTGCTCCCA CACGGCTAAC 3300
CGCTCCAGGT TCCGGATCAG TGACGATGAC CCCCGCCAGA ATCCCTACCC TGTGAGGGTG 3360
ATGGAGACAG CGAACAACGG GACAGAAGTC TGGTACAGCA ATGGGCCCGG CCTGCTGGTC 3420
ATTGACTGTG CGGCCATGGA GATCACCAGG CGGCTGGAGC CCTACTGCCC TCCCTCCGTG 3480
GTTGTTTCCA TAGCGTGCAG CTCGGAGTGC AGTGGGGAGG AGGTGGCCTG GTGCCTGGAC 3540
GAGGCAACCA ATTTCCTGGT GATGTACCAC ACTGCCAGCT ACCAGCTCTG TGCCCGCTAT 3600
TTCTGTGGGG ACCAAAGCCC TTTGCGAGAC ATGTTCACCC TTCAGCCGCT GCCTGACTCT 3660
ATTCCCTCCG CGTTGGCTCC GGAGAGCAGC TCTCTAGCAG GCATGGACAT TCTGCAAAGC 3720
CAAGAGCTGG GGATCCAAAT ACTCAACCAT CAGGACTCCC TGACGGACTA CTGCTCAGTG 3780
TCCTCTCACT CGTCCTTGCC GTCACCCGCC AACCAGACGG CGAGATCCTT CTCAAGCCTG 3840
CCAAGCTCCC CCACAAGCTC TTCCGGTGTG CCTTTCTCAA CAGATGGTGA GGAACCGGAC 3900
AAGACCCAGG AGCAAAATCT TCTTCCCCTG GGGAGGCCTG GAGAGGATTT GGCACCGACC 3960
GGTGATGGCA TTAGTTCCCT GCAAGCCGTG AGAATCCTCC CTGTGAAAGA CCTCATATGG 4020
ATCCCCAGGC GAGGAGGAGA TATCATTGTG ATTGGCCTGG AGAAAGAAGC CACTTCTCAG 4080
CGGGGCAGAG TCATTGCTGT GTTGAAGGCT GCGGAGCTGG CTGCCTATGG GTCACTGGTG 4140
GACGCCGCTG TCCTGGCTAA GGAGCGTGTT GTGTGCTGCT TTCAGAACGA GGCCAAGGAG 4200
TGTTGCCTGG CTGCCTGGAG CGGCTGGGGC GCCCAAGACT TTGATACTTT CTACCATTCA 4260
TATGAAGAGC TGGGGAGGCT CGAGGCCTGC ATGCGGAAGA GGAGGTAG 4308
Domain Profile
S: 2     kkgsllGrGafGsv.yraavkGeevavkafki..........aadklkrdslelalkays  50
         +++++lG+G++G+v y+a+++G+ vavk+f+i          ++++l+++++++a+k++s
Q: 668   NESNVLGQGGSGTViYQAQYQGKLVAVKRFQIkkcqssacsaTDTMLRHLRAMDAMKTFS  727
         6799*************************************8899***************
S: 51    elrqelsvLlalkhPsivsLvgisikPlalvleLaplgsLdrlLsedkksss..klgrtl  108
         e+rqe+ +L++l+hP+ivsLvgisi+Pl+l+leLaplgsL ++L e++k +s  +lgr+l
Q: 728   EFRQEACMLHSLQHPCIVSLVGISIHPLCLALELAPLGSLTTVLAENAKGASfvPLGRML  787
         *************************************************99999******
S: 109   tkkialqvargleyLhkkkiiyrdLksenvLvwslspkeailikladyGisrqslrsGak  168
         t k a+q+a gl+yLhkk ii++dLks+n+Lvwsl ++e+i+ikl+dyGisrqs+++Ga+
Q: 788   TLKAAYQIAAGLAYLHKKSIIFCDLKSDNILVWSLAVEESINIKLSDYGISRQSFHEGAL  847
         ************************************************************
S: 169   gveGteGfraPeivrgevvydekvdvfsfGlllyellsgkrpvegeeqlkivekllkGkr  228
         gveGt+G++aPei r+++vydekvd+fs+G++lyellsg+rpv+g++ql+i++kl+kG+r
Q: 848   GVEGTPGYQAPEI-RPRIVYDEKVDMFSYGMVLYELLSGQRPVLGQHQLQIAKKLSKGIR  906
         *************.**********************************************
S: 229   PvlvkeeevlptplldLlveCwkekPekrPtasqvvs  265
         Pvl+++eev+++++++L+veCw++kPekrP+a+ vv+
Q: 907   PVLGRSEEVQFHRMQALMVECWDTKPEKRPLATAVVG  943
         *********************************9985
Domain Sequence
(FASTA)
NESNVLGQGG SGTVIYQAQY QGKLVAVKRF QIKKCQSSAC SATDTMLRHL RAMDAMKTFS 60
EFRQEACMLH SLQHPCIVSL VGISIHPLCL ALELAPLGSL TTVLAENAKG ASFVPLGRML 120
TLKAAYQIAA GLAYLHKKSI IFCDLKSDNI LVWSLAVEES INIKLSDYGI SRQSFHEGAL 180
GVEGTPGYQA PEIRPRIVYD EKVDMFSYGM VLYELLSGQR PVLGQHQLQI AKKLSKGIRP 240
VLGRSEEVQF HRMQALMVEC WDTKPEKRPL ATAVVG 276
KeywordComplete proteome; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00113
EKS-BOT-00121
EKS-CAE-00098
EKS-CAJ-00123
EKS-CAF-00124
EKS-CAP-00118
EKS-DAR-00378
EKS-EQC-00117
EKS-FEC-00112
EKS-GAG-00101
EKS-GAA-00140
EKS-GOG-00120
EKS-HOS-00123
EKS-ICT-00114
EKS-LAC-00126
EKS-LOA-00116
EKS-MAM-00117
EKS-MEG-00091
EKS-MOD-00118
EKS-MUM-00122
EKS-MUP-00124
EKS-MYL-00132
EKS-NOL-00113
EKS-ORN-00148
EKS-ORA-00099
EKS-ORC-00113
EKS-OTG-00124
EKS-PAT-00110
EKS-PES-00104
EKS-PEM-00066
EKS-POA-00114
EKS-RAN-00118
EKS-SAH-00113
EKS-SUS-00107
EKS-TAG-00150
EKS-TAR-00153
EKS-TEN-00140
EKS-XET-00100
EKS-XIM-00145
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0005525; F:GTP binding
GO:0004672; F:protein kinase activity
GO:0007264; P:small GTPase mediated signal transduction
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR013684; MIRO-like.
IPR000719; Prot_kinase_cat_dom.
IPR020859; ROC_GTPase.
Pfam
PF08477; Miro; 1.
PF00069; Pkinase; 1.
SMARTs
Prosites
PS50011; PROTEIN_KINASE_DOM; 1.
PS51424; ROC; 1.
Prints
Created Date20-Feb-2013