EKS-ANC-00008
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ANC-00008
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph485.81.9E-146595851257
StatusUnreviewed
Ensembl ProteinENSACAP00000014651
UniProt AccessionH9GLN7;
Protein Name
Protein Synonyms/Alias
Gene NameEPHA8
Gene Synonyms/Alias EPHA8;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSACAG00000014526ENSACAP00000014651ENSACAT00000014948
OrganismAnolis carolinensis
Functional Description
Protein Length959
Protein Sequence
(FASTA)
VNLLDTSTII GDWGWLTYPS HGWDSINEMD EFFNPIHTYQ VCNVMSPNQN NWLRTSWVQR 60
HGAHRVYAEI RFTLRDCNSM PGVLGTCKET FNLYYLQSDR DLGSAPRESQ FVKIDTIAAD 120
ESFTNVDLGV RRLKLNTEVR GVGPLTKRGF YLAFQDIGAC IAVVSVRVYY KKCPAMVRNL 180
ASFSEAITGA DSSSLVEVRG ECVRNAEERD TPKMYCSAEG EWLVPIGKCV CSAGYEELRD 240
SCRACQVGSY KSSPGDQLCA KCPPHSYSET PAAQVCRCET GFYRAALDLP SVACTRPPSA 300
PMGLLSSVNG TSVTLDWAPP QDKGGRSDVI YNVICRRCTW DSGQCEACGA GIRFVPQQMN 360
LAQGSLAVGN LLAHTNYSFW VEAVNGVSDL SPEPPQFTAV NITTNQAAPS QVVGVHQENV 420
GQSSITLLWQ EPEQPNGIIL EYEIKYYEKD KEMQSYSTLK SKGNSTTVSG LKPATRYVFQ 480
VRARTSAGCG RFSQAMEVET AKATVPRYDT ATVVWVCLTL ISGLVTLLLF LICKKRCARH 540
CGYSKAFQDS DEEKMHYQNG QVKFPESKFY VEPHTYEDPC QAVHEFTREI EASRIKIEKV 600
IGCGESGEVC YGRLKLPGKR EMPVAVKALK AGYTETQRRD FLSEASIMAQ FDHPYVIHLE 660
GVVTKSKLVM IVTEYMENGS LDSFLRKHDG QFTVLQLVVM LRGIGAGMRY LADLGYVHRD 720
LAARNILVNG NLVCKVSDFG LSRVLENNPE AAYTTTGGKI PVRWTAPEAI TYRKFSSASD 780
VWSYGIVMWE VLAYGERPYW NMTNRDVIQS VEEGYRLPAP MGCPTALHQL MLDCWQKDRN 840
ERPRFSQIVG ILDKLIRSPQ NLKCTATVSR FTQTLSERGC IEFTSCSTVE DWLDSIRLGR 900
YRDNFALAGY SSLGMVMRMS IEDVQSLGIS LVGHQRKILT SIQIMRSQLL NTMGSQRHL 959
Nucleotide Sequence
(FASTA)
GTGAATTTGC TGGACACTTC CACCATTATC GGCGACTGGG GCTGGCTCAC CTACCCTTCT 60
CATGGGTGGG ACTCCATCAA TGAAATGGAC GAGTTTTTCA ACCCGATCCA CACCTACCAA 120
GTGTGCAACG TCATGTCGCC GAACCAGAAC AACTGGCTGC GGACGAGTTG GGTGCAGCGG 180
CACGGGGCGC ACCGGGTCTA TGCGGAGATC CGCTTCACCC TGCGGGACTG CAACAGCATG 240
CCCGGGGTGC TGGGCACCTG CAAGGAGACC TTCAACCTCT ACTACCTCCA GTCCGACCGG 300
GACTTGGGCA GCGCCCCCCG CGAGAGCCAG TTCGTGAAGA TCGACACCAT CGCGGCCGAC 360
GAGAGCTTCA CCAACGTGGA CCTGGGCGTC CGGCGGCTCA AGCTCAACAC CGAGGTGCGG 420
GGCGTCGGGC CGCTGACCAA GCGAGGCTTC TACTTGGCCT TCCAGGACAT CGGCGCCTGC 480
ATCGCCGTCG TCTCCGTCCG CGTCTACTAC AAGAAGTGCC CAGCCATGGT GAGGAACCTG 540
GCCTCGTTCT CCGAGGCCAT CACCGGGGCC GACTCCTCGT CTCTCGTGGA AGTCCGCGGC 600
GAGTGCGTCC GGAACGCGGA GGAGAGGGAC ACCCCCAAAA TGTACTGCAG CGCGGAAGGA 660
