EKS-ANC-00267

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ANC-00267

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	451.2	1.3E-135	232	519	288

Status

Unreviewed

Ensembl Protein

ENSACAP00000013548

UniProt Accession

G1KP73;

Protein Name

Protein Synonyms/Alias

Gene Name

BMPR1B

Gene Synonyms/Alias

BMPR1B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSACAG00000013701	ENSACAP00000013548	ENSACAT00000013826

Organism

Anolis carolinensis

Functional Description

Protein Length

530

Protein Sequence
(FASTA)

LGWLIHGSVL VTYFLLCLLS SAGNFLDSRP LRSSGKVNME PRKEDGGSTA APPQKMLWCH 60

CHHYCPENSK NNTCSTDGYC FAMVEDDDIG GQTFTTGCIG LEGSDFQCRD TPLSQPRRLI 120

ACCTDQNFCN KDLHPTLPPL EGRGFAEGNA HHKALLISVT ICSILLVLVI IFCYFRYKRQ 180

ESRPPRYSIG LEQDETYIPP GESLKDLIEQ SQSSGSGSGL PLLVQRTIAK QIQMVKQIGK 240

GRYGEVWMGK WRGEKVAVKV FFTTEEASWF RETEIYQTVL MRHENILGFI AADIKGTGSW 300

TQLYLITDYH ENGSLYDYLK STTLDTKAML KLAYSSVSGL CHLHTEIFST QGKPAIAHRD 360

LKSKNILVKK NGTCCIADLG LAVKFISDTN EVDIPPNTRV GTKRYMPPEV LDESLNRNHF 420

QSYIMADMYS FGLILWEIAR RCVSGGIVEE YQLPYHDLVP SDPSYEDMRE IVCIKKLRPS 480

FPNRWSSDEC LRQMGKLMTE CWAHNPASRL TALRVKKTLA KMSESQDIKL 530

Nucleotide Sequence
(FASTA)

