EKS-ANC-00384
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ANC-00384
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Axl515.03.8E-155480745266
StatusUnreviewed
Ensembl ProteinENSACAP00000014027
UniProt AccessionG1KPQ5;
Protein Name
Protein Synonyms/Alias
Gene NameTYRO3
Gene Synonyms/Alias TYRO3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSACAG00000014118ENSACAP00000014027ENSACAT00000014314
OrganismAnolis carolinensis
Functional Description
Protein Length846
Protein Sequence
(FASTA)
GCFLSGTKVT GMPIKLKVSQ GQPVKLNCSL EGMEDPEMLW IKDGAVVQSV DQVYIPVDEE 60
HWIGFLSLKS VDRTDSGKYW CQIETNGKKE ESQQVWLIVE GVPYFTVEPE DLSVVPNTPF 120
HMVCAAAGPP EPVTIVWWMG DSRIGPSDVS PSTLNVSGIN QSTVFSCEAH NIRGLSSSRT 180
ATVHIKVLPF PPLNVTVTQI TSNNANVIWL PGFDGLSPLL SCTVQVAESQ AEEEVVTEVV 240
PVPSFNRALL GLKHSTNYSV RVQCTNEMGS SPFTDWVNFQ TLGLAPNNTP QNVHIIHRDS 300
CLILEWEPAV QEMLRDNTLG YRLEWSQDNI TQGEMVVQDT RANLTMWNPL KDLLIRVCIL 360
NSAGCGPWSE PLLITAEDLI EGQRQPPYGT SWVPVVLGIL TALVTAVSLA LILLRKRRKE 420
TRFGHAFGSM VGGDPIVHFR AVRSFNREVP ELIEATLDSI GISDELKTKL KDVLIQEQQF 480
TLGRMLGKGE FGSVREGQLK LPDGSLQKVA VKMLKADIFT SSDIEDFLKE AACMKEFDHP 540
HVTKLIGVSL RNRPKGRLPI PMVILPFMKH GDLHSFLLMS RIGETPFNLP LRTLLKFMID 600
IASGMEYLSS KNFIHRDLAA RNCMLDENMN VCVADFGLSK KIYSGDYYRQ GCASKLPVKW 660
LALESLADNL YTTHSDVWAF GVTMWEIVTR GQTPYAGIEN AEIYNYLISG NRLKQPPECL 720
EDVYDLMCRC WHSEPKLRPN FAALKLQLEM ILARLSLLST SQDPLYVNIG KPQEACRNDA 780
TANCPFGTLD GEVNITGAAA AVTSDYRYIM SPLCLGNDAE SERHPGLPDG EARGLLYDLE 840
MGAKQC 846
Nucleotide Sequence
(FASTA)
GGTTGTTTTC TTTCAGGAAC GAAGGTTACT GGAATGCCAA TCAAACTGAA GGTGTCTCAG 60
GGGCAGCCGG TAAAACTGAA TTGCAGCCTC GAGGGAATGG AAGATCCAGA GATGCTGTGG 120
ATCAAGGATG GAGCTGTGGT GCAAAGTGTA GACCAGGTGT ACATTCCAGT AGATGAAGAA 180
CACTGGATTG GTTTCCTCAG CTTGAAGTCT GTAGACCGGA CAGATTCTGG GAAATACTGG 240
TGCCAAATTG AGACCAATGG TAAAAAGGAA GAATCGCAGC AAGTGTGGCT CATTGTGGAA 300
GGTGTTCCTT ACTTCACTGT TGAGCCGGAA GATTTGTCTG TTGTCCCGAA TACACCTTTT 360
CATATGGTCT GTGCTGCTGC TGGCCCACCT GAACCAGTTA CAATTGTCTG GTGGATGGGT 420
GATTCCAGAA TAGGGCCTTC AGATGTTTCC CCCTCCACTT TAAATGTGTC AGGTATCAAT 480
CAAAGCACAG TTTTCTCCTG CGAAGCCCAC AACATAAGAG GGCTGTCTTC ATCTCGGACA 540
GCTACTGTGC ATATTAAAGT TCTCCCCTTT CCACCTCTCA ATGTGACAGT AACTCAGATC 600
ACCAGCAACA ATGCCAATGT AATTTGGCTA CCAGGATTCG ACGGGCTTTC TCCACTTCTT 660
TCTTGTACCG TACAGGTGGC TGAATCCCAG GCAGAAGAGG AAGTGGTTAC AGAAGTTGTC 720
CCTGTTCCCT CCTTCAATAG AGCTTTGCTG GGCTTAAAGC ATTCAACCAA TTATAGTGTG 780
CGGGTTCAGT GCACCAATGA AATGGGCAGC TCCCCTTTTA CAGACTGGGT CAATTTTCAG 840
ACCTTGGGAT TAGCTCCAAA TAATACTCCA CAAAATGTAC ACATTATCCA CAGAGACTCT 900
