EKS-ANC-00382

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ANC-00382

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	324.8	4.7E-97	1075	1339	265

Status

Unreviewed

Ensembl Protein

ENSACAP00000014475

UniProt Accession

G1KQ87;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K1

Gene Synonyms/Alias

MAP3K1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSACAG00000014703	ENSACAP00000014475	ENSACAT00000014770

Organism

Anolis carolinensis

Functional Description

Protein Length

1344

Protein Sequence
(FASTA)

REMENKETLR GLQKMDDRPE ERMIREKLKA TCMPAWKHEW LERRSRRGPV VVKPIPIKGD 60

GCEANKLAAD PPPEGHPPAT SPTQKGRRSP SPSSTSSSSS RTVKSESPGV RRKRVSPVPF 120

QSGRITPPRR APSPDGFSPY SPEETSRRVN KVMRARLYLL QQIGPNSFLI GGDSPDNKYR 180

VFIGPQTCSC GRGTFCIHLL FVMLRVFQLE SSDPMLWRKT LKNFEVESLF QKYHSRRSSR 240

IKAPSRNTIQ KFVSRMSNSH TLSSSSTSTS SSENSIKDEE EQMCPICLLG MLDEESLTVC 300

EDGCRNKLHH HCMSIWAEEC RRNREPLICP LCRSKWRSHD FYSHELPSPV DSPSVLRVVQ 360

QQTQQSTPGS PRRNQDSNFN LPHYGVQQIP PAYKDLAEPW IQVFGMELVG CLFSRNWNIR 420

EMALRRLSHD VSGALLLANG ESTGNSGSNG GNTTSAGTLG AASGSSQTII SGEIVVESCC 480

SVLSMVCADP VYKVYVAALK TLRAMLVYTP CHSLAERAKL QQLLKPVVET ILVKCADANS 540

RTSQLSVSTL LEMCKGQAGE LAVGREILKS GSIGIGGIDF VLNCILGTQH ESNNWQALLG 600

RLCLIDRLLL EFPGEFYPHI VSGDVLQADS VVDRYKKLLS LLSFALQSID NSHSMVGKLS 660

RRVFLSAARM VARVPHVFVK LLEMLSITSS THHTRMRRRL MAIADEMEIA EAIQLGMEEM 720

HSSECRHVFV QPLVPDNSPE STESNTPNNT IQLSGRNGKD VVDKKLASPE DISDTVAGIS 780

LGLPVSSGST EQPKPAVQTK GRSHGQCLNS SLSPCHSQSV FPISPSPPTS IPAGADIAKH 840

RPQGFVPCKI PSASPQTQRK LSLQIQRNCA EHKESEKLSP VFTQPRHLPF SHIHRPKPSR 900

PNPCDMNKQG EPSKNSMTLN LNDIAHCDGG GSGNAVIPSG ETVFTPVEEK HDQLDINPEL 960

NSSMEDLLEA SMPTSDGTVT FKSEVAVLSP ERAENDNTYK DDVNHNQKCK EKMEAEEEEA 1020

LAIAMAMSAS QDALPIVPQL QVENGQDIII IQQDTPETLP GHTKAKHHYR EDVEWLKGQQ 1080

IGLGAFSSCY QAQDVGTGTL MAVKQVTYVR NTSSEQEEVV EALREEIRMM NHLNHPNIIR 1140

MLGATCEKSN YNLFIEWMAG GSVAHLLSKY GAFKESVVAN YTEQLLRGLA YLHENQIIHR 1200

DVKGANLLID STGHRLRIAD FGAAARLASK GTGAGEFQGQ LLGTIAFMAP EVLRGQQYGR 1260

SCDVWSVGCA IIEMACAKPP WNAEKHSNHL ALIFKIASAT TAPSIPPHLT PGLRDVALRC 1320

LELQPQDRPP ARELLKHPVF RTTW 1344

Nucleotide Sequence
(FASTA)

