EKS-ANC-00402

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ANC-00402

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/DAPK	464.1	1.1E-139	13	273	261

Status

Unreviewed

Ensembl Protein

ENSACAP00000013245

UniProt Accession

G1KNU5;

Protein Name

Protein Synonyms/Alias

Gene Name

DAPK1

Gene Synonyms/Alias

DAPK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSACAG00000013377	ENSACAP00000013245	ENSACAT00000013511

Organism

Anolis carolinensis

Functional Description

Protein Length

1429

Protein Sequence
(FASTA)

ITPYWQTHIL YETVSQVSSG QFAVVRKCRE KSTGAQYAAK FIKKRRTKSS RRGVSREDIE 60

REVNILKEIQ HPNVITLHDV YESKMDVILI LELVAGGELF DFLAEKESLT EEEATEFLKQ 120

ILNGVNYLHS LQIAHFDLKP ENIMLLDRNV PKPRIKIIDF GLAHKIDFSN EFKNIFGTPE 180

FVAPEIVNYE PLGLEADMWS IGVITYILLS GASPFLGESK QETLANVSAV NYDFEEEFFS 240

NTSALAKDFI RRLLIKDPKK RMTIQDSLQH PWIKPKDTLQ ALSRKASAVN MEKFKKFAAR 300

RKWKQSVRLI SLCQRLSRSF LSRSNMSVAR SDDTLDEEDS FVMKAIIHAI NDDNVPGLQH 360

LLGSLTNYDI NQPNRHGTPP FLIAAGCGNV QMLQLFLKRG ARIDVQDKAG SNAIYWASRH 420

GHVETLKFLH GSKCPLDVRD KSGETALHVA SRYGHVDVVH YLCSIGSNPN FQDKEEESPL 480

HCAAWHGYYP VTKALCTAGC NVNVKNREGE TPLLTASARG YHDIVECLAE HGADLDATDK 540

DGHIALHLAV RRCQMEVVKT LLSQGSSIDF QDRHGNTPLH VACKDGNMPI VMALCEANCN 600

IDVTNKYGRT PLHLAANNGI LDVVRYLCLS GANVEALTSD GKTAEDLARA EQHEHVASLL 660

TRLKKDTHRT MFIHQLRPTH NLQPRIKLKL FGHSASGKTA LVESLKCGLL RSFFRRRRPR 720

LASTNSVRFP PSPLSNRPTV SVSITNLYPG CENVSVRSRS MMFEPGLTKG MLEVFVSPSH 780

HSHCSADDQS TKAIDVQNAY LNGVGDFSVW EFSGNPVYFC CYDYFAANDP TSVHIVLFSL 840

EEPYEIQLNQ VTFWLSFLKS LVPVEEHIAF GGKLKTPLHV ALVATHADIV NLPRSAAGEF 900

LYDKDSSLMK EIRNSRFGND LHILDRLFIL DAGASGSKDM KILRNHLQEL RGHIISACPP 960

MTHLCEKIIS TLPSWRKMNG PNQLMSLQQF VYDVQDQLNP LASEDELRHI AQQLHSIGEI 1020

NIMQSETVQD VVLLDPRWLC SNVLGKLLSV ESPKALHHYR GRYTIEDIQR LIPDSDIEEL 1080

IQILDAMDIC ARDLSSGTMI DIPALIKTDS LHRSWADEED EVMIYGGIRI VPVEHLTPLP 1140

CGIFHKVQVN LCRWIHQQST EGDADIRLWV NGSKIMNRGA ELLVLLVNNG QGIEVQVRGL 1200

ETEKIKCCLF LDSVCSTIDN LMATTLPGLL TVKHYLSPQQ LREHHEPIMI YQPRDFFRAQ 1260

SQKETSLTNT MGGYKESFSS ILCFGCLDVY SQGSLGMDIH VSDLNLLTRR KLSRLLDPPD 1320

PMGKDWCLLA MNLGLPDLVA KYNTNNGNHH DFTSSPSYAL LHEWGNAPES TVGILMSKLR 1380

ELGRRDAADF LLKASSVFRV SLDANGQEAY ASSCNSGTSY NSISSVVSR 1429

Nucleotide Sequence
(FASTA)