TGCCTGATTT TGGAATGGGA ACCAGCAGTT CAAGAAATGC TTAGGGACAA TACACTTGGA 960
TACAGATTGG AATGGAGTCA AGATAATATA ACACAGGGAG AGATGGTAGT ACAAGACACA 1020
AGAGCTAATC TAACTATGTG GAATCCCTTA AAAGACCTTC TGATCAGGGT GTGCATATTA 1080
AATTCGGCTG GCTGCGGACC ATGGAGTGAG CCTTTATTGA TTACAGCGGA AGATTTAATA 1140
GAAGGACAAC GACAGCCTCC GTATGGGACA TCTTGGGTTC CTGTGGTTTT AGGTATTCTG 1200
ACGGCACTGG TCACAGCTGT TTCCTTGGCA CTGATCCTCC TGAGGAAAAG AAGAAAAGAA 1260
ACCCGTTTTG GTCATGCCTT TGGCAGCATG GTGGGAGGGG ATCCTATAGT CCATTTCCGA 1320
GCAGTGAGAT CTTTCAACAG AGAAGTGCCA GAGCTTATTG AGGCAACATT GGACAGTATA 1380
GGAATCAGTG ATGAACTGAA GACTAAACTG AAAGATGTCC TGATTCAAGA GCAGCAGTTT 1440
ACACTGGGAA GAATGCTAGG CAAGGGAGAA TTTGGTTCTG TAAGAGAAGG TCAGCTGAAA 1500
CTGCCTGATG GCTCTCTTCA AAAAGTTGCA GTGAAAATGC TAAAAGCGGA CATCTTCACT 1560
TCAAGTGATA TAGAAGACTT CCTGAAGGAA GCTGCCTGCA TGAAGGAGTT TGATCATCCA 1620
CATGTTACCA AGCTGATTGG AGTCAGTTTG CGCAACCGGC CTAAAGGCCG TCTTCCAATC 1680
CCAATGGTTA TCCTACCATT TATGAAGCAC GGAGACCTTC ACTCTTTTCT ACTGATGTCT 1740
CGGATTGGAG AAACCCCTTT TAACTTGCCC CTCCGGACCC TCTTAAAATT TATGATTGAT 1800
ATTGCTAGTG GCATGGAGTA CTTGAGCTCC AAAAACTTCA TACACAGGGA CTTGGCTGCC 1860
CGAAACTGCA TGCTGGATGA AAACATGAAT GTATGTGTAG CTGACTTTGG GCTTTCAAAG 1920
AAAATCTATA GTGGAGACTA TTACCGTCAG GGCTGTGCCT CTAAGCTGCC AGTGAAGTGG 1980
CTTGCATTGG AAAGTCTGGC GGACAATCTC TACACAACAC ATAGCGATGT GTGGGCATTT 2040
GGAGTGACAA TGTGGGAGAT TGTGACCCGA GGACAAACTC CTTACGCAGG CATTGAGAAT 2100
GCAGAAATTT ACAACTACCT CATCAGTGGG AACAGACTGA AGCAACCCCC TGAGTGCCTG 2160
GAGGATGTGT ATGATCTCAT GTGTCGATGT TGGCATTCAG AACCCAAGCT ACGCCCTAAC 2220
TTTGCAGCAC TGAAATTGCA ACTTGAAATG ATTTTGGCAA GACTGTCTTT GCTCTCCACC 2280
AGCCAGGATC CTCTTTATGT CAACATTGGG AAACCACAAG AAGCTTGTAG AAATGATGCC 2340
ACAGCAAATT GTCCCTTTGG AACCTTGGAC GGTGAAGTGA ATATTACAGG AGCAGCCGCT 2400
GCTGTCACCA GTGACTATCG TTACATCATG AGCCCCTTGT GCCTTGGGAA TGATGCTGAA 2460
AGTGAAAGAC ATCCAGGTTT ACCGGATGGG GAAGCCAGGG GTCTTCTTTA TGATTTGGAG 2520
ATGGGAGCCA AACAGTGTTA G 2541
Domain Profile
S: 1     lvlgkvlgegefgsvmegqlkqedgsilkvavktlkldiiarseieeflseaacmkefdh  60
         ++lg++lg+gefgsv+egqlk  dgs++kvavk+lk+di+++s+ie+fl+eaacmkefdh
Q: 480   FTLGRMLGKGEFGSVREGQLKLPDGSLQKVAVKMLKADIFTSSDIEDFLKEAACMKEFDH  539
         68**********************************************************
S: 61    pnvirlvgvslessekgrlpkpvvilpfmkygdlhafllysrlgenpvylplqtlvkfmv  120
         p+v +l+gvsl+++ kgrlp+p+vilpfmk+gdlh+fll+sr+ge p++lpl+tl+kfm+
Q: 540   PHVTKLIGVSLRNRPKGRLPIPMVILPFMKHGDLHSFLLMSRIGETPFNLPLRTLLKFMI  599
         ************************************************************
