EKS-ANC-00272

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ANC-00272

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	389.6	8.0E-117	204	497	294

Status

Unreviewed

Ensembl Protein

ENSACAP00000014029

UniProt Accession

G1KPQ7;

Protein Name

Protein Synonyms/Alias

Gene Name

TGFBR2

Gene Synonyms/Alias

TGFBR2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSACAG00000014301	ENSACAP00000014029	ENSACAT00000014316

Organism

Anolis carolinensis

Functional Description

Protein Length

527

Protein Sequence
(FASTA)

NGKIKFPTLC KFCDVKLTNC KNEGQCKSHC NLTSICEKKT EVCAAVWRKN DENITLETIC 60

HDPSQKLHGH ELTDYNSKKC IMSERRETGG LLYMCSCDEE ECNDVLIFSP EYWQTATDMV 120

NVISKVALIS LVPLLVSAIA VSFIFYCYRI QRRRKLNKAW EKNVKSRKRK DCSDVCAIML 180

DDDRSDISST CANNINHNTE LLPIELDTLV GKGRFAEVYK AKLKQNTSEQ FETVAVKIFS 240

YEEYASWKTE KDIFSDINLK HENILQFLTA EERKTDLGKQ YWLITAFHSR GNLQEYLIKH 300

VISWEDLWKL GGSLARGIAH LHSDHTPCGR PKTPIVHRDL KSSNILVKND LTCCLCDFGL 360

SLRLDPTLSV DDLANSGQVG TARYMAPEVL ESRMNLDNVE SFKQTDVYSM ALVLWELTSR 420

CNGVGEVKDY EPPFGSKVRE HPCVESMKDN VLRDRGRPEI PNSWLNHQGI QKVCETLVEC 480

WDHDPEARLT AQCVAERFND FEYQDTLSGR SSSEEKIPEE VSVNSAN 527

Nucleotide Sequence
(FASTA)