CGTGAGATGG AGAATAAAGA AACACTTAGG GGATTGCAGA AAATGGACGA CCGCCCAGAA 60

GAGCGCATGA TCAGGGAGAA GCTCAAAGCA ACATGTATGC CTGCCTGGAA GCATGAGTGG 120

CTTGAAAGAA GAAGTAGGAG AGGCCCTGTG GTGGTAAAGC CAATACCAAT TAAAGGAGAT 180

GGCTGTGAAG CAAACAAACT AGCAGCAGAC CCTCCTCCTG AAGGACATCC TCCTGCTACT 240

TCACCTACTC AGAAGGGAAG ACGGAGCCCT TCCCCTAGCA GTACTTCTTC ATCTTCTTCT 300

AGGACTGTTA AATCTGAATC ACCTGGTGTA AGAAGGAAGA GGGTATCTCC CGTCCCTTTT 360

CAGAGTGGAC GAATAACTCC ACCACGCAGG GCTCCATCTC CAGATGGCTT CTCACCTTAT 420

AGTCCAGAGG AAACAAGTCG GCGGGTCAAC AAAGTCATGA GAGCCAGATT GTACCTCTTA 480

CAGCAGATAG GACCCAATTC TTTCTTGATA GGAGGAGACA GCCCTGATAA TAAATATAGG 540

GTATTCATTG GTCCTCAGAC CTGTAGTTGT GGACGTGGAA CGTTTTGCAT TCATCTGCTG 600

TTTGTTATGC TTCGAGTATT TCAACTTGAA TCTTCAGATC CAATGCTCTG GCGAAAGACT 660

TTGAAGAATT TTGAGGTTGA GAGTTTGTTC CAGAAATATC ACAGTAGGCG TAGCTCAAGG 720

ATCAAAGCCC CATCTCGTAA CACCATCCAG AAGTTTGTCT CACGCATGTC AAATTCTCAT 780

ACATTGTCAT CATCTAGTAC GTCTACATCT AGTTCAGAAA ACAGTATCAA GGATGAAGAA 840

GAACAGATGT GCCCCATTTG TTTGCTGGGC ATGTTGGATG AAGAGAGCTT AACTGTGTGT 900

GAAGATGGCT GTAGAAATAA GCTTCACCAC CACTGCATGT CAATATGGGC AGAGGAATGT 960

AGAAGAAACA GAGAACCTCT TATATGCCCA CTTTGTAGAT CTAAGTGGCG ATCTCATGAT 1020

TTCTATAGCC ATGAGTTGCC AAGCCCAGTT GATTCTCCTT CTGTCCTTCG TGTGGTCCAG 1080

CAGCAGACTC AGCAGTCGAC ACCTGGCTCA CCGAGGAGGA ACCAAGATAG TAATTTTAAC 1140

CTTCCTCATT ATGGGGTTCA GCAAATCCCA CCAGCCTACA AAGATTTAGC TGAACCATGG 1200

ATTCAGGTAT TTGGAATGGA ATTAGTTGGC TGCTTGTTTT CACGAAACTG GAATATACGT 1260

GAGATGGCCC TTAGACGTCT CTCCCATGAT GTTAGTGGTG CTCTGTTACT GGCTAATGGT 1320

GAAAGCACTG GAAATTCTGG AAGCAACGGT GGCAATACCA CAAGTGCTGG AACTCTAGGA 1380

GCAGCTAGTG GGTCATCACA GACCATTATC TCAGGAGAAA TTGTTGTGGA GTCCTGCTGC 1440

AGTGTACTTT CCATGGTTTG CGCTGATCCT GTCTACAAAG TGTATGTTGC TGCTTTAAAA 1500

ACCCTAAGAG CCATGCTGGT ATACACACCC TGCCATAGCC TAGCAGAGAG GGCAAAATTG 1560

CAACAACTTC TAAAGCCAGT TGTGGAGACT ATATTGGTGA AGTGTGCAGA TGCCAACAGC 1620

CGTACAAGCC AACTTTCTGT TTCAACACTG CTGGAGATGT GCAAAGGCCA GGCAGGAGAG 1680

CTAGCAGTTG GCAGAGAAAT ACTTAAATCT GGATCTATTG GCATTGGTGG CATTGATTTT 1740

GTCTTAAATT GCATCCTTGG AACACAACAT GAATCAAACA ACTGGCAAGC GCTGCTTGGA 1800

CGTCTTTGTC TTATAGATAG ACTGCTGTTG GAGTTTCCGG GTGAATTTTA TCCGCACATT 1860

GTTAGTGGGG ATGTTTTGCA GGCTGACTCT GTTGTAGACA GGTACAAAAA GCTGCTGTCA 1920

CTGTTGAGCT TTGCTCTGCA GTCAATTGAC AACTCTCATT CAATGGTTGG CAAGCTGTCC 1980

CGGAGGGTAT TTTTAAGTGC TGCCAGAATG GTTGCAAGAG TGCCCCATGT GTTTGTAAAG 2040

CTGTTAGAAA TGTTGAGTAT TACAAGTTCA ACACATCATA CAAGGATGCG TCGACGGCTG 2100