ATCACACCTT ACTGGCAGAC TCATATTTTG TATGAAACTG TTTCCCAGGT TTCTAGTGGG 60

CAGTTTGCAG TAGTAAGGAA ATGCCGTGAG AAGAGCACCG GTGCCCAATA TGCTGCAAAA 120

TTCATCAAGA AACGAAGAAC GAAATCCAGT CGTAGAGGAG TGAGTCGAGA GGACATTGAA 180

CGAGAAGTGA ACATATTAAA AGAAATCCAA CACCCCAACG TAATCACGCT GCATGATGTT 240

TACGAAAGTA AAATGGATGT AATTCTTATT CTGGAGCTTG TTGCAGGAGG GGAACTCTTT 300

GATTTTCTAG CTGAAAAGGA ATCCCTGACT GAAGAGGAAG CTACAGAGTT TCTCAAGCAA 360

ATCCTTAATG GTGTTAACTA TCTCCACTCT TTGCAAATTG CACACTTTGA TCTCAAGCCT 420

GAAAACATAA TGCTGCTGGA TAGAAACGTA CCAAAGCCTC GCATCAAGAT TATTGACTTT 480

GGCTTAGCAC ACAAAATAGA CTTTAGCAAC GAGTTCAAGA ACATTTTTGG GACACCCGAA 540

TTTGTTGCTC CTGAAATAGT TAACTATGAA CCTCTGGGTC TTGAGGCAGA TATGTGGAGC 600

ATAGGAGTAA TAACTTACAT TCTCCTGAGT GGTGCATCGC CATTTCTTGG AGAAAGTAAA 660

CAAGAAACAT TAGCAAATGT GTCTGCAGTG AACTATGACT TTGAGGAAGA ATTTTTCAGT 720

AATACCAGTG CGCTAGCTAA AGATTTCATA AGAAGACTTT TAATTAAGGA CCCAAAGAAG 780

AGAATGACAA TTCAAGATAG CTTGCAGCAT CCCTGGATCA AGCCTAAAGA TACCCTTCAA 840

GCACTTAGTA GAAAAGCATC AGCAGTCAAT ATGGAGAAGT TTAAAAAGTT TGCAGCACGA 900

AGGAAATGGA AGCAATCTGT GCGCTTAATA TCACTATGCC AAAGATTATC AAGATCCTTT 960

TTGTCCAGAA GTAACATGAG CGTGGCTAGG AGCGATGACA CTCTGGATGA GGAAGATTCA 1020

TTTGTAATGA AAGCCATCAT ACATGCCATC AATGATGACA ACGTTCCTGG TCTCCAGCAC 1080

CTTTTGGGGT CTTTAACCAA TTATGACATC AATCAACCAA ATAGGCATGG AACACCACCA 1140

TTTCTAATTG CAGCTGGATG TGGGAATGTT CAGATGCTTC AGTTGTTCCT GAAGCGAGGT 1200

GCTCGGATTG ATGTCCAAGA TAAGGCAGGA TCTAATGCAA TCTATTGGGC ATCTCGACAT 1260

GGTCACGTAG AAACCCTGAA ATTTCTCCAT GGGAGCAAAT GCCCTTTGGA TGTCAGAGAC 1320

AAGTCTGGAG AAACTGCTCT GCATGTGGCC TCTCGGTATG GTCATGTGGA CGTGGTTCAC 1380

TACCTGTGTA GCATTGGATC AAATCCAAAT TTTCAAGATA AGGAAGAAGA ATCACCTTTG 1440

CACTGTGCTG CTTGGCATGG CTACTACCCT GTTACCAAAG CACTGTGTAC GGCAGGCTGT 1500

AATGTGAACG TTAAAAATAG AGAAGGGGAA ACCCCACTCT TGACAGCGTC AGCAAGAGGC 1560

TACCATGATA TTGTGGAATG TTTGGCAGAG CATGGCGCCG ACCTTGATGC GACTGACAAG 1620

GATGGACACA TAGCTCTTCA CCTGGCAGTC CGAAGATGTC AGATGGAAGT GGTTAAAACA 1680

CTCCTCAGTC AGGGAAGCTC TATAGATTTC CAAGACAGAC ATGGGAACAC TCCTCTCCAT 1740

GTAGCCTGCA AAGATGGAAA CATGCCCATA GTGATGGCAC TCTGTGAAGC AAATTGCAAC 1800

ATAGATGTCA CTAATAAGTA CGGGCGAACA CCACTACATC TGGCAGCAAA TAATGGCATT 1860

CTTGATGTGG TCCGGTACCT CTGTCTCAGC GGAGCCAATG TGGAAGCTTT AACTTCTGAT 1920

GGAAAAACAG CAGAGGATTT GGCTAGAGCC GAGCAGCATG AACATGTAGC CAGCCTGCTT 1980

ACAAGGCTTA AAAAGGATAC ACATAGAACA ATGTTCATCC ACCAACTCAG ACCTACTCAT 2040

AATCTGCAGC CAAGGATAAA ATTAAAGCTC TTTGGCCATT CAGCATCTGG GAAAACTGCT 2100

CTAGTAGAGT CCTTGAAGTG TGGTCTTTTG CGAAGCTTTT TCAGAAGGCG CAGACCAAGG 2160

CTTGCTTCTA CGAACTCAGT CAGGTTTCCT CCTTCACCAT TATCTAATAG GCCAACAGTT 2220