AATGGGAAAA TCAAGTTTCC AACACTTTGC AAATTTTGTG ATGTGAAATT AACAAACTGC 60

AAAAATGAAG GCCAGTGCAA GAGTCACTGC AACCTCACAT CTATTTGCGA AAAAAAAACT 120

GAAGTATGTG CAGCTGTTTG GAGAAAAAAT GATGAAAACA TAACATTGGA AACAATATGT 180

CATGATCCAT CGCAAAAGCT CCATGGGCAT GAATTGACAG ACTACAATTC AAAGAAATGT 240

ATAATGTCAG AGAGGAGGGA AACTGGAGGG TTGCTTTATA TGTGCTCCTG CGATGAGGAG 300

GAATGCAATG ATGTACTTAT TTTTTCTCCA GAGTACTGGC AGACAGCAAC AGATATGGTA 360

AATGTGATAT CTAAAGTTGC ACTAATAAGC CTCGTTCCAT TGCTTGTGAG TGCCATTGCT 420

GTGAGCTTTA TCTTCTACTG CTACCGTATT CAGAGGAGGA GGAAGCTGAA CAAGGCATGG 480

GAGAAAAATG TGAAATCCAG GAAACGTAAA GACTGTAGCG ATGTGTGTGC CATTATGTTA 540

GATGATGACC GCTCTGATAT TAGTTCGACT TGTGCCAATA ACATAAACCA TAATACGGAA 600

CTGTTGCCCA TTGAACTGGA TACCCTGGTG GGCAAAGGGC GCTTTGCTGA AGTCTATAAG 660

GCTAAATTGA AACAGAACAC ATCAGAGCAA TTTGAGACAG TGGCTGTCAA GATCTTTTCC 720

TATGAAGAAT ATGCATCCTG GAAGACCGAG AAGGATATAT TCTCCGATAT AAATCTGAAA 780

CATGAGAACA TCCTCCAGTT CCTCACAGCA GAAGAGCGCA AGACGGATCT AGGCAAGCAA 840

TACTGGTTGA TCACTGCTTT CCACTCAAGG GGCAATTTGC AGGAATACCT CATAAAACAC 900

GTAATTAGCT GGGAAGACCT CTGGAAATTG GGTGGATCTT TGGCTCGAGG GATTGCCCAT 960

CTCCACAGTG ACCATACACC CTGTGGCCGC CCCAAAACAC CTATTGTACA CAGGGACCTG 1020

AAGAGCTCCA ATATCTTGGT GAAAAATGAC TTAACCTGCT GCCTCTGTGA TTTTGGACTT 1080

TCATTGAGGC TGGATCCTAC TCTTTCTGTA GATGACCTAG CCAACAGTGG TCAGGTCGGC 1140

ACTGCAAGAT ACATGGCTCC TGAAGTCCTG GAATCACGAA TGAATTTGGA TAATGTTGAA 1200

TCCTTCAAGC AGACAGATGT GTATTCCATG GCCTTAGTTC TATGGGAACT GACATCCCGT 1260

TGCAATGGTG TTGGAGAGGT CAAAGACTAT GAGCCCCCAT TTGGTTCTAA AGTGAGAGAA 1320

CATCCTTGCG TGGAAAGCAT GAAGGACAAC GTTTTGAGGG ACAGAGGGCG ACCAGAGATT 1380

CCTAACTCAT GGCTCAACCA TCAGGGCATC CAGAAAGTCT GTGAGACTCT TGTGGAGTGC 1440

TGGGACCATG ACCCTGAAGC CCGGCTCACT GCTCAGTGCG TAGCTGAGCG GTTCAATGAT 1500

TTTGAATACC AGGACACACT TTCAGGAAGA AGCAGCTCTG AAGAGAAGAT CCCTGAGGAG 1560

GTCTCTGTGA ACAGTGCCAA CTAA 1584

Domain Profile

S: 1     lklleligkGrygeVwkaklrg......eevAvKifstedeaswkrEkeiyqtvllrhen  54

         ++l +l+gkGr++eV+kakl++      e+vAvKifs+e+ aswk+Ek+i++ ++l+hen

Q: 204   IELDTLVGKGRFAEVYKAKLKQntseqfETVAVKIFSYEEYASWKTEKDIFSDINLKHEN  263

         678899***************99999999*******************************

S: 55    ilqfiaadkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHe  114

         ilqf++a+++++d+ ++++l+t++h +g+L++yL ++++++e+l +l  sla+G+ahLH+

Q: 264   ILQFLTAEERKTDLGKQYWLITAFHSRGNLQEYLIKHVISWEDLWKLGGSLARGIAHLHS  323

         ************************************************************

S: 115   eivgtkgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtk  174

         + ++ +g+ K  i+HRDlks Nilvk+dltcc++D+GL+l+l+ + ++ dla++ qvGt

Q: 324   D-HTPCGRPKTPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTA  382

         *.8999******************************************************

S: 175   RYmaPEvleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsd  234

         RYmaPEvle+++nl+++e+fk++DvYs++LvlWE++sRc+   +ev++y++pf ++v+++

Q: 383   RYMAPEVLESRMNLDNVESFKQTDVYSMALVLWELTSRCNG-VGEVKDYEPPFGSKVREH  441

         *****************************************.999***************

S: 235   PsleemkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkr  290

         P++e+mk+ v++++ rP+ip++w +++ +++++++l ecWd+dpeaRlta++v++r

Q: 442   PCVESMKDNVLRDRGRPEIPNSWLNHQGIQKVCETLVECWDHDPEARLTAQCVAER  497

         *****************************************************987

Domain Sequence
(FASTA)

IELDTLVGKG RFAEVYKAKL KQNTSEQFET VAVKIFSYEE YASWKTEKDI FSDINLKHEN 60

ILQFLTAEER KTDLGKQYWL ITAFHSRGNL QEYLIKHVIS WEDLWKLGGS LARGIAHLHS 120

DHTPCGRPKT PIVHRDLKSS NILVKNDLTC CLCDFGLSLR LDPTLSVDDL ANSGQVGTAR 180

YMAPEVLESR MNLDNVESFK QTDVYSMALV LWELTSRCNG VGEVKDYEPP FGSKVREHPC 240

VESMKDNVLR DRGRPEIPNS WLNHQGIQKV CETLVECWDH DPEARLTAQC VAER 294

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005901	; C:caveola
GO:0009897	; C:external side of plasma membrane
GO:0016021	; C:integral to membrane
GO:0043235	; C:receptor complex
GO:0005524	; F:ATP binding
GO:0005539	; F:glycosaminoglycan binding
GO:0046872	; F:metal ion binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005026	; F:transforming growth factor beta receptor activity, type II
GO:0032147	; P:activation of protein kinase activity
GO:0006915	; P:apoptotic process
GO:0060389	; P:pathway-restricted SMAD protein phosphorylation
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:0002663	; P:positive regulation of B cell tolerance induction
GO:0010634	; P:positive regulation of epithelial cell migration
GO:0002053	; P:positive regulation of mesenchymal cell proliferation
GO:0051138	; P:positive regulation of NK T cell differentiation
GO:2000379	; P:positive regulation of reactive oxygen species metabolic process
GO:0002666	; P:positive regulation of T cell tolerance induction
GO:0002651	; P:positive regulation of tolerance induction to self antigen
GO:0070723	; P:response to cholesterol
GO:0042493	; P:response to drug
GO:0023014	; P:signal transduction by phosphorylation
GO:0007224	; P:smoothened signaling pathway
GO:0007179	; P:transforming growth factor beta receptor signaling pathway

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR017194	; Transform_growth_fac-b_typ-2.
IPR015013	; Transforming_GF_b_rcpt_2_ecto.

Pfam

PF08917	; ecTbetaR2; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013