ATGGCAATAG CAGATGAAAT GGAAATTGCA GAGGCCATCC AGTTAGGGAT GGAAGAGATG 2160

CATTCCAGTG AATGCAGGCA TGTATTTGTG CAGCCTCTGG TTCCTGATAA CTCTCCAGAG 2220

TCAACAGAGA GCAATACTCC AAATAACACA ATCCAGTTAT CAGGGAGAAA TGGAAAAGAT 2280

GTGGTTGATA AAAAACTTGC CAGTCCTGAA GACATTTCTG ACACAGTGGC TGGTATTTCC 2340

CTGGGACTTC CTGTTTCTTC AGGATCAACG GAGCAACCAA AGCCAGCTGT TCAGACAAAA 2400

GGCAGATCCC ATGGTCAATG CTTGAACTCT TCCCTCTCAC CTTGTCATTC CCAGTCGGTC 2460

TTCCCAATTT CACCTTCCCC TCCTACTTCT ATACCTGCAG GAGCAGATAT TGCTAAACAC 2520

AGACCTCAGG GATTTGTTCC CTGCAAAATA CCCTCTGCTT CTCCTCAAAC GCAGCGGAAG 2580

CTTTCCCTCC AAATTCAAAG AAACTGTGCT GAACATAAAG AATCAGAAAA ACTTTCCCCA 2640

GTTTTTACAC AGCCCAGGCA CCTGCCGTTC AGTCATATAC ACCGGCCAAA GCCATCTCGA 2700

CCCAATCCTT GTGACATGAA TAAACAGGGA GAACCCTCTA AAAATAGCAT GACACTTAAT 2760

TTAAATGATA TAGCACATTG TGATGGTGGT GGTAGTGGTA ATGCAGTAAT ACCAAGTGGA 2820

GAGACTGTTT TCACACCTGT GGAAGAAAAA CATGATCAAC TGGATATTAA TCCTGAGCTT 2880

AATTCCAGTA TGGAGGATTT ACTTGAGGCA TCTATGCCAA CTAGTGATGG AACAGTCACC 2940

TTCAAGTCTG AAGTGGCGGT TCTGTCACCT GAACGTGCAG AAAATGACAA CACATACAAA 3000

GATGATGTAA ATCACAATCA GAAGTGCAAG GAAAAGATGG AAGCTGAGGA AGAAGAAGCG 3060

TTAGCTATTG CAATGGCAAT GTCAGCATCT CAGGATGCCC TACCAATTGT TCCTCAACTA 3120

CAGGTTGAGA ATGGTCAAGA TATCATCATT ATTCAGCAGG ATACACCAGA GACCCTGCCT 3180

GGGCATACCA AAGCAAAGCA CCATTACAGG GAAGATGTAG AATGGCTTAA AGGTCAACAG 3240

ATTGGCCTTG GTGCATTTTC TTCATGCTAT CAAGCTCAGG ATGTTGGAAC TGGGACATTA 3300

ATGGCAGTGA AACAGGTGAC ATATGTCAGG AATACATCAT CTGAACAGGA AGAAGTGGTA 3360

GAAGCATTGA GGGAAGAGAT AAGGATGATG AATCATTTGA ACCATCCCAA TATCATTCGA 3420

ATGCTGGGAG CGACATGTGA AAAGAGCAAC TACAATCTCT TTATAGAATG GATGGCAGGG 3480

GGATCTGTTG CTCATTTGTT AAGTAAATAT GGAGCCTTTA AAGAATCTGT GGTTGCAAAC 3540

TACACAGAGC AGTTGCTTCG TGGCCTTGCT TACCTTCATG AGAATCAGAT CATTCACAGA 3600

GACGTTAAAG GTGCCAACTT ACTCATTGAC AGTACAGGCC ATAGACTAAG AATTGCTGAT 3660

TTTGGAGCTG CAGCTAGGTT GGCATCGAAA GGAACGGGTG CTGGAGAGTT TCAAGGACAG 3720

TTGTTGGGGA CCATTGCATT TATGGCACCT GAGGTGTTGA GAGGCCAGCA GTATGGCAGG 3780

AGCTGTGATG TGTGGAGCGT TGGTTGTGCG ATTATAGAAA TGGCTTGTGC TAAACCCCCC 3840

TGGAACGCTG AGAAACATTC CAATCATCTT GCTTTGATAT TTAAGATTGC CAGTGCAACT 3900

ACAGCTCCTT CGATTCCGCC ACATCTGACT CCAGGCTTAA GGGATGTGGC GCTTCGATGC 3960

TTGGAGCTTC AACCTCAGGA CAGACCCCCC GCAAGGGAGT TGCTGAAACA CCCCGTCTTC 4020

CGCACTACGT GGTAA 4035

Domain Profile

S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikpekksekk.evkalkeEikllkelk  59

         w k+++ig G+f+s+y+a+dv tg+l+avK+v++ ++++se++ +v+al+eEi+++++l+

Q: 1075  WLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEeVVEALREEIRMMNHLN  1134

