EKS-ANC-00057

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ANC-00057

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	343.1	1.0E-102	9	295	287

Status

Unreviewed

Ensembl Protein

ENSACAP00000013027

UniProt Accession

G1KNG9;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK4

Gene Synonyms/Alias

CDK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSACAG00000013219	ENSACAP00000013027	ENSACAT00000013286

Organism

Anolis carolinensis

Functional Description

Protein Length

303

Protein Sequence
(FASTA)

MAMGRCEQYE PVAEIGIGAY GTVFKARDLQ SGKFVALKNV RFQNSENGLP HSTVREVALL 60

KRLENFDHPN VVRLMDVCTT TRTERETKVT LVFEHVDQDL KAFLEKTPPP GLPAEMIKDM 120

MHQFLSGLDF LHTNCIVHRD LKPENILVTS SGQVKLADFG LARVYSCQMA LTPLVVTLWY 180

RAPEVLLQSA YATPVDLWSV GCIFAEMFRR KPLFCGNSEA DQLGKIFDLI GLPPEEDWPL 240

DVSLPRCAFA PCSPQPIERF VPEIDTLGIQ LLLEMLTFNP LKRISAFQAL HHQYFQDMSA 300

GEG 303

Nucleotide Sequence
(FASTA)

ATGGCCATGG GGAGATGCGA ACAGTATGAA CCTGTGGCCG AAATCGGCAT TGGGGCTTAT 60

GGCACTGTCT TCAAGGCCCG TGACCTGCAA AGTGGCAAGT TTGTGGCCCT TAAGAATGTG 120

CGATTCCAGA ACAGCGAGAA TGGGTTGCCG CACTCCACGG TCCGTGAAGT GGCCCTGCTG 180

AAACGCCTGG AGAACTTTGA CCACCCCAAC GTTGTGCGGC TAATGGACGT TTGCACAACA 240

ACACGGACAG AGCGTGAGAC CAAAGTAACA TTGGTCTTTG AGCATGTGGA TCAGGATCTG 300

AAAGCATTTT TGGAGAAAAC TCCGCCTCCT GGCTTACCAG CAGAGATGAT CAAGGATATG 360

ATGCATCAGT TCTTGAGTGG CTTGGATTTC CTGCATACAA ACTGCATTGT TCATCGTGAC 420

CTCAAGCCAG AAAATATCTT GGTGACCAGT TCTGGTCAAG TCAAGTTGGC TGACTTTGGC 480

CTGGCTCGCG TCTACAGCTG TCAGATGGCC CTGACACCTC TGGTGGTCAC TCTCTGGTAC 540

CGGGCTCCAG AAGTGCTGCT CCAGTCAGCT TATGCCACCC CTGTGGACCT GTGGAGTGTG 600

GGGTGCATCT TTGCAGAGAT GTTTCGAAGG AAGCCTCTCT TCTGTGGCAA CTCCGAAGCT 660

GATCAGCTGG GCAAGATCTT TGATTTGATT GGGCTCCCAC CTGAGGAGGA TTGGCCCCTG 720

GACGTTTCTC TGCCACGCTG TGCCTTTGCT CCCTGCTCCC CACAGCCTAT TGAGAGGTTT 780

GTGCCAGAAA TAGACACCCT GGGGATCCAG CTGCTTTTGG AAATGCTGAC ATTCAATCCC 840

TTGAAACGCA TCTCTGCTTT CCAAGCACTG CATCATCAGT ACTTTCAGGA CATGAGCGCA 900

GGTGAAGGGT AG 912

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkel...kh  57

         ye +++ig G+yg+v+ka+d ++g++vAlK++r +++++g+p++++rE++llk+l   +h

Q: 9     YEPVAEIGIGAYGTVFKARDLQSGKFVALKNVRFQNSENGLPHSTVREVALLKRLenfDH  68

         88899************************************************998889*

S: 58    knivkLlevva....kdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqllegl  113

         +n+v+L++v++    ++++k++Lvfe+++qdLk +l+k++  +l+ e++k +++q+l+gl

Q: 69    PNVVRLMDVCTttrtERETKVTLVFEHVDQDLKAFLEKTPPPGLPAEMIKDMMHQFLSGL  128

         ***********99866669*****************************************

S: 114   aylHsnkilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLl  173

         ++lH+n i+HRDlKp+N+L++++g++klaDfGlar +s ++  +t+ vvTlwYraPe+Ll

Q: 129   DFLHTNCIVHRDLKPENILVTSSGQVKLADFGLARVYSCQMA-LTPLVVTLWYRAPEVLL  187

         **************************************9999.*****************

S: 174   gakeYstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpe  233

         ++  Y t vD+Wsvgci+ae+++rkplf g+se dql +if+l+g p e++wp   +lp+

Q: 188   QS-AYATPVDLWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEEDWPLDVSLPR  246

         88.5********************************************************

S: 234   ykksfpkkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         +   f + +++ +++ v+++++ +++ll ++l+++p kRisa +al+h+yf

Q: 247   CA--FAPCSPQPIERFVPEIDTLGIQLLLEMLTFNPLKRISAFQALHHQYF  295

         76..99999*****************************************9

Domain Sequence
(FASTA)

YEPVAEIGIG AYGTVFKARD LQSGKFVALK NVRFQNSENG LPHSTVREVA LLKRLENFDH 60

PNVVRLMDVC TTTRTERETK VTLVFEHVDQ DLKAFLEKTP PPGLPAEMIK DMMHQFLSGL 120

DFLHTNCIVH RDLKPENILV TSSGQVKLAD FGLARVYSCQ MALTPLVVTL WYRAPEVLLQ 180

SAYATPVDLW SVGCIFAEMF RRKPLFCGNS EADQLGKIFD LIGLPPEEDW PLDVSLPRCA 240

FAPCSPQPIE RFVPEIDTLG IQLLLEMLTF NPLKRISAFQ ALHHQYF 287

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0000785	; C:chromatin
GO:0000307	; C:cyclin-dependent protein kinase holoenzyme complex
GO:0005829	; C:cytosol
GO:0031965	; C:nuclear membrane
GO:0005730	; C:nucleolus
GO:0005667	; C:transcription factor complex
GO:0005524	; F:ATP binding
GO:0004693	; F:cyclin-dependent protein kinase activity
GO:0000082	; P:G1/S transition of mitotic cell cycle
GO:0048146	; P:positive regulation of fibroblast proliferation
GO:0051726	; P:regulation of cell cycle
GO:0010468	; P:regulation of gene expression
GO:0042493	; P:response to drug
GO:0007165	; P:signal transduction

KEGG

acs:100559515

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013