TCAGTAAGTA TTACCAACCT GTATCCTGGC TGTGAGAATG TGAGTGTGAG AAGCCGAAGC 2280

ATGATGTTTG AGCCAGGCCT GACCAAAGGG ATGCTGGAAG TGTTTGTTTC GCCCTCTCAC 2340

CATTCCCACT GCTCAGCAGA TGACCAGTCA ACCAAGGCCA TTGACGTTCA GAATGCTTAC 2400

TTGAATGGAG TCGGTGACTT CAGTGTGTGG GAATTCTCTG GGAATCCTGT GTATTTCTGC 2460

TGCTACGATT ATTTTGCTGC AAATGACCCC ACCTCAGTTC ACATTGTGCT TTTTAGTCTT 2520

GAAGAGCCCT ATGAAATCCA ATTGAACCAA GTGACCTTTT GGCTTAGTTT CCTAAAATCC 2580

CTTGTCCCAG TTGAAGAACA TATAGCATTT GGAGGAAAGC TGAAAACTCC TTTGCACGTG 2640

GCACTGGTGG CTACCCATGC GGACATTGTC AATCTTCCAC GTTCTGCTGC AGGAGAGTTC 2700

CTATATGACA AGGATTCTTC ACTTATGAAA GAAATTCGGA ATAGTAGGTT TGGGAATGAC 2760

CTCCATATTT TGGATAGATT ATTTATTTTG GATGCTGGTG CATCTGGGTC AAAAGATATG 2820

AAGATTCTCC GAAATCACCT TCAAGAATTG CGTGGTCACA TTATCTCTGC ATGTCCACCA 2880

ATGACTCATT TGTGTGAAAA AATCATCTCT ACCTTGCCGT CATGGAGAAA AATGAATGGA 2940

CCCAACCAAC TCATGTCATT GCAGCAGTTT GTGTATGATG TGCAAGATCA GCTTAATCCA 3000

TTAGCAAGTG AAGATGAATT AAGACATATA GCCCAGCAGC TACACAGTAT AGGAGAAATC 3060

AATATCATGC AGAGTGAAAC TGTCCAAGAC GTTGTCCTGC TGGATCCTCG TTGGCTGTGT 3120

TCAAACGTCC TTGGAAAACT TCTATCAGTA GAAAGCCCTA AAGCTCTCCA CCATTACAGA 3180

GGTCGGTATA CAATAGAAGA CATTCAGCGC TTGATACCAG ATAGTGATAT AGAAGAACTT 3240

ATACAAATCT TGGATGCTAT GGATATCTGT GCCAGAGATC TCAGCAGTGG AACAATGATT 3300

GACATCCCTG CCTTAATCAA GACTGATAGT CTCCATAGAT CTTGGGCTGA TGAAGAGGAT 3360

GAAGTTATGA TTTATGGTGG TATAAGAATT GTTCCTGTGG AACACCTAAC GCCGCTTCCT 3420

TGTGGAATTT TCCACAAAGT TCAGGTGAAT CTGTGTAGGT GGATTCATCA ACAGAGCACA 3480

GAGGGAGATG CAGATATACG TCTTTGGGTA AATGGATCAA AGATTATGAA TCGTGGAGCT 3540

GAGCTCCTTG TGTTACTTGT CAACAACGGT CAAGGAATTG AAGTTCAAGT TAGAGGCCTG 3600

GAAACAGAGA AGATCAAATG CTGCTTGTTC CTAGACTCGG TGTGCAGCAC CATTGATAAT 3660

CTGATGGCCA CAACATTGCC AGGTCTCTTA ACAGTCAAAC ATTATCTCAG CCCTCAGCAA 3720

CTGAGAGAAC ATCATGAACC AATAATGATC TACCAGCCAA GAGATTTTTT CCGGGCACAG 3780

AGTCAAAAGG AGACATCACT GACAAATACC ATGGGTGGAT ATAAAGAAAG CTTTAGCAGT 3840

ATATTGTGCT TTGGGTGTCT TGACGTCTAT TCCCAGGGAA GCTTGGGGAT GGATATTCAT 3900

GTATCAGATC TGAATCTGCT TACAAGGAGG AAACTGAGTC GACTTCTGGA CCCACCTGAT 3960

CCCATGGGCA AGGACTGGTG CCTTCTTGCT ATGAACTTGG GCCTTCCTGA CCTTGTGGCA 4020

AAATACAACA CGAACAATGG GAATCACCAT GACTTCACAT CAAGCCCATC CTATGCCCTT 4080

CTGCATGAAT GGGGAAATGC CCCTGAAAGT ACTGTGGGCA TCCTCATGTC CAAACTGAGG 4140

GAACTGGGCC GCAGAGATGC CGCTGACTTC TTACTGAAAG CATCCTCCGT GTTTAGAGTC 4200

AGTCTAGATG CAAATGGCCA AGAAGCCTAT GCATCGAGCT GTAACAGTGG GACATCGTAC 4260

AATTCAATTA GCTCAGTTGT GTCTCGGTGA 4290

Domain Profile

S: 3     tgkelgsGkfavvrkcrekstGkeyaakflkkrrlkssrrgvsreeierevavlkeirse  62