CTGGGTTGGC TTATCCATGG CTCAGTCCTA GTAACTTATT TCTTACTTTG TTTACTTTCT 60

TCTGCAGGAA ACTTCCTAGA CAGCAGACCC CTGAGGAGTT CTGGGAAAGT GAACATGGAA 120

CCCAGGAAAG AGGATGGTGG AAGTACAGCT GCCCCTCCCC AGAAGATGTT GTGGTGTCAT 180

TGTCATCACT ACTGTCCTGA AAACTCAAAA AACAACACCT GCAGTACTGA TGGCTACTGT 240

TTTGCCATGG TAGAAGATGA CGACATTGGA GGGCAGACTT TCACCACAGG CTGTATAGGA 300

CTGGAAGGCT CTGATTTCCA ATGCCGGGAC ACCCCACTGT CCCAACCAAG ACGATTGATT 360

GCCTGCTGCA CGGATCAAAA TTTCTGTAAC AAAGATCTTC ACCCTACTCT GCCACCACTG 420

GAAGGTCGAG GTTTCGCAGA GGGAAATGCT CACCACAAGG CTTTGCTGAT TTCAGTCACC 480

ATTTGTAGTA TACTGCTAGT GCTTGTCATC ATATTCTGTT ATTTCAGGTA TAAAAGGCAA 540

GAAAGCAGGC CTCCTCGCTA CAGTATTGGG CTCGAACAAG ACGAGACTTA CATTCCTCCC 600

GGAGAATCCT TGAAAGACCT CATTGAACAG TCACAGAGCT CTGGAAGTGG CTCTGGGCTC 660

CCTCTGCTGG TACAGAGGAC TATAGCAAAG CAGATTCAGA TGGTGAAGCA GATTGGTAAA 720

GGTCGCTATG GAGAGGTCTG GATGGGGAAA TGGCGAGGAG AAAAGGTGGC TGTCAAAGTC 780

TTCTTCACCA CCGAGGAAGC CAGTTGGTTC CGAGAGACGG AAATCTATCA GACTGTTTTG 840

ATGAGGCATG AAAATATTTT AGGTTTTATT GCTGCAGACA TTAAAGGCAC AGGGTCTTGG 900

ACTCAGCTAT ATCTTATCAC TGACTACCAT GAGAATGGAT CATTGTATGA CTACCTGAAG 960

TCCACAACAT TGGATACAAA AGCCATGCTT AAACTAGCAT ATTCCTCTGT CAGTGGATTG 1020

TGTCACTTGC ACACTGAGAT CTTCAGTACT CAAGGCAAGC CAGCTATTGC CCACCGGGAC 1080

CTCAAAAGTA AAAACATTCT AGTGAAAAAG AATGGCACCT GTTGTATAGC AGATCTTGGT 1140

TTGGCAGTTA AATTTATTAG TGATACAAAT GAGGTAGACA TACCACCGAA CACGAGAGTA 1200

GGAACAAAAC GGTACATGCC TCCTGAGGTC TTGGATGAAA GTCTGAACCG GAATCATTTC 1260

CAGTCATACA TCATGGCCGA TATGTACAGT TTCGGACTCA TCCTTTGGGA AATAGCAAGG 1320

AGATGTGTTT CTGGAGGTAT AGTTGAAGAA TATCAGCTTC CATATCATGA CCTTGTTCCT 1380

AGTGACCCCT CATATGAAGA CATGAGGGAA ATAGTGTGTA TTAAGAAGTT ACGGCCTTCA 1440

TTTCCAAACA GATGGAGTAG TGATGAGTGC TTAAGACAAA TGGGCAAACT AATGACAGAA 1500

TGCTGGGCTC ACAACCCTGC TTCTCGGCTC ACAGCTCTAC GAGTAAAGAA AACGCTTGCC 1560

AAAATGTCAG AGTCACAGGA CATTAAACTC TGA 1593

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         ++++++igkGrygeVw++k+rge+vAvK+f+t++easw+rE+eiyqtvl+rhenil+fia

Q: 232   IQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIA  291

         799*********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k ++s+t+l+l+t+yhe+gsL+dyLk++tld++ +l+la+s +sGl+hLH+ei+ t+

Q: 292   ADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDTKAMLKLAYSSVSGLCHLHTEIFSTQ  351

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNilvkk++tcciaDlGLa+k+ ++++e+d+  n++vGtkRYm PE

Q: 352   G--KPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPE  409

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e+ln ++f+++ +aD+Ys+gL+lWE+a+Rc + +++veey+lp+++ v+sdPs+e+m

Q: 410   VLDESLNRNHFQSYIMADMYSFGLILWEIARRCVS-GGIVEEYQLPYHDLVPSDPSYEDM  468

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         +e+v+ kklrP++p++w+++e+l+++ kl++ecW+++p++Rltalrvkk+l

Q: 469   REIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTL  519

         *************************************************97

Domain Sequence
(FASTA)

IQMVKQIGKG RYGEVWMGKW RGEKVAVKVF FTTEEASWFR ETEIYQTVLM RHENILGFIA 60

ADIKGTGSWT QLYLITDYHE NGSLYDYLKS TTLDTKAMLK LAYSSVSGLC HLHTEIFSTQ 120

GKPAIAHRDL KSKNILVKKN GTCCIADLGL AVKFISDTNE VDIPPNTRVG TKRYMPPEVL 180

DESLNRNHFQ SYIMADMYSF GLILWEIARR CVSGGIVEEY QLPYHDLVPS DPSYEDMREI 240

VCIKKLRPSF PNRWSSDECL RQMGKLMTEC WAHNPASRLT ALRVKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005025	; F:transforming growth factor beta receptor activity, type I
GO:0030509	; P:BMP signaling pathway
GO:0030154	; P:cell differentiation
GO:0006954	; P:inflammatory response
GO:0030501	; P:positive regulation of bone mineralization
GO:0045669	; P:positive regulation of osteoblast differentiation
GO:0023014	; P:signal transduction by phosphorylation

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013