GAATGGCTGG TGCCCATCGG GAAGTGCGTC TGCAGCGCCG GATACGAAGA GCTGAGGGAT 720
TCTTGCCGAG CCTGTCAAGT GGGCTCTTAC AAGTCTTCCC CGGGGGACCA GCTTTGTGCC 780
AAGTGCCCAC CCCACAGCTA TTCGGAGACC CCGGCGGCGC AGGTGTGTCG TTGCGAAACT 840
GGCTTTTACC GAGCGGCACT GGACCTCCCT TCGGTGGCCT GCACACGTCC TCCCTCGGCG 900
CCCATGGGCC TGTTGTCCAG CGTGAACGGC ACCTCGGTGA CCCTGGACTG GGCCCCTCCG 960
CAGGACAAAG GGGGCCGCAG TGACGTCATC TACAACGTCA TCTGTCGCCG CTGCACGTGG 1020
GACTCGGGGC AGTGCGAAGC CTGTGGGGCC GGCATCCGCT TTGTGCCCCA GCAGATGAAC 1080
CTGGCCCAGG GCTCTCTGGC GGTCGGCAAC CTCCTGGCTC ACACCAACTA CTCCTTCTGG 1140
GTGGAGGCCG TCAACGGGGT CTCGGACCTG AGCCCCGAGC CACCACAGTT CACGGCCGTC 1200
AACATCACCA CGAACCAGGC AGCTCCGTCG CAAGTGGTGG GCGTCCACCA GGAGAACGTG 1260
GGTCAAAGCA GCATCACACT TCTGTGGCAA GAACCGGAAC AACCCAACGG CATTATCCTG 1320
GAATATGAAA TCAAGTACTA CGAGAAGGAC AAAGAAATGC AGAGTTACTC CACCTTGAAG 1380
TCCAAAGGCA ACAGCACCAC CGTTTCCGGT CTGAAGCCGG CCACCCGCTA TGTCTTCCAG 1440
GTCCGAGCCC GGACCTCCGC CGGCTGCGGC CGATTCAGCC AAGCCATGGA AGTCGAAACG 1500
GCCAAAGCAA CAGTTCCTCG TTACGACACC GCCACCGTCG TCTGGGTCTG CCTCACACTT 1560
ATCAGCGGAC TCGTCACCCT GCTTTTGTTT CTGATTTGCA AAAAGAGGTG TGCCAGGCAC 1620
TGCGGCTACA GCAAAGCTTT CCAGGACTCC GATGAGGAGA AGATGCATTA CCAGAACGGA 1680
CAAGTGAAGT TCCCTGAGTC CAAGTTCTAT GTGGAGCCGC ACACTTACGA GGACCCTTGC 1740
CAAGCGGTGC ACGAATTCAC CCGGGAGATC GAAGCCTCCA GGATTAAGAT CGAGAAAGTC 1800
ATTGGATGTG GGGAGTCGGG CGAAGTGTGC TACGGCCGGC TGAAGTTGCC CGGCAAGCGG 1860
GAGATGCCCG TGGCGGTCAA GGCTCTGAAG GCCGGCTACA CCGAGACGCA GAGGCGGGAC 1920
TTCCTGAGCG AAGCCAGCAT CATGGCGCAA TTCGACCACC CCTACGTCAT CCACCTGGAA 1980
GGGGTCGTCA CCAAAAGCAA ATTAGTCATG ATTGTGACCG AGTACATGGA GAACGGCTCG 2040
CTGGATTCCT TCCTCCGGAA ACACGACGGG CAGTTCACCG TCCTCCAGCT GGTGGTCATG 2100
CTGCGGGGCA TCGGTGCCGG CATGCGCTAT CTCGCTGACC TGGGCTACGT GCACCGCGAC 2160
CTGGCTGCCC GCAACATCCT GGTCAATGGC AACTTGGTCT GCAAAGTCTC CGACTTCGGA 2220
CTCTCCCGGG TCCTGGAGAA TAATCCCGAG GCAGCTTATA CCACCACGGG TGGGAAGATC 2280
CCAGTTCGGT GGACGGCGCC CGAAGCCATC ACATACCGGA AGTTCTCCTC GGCCAGCGAC 2340
GTGTGGAGCT ATGGCATTGT CATGTGGGAA GTGCTGGCGT ACGGAGAGCG GCCATATTGG 2400
AACATGACGA ACCGGGATGT CATCCAGTCC GTGGAGGAAG GCTACCGGCT GCCGGCCCCC 2460
ATGGGCTGCC CCACCGCCCT CCACCAGCTC ATGCTGGACT GCTGGCAGAA AGACCGCAAC 2520
GAGAGGCCGC GCTTCTCCCA AATCGTCGGC ATCCTGGACA AGCTCATCCG CAGCCCACAG 2580
AACCTGAAGT GCACGGCCAC CGTCAGCCGG TTCACCCAAA CCCTTTCGGA GAGAGGCTGC 2640
ATCGAATTCA CCAGCTGCTC CACCGTCGAA GACTGGTTGG ACTCCATTCG GCTGGGCCGA 2700