S: 121   diasgmeylssrnfihrdlaarncmlaedmtvcvadfglskkiysgdyyrqgriaklpvk  180
         diasgmeylss+nfihrdlaarncml+e+m vcvadfglskkiysgdyyrqg+++klpvk
Q: 600   DIASGMEYLSSKNFIHRDLAARNCMLDENMNVCVADFGLSKKIYSGDYYRQGCASKLPVK  659
         ************************************************************
S: 181   wiaiesladrvytsksdvwafgvtmweiatrgqtpyagvenaeiydyllqgnrlkqpedc  240
         w+a+eslad++yt++sdvwafgvtmwei+trgqtpyag+enaeiy+yl+ gnrlkqp++c
Q: 660   WLALESLADNLYTTHSDVWAFGVTMWEIVTRGQTPYAGIENAEIYNYLISGNRLKQPPEC  719
         ************************************************************
S: 241   ldelydlmyrcweadpkdrpsfsvlr  266
         l+++ydlm rcw+ +pk rp f+ l+
Q: 720   LEDVYDLMCRCWHSEPKLRPNFAALK  745
         **********************9987
Domain Sequence
(FASTA)
FTLGRMLGKG EFGSVREGQL KLPDGSLQKV AVKMLKADIF TSSDIEDFLK EAACMKEFDH 60
PHVTKLIGVS LRNRPKGRLP IPMVILPFMK HGDLHSFLLM SRIGETPFNL PLRTLLKFMI 120
DIASGMEYLS SKNFIHRDLA ARNCMLDENM NVCVADFGLS KKIYSGDYYR QGCASKLPVK 180
WLALESLADN LYTTHSDVWA FGVTMWEIVT RGQTPYAGIE NAEIYNYLIS GNRLKQPPEC 240
LEDVYDLMCR CWHSEPKLRP NFAALK 266
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00372
EKS-BOT-00399
EKS-CAJ-00404
EKS-CAF-00400
EKS-CAP-00424
EKS-CIS-00152
EKS-DAR-00777
EKS-EQC-00387
EKS-FEC-00382
EKS-GAG-00338
EKS-GAA-00488
EKS-GOG-00387
EKS-HOS-00403
EKS-ICT-00375
EKS-LAC-00416
EKS-LOA-00403
EKS-MAM-00399
EKS-MEG-00329
EKS-MOD-00385
EKS-MUM-00432
EKS-MUP-00390
EKS-MYL-00393
EKS-NOL-00364
EKS-ORN-00511
EKS-ORA-00344
EKS-ORC-00374
EKS-ORL-00465
EKS-OTG-00402
EKS-PAT-00374
EKS-PES-00355
EKS-POA-00391
EKS-PTV-00110
EKS-RAN-00411
EKS-SAH-00365
EKS-SUS-00346
EKS-TAG-00471
EKS-TAR-00502
EKS-TAS-00046
EKS-XET-00511
EKS-XIM-00503
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0043277; P:apoptotic cell clearance
GO:0050728; P:negative regulation of inflammatory response
GO:0045824; P:negative regulation of innate immune response
GO:0051250; P:negative regulation of lymphocyte activation
GO:0043524; P:negative regulation of neuron apoptotic process
GO:0034122; P:negative regulation of toll-like receptor signaling pathway
GO:0070050; P:neuron homeostasis
GO:0046777; P:protein autophosphorylation
GO:0043491; P:protein kinase B signaling cascade
GO:0032940; P:secretion by cell
KEGG
InterPros
IPR003961; Fibronectin_type3.
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF00041; fn3; 1.
PF07679; I-set; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00060; FN3; 2.
SM00409; IG; 1.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50853; FN3; 2.
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013