         t  ++ sG+favvrkcrekstG +yaakf+kkrr+kssrrgvsre+ierev++lkei+ +

Q: 13    TVSQVSSGQFAVVRKCREKSTGAQYAAKFIKKRRTKSSRRGVSREDIEREVNILKEIQ-H  71

         667899****************************************************.*

S: 63    pnvinlhevyenksdvililelvaGGelfdllaekeslseeeatellkqilegvkylhsk  122

         pnvi+lh+vye+k dvililelvaGGelfd+laekesl+eeeate+lkqil+gv+ylhs

Q: 72    PNVITLHDVYESKMDVILILELVAGGELFDFLAEKESLTEEEATEFLKQILNGVNYLHSL  131

         ************************************************************

S: 123   kivhldlkPenillldkkvpkgdiklidfGlsrkieegaelkeilGtPefvaPeivnyep  182

         +i+h+dlkPeni+lld++vpk++ik+idfGl++ki+ ++e+k+i+GtPefvaPeivnyep

Q: 132   QIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFSNEFKNIFGTPEFVAPEIVNYEP  191

         ************************************************************

S: 183   lsletdmwsiGvityillsgasPflGdtkqetllnisavnldfseelfssvselakdfir  242

         l+le+dmwsiGvityillsgasPflG++kqetl+n+savn+df+ee+fs++s lakdfir

Q: 192   LGLEADMWSIGVITYILLSGASPFLGESKQETLANVSAVNYDFEEEFFSNTSALAKDFIR  251

         ************************************************************

S: 243   rllvkdpekrltieeclehswl  264

         rll+kdp+kr+ti+++l+h+w+

Q: 252   RLLIKDPKKRMTIQDSLQHPWI  273

         *********************8

Domain Sequence
(FASTA)

TVSQVSSGQF AVVRKCREKS TGAQYAAKFI KKRRTKSSRR GVSREDIERE VNILKEIQHP 60

NVITLHDVYE SKMDVILILE LVAGGELFDF LAEKESLTEE EATEFLKQIL NGVNYLHSLQ 120

IAHFDLKPEN IMLLDRNVPK PRIKIIDFGL AHKIDFSNEF KNIFGTPEFV APEIVNYEPL 180

GLEADMWSIG VITYILLSGA SPFLGESKQE TLANVSAVNY DFEEEFFSNT SALAKDFIRR 240

LLIKDPKKRM TIQDSLQHPW I 261

Keyword

ANK repeat; Complete proteome; Reference proteome; Repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0015629	; C:actin cytoskeleton
GO:0005737	; C:cytoplasm
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006915	; P:apoptotic process
GO:0006917	; P:induction of apoptosis
GO:0007243	; P:intracellular protein kinase cascade
GO:2000310	; P:regulation of N-methyl-D-aspartate selective glutamate receptor activity

KEGG

InterPros

IPR002110	; Ankyrin_rpt.
IPR020683	; Ankyrin_rpt-contain_dom.
IPR000488	; Death.
IPR020676	; Death-assoc_prot_kinase.
IPR011029	; DEATH-like.
IPR011009	; Kinase-like_dom.
IPR020675	; Myosin_light_ch_kinase-rel.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF12796	; Ank_2; 3.
PF00531	; Death; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00248	; ANK; 10.
SM00005	; DEATH; 1.
SM00220	; S_TKc; 1.

Prosites

PS50297	; ANK_REP_REGION; 1.
PS50088	; ANK_REPEAT; 7.
PS50017	; DEATH_DOMAIN; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01415

; ANKYRIN.

Created Date

20-Feb-2013