TATCGAGACA ACTTTGCCCT GGCCGGCTAC TCATCCCTCG GCATGGTGAT GCGGATGAGC 2760
ATCGAGGATG TGCAGAGCCT GGGGATCAGC CTGGTGGGAC ACCAGAGGAA AATCTTGACC 2820
AGCATCCAGA TCATGCGGTC TCAGCTGCTC AACACCATGG GCTCCCAAAG ACACCTCTGA 2880
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         +kiekviG Ge Gevc Grlklpgkre++va+k+lkag+te qrrdflseasi+ qfdhp
Q: 595   IKIEKVIGCGESGEVCYGRLKLPGKREMPVAVKALKAGYTETQRRDFLSEASIMAQFDHP  654
         79**********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
          +i+leGvvtksk vmivteymeng+ldsflrk+dgqftv+qlv mlrGi++gm+yl+d+
Q: 655   YVIHLEGVVTKSKLVMIVTEYMENGSLDSFLRKHDGQFTVLQLVVMLRGIGAGMRYLADL  714
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrk  180
         gyvhrdlaarnilvn nlvckvsdfGlsrvle+++eaaytt+ggkip+rwtapeai+yrk
Q: 715   GYVHRDLAARNILVNGNLVCKVSDFGLSRVLENNPEAAYTTTGGKIPVRWTAPEAITYRK  774
         ************************************************************
S: 181   ftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldc  240
         f+sasdvwsyGiv+wevl+yGerpyw+m+n+dvi+++eegyrlp+pm+cp+al+qlmldc
Q: 775   FSSASDVWSYGIVMWEVLAYGERPYWNMTNRDVIQSVEEGYRLPAPMGCPTALHQLMLDC  834
         ************************************************************
S: 241   wqkdraerpkfeqivsi  257
         wqkdr+erp+f+qiv i
Q: 835   WQKDRNERPRFSQIVGI  851
         **************987
Domain Sequence
(FASTA)
IKIEKVIGCG ESGEVCYGRL KLPGKREMPV AVKALKAGYT ETQRRDFLSE ASIMAQFDHP 60
YVIHLEGVVT KSKLVMIVTE YMENGSLDSF LRKHDGQFTV LQLVVMLRGI GAGMRYLADL 120
GYVHRDLAAR NILVNGNLVC KVSDFGLSRV LENNPEAAYT TTGGKIPVRW TAPEAITYRK 180
FSSASDVWSY GIVMWEVLAY GERPYWNMTN RDVIQSVEEG YRLPAPMGCP TALHQLMLDC 240
WQKDRNERPR FSQIVGI 257
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00010
EKS-BOT-00009
EKS-CAJ-00010
EKS-CAF-00011
EKS-CAP-00008
EKS-DAR-00014
EKS-EQC-00011
EKS-FEC-00008
EKS-GAG-00009
EKS-GAA-00013
EKS-GOG-00010
EKS-HOS-00010
EKS-ICT-00010
EKS-LOA-00011
EKS-MAM-00008
EKS-MEG-00008
EKS-MOD-00010
EKS-MUM-00011
EKS-MUP-00011
EKS-MYL-00012
EKS-NOL-00010
EKS-OCP-00001
EKS-ORN-00013
EKS-ORC-00010
EKS-ORL-00016
EKS-OTG-00011
EKS-PES-00012
EKS-RAN-00010
EKS-SAH-00010
EKS-SUS-00008
EKS-TAG-00007
EKS-XIM-00014
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005004; F:GPI-linked ephrin receptor activity
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR020691; EphrinA_rcpt8.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013