         899*******************************999998887699**************

S: 60    HenivkyyGveveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLHe  119

         H+ni++++G+++e++++++f+E+++gGs+++ll+kyg+++esv+ +yt+q+l+glayLHe

Q: 1135  HPNIIRMLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFKESVVANYTEQLLRGLAYLHE  1194

         ************************************************************

S: 120   kkivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaae.lesltGtlaymaPEvik  177

         ++i+HRD+KgaN+l+ds    ++++DFGa++rla++ t a+e + +l Gt+a+maPEv++

Q: 1195  NQIIHRDVKGANLLIDStGHRLRIADFGAAARLASKGTGAGEfQGQLLGTIAFMAPEVLR  1254

         *****************5668******************9996779*************9

S: 178   kkekgygrkaDiWslgcvviemltgkrPfa..eldeelaimfkvgakktkPeipeklsee  235

         ++  +ygr++D+Ws+gc++iem+++k+P++  +++++la++fk+++++t+P+ip +l++

Q: 1255  GQ--QYGRSCDVWSVGCAIIEMACAKPPWNaeKHSNHLALIFKIASATTAPSIPPHLTPG  1312

         98..8************************87678899***********************

S: 236   gkdflekcleldpkkrpsaeeLLkhef  262

          +d+  +clel+p++rp a+eLLkh++

Q: 1313  LRDVALRCLELQPQDRPPARELLKHPV  1339

         *************************86

Domain Sequence
(FASTA)

WLKGQQIGLG AFSSCYQAQD VGTGTLMAVK QVTYVRNTSS EQEEVVEALR EEIRMMNHLN 60

HPNIIRMLGA TCEKSNYNLF IEWMAGGSVA HLLSKYGAFK ESVVANYTEQ LLRGLAYLHE 120

NQIIHRDVKG ANLLIDSTGH RLRIADFGAA ARLASKGTGA GEFQGQLLGT IAFMAPEVLR 180

GQQYGRSCDV WSVGCAIIEM ACAKPPWNAE KHSNHLALIF KIASATTAPS IPPHLTPGLR 240

DVALRCLELQ PQDRPPAREL LKHPV 265

Keyword

ATP-binding; Complete proteome; Metal-binding; Nucleotide-binding; Reference proteome; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Vicugna pacos"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0008545	; F:JUN kinase kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0008270	; F:zinc ion binding
GO:0008637	; P:apoptotic mitochondrial changes
GO:0071260	; P:cellular response to mechanical stimulus
GO:0030838	; P:positive regulation of actin filament polymerization
GO:0030334	; P:regulation of cell migration
GO:0007179	; P:transforming growth factor beta receptor signaling pathway
GO:0042060	; P:wound healing

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR001841	; Znf_RING.
IPR013083	; Znf_RING/FYVE/PHD.
IPR007527	; Znf_SWIM.

Pfam

PF00069	; Pkinase; 1.
PF04434	; SWIM; 1.

SMARTs

SM00184	; RING; 1.
SM00220	; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50089	; ZF_RING_2; 1.
PS50966	; ZF_SWIM; 1.

Prints

Created Date

20-